期刊
NATURE REVIEWS CLINICAL ONCOLOGY
卷 12, 期 6, 页码 313-314出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrclinonc.2015.89
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Investigational metronomic chemotherapy involves frequent, regularly spaced, long-term administration of a sub-maximum tolerated dose. The phase III CAIRO3 trial evaluated continuous metronomic oral capecitabine, with bevacizumab, as a maintenance treatment in patients with metastatic colorectal cancer; a benefit in progression-free survival compared with observation only was observed, highlighting that metronomic chemotherapy could be a less toxic and convenient therapy.
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