Article
Chemistry, Applied
Yi-Qiang Zhang, Yan Liu, Yu-Qing Wang, Peng Jiang, Meng-Meng Li, Juan Pan, Wei Guan, Anam Naseem, Hai-Xue Kuang, Bing-You Yang
Summary: Three new schinortriterpenoids were identified from the leaves of Schisandra chinensis, along with five known compounds. The structures of the new compounds were determined through various spectroscopic techniques. These compounds showed moderate neuroprotective effects in human neuroblastoma cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Naonobu Tanaka, Saidanxia Amuti, Sakura Takahashi, Daisuke Tsuji, Kohji Itoh, Yoshiki Kashiwada
Summary: A phytochemical study on the roots of Schisandra chinensis, a non-medicinal part used in herbal medicine, isolated five new triterpenes and 21 known compounds. Some of the triterpenes showed significant antiproliferative activities against human breast carcinoma MCF-7 cells compared to other cell lines.
Review
Pharmacology & Pharmacy
Feng Zhang, Jianxiu Zhai, Nan Weng, Jie Gao, Jun Yin, Wansheng Chen
Summary: This review summarized the effects of Wu Wei Zi extract and its major lignan components on cytochrome P450 and P-glycoprotein activities, as well as the absorption, distribution, metabolism, and elimination of the major lignans. The results enhance our understanding of the drug-drug interaction mechanisms involving Wu Wei Zi.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Dan Su, Jian Luo, Junqi Ge, Yali Liu, Chen Jin, Pengfei Xu, Ruowen Zhang, Genhua Zhu, Ming Yang, Zhifu Ai, Yonggui Song
Summary: This study found that Schisandra chinensis and wine processed Schisandra chinensis can alleviate cardiovascular dysfunction, promote sleep, and improve abnormal cardiovascular system of rats by regulating neurotransmitters and amino acid levels.
Article
Biochemistry & Molecular Biology
Zi-Qiao Xu, Shuai Li, Guo-Qing Long, Dong-Dong Wang, Zi-Feng Guo, Yong-Cheng Yang
Summary: This study reports seven previously undescribed SNTs from the stem and leaves of S. chinensis, and evaluates their neuroprotective effects on PC12 cell injury. The results show that three compounds have neuroprotective effects.
Article
Biochemistry & Molecular Biology
Ewelina Sobstyl, Agnieszka Szopa, Malgorzata Olszowy-Tomczyk, Sebastian Gnat, Karolina Jafernik, Irena Maria Choma
Summary: HPLC and TLC profiling were conducted on leaf and fruit extracts of five species from the Schisandraceae family. Lignans and phenolic compounds were found in both fruits and leaves of all species. The highest abundance of lignans was detected in the fruit extract of Schisandra chinensis, with 15 compounds identified. The fruit extracts of S. chinensis and S. rubriflora exhibited exceptional antibacterial activity, while all fruit and leaf extracts showed enzyme-inhibiting abilities, except for the fruit extract of Kadsura japonica. Antioxidant activity was stronger in the leaf extracts compared to the fruit extracts, assessed using TLC-direct bioautography and spectrophotometric measurements.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Oncology
Maobo Huang, Yuanfei Zhou, Dongzhu Duan, Chuanyu Yang, Zhongmei Zhou, Fubing Li, Yanjie Kong, Yi-Ching Hsieh, Ruihan Zhang, Wenping Ding, Weilie Xiao, PemaTenzin Puno, Ceshi Chen
Summary: The study reveals the important role of ubiquitin enzymes in therapeutic resistance in TNBC cells, suggesting that small molecule inhibitors can restore sensitivity to treatment. Specifically, PC3-15 was found to block auto-ubiquitination of HECTD3/UbcH5b and inhibit UbcH5b-mediated p62 ubiquitination, leading to increased sensitivity to lapatinib in TNBC.
Review
Chemistry, Organic
Lu Guo, Pingping Tang
Summary: Schisandraceae, a traditional Chinese herb known for its anti-hepatitis bioactivity, has diverse and unique structures that have caught the interest of synthetic chemists. Recent efforts towards the total synthesis of schisandra triterpenoid have been summarized.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Dalia M. Kopustinskiene, Jurga Bernatoniene
Summary: Schisandra chinensis fruits, their extracts, and bioactive compounds have potent antioxidant and mitoprotective effects, exerting anti-inflammatory, antiviral, anticancer, and anti-aging properties. The polyphenolic compounds in S. chinensis are responsible for its antioxidant activities, which play a significant role in protecting cells under normal and pathological conditions.
Article
Marine & Freshwater Biology
Jana Valickova, Stepan Zezulka, Eliska Marsalkova, Josef Kotlik, Blahoslav Marsalek, Radka Opatrilova
Summary: Schisandra chinensis is a potential plant for production of nutrient supplements, but it can have allelopathic effects on other plants. The eco-toxicological properties of S. chinensis have not been verified in European ecosystems. In this study, Lemna minor was used as a model aquatic plant to test the impact of S. chinensis extract on the aquatic environment. The extract caused significant limitations in duckweed growth and photosynthetic performance at higher concentrations, and extreme toxicity at the highest concentration of 45 mg/L.
AQUATIC TOXICOLOGY
(2023)
Article
Plant Sciences
Hai-Ying Wang, Xiao-Ling Wang, Li-Qin Xu, Jun Liu
Summary: Three new lanostane triterpenoids were isolated from the stems of Schisandra viridis, with compound 1 showing cytotoxic activities on all six tested human lung cancer cell lines. Structural elucidation was performed using NMR spectroscopy and high resolution mass spectrometry.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Chemistry, Medicinal
Jun-nan Hu, Yi-ming Wang, Hao Zhang, Hui-ping Li, Zi Wang, Mei Han, Shen Ren, Shan Tang, Shuang Jiang, Wei Li
Summary: The study found that Scheme B has a protective effect on cisplatin-induced rat intestinal crypt epithelial cell injury. It achieves this by reducing oxidative stress, inhibiting cell apoptosis and inflammation, and repairing intestinal barrier function.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Woo Sung Park, Kyung Ah Koo, Ji-Yeong Bae, Hye-Jin Kim, Dong-Min Kang, Ji-Min Kwon, Seung-Mann Paek, Mi Kyeong Lee, Chul Young Kim, Mi-Jeong Ahn
Summary: A study analyzed the content of seven lignans in Schisandra chinensis fruit using HPLC-DAD, revealing that seeds had the highest content. The addition of oligosaccharide/white sugar to fermented beverages significantly increased lignan content.
Article
Food Science & Technology
Zhou Si, Haoxiang Chen, Chensi Gu, Tingting Wang, Ziluan Fan
Summary: Schisandra chinensis extract (SCE) has significant anti-fatigue effects in mice by prolonging swimming time, increasing levels of hepatic and muscular glycogen, reducing levels of lactic acid, blood urea nitrogen, and malondialdehyde, enhancing activities of antioxidant enzymes, and activating the AMPK/PGC-1 alpha signaling pathway.
Article
Chemistry, Applied
Nguyen Thi Mai, Vu Van Doan, Hoang Thi Tuyet Lan, Bui Thi Mai Anh, Nguyen Huy Hoang, Bui Huu Tai, Nguyen Xuan Nhiem, Pham Hai Yen, Seon Ju Park, Yohan Seo, Wan Namkung, Seung Hyun Kim, Phan Van Kiem
Summary: Phytochemical investigation of Schisandra sphenanthera leaves led to the isolation of new compounds, with schirubrisin B showing strong cytotoxic effects on prostate and breast cancer cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Zhen Li, Meiqi Li, Bo Peng, Bingqing Zhu, Jian-rong Wang, Xuefeng Mei
CRYSTAL GROWTH & DESIGN
(2019)
Article
Chemistry, Organic
Jing Chen, Yiwei Fu, Yang Yu, Jian-Rong Wang, Yue-Wei Guo, Hao Li, Wei Wang
Correction
Agriculture, Multidisciplinary
Qingbin Guo, Tongtong Zhang, Nifei Wang, Yongmei Xia, Zhuoyu Zhou, Jian-rong Wang, Xuefeng Mei
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Chemistry, Organic
Jiao Liu, Heng Li, Meng-Jun Wu, Wei Tang, Jian-Rong Wang, Yu-Cheng Gu, Hong Wang, Xu-Wen Li, Yue-Wei Guo
Summary: A novel diterpenoid, sinueretone A, was isolated from the South China Sea soft coral Sinularia erecta, along with two new and one known casbane diterpenoids. The structures of the new compounds were determined by extensive spectroscopic analysis and quantum chemical calculations, and a biogenetic relationship between them was proposed. Compounds 1 and 2 showed interesting anti-inflammatory activity in a bioassay.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Zi-Hui Chen, Wang-Sheng Li, Zai-Yong Zhang, Hui Luo, Jian-Rong Wang, Hai-Yan Zhang, Zi-Rong Zeng, Bao Chen, Xu-Wen Li, Yue-Wei Guo
Summary: A novel norditerpenoid and four polyoxygenated cembranoids were isolated from the Hainan soft coral Sinularia siaesensis, with their structures elucidated through various methodologies. The study also proposed a biosynthetic pathway for the novel compound and demonstrated their inhibitory activity against inflammation in BV-2 microglial cells.
Review
Chemistry, Multidisciplinary
Liyu Liu, Jian-Rong Wang, Xuefeng Mei
Summary: This review discusses the successful application of cocrystallization in addressing the stability issues of active pharmaceutical ingredients (APIs) and the molecular mechanism behind it. By tailored design, delicate modification, and ingenious construction of cocrystals, the stability of APIs can be enhanced. A multidimensional structural understanding is necessary to manipulate interaction strength, molecular conformation, packing styles, and electronic effect. Prominent examples of cocrystals that have successfully dealt with stability problems are summarized, providing insights into vital structural factors in different scenarios and guiding future stable cocrystal design.
Article
Chemistry, Medicinal
Meng Y. Xia, Bing Q. Zhu, Jian-R Wang, Ze E. Yang, Xue F. Mei
Summary: This article provides an overview of cocrystals in terms of their history, development, differences with salts, mechanisms for improved dissolution, as well as regulatory guidelines from FDA and EMA. It also discusses the correlation between cocrystals and IVIVC data, and highlights the potential of cocrystals in patent generation using D-alpha-tocopherol as an example.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Yinxiang Cheng, Yihua Jiang, Bingrui Zhang, Xiaoyi Rong, Qiaoce Ding, Zaiyong Zhang, Jian-Rong Wang, Xuefeng Mei
Summary: This study designed and synthesized four cocrystals of ITT, and found that the cocrystal between ITT and ethyl nicotinate (ENT) showed better chemical stability, dissolution, and absorption. The ITT-ENT cocrystal capsules had higher bioavailability in the fasted state compared to the commercially available ITT capsules.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Liyu Liu, Zaiyong Zhang, Yinxiang Cheng, Yihua Jiang, Liye Lu, Jian-Rong Wang, Xuefeng Mei
Summary: L-menthol is an important flavoring additive with diverse applications. The manufacturing and storage of L-menthol face challenges due to its high volatility and low melting point. In this study, six new solid forms of L-menthol were synthesized through cocrystallization, which significantly increased the melting point and reduced the vapor pressure, leading to higher stability under storage conditions. This superior stability can be attributed to the supramolecular cavities assembled by coformers, which restrict the movement of L-menthol molecules through hydrogen bonds.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Organic
Meng-Jun Wu, Dan-Dan Yu, Ming-Zhi Su, Jian-Rong Wang, Lei Gong, Zai-Yong Zhang, Hong Wang, Yue-Wei Guo
Summary: Two novel compounds were isolated from South China Sea soft coral, featuring a unique carbon framework. A new diterpenoid and two related known compounds were also discovered. These compounds showed inhibitory effects on inflammatory responses in cells.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Meng-Jun Wu, Dan-Dan Yu, Ming-Zhi Su, Jian-Rong Wang, Lei Gong, Zai-Yong Zhang, Hong Wang, Yue-Wei Guo
Summary: Two novel diterpenoids with unprecedented carbon framework were isolated from South China Sea soft coral. These compounds exhibited inhibitory effects on inflammatory responses.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Mengfei Guo, Zaiyong Zhang, Zhaoqiang Chen, Qiaoce Ding, Liye Lu, Qi Zhang, Jian-Rong Wang, Xuefeng Mei
Article
Chemistry, Multidisciplinary
Meiqi Li, Zhen Li, Jian-rong Wang, Xuefeng Mei
Article
Chemistry, Multidisciplinary
Jian-Rong Wang, Meiqi Li, Qihui Yu, Zaiyong Zhang, Bingqing Zhu, Wenming Qin, Xuefeng Mei
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Analytical
Bo Peng, Zaiyong Zhang, Jian-Rong Wang, Meiqi Li, Qi Zhang, Xuefeng Mei
