Article
Microbiology
Huimin Huang, Yongtao Li, Dongliang Li, Li Wang, Wenqiang Jiao, Yilin Bai, Gaiping Zhang
Summary: This study reveals the role of PTPN14 in PEDV infection. PTPN14 overexpression inhibits PEDV infection, while PTPN14 knockdown or phosphatase inhibitor treatment promotes PEDV proliferation. Furthermore, PTPN14 may regulate PEDV infection by dephosphorylating STAT3 in the cytoplasm.
VETERINARY MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ana E. F. Ferreira, Joana Santiago, Joana V. V. Silva, Pedro E. F. Oliveira, Margarida Fardilha
Summary: This review provides an overview of the protein phosphorylation-dependent biochemical pathways underlying sperm motility acquisition and hyperactivation, as well as the research advances in PP inhibitors. Further research in this area, particularly using other PP inhibitors, is necessary due to the increasing cases of male infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Zina Wen, Zhen Lei, Erpo Tian, Yiyan Wang, Ying Zhong, Ren-shan Ge
Summary: Ziram, an endocrine disruptor, can effectively inhibit sperm motility and forward motility, reduce the level of tyrosine protein kinase, and irreversibly impact sperm capacitation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Obstetrics & Gynecology
Joana Vieira Silva, Maria Joao Freitas, Joana Santiago, Sarah Jones, Sofia Guimaraes, Srinivasan Vijayaraghavan, Steven Publicover, Giorgio Colombo, John Howl, Margarida Fardilha
Summary: By designing bioportides with targeting PP1 disrupting function, the sperm vitality and motility were significantly affected, providing a new research approach for predicting male fertility indicators.
FERTILITY AND STERILITY
(2021)
Article
Biochemical Research Methods
Raiha Tahir, Anil K. Madugundu, Savita Udainiya, Jevon A. Cutler, Santosh Renuse, Li Wang, Nicole A. Pearson, Christopher J. Mitchell, Nupam Mahajan, Akhilesh Pandey, Xinyan Wu
Summary: In this study, the researchers used BioID to explore the interactome of TNK2, identifying both known and novel interacting partners. They also validated the interaction between TNK2 and CLINT1 through co-immunoprecipitation and immunofluorescence analysis, highlighting the potential functional significance of these molecules in TNK2-mediated signaling.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Cell Biology
Yongjie Xu, Qiu Han, Chaofeng Ma, Yaling Wang, Pengpeng Zhang, Cencen Li, Xiaofang Cheng, Haixia Xu
Summary: Comprehensive proteomics analysis of sperm from Yorkshire and Duroc boars revealed differential expression of proteins and phosphorylated proteins related to crucial physiological functions such as sperm development, motility, and energy metabolism. Proteins involved in axonemal dynein complex assembly and sperm-egg recognition were found to be significantly higher in Duroc spermatozoa, indicating potential differences in sperm function between the two boar breeds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Rita I. Pacheco, Maria I. Cristo, Sandra I. Anjo, Andreia F. Silva, Maria Ines Sousa, Renata S. Tavares, Ana Paula Sousa, Teresa Almeida Santos, Mariana Moura-Ramos, Francisco Caramelo, Bruno Manadas, Joao Ramalho-Santos, Sandra Gomes Amaral
Summary: The global trend of rising (male) infertility is concerning. This study aimed to understand unknown origin male infertility (UOMI) by evaluating the male gamete. The study found that idiopathic (ID) patients had the worst sperm functional profile, while unexplained male infertility (UMI) patients were similar to controls. Proteomic analysis identified several differentially expressed proteins in ID and UMI samples. SACA4 and LAMB2 were identified as potential biomarkers for distinguishing ID and UMI patients.
Article
Biochemistry & Molecular Biology
Kogiku Shiba, Kazuo Inaba
Summary: Flagellar motility in sperm is activated and regulated by factors related to the eggs at fertilization. In this study, the researchers focused on the role of soluble adenylyl cyclase (sAC) in the regulation of flagellar motility in Ciona sperm chemotaxis. The results showed that sAC plays a key role in sperm chemotaxis by regulating the clearance of intracellular calcium ions ([Ca2+]i) and modulating Ca2+-dependent flagellar waveform conversion.
Article
Neurosciences
Weiwei Liang, Zhuojun Xie, Dong Liao, Ying Li, Zhengyu Li, Yuanru Zhao, Xiaobo Li, Manli Dong
Summary: The study found that miR-142-5p targets PTPN1 to activate the Akt pathway, improving learning and memory in AD rats.
BRAIN RESEARCH BULLETIN
(2023)
Article
Cell Biology
Shahab Mirshahvaladi, Tohid Rezaei Topraggaleh, Mustafa Numan Bucak, Pegah Rahimizadeh, Abdolhossein Shahverdi
Summary: Asthenozoospermia, characterized by low sperm motility, is a common cause of male infertility. This study identified and quantified a total of 2140 proteins in the sperm tails of asthenozoospermic patients and controls, with 409 differentially expressed proteins. Bioinformatics analysis further revealed alterations in mitochondrial energy production, stress response, and other biological processes in asthenozoospermic sperm tails.
CELL AND TISSUE RESEARCH
(2023)
Article
Oncology
Xinyan Wu, Li Wang, Nicole A. Pearson, Santosh Renuse, Ran Cheng, Ye Liang, Dong-Gi Mun, Anil K. Madugundu, Yaoyu Xu, Parkash S. Gill, Akhilesh Pandey
Summary: This study utilized mass spectrometry-based proteomics to quantify cancer signaling regulated by AXL activation, identifying over 1000 phosphotyrosine sites and upregulation of cancer-promoting and cell migration pathways. Rapid phosphorylation of multiple receptor tyrosine kinases and protein tyrosine phosphatases was observed upon GAS6 stimulation. The study provides insights into AXL's oncogenic role and potential therapeutic targets.
Article
Chemistry, Multidisciplinary
Jinmin Miao, Jiajun Dong, Yiming Miao, Yunpeng Bai, Zihan Qu, Brenson A. Jassim, Bo Huang, Quyen Nguyen, Yuan Ma, Allison A. Murray, Jinyue Li, Philip S. Low, Zhong-Yin Zhang
Summary: In this study, researchers discovered the first highly potent and selective TC-PTP degrader called TP1L, which can induce degradation of TC-PTP and enhance T-cell signaling and tumor killing efficacy.
Article
Reproductive Biology
William C. Lester, Taylor Johnson, Ben Hale, Nicholas Serra, Brian Elgart, Rong Wang, Christopher B. Geyer, Ann O. Sperry
Summary: Aurora A kinase (AURKA) plays multiple important roles in spermatogenesis, involving in mitotic division, affecting sperm count and fertility, and regulating sperm morphology and motility. Deletion of AURKA in spermatogonia and spermatocytes led to different outcomes, highlighting the diverse functions of AURKA in different stages of sperm development.
BIOLOGY OF REPRODUCTION
(2021)
Review
Cell Biology
Francisca Cornejo, Bastian I. Cortes, Greg M. Findlay, Gonzalo I. Cancino
Summary: Protein phosphatases are key regulators of signal transduction, with the LAR-RPTP subfamily playing an important role in neurobiology, from neurodevelopment to brain disorders. The LAR-RPTP subfamily consists of three members in vertebrates and is involved in various brain functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Wei-Hsiang Chang, Sih-Syuan Li, Meng-Hsing Wu, Hsien-An Pan, Ching-Chang Lee
HUMAN REPRODUCTION
(2015)
Article
Pathology
Ying-Hung Lin, Yung-Ming Lin, Ya-Yun Wang, I-Shing Yu, Yi-Wen Lin, Yun-Han Wang, Ching-Ming Wu, Hsien-An Pan, Shin-Chih Chao, Pauline H. Yen, Shu-Wha Lin, Pao-Lin Kuo
AMERICAN JOURNAL OF PATHOLOGY
(2009)
Article
Obstetrics & Gynecology
Hsien-An Pan, Rui-Wen Liao, Chia-Ling Chung, Yen-Ni Teng, Yung-Ming Lin, Pao-Lin Kuo
FERTILITY AND STERILITY
(2008)
Article
Obstetrics & Gynecology
Hsien-An Pan, Yeu-Chin Lee, Yen-Ni Teng, Show-Jeng Tsai, Yung-Ming Lin, Pao-Lin Kuo
FERTILITY AND STERILITY
(2009)
Article
Genetics & Heredity
Yung-Che Kuo, Ying-Hung Lin, Hau-Inh Chen, Ya-Yun Wang, Yu-Wei Chiou, Hsi-Hui Lin, Hsien-An Pan, Ching-Ming Wu, Shih-Ming Su, Chao-Chin Hsu, Pao-Lin Kuo
Article
Obstetrics & Gynecology
Mei-Tsz Su, Sheng-Hsiang Lin, I-Wen Lee, Yi-Chi Chen, Chao-Chin Hsu, Hsien-An Pan, Pao-Lin Kuo
HUMAN REPRODUCTION
(2010)
Article
Genetics & Heredity
Hsin-Chih Albert Chao, Ying-Hung Lin, Yung-Che Kuo, Chiung-Jiung Shen, Hsian-Ann Pan, Pao-Lin Kuo
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2010)
Article
Genetics & Heredity
Yung-Chieh Tasi, Hsin-Chih Albert Chao, Chia-Ling Chung, Xiu-Ying Liu, Ying-Ming Lin, Pao-Chi Liao, Hsien-An Pan, Han-Sun Chiang, Pao-Lin Kuo, Ying-Hung Lin
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2013)
Article
Geriatrics & Gerontology
Wei-Jen Yao, Hsien-An Pan, Yen-Kuang Yang, Yuan-Hwa Chou, Shan-Tair Wang, Chin-Yin Yu, Hong-Dun Lin
Article
Obstetrics & Gynecology
Pei-Yi Chou, Meng-Hsing Wu, Hsien-An Pan, Kuei-Hsiang Hung, Fong-Ming Chang
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Keng-Fu Hsu, Hsien-An Pan, Yu-Yun Hsu, Ching-Ming Wu, Wen-Ju Chung, Soon-Cen Huang
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2014)
Article
Andrology
Jui-Hsiang Hung, Han-Yi Cheng, Yung-Chieh Tsai, Hsien-An Pan, Hany A. Omar, Chien-Chih Chiu, Yin-Mei Su, Yung-Ming Lin, Yen-Ni Teng
Summary: The study showed that the hypermethylation of LRWD1 promoter reduces transcriptional activity, while methylation inhibitors increase the expression of LRWD1. Additionally, the methylation status of LRWD1 promoter is correlated with sperm activity.
BASIC AND CLINICAL ANDROLOGY
(2021)
Article
Genetics & Heredity
Ching-Yuan Wang, Yen-An Tang, I-Wen Lee, Fong-Ming Chang, Chun-Wei Chien, Hsien-An Pan, H. Sunny Sun
Summary: A NGS-based assay for detecting genetic defects in association with SD has been developed, showing high accuracy and coverage for early diagnosis. This method provides a rapid and cost-effective genetic detection of SD, which is flexible to be conducted in the majority of the NGS instruments.
BMC MEDICAL GENOMICS
(2021)
Article
Environmental Sciences
Wei-Hsiang Chang, Meng-Hsing Wu, Hsien-An Pan, Pao-Lin Guo, Ching-Chang Lee