Article
Oncology
Tze Min Wah, Jim Zhong, Michelle Wilson, Naveen S. Vasudev, Rosamonde E. Banks
Summary: Ablation techniques using extreme temperatures can kill cancer cells and stimulate an immune response in patients, acting like a vaccine. Combining ablation with immune-targeting drugs may enhance treatment effects, but further understanding of the impact on patients' immune systems and cancer cells is needed. Studying the biological changes induced by ablation is crucial for informing the design of trials testing combined immunotherapies with ablation.
Review
Medicine, General & Internal
Arian Mansur, Tushar Garg, Apurva Shrigiriwar, Vahid Etezadi, Christos Georgiades, Peiman Habibollahi, Timothy C. Huber, Juan C. Camacho, Sherif G. Nour, Alan Alper Sag, John David Prologo, Nariman Nezami
Summary: Image-guided percutaneous ablation methods offer precise tumor destruction with lower risks, shorter recovery periods, and more preservation of organ parenchyma compared to conventional methods. They have been widely utilized for the treatment of primary and metastatic tumors in various organs.
Article
Radiology, Nuclear Medicine & Medical Imaging
Vinson Wai-Shun Chan, Filzah Hanis Osman, Jon Cartledge, Walter Gregory, Michael Kimuli, Naveen S. Vasudev, Christy Ralph, Satinder Jagdev, Selina Bhattarai, Jonathan Smith, James Lenton, Tze Min Wah
Summary: A retrospective study compared the long-term and peri-operative outcomes of image-guided ablation (IGA) and laparoscopic partial nephrectomy (LPN) in localized RCC patients. The study found that IGA had better local recurrence-free survival (LRFS) and metastasis-free survival compared to LPN, and also preserved kidney function better post-operatively.
EUROPEAN RADIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Robrecht R. M. M. Knapen, Remon Korenblik, Sinead James, Glenn Dams, Bram Olij, Sanne W. W. de Boer, Ronald M. M. van Dam, Christiaan van der Leij
Summary: The aim of this study was to assess the influence of radiofrequency or microwave ablation (RFA/MWA) on liver volume in patients with primary and secondary liver lesions. The results showed that in patients with secondary liver lesions, the absolute liver volume and the volume of segments II/III increased by approximately 6% after ablation, while the liver volume in patients with primary liver lesions remained stable. These findings indicate the potential added benefit of thermal liver ablation on FLR hypertrophy inducing procedures in patients with secondary liver lesions.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Review
Medicine, General & Internal
Terrence C. H. Hui, Justin Kwan, Uei Pua
Summary: Percutaneous ablation is a common treatment for liver tumors, with a focus on achieving necrosis of tumor cells while minimizing damage to surrounding tissue. Considerations include choosing appropriate imaging and protective techniques to optimize outcomes and achieve satisfactory ablation margins.
Review
Chemistry, Analytical
Matteo Calvarese, Tobias Meyer-Zedler, Michael Schmitt, Orlando Guntinas-Lichius, Juergen Popp
Summary: In this article, recent developments and advances in femtosecond laser ablation, particularly in the field of biomedical applications, are reviewed. The focus has shifted towards expanding the use of ultrafast laser ablation in various fields beyond ophthalmology, such as dental and orthopaedic surgery. The integration of spectroscopic analytical imaging techniques and the development of endoscopic probes for ultrafast laser surgery have paved the way for clinical applications in otolaryngology, inner ear surgery, as well as cancer detection and simultaneous tumor removal.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fangyi Liu, Yang Liu, Chengzhong Peng, Mingan Yu, Songsong Wu, Linxue Qian, Zhiyu Han, Jie Yu, Huihui Chai, Ping Liang
Summary: This study aimed to investigate the efficacy and safety of ultrasound-guided microwave ablation and radiofrequency ablation for primary hyperparathyroidism. The results showed that these two treatment methods have high efficacy and safety in treating PHPT, and the pre-ablation PTH level is a key factor affecting the cure rate.
EUROPEAN RADIOLOGY
(2022)
Article
Biology
Benjamin Weixler, Leonard A. Lobbes, Luis Scheiner, Johannes C. Lauscher, Sebastian M. Staubli, Markus Zuber, Dimitri A. Raptis
Summary: This study evaluates the value of ICG visualization in determining R0 resection in primary liver cancer and liver metastases surgery. The results show that ICG NIRF guidance helps to identify R0 resection intraoperatively and allows for the detection of additional malignant lesions.
Review
Gastroenterology & Hepatology
Andras Bibok, Dae Won Kim, Mokenge Malafa, Bela Kis
Summary: Pancreatic cancer presents challenges with limited treatment options and poor prognosis. Chemotherapy is the standard first-line treatment for locally advanced pancreatic cancer, while it is also the primary option for patients with metastatic pancreatic cancer. New ablative techniques and liver-directed therapies are emerging as potential treatment options for these patients, showing promise in improving overall survival.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Yuan Song, Meng Wu, Ruhai Zhou, Ping Zhao, Dan Mao
Summary: This study compared the safety and mid-term outcomes of hydrodissection-assisted microwave ablation (MWA) with conventional MWA for hepatocellular carcinoma (HCC) in different locations. The results showed that hydrodissection-assisted MWA demonstrated similar complete ablation rates and mid-term outcomes as conventional treatment for HCC in various difficult locations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Gaetano Aurilio, Giovanni Mauri, Duccio Rossi, Paolo Della Vigna, Guido Bonomo, Gianluca Maria Varano, Daniele Maiettini, Maria Cossu Rocca, Elena Verri, Daniela Cullura, Franco Nole, Franco Orsi
Summary: Renal cell carcinoma is a common tumor with high recurrence and metastasis rates. Image-guided ablation techniques, such as microwave, radiofrequency, cryo, and laser, can effectively control tumor progression. Systemic treatment can be initiated at a certain time after the ablation. The primary success and efficacy rates were high, and no significant complications occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Wenjing Ni, Yue Yuan, Xiaoqiu Chu, Guofang Chen, Xue Han, Jie Li, Xinping Wu, Jianhua Wang, Chao Liu, Shuhang Xu
Summary: The study showed that ultrasound-guided microwave ablation is effective and safe in treating primary hyperparathyroidism, leading to a decrease in serum PTH levels and reduction in the volume of parathyroid adenomas. Furthermore, MWA can impede bone remodeling to suppress hyperparathyroidism in patients with PHPT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Fenghai Liu, Baozhou Hou, Zhuofu Li, Lei Zhang, Yingwen Zhou, Hao Bian, Zhaoyang Huo
Summary: This study aimed to investigate the feasibility and efficacy of real-time 3.0 T magnetic resonance imaging (MRI) guided percutaneous microwave ablation (MWA) in the treatment of multifocal liver cancer. A total of 76 lesions in 26 patients were analyzed retrospectively. The results showed that MWA had a high technical success rate and excellent short-term efficacy with minimal complications.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Raul N. Uppot, Tze Min Wah, Peter R. Mueller
Summary: Image-guided ablation is a well-accepted treatment option for renal cell carcinoma, providing minimally invasive treatment and preserving renal function. Recent advances in tools and techniques have enhanced safety and patient outcomes. This article provides a comprehensive review of percutaneous ablation in the management of renal cell carcinoma.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Shuwei Xing, Joeana Cambranis Romero, Derek W. Cool, Amol Mujoomdar, Elvis C. S. Chen, Terry M. Peters, Aaron Fenster
Summary: In this study, 3D ultrasound imaging was used to evaluate intra-procedural tumor coverage and provide applicator adjustment information for optimization. The results showed that some cases had incomplete tumor coverage, but most cases achieved 100% tumor coverage after adjusting the applicator.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Article
Oncology
Thomas C. C. Yau, Riccardo Lencioni, Wattana Sukeepaisarnjaroen, Yee Chao, Chia-Jui Yen, Wirote Lausoontornsiri, Pei-Jer Chen, Theeranun Sanpajit, Aaron Camp, Donna S. Cox, Robert C. Gagnon, Yuan Liu, Kristen E. Raffensperger, Diptee A. Kulkarni, Howard Kallender, Lone Harild Ottesen, Ronnie T. P. Poon, Donald P. Bottaro
CLINICAL CANCER RESEARCH
(2017)
Letter
Gastroenterology & Hepatology
Robert Montal, Riccardo Lencioni, Josep M. Llovet
JOURNAL OF HEPATOLOGY
(2017)
Article
Gastroenterology & Hepatology
Riccardo Lencioni, Robert Montal, Ferran Torre, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, Jose Rios, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet
JOURNAL OF HEPATOLOGY
(2017)
Article
Paleontology
Valentina Giuffra, Simona Minozzi, Giulia Riccomi, Antonio Giuseppe Naccarato, Maura Castagna, Riccardo Lencioni, Silvio Chericoni, Valeria Mongelli, Cristina Felici
INTERNATIONAL JOURNAL OF PALEOPATHOLOGY
(2019)
Article
Oncology
M. Moehler, J. Heo, H. C. Lee, W. Y. Tak, Y. Chao, S. W. Paik, H. J. Yim, K. S. Byun, A. Baron, G. Ungerechts, D. Jonker, L. Ruo, M. Cho, A. Kaubisch, H. Wege, P. Merle, O. Ebert, F. Habersetzer, J. F. Blanc, Olivier Rosmorduc, R. Lencioni, R. Patt, A. M. Leen, F. Foerster, M. Homerin, N. Stojkowitz, M. Lusky, J. M. Limacher, M. Hennequi, N. Gaspar, B. McFadden, N. De Silva, D. Shen, A. Pelusio, D. H. Kirn, C. J. Breitbach, J. M. Burke
Article
Dermatology
Teresa Oranges, Saverio Vitali, Bianca Benincasa, Rossana Izzetti, Riccardo Lencioni, Davide Caramella, Marco Romanelli, Valentina Dini
SKIN RESEARCH AND TECHNOLOGY
(2020)
Review
Gastroenterology & Hepatology
Josep M. Llovet, Augusto Villanueva, Jorge A. Marrero, Myron Schwartz, Tim Meyer, Peter R. Galle, Riccardo Lencioni, Tim F. Greten, Masatoshi Kudo, Sumithra J. Mandrekar, Andrew X. Zhu, Richard S. Finn, Lewis R. Roberts
Article
Medicine, General & Internal
Josep M. Llovet, Robin Kate Kelley, Augusto Villanueva, Amit G. Singal, Eli Pikarsky, Sasan Roayaie, Riccardo Lencioni, Kazuhiko Koike, Jessica Zucman-Rossi, Richard S. Finn
Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.
NATURE REVIEWS DISEASE PRIMERS
(2021)
Review
Gastroenterology & Hepatology
Josep M. Llovet, Thierry De Baere, Laura Kulik, Philipp K. Haber, Tim F. Greten, Tim Meyer, Riccardo Lencioni
Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Piero Boraschi, Francescamaria Donati, Rosa Cervelli, Federica Pacciardi, Gaia Tarantini, Maura Castagna, Lucio Urbani, Riccardo Lencioni
Summary: The preADC value can be predictive of the lesion ChT response; PostADC and Delta ADC values are important for evaluating tumor treatment response after preoperative ChT in patients with colorectal liver metastases; There is a significant correlation between TRG and RECIST1.1 criteria in assessing the chemoresponse of liver metastases.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Riad Salem, Daneng Li, Nicolas Sommer, Sairy Hernandez, Wendy Verret, Beiying Ding, Riccardo Lencioni
Summary: The IMbrave150 trial demonstrated significant improvement in clinical outcomes with atezolizumab + bevacizumab compared to sorafenib in unresectable hepatocellular carcinoma patients, showing higher objective response rate and deeper response depth.
Article
Oncology
Tim F. Greten, Ghassan K. Abou-Alfa, Ann-Lii Cheng, Austin G. Duffy, Anthony B. El-Khoueiry, Richard S. Finn, Peter R. Galle, Lipika Goyal, Aiwu Ruth He, Ahmed O. Kaseb, Robin Kate Kelley, Riccardo Lencioni, Amaia Lujambio, Donna Mabry Hrones, David J. Pinato, Bruno Sangro, Roberto Troisi, Andrea Wilson Woods, Thomas Yau, Andrew X. Zhu, Ignacio Melero
Summary: The standard of care for advanced HCC has been transformed by the combination of immunotherapy and anti-VEGF therapy, showing improved overall survival rates. The use of immunotherapy in later stages of treatment has been proven safe and effective, with ongoing research focusing on novel combinations of ICI and TKI for earlier intervention in HCC treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Gastroenterology & Hepatology
Josep M. Llovet, Riccardo Lencioni
JOURNAL OF HEPATOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haydar Celik, Paul Wakim, William F. Pritchard, Meryll Castro, Shelby Leonard, John W. Karanian, Mark W. Dewhirst, Riccardo Lencioni, Bradford J. Wood
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2019)
Article
Oncology
Won Young Tak, Shi-Ming Lin, Yijun Wang, Jiasheng Zheng, Aldo Vecchione, Soo Young Park, Min Hua Chen, Stephen Wong, Ruocai Xu, Cheng-Yuan Peng, Yi-You Chiou, Guan-Tarn Huang, Jianqiang Cai, Basri Johan Jeet Abdullah, June Sung Lee, Jae Young Lee, Jong-Young Choi, Julieta Gopez-Cervantes, Morris Shermans, Richard S. Finn, Masao Omata, Michael O'Neal, Lukas Makris, Nicholas Borys, Ronnie Poon, Riccardo Lencioni
CLINICAL CANCER RESEARCH
(2018)