Review
Obstetrics & Gynecology
Maeliss Peigne, Valerie Bernard, Laura Dijols, Helene Creux, Geoffroy Robin, Claude Hocke, Michael Grynberg, Didier Dewailly, Charlotte Sonigo
Summary: This study conducted a systematic review and meta-analysis to evaluate whether serum anti-Mullerian hormone (AMH) level can predict the cumulative live birth (CLB) rate after assisted reproductive technology (ART) or in women trying to conceive naturally. The results showed a positive relation between serum AMH level and CLB after IVF/ICSI, but there is a lack of data for IUI or natural conception without ART.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Yumei He, Ling Liu, Fei Yao, Chenyu Sun, Muzi Meng, Yunzhu Lan, Chengliang Yin, Xingyu Sun
Summary: This study aimed to investigate the correlation between FSH/LH ratio and ovarian response in a population with normal levels of AMH. The results showed that increased basal FSH/LH reduces ovarian response in the AMH normal group, and a basal FSH/LH of 3.5 was found to be a useful diagnostic threshold for assessing ovarian response in people with normal AMH levels. OSI can be used as an indicator of ovarian response in ART treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Horace Roman, Isabella Chanavaz-Lacheray, Oana Mircea, Benoit Berby, Lise Dehan, Sophia Braund, Eric Verspyck, Lucian Puscasiu
Summary: The study examined the association between large ovarian endometriomas and high pre-operative AMH concentrations in 332 women with endometriosis. Results showed that women with cysts measuring over 6 cm had significantly increased AMH concentrations, regardless of age or presence of bilateral endometriomas. Surgeons and patients should take into consideration the impact of large endometriomas on AMH levels when planning surgery and post-operative conception.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Dang Kien Nguyen, Sean O'Leary, Moustafa Abdelhafez Gadalla, Bronnie Roberts, Helen Alvino, Kelton P. Tremellen, Ben W. Mole
Summary: This study investigated the predictive value of serum anti-Mullerian hormone (AMH) level for natural conception and its clinical effect on subfertile couples. The results showed that the addition of AMH to the fertility work-up improved prognosis-based treatment policy and helped prevent unnecessary costs and stress.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Endocrinology & Metabolism
Chenxi Lin, Miaomiao Jing, Wenjun Zhu, Xiaoyu Tu, Qi Chen, Xiufang Wang, Youbing Zheng, Runju Zhang
Summary: The study aimed to determine whether serum anti-Mullerian hormone (AMH) level is a predictor of clinical pregnancy in women trying to achieve a natural conception. The results showed that serum AMH levels have poor predictive value for natural pregnancy, regardless of age groups. These findings suggest that low serum AMH levels are not associated with reduced fertility in women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
C. Lapuente, M. Faya, P. G. Blanco, M. Grisolia-Romero, C. Marchetti, C. Gobello
Summary: The objectives of this study were to report the AMH serum concentrations in female cats at different developmental stages, establish the relationship between serum AMH and age or estrous cycle, and correlate the total number of ovarian follicle types with AMH in adult queens. The results showed that neonatal females had lower AMH serum concentrations than males, and AMH levels increased from neonatal to prepubertal and postpubertal stages. Age was inversely correlated with AMH, and AMH concentrations were lower in females in the follicular phase compared to anestrus females. Small antral follicles had a high correlation with AMH concentrations. It was concluded that AMH can serve as an indirect marker for assessing ovarian follicle size and functionality, and age and pubertal state should be considered when evaluating AMH concentrations in cats.
Article
Endocrinology & Metabolism
Xingyu Sun, Wang Xiong, Liting Liu, Junjun Xiong, Chenlu Liao, Yunzhu Lan, Feifei Li, Shufei Tao, Muzi Meng, Chenyu Sun, Xiguang Mao
Summary: This study demonstrated that AFC and AMH were positively correlated with the number of retrieved oocytes, while age and BMI were negatively correlated. AFC showed better predictive performance in ovarian response prediction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kai-Lun Hu, Kwanghann Gan, Yue Ying, Junyan Zheng, Ruixue Chen, Jinglei Xue, Yiqing Wu, Yifeng Liu, Yimin Zhu, Lanfeng Xing, Dan Zhang
Summary: The study found a close association between menstrual cycle length and anti-Mullerian hormone (AMH) levels and ovarian response. In women without polycystic ovary syndrome (PCOS), those with short cycles and oligo/amenorrhea showed different levels of antral follicle count and serum AMH levels. This association differed in women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Lida Zafeiri, Torbjoern akerfeldt, Andreas Tolf, Kristina Carlson, Alkistis Skalkidou, Joachim Burman
Summary: This study investigated the relationship between AMH levels and age and reproductive potential in MS patients treated with AHSCT. The results showed that although AMH concentration significantly decreased after AHSCT, six patients successfully conceived despite low concentrations, suggesting that high-dose cyclophosphamide treatment may not negatively impact fertility.
Article
Medicine, General & Internal
Qiumin Wang, Dan Qi, Lixia Zhang, Jingru Wang, Yanbo Du, Hong Lv, Lei Yan
Summary: This study retrospectively analyzed 16,583 patients undergoing the first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to determine the dose-response relationships and optimal ranges of age, AMH, basal FSH, number of cryopreserved embryos, and number of total transferred embryos associated with a higher cumulative live birth rate (CLBR). The study proposed the optimal ranges of these five factors that were correlated with a higher CLBR in the first oocyte retrieval cycle.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Nathalie di Clemente, Chrystele Racine, Alice Pierre, Joelle Taieb
Summary: Anti-Mullerian hormone (AMH) plays a significant role in regulating folliculogenesis and serves as a reliable marker for ovarian reserve. It is also involved in the pathogenesis of conditions like polycystic ovary syndrome (PCOS) and primary ovarian failure.
Article
Agriculture, Dairy & Animal Science
S. J. Huang, L. Purevsuren, F. Jin, Y. P. Zhang, C. Y. Liang, M. Q. Zhu, F. Wang, C. L. Jia, Z. H. Wei
Summary: The study elucidated the role of AMH in regulating ovarian follicle development in laying hens by measuring expression of relevant genes and treating hens with AMH. Results showed changes in gene expressions post-follicular selection and significant effects on ovarian morphology and hormone levels after AMH injection.
Review
Endocrinology & Metabolism
Akira Iwase, Yuko Hasegawa, Yumiko Tsukui, Mio Kobayashi, Hikaru Hiraishi, Tomoko Nakazato, Yoshikazu Kitahara
Summary: Anti-Mullerian hormone (AMH) is an indirect indicator of ovarian reserve and fertility. It is used to test the number of remaining follicles. A decline in AMH suggests a decrease in follicles, while polycystic ovary syndrome patients often have elevated AMH levels. AMH varies with folliculogenesis and changes in the follicle cohort, which play a crucial role in ovarian activity throughout a woman's lifetime.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Zhou Yanzhen, Huang Xinxin, Shi Mengjing, Chen Li
Summary: The study found that large ovarian endometriomas significantly affect serum AMH levels and are significantly correlated with postoperative pregnancy outcomes. Proper surgical intervention can greatly improve the fertility success rates of patients with endometriosis.
JOURNAL OF REPRODUCTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Depeng Zhao, Jing Fan, Ping Wang, Xuan Jiang, Jilong Yao, Xuemei Li
Summary: The study aimed to define an age-specific reference for low AMH and evaluate the outcomes of IVF treatment in women. Results showed that women with AMH levels above the 10th centile had better outcomes in ovarian stimulation, with significantly higher clinical pregnancy and ongoing pregnancy rates in the subgroup with AMH levels above the 10th centile compared to those with low AMH levels in patients under 35 years old.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Endocrinology & Metabolism
Evelyn Wong, Ernest H. Y. Ng, Raymond H. W. Li, Jennifer K. Y. Ko
Summary: The intercycle variation of serum AMH and AFC was compared in this study. The results showed that the repeatability of AMH was significantly better than AFC. Both AMH and AFC had similar predictive performance on poor ovarian response when assessed within three months before IVF treatment.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Andrology
Yu-Jun Liu, Xin-Jie Zhuang, Jian-Ting An, Hui Jiang, Rong Li, Jie Qiao, Li-Ying Yan, Xu Zhi
Summary: This study aimed to investigate potential high-risk genes associated with spermatogenesis in idiopathic nonobstructive azoospermia (NOA) patients by whole-exome sequencing. The frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene pathogenic variant carriers was higher in the NOA patients compared with the healthy controls. In addition, seven potential risk genes that were highly or specifically expressed in the testes were identified, including four previously reported risk genes and three novel risk genes.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Medical Laboratory Technology
Xianhua Zhang, Huiyu Xu, Guoshuang Feng, Li Yang, Libo Zhao, Rong Li, Rongsheng Zhao
Summary: A fast and sensitive HPLC-DMS/MS/MS method was developed for the simultaneous determination of seven androgens and 17-hydroxyprogesterone. Dispersive magnetic solid phase extraction (DMSPE) using Fe3O4@GO nanoparticles and in situ derivatization with Girard's Reagent P were employed. The method showed good precision, accuracy, and extraction recoveries, and was successfully applied to clinical sample analysis.
CLINICA CHIMICA ACTA
(2023)
Article
Endocrinology & Metabolism
Congcong Ma, Huiyu Xu, Haiyan Wang, Guoshuang Feng, Yong Han, Kannan Alpadi, Rong Li, Jie Qiao
Summary: Mathematical models using early Delta inhibin B and other biomarkers can predict ovarian response in controlled ovarian stimulation. Early Delta inhibin B and basal antimullerian hormone (AMH) levels were the best measures for predicting excessive and poor ovarian responses. These models may help in counseling patients and reducing iatrogenic poor or excessive ovarian responses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Wing Tong, Jennifer Ka Yee Ko, Karen Siu Ling Lam, Sidney Tam, Vivian Chi Yan Lee, Pak Chung Ho, Ernest Hung Yu Ng, Raymond Hang Wun Li
Summary: This study evaluated the association between serum advanced glycation end-products (AGEs) and soluble receptor of AGEs (sRAGE) levels with dysglycaemia and metabolic syndrome in women with polycystic ovary syndrome (PCOS). The results showed that women with dysglycaemia or metabolic syndrome had significantly lower sRAGE levels. However, after adjusting for body mass index, free androgen index and homeostatic model assessment for insulin resistance (HOMA-IR), sRAGE did not have a significant independent association with these outcome measures.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Minji De, Lixue Chen, Lin Zeng, Yang Wang, Rui Yang, Rong Li, Hongbin Chi
Summary: This study compared the effects of two types of luteal support on pregnancy outcomes after fresh embryo transfer using the antagonist protocol. The results showed that the combination of progesterone vaginal gel and dydrogesterone had significantly higher clinical pregnancy and ongoing pregnancy rates compared to the use of progesterone vaginal gel alone.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Manfei Si, Huahua Jiang, Yue Zhao, Xinyu Qi, Rong Li, Xiaoyu Long, Jie Qiao
Summary: A predictive model for live birth after the first fresh embryo transfer in patients with polycystic ovary syndrome (PCOS) was developed based on factors including BMI, AMH level, initial FSH dosage, serum LH and progesterone levels, and endometrial thickness. The model showed good predictive ability and could assist clinicians and patients in decision-making and outcome evaluation.
Editorial Material
Family Studies
Sharon Cameron, Hang Wun Raymond Li, Kristina Gemzell-Danielsson
BMJ SEXUAL & REPRODUCTIVE HEALTH
(2023)
Article
Biology
Liang Chang, Haining Jiao, Jiucheng Chen, Guanlin Wu, Ping Liu, Rong Li, Jianying Guo, Wenqing Long, Xiaojian Tang, Bingjie Lu, Haibin Xu, Han Wu
Summary: Monogenic inherited diseases are a common cause of congenital disabilities, resulting in significant burdens on affected families. This study demonstrates the feasibility of using cell-based noninvasive prenatal testing (cbNIPT) with single-cell whole-genome sequencing (WGS) and haplotype analysis to diagnose various monogenic diseases prenatally. The results show that WGS performs better than targeted sequencing in terms of genome coverage, allele dropout, and false-positive rates. This research highlights the potential of cbNIPT by WGS and haplotype analysis in the prenatal diagnosis of monogenic diseases.
LIFE SCIENCE ALLIANCE
(2023)
Editorial Material
Multidisciplinary Sciences
Huiyu Xu, Guoshuang Feng, Yong Han, Antonio La Marca, Rong Li, Jie Qiao
Article
Obstetrics & Gynecology
Libei Du, Hang Wun Raymond Li, Kristina Gemzell-Danielsson, Zhiqiang Zhang, Yanhong Du, Wenju Zhang, Bo Xu, Xiaozhong Wang, Yaokai Wang, Wenjuan Wan, Ying Chang, Weiyu Diao, Yanli Wang, Li Zhang, Pak Chung Ho
Summary: This study investigated whether letrozole pre-treatment is as effective as mifepristone pre-treatment, followed by misoprostol, for the medical treatment of first-trimester missed miscarriage. The results showed that letrozole is non-inferior to mifepristone in achieving complete evacuation, with the letrozole group having less post-treatment bleeding and an earlier return of menses.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Raymond Hang Wun Li, Sue Seen Tsing Lo, Kristina Gemzell-Danielsson, Carol Ho Yi Fong, Pak Chung Ho, Ernest Hung Yu Ng
Summary: This study found that co-administration of oral piroxicam 40 mg with levonorgestrel improved the efficacy of emergency contraception. The use of piroxicam could be considered in clinical settings where levonorgestrel emergency contraception is the chosen option.
Article
Medicine, General & Internal
Manfei Si, Wanxue Xu, Xinyu Qi, Huahua Jiang, Yue Zhao, Rong Li, Xiaoyu Long, Jie Qiao
Summary: Polycystic ovary syndrome (PCOS) is a metabolic disorder affecting fertility. This comprehensive study identified reliable phenotypes that can predict IVF and pregnancy outcomes in PCOS patients. The metabolic syndrome (MetS) phenotype was found to be associated with cumulative live birth, preterm birth, and gestational diabetes mellitus in PCOS patients undergoing IVF (p < 0.05), suggesting its potential for clinical management strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Kunfeng Bai, Jianlin Li, Leqian Lin, Qingqing Zhang, Jiangming Zhong, Xiaofeng Liu, Dandan Cao, Yong-Gang Duan, Yuanqing Yao, Raymond H. W. Li, Ka-Wang Cheung, William S. B. Yeung, Philip C. N. Chiu, Cheuk-Lun Lee
Summary: Exosomes derived from human placenta can induce macrophage polarization to acquire a decidual-like macrophage phenotype by miRNA-30d-5p/histone deacetylase 9 axis. These placenta-derived exosomes also promote trophoblast migration and invasion while impairing endothelial cell tube formation and migration. However, they do not affect T-cell proliferation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Medicine, General & Internal
Jingwen Yin, Yang Wang, Liyuan Tao, Lixue Chen, Ping Liu, Rong Li
Summary: This study compared the outcomes of IVF-ET and the development of follicles and embryos between vaccinated and unvaccinated groups. The results showed that vaccination against COVID-19 did not have a significant effect on the outcomes of IVF-ET and the development of follicles and embryos. Gender and vaccine type also did not show significant effects.
CHINESE MEDICAL JOURNAL
(2023)
