Computational oncology — mathematical modelling of drug regimens for precision medicine
出版年份 2015 全文链接
标题
Computational oncology — mathematical modelling of drug regimens for precision medicine
作者
关键词
-
出版物
Nature Reviews Clinical Oncology
Volume 13, Issue 4, Pages 242-254
出版商
Springer Nature
发表日期
2015-11-24
DOI
10.1038/nrclinonc.2015.204
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Multiparameter Phase I trials: a tool for model-based development of targeted agent combinations – example of EVESOR trial
- (2015) Mevidette El-Madani et al. Future Oncology
- Incorporating Cancer Stem Cells in Radiation Therapy Treatment Response Modeling and the Implication in Glioblastoma Multiforme Treatment Resistance
- (2015) Victoria Y. Yu et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
- (2015) Jun J. Yang et al. JOURNAL OF CLINICAL ONCOLOGY
- Modeling intrinsic heterogeneity and growth of cancer cells
- (2015) James M. Greene et al. JOURNAL OF THEORETICAL BIOLOGY
- Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer
- (2015) Rebecca S. Heist et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systems oncology: Towards patient-specific treatment regimes informed by multiscale mathematical modelling
- (2015) Gibin G. Powathil et al. SEMINARS IN CANCER BIOLOGY
- Simulating cancer growth with multiscale agent-based modeling
- (2015) Zhihui Wang et al. SEMINARS IN CANCER BIOLOGY
- Population Pharmacokinetics of Busulfan in Pediatric and Young Adult Patients Undergoing Hematopoietic Cell Transplant
- (2015) Janel R. Long-Boyle et al. THERAPEUTIC DRUG MONITORING
- Network pharmacodynamic models for customized cancer therapy
- (2015) James M. Gallo et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Spatial Heterogeneity in Drug Concentrations Can Facilitate the Emergence of Resistance to Cancer Therapy
- (2015) Feng Fu et al. PLoS Computational Biology
- A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design
- (2015) Christina Vasalou et al. PLoS One
- A 3-Compartment Model for Chemotherapy of Heterogeneous Tumor Populations
- (2014) Urszula Ledzewicz et al. ACTA APPLICANDAE MATHEMATICAE
- Metronomics chemotherapy: time for computational decision support
- (2014) Dominique Barbolosi et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Mechanistic pharmacokinetic/pharmacodynamic modeling of in vivo tumor uptake, catabolism, and tumor response of trastuzumab maytansinoid conjugates
- (2014) Russ Wada et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Abstract 402: A new mathematical model for describing metastatic spreading: Validation in tumor-bearing mice, confrontation with clinical data and in silico simulations to optimize treatment modalities.
- (2014) Severine Mollard et al. CANCER RESEARCH
- Mathematical Modeling of Tumor Growth and Metastatic Spreading: Validation in Tumor-Bearing Mice
- (2014) N. Hartung et al. CANCER RESEARCH
- Preclinical Optimization of MDM2 Antagonist Scheduling for Cancer Treatment by Using a Model-Based Approach
- (2014) B. Higgins et al. CLINICAL CANCER RESEARCH
- Semi-Mechanistic Pharmacokinetic/Pharmacodynamic Modeling of the Antitumor Activity of LY2835219, a New Cyclin-Dependent Kinase 4/6 Inhibitor, in Mice Bearing Human Tumor Xenografts
- (2014) S. C. Tate et al. CLINICAL CANCER RESEARCH
- Review of therapeutic drug monitoring of anticancer drugs part two – Targeted therapies
- (2014) Nicolas Widmer et al. EUROPEAN JOURNAL OF CANCER
- Review of therapeutic drug monitoring of anticancer drugs part 1 – Cytotoxics
- (2014) Angelo Paci et al. EUROPEAN JOURNAL OF CANCER
- Therapeutic drug monitoring in cancer – Are we missing a trick?
- (2014) Christophe Bardin et al. EUROPEAN JOURNAL OF CANCER
- Role of the lean body mass and of pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of sunitinib in cancer patients
- (2014) C. Narjoz et al. INVESTIGATIONAL NEW DRUGS
- Oral Anticancer Drugs: How Limited Dosing Options and Dose Reductions May Affect Outcomes in Comparative Trials and Efficacy in Patients
- (2014) Vinay Prasad et al. JOURNAL OF CLINICAL ONCOLOGY
- Metronomics: towards personalized chemotherapy?
- (2014) Nicolas André et al. Nature Reviews Clinical Oncology
- Rapid learning for precision oncology
- (2014) Jeff Shrager et al. Nature Reviews Clinical Oncology
- Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas
- (2014) M. A. Karajannis et al. NEURO-ONCOLOGY
- Predictive Performance of a Physiologically Based Pharmacokinetic Model of Busulfan in Children
- (2014) Christian Diestelhorst et al. PEDIATRIC HEMATOLOGY AND ONCOLOGY
- Personalizing oncology treatments by predicting drug efficacy, side-effects, and improved therapy: mathematics, statistics, and their integration
- (2014) Zvia Agur et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Classical Mathematical Models for Description and Prediction of Experimental Tumor Growth
- (2014) Sébastien Benzekry et al. PLoS Computational Biology
- Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research
- (2014) Tove Tuntland et al. Frontiers in Pharmacology
- A mathematical model for the administration of temozolomide: comparative analysis of conventional and metronomic chemotherapy regimens
- (2013) C. Faivre et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Center of Cancer Systems Biology Second Annual Workshop--Tumor Metronomics: Timing and Dose Level Dynamics
- (2013) P. Hahnfeldt et al. CANCER RESEARCH
- The Model Muddle: In Search of Tumor Growth Laws
- (2013) P. Gerlee CANCER RESEARCH
- Model-Based Drug Development in Oncology: What’s Next?
- (2013) R Bruno et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Without Therapeutic Drug Monitoring, There Is No Personalized Cancer Care
- (2013) J H Beumer CLINICAL PHARMACOLOGY & THERAPEUTICS
- Evaluation of Tumor-Size Response Metrics to Predict Overall Survival in Western and Chinese Patients With First-Line Metastatic Colorectal Cancer
- (2013) Laurent Claret et al. JOURNAL OF CLINICAL ONCOLOGY
- Clinical Outcomes for Patients with Metastatic Renal Cell Carcinoma Treated with Alternative Sunitinib Schedules
- (2013) Bradley J. Atkinson et al. JOURNAL OF UROLOGY
- Model-Based Approach to Describe G-CSF Effects in Carboplatin-Treated Cancer Patients
- (2013) Mélanie L. Pastor et al. PHARMACEUTICAL RESEARCH
- Personalized medicine in oncology: where have we come from and where are we going?
- (2013) Fabrice André et al. PHARMACOGENOMICS
- Outcomes in patients with metastatic renal cell cancer treated with individualized sunitinib therapy: Correlation with dynamic microbubble ultrasound data and review of the literature
- (2013) Georg A. Bjarnason et al. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Mathematical modeling of folate metabolism
- (2013) John C. Panetta et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- The Technologically Integrated Oncosimulator: Combining Multiscale Cancer Modeling With Information Technology in the In Silico Oncology Context
- (2013) Georgios Stamatakos et al. IEEE Journal of Biomedical and Health Informatics
- Covariate Pharmacokinetic Model Building in Oncology and its Potential Clinical Relevance
- (2012) Markus Joerger AAPS Journal
- Personalising docetaxel and G-CSF schedules in cancer patients by a clinically validated computational model
- (2012) O Vainas et al. BRITISH JOURNAL OF CANCER
- Dose banding as an alternative to body surface area-based dosing of chemotherapeutic agents
- (2012) E Chatelut et al. BRITISH JOURNAL OF CANCER
- Model-based treatment optimization of a novel VEGFR inhibitor
- (2012) Ron J. Keizer et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Evaluation of a Pharmacology-Driven Dosing Algorithm of 3-Weekly Paclitaxel Using Therapeutic Drug Monitoring
- (2012) Markus Joerger et al. CLINICAL PHARMACOKINETICS
- A Guide to Rational Dosing of Monoclonal Antibodies
- (2012) Shuang Bai et al. CLINICAL PHARMACOKINETICS
- Models of Excellence: Improving Oncology Drug Development
- (2012) M R Sharma et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2
- (2012) David R. Plowchalk et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Body-Surface Area–Based Chemotherapy Dosing: Appropriate in the 21st Century?
- (2012) Jan H. Beumer et al. JOURNAL OF CLINICAL ONCOLOGY
- Evidence for Therapeutic Drug Monitoring of Targeted Anticancer Therapies
- (2012) Bo Gao et al. JOURNAL OF CLINICAL ONCOLOGY
- Mathematical Modeling in Immunotherapy of Cancer: Personalizing Clinical Trials
- (2012) Zvia Agur et al. MOLECULAR THERAPY
- The Pharmacokinetic/Pharmacodynamic Pipeline: Translating Anticancer Drug Pharmacology to the Clinic
- (2011) Qingyu Zhou et al. AAPS Journal
- Multiscale Cancer Modeling
- (2011) Thomas S. Deisboeck et al. Annual Review of Biomedical Engineering
- Dose adaptation of capecitabine based on individual prediction of limiting toxicity grade: evaluation by clinical trial simulation
- (2011) Ines Paule et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Pharmacogenetics: From Bench to Byte— An Update of Guidelines
- (2011) J J Swen et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation
- (2011) Nicolas Picard et al. Expert Opinion on Drug Metabolism & Toxicology
- Integrating pharmacogenetics into gemcitabine dosing—time for a change?
- (2011) Joseph Ciccolini et al. Nature Reviews Clinical Oncology
- Modélisation du risque d’évolution métastatique chez les patients supposés avoir une maladie localisée
- (2011) D. Barbolosi et al. Oncologie
- Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
- (2011) Piet H. van der Graaf et al. PHARMACEUTICAL RESEARCH
- Pharmacokinetic drug–drug interactions with methotrexate in oncology
- (2011) Dominique Levêque et al. Expert Review of Clinical Pharmacology
- DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity
- (2010) Chen Guang Yang et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Moving towards dose individualization of tyrosine kinase inhibitors
- (2010) Heinz-Josef Klümpen et al. CANCER TREATMENT REVIEWS
- Routine Dihydropyrimidine Dehydrogenase Testing for Anticipating 5-Fluorouracil–Related Severe Toxicities: Hype or Hope?
- (2010) Joseph Ciccolini et al. Clinical Colorectal Cancer
- Factors for Hematopoietic Toxicity of Carboplatin: Refining the Targeting of Carboplatin Systemic Exposure
- (2010) Antonin Schmitt et al. JOURNAL OF CLINICAL ONCOLOGY
- High-dose methotrexate in adults with osteosarcoma: a population pharmacokinetics study and validation of a new limited sampling strategy
- (2009) Charlotte Dupuis et al. ANTI-CANCER DRUGS
- Model-Based Neutrophil-Guided Dose Adaptation in Chemotherapy: Evaluation of Predicted Outcome with Different Types and Amounts of Information
- (2009) Johan E. Wallin et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis
- (2009) John M.L. Ebos et al. CANCER CELL
- A Universal Formula Based on Cystatin C to Perform Individual Dosing of Carboplatin in Normal Weight, Underweight, and Obese Patients
- (2009) A. Schmitt et al. CLINICAL CANCER RESEARCH
- Dose calculation of anticancer drugs
- (2008) Bo Gao et al. Expert Opinion on Drug Metabolism & Toxicology
- An interface model for dosage adjustment connects hematotoxicity to pharmacokinetics
- (2008) C. Meille et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started