☆ 4.7 Article

Antimicrobial Activity of Solithromycin against Serotyped Macrolide-Resistant Streptococcus pneumoniae Isolates Collected from US Medical Centers in 2012

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2015)

期刊

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

卷 59, 期 4, 页码 2432-2434

出版社

AMER SOC MICROBIOLOGY

DOI: 10.1128/AAC.04568-14

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Microbiology Pharmacology & Pharmacy

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CEMPRA Pharmaceuticals (Chapel Hill, NC)

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Reagent

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Solithromycin, a next-generation macrolide and novel fluoroketolide, was tested against a 2012 collection of serotyped U.S. macrolide-resistant Streptococcus pneumoniae isolates associated with community-acquired bacterial pneumonia (CABP). Against all 272 isolates, solithromycin demonstrated high potency (MIC50/90, 0.06/0.25 mu g/ml), and it inhibited all strains at MICs of <= 0.5 mu g/ml, including the two most prevalent macrolide-resistant serotypes (19A and 35B). These data support the continued clinical development of solithromycin for the treatment of multidrug-resistant CABP.

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