期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 13, 期 5, 页码 444-448出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2011.570262
关键词
deep-sea sediment; metagenomic clone; N-{1-[4-(acetylamino)phenyl]-3-hydroxy-1-(1H-indol-3-yl)propan-2-yl}-2; 2-dichloroacetamide; indole alkaloids
资金
- National High Technology Research and Development Plan (863) of China [2007AA091904]
- China Ocean Mineral Resources R& D Association Fund [DYXM-115-02-2-9]
To explore secondary metabolites in deep-sea sediment metagenomic clone-derived Escherichia coli fermentation broth, different kinds of chromatography methods were used in the isolation procedures, while the structures of the isolated compounds were assigned based on the MS analysis and their 1H and 13C NMR spectra including 2D NMR techniques such as COSY, HMQC, and HMBC experiments. As a result, a novel compound was isolated and characterized as N-{1-[4-(acetylamino)phenyl]-3-hydroxy-1-(1H-indol-3-yl)propan-2-yl}-2,2-dichloroacetamide (1). In addition, eight known compounds were also obtained. Fatty acid amide hydrolase and monoacylglycerol lipase were used to screen analgesic activity, and the new compound showed analgesic activity to some extent in pharmacological test.
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