期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 5, 页码 2956-2959出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00041-15
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资金
- National Institutes of Health [R01AI090155, R01AI072219, R01AI063517]
- Cleveland Department of Veterans Affairs
- Veterans Affairs Merit Review Program
- Geriatric Research Education and Clinical Center [10]
Horizontal transfer of bla(KPC)-harboring plasmids contributes significantly to the inter-and intraspecies spread of Klebsiella pneumoniae carbapenemase (KPC). Here we report the complete nucleotide sequence of a bla(KPC)-harboring IncFIA plasmid, pBK32533, from Escherichia coli. pBK32533 is a cointegrate plasmid comprising of a 72-kb sequence identical to that of the non-conjugative pBK30661 plasmid plus an additional 170-kb element that harbors the genes for plasmid transfer. pBK32533 demonstrates how bla(KPC) can be spread from a nonconjugative plasmid through cointegration.
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