期刊
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
卷 11, 期 9, 页码 771-778出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020903128470
关键词
Chrysanthemum morifolium Ramat.; flavonoids; cytotoxicity; Colon205
资金
- Liaoning Province Government, China
A new p-hydroxyphenylacetyl flavonoid, diosmetin 7-(6 ''-O-p-hydroxyphenylacetyl)O-beta-D-glucopyranoside (1), was isolated from the flowers of Chrysanthemum morifolium Ramat. 'huaiju' cv. nov. (Compositae), together with five known flavonoids, luteolin (2), diosmetin (3), diosmetin 7-O-beta-D-glucopyranoside (4), diosmin (5), and scolimoside (6), and four known caffeoylquinic acid derivatives, macranthoin F (7), 3,5-dicaffeoylquinic acid (8), 1,3-dicaffeoyl-epi-quinic acid (9), and chlorogenic acid (10). The structure of 1 was elucidated by UV, IR, ESI-TOF-MS, 1D, and 2D NMR spectroscopic methods. Cytotoxic activity of compounds 1-5 against human colon cancer cell Colon205 was investigated using MTT assays. Compounds 2 and 3 showed significant cytotoxicities against Colon205, with their IC50 values being 96.9 and 82.9 mu M, respectively. However, compounds 1, 4, and 5 showed little cytotoxic activity.
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