Article
Mathematics, Applied
Saima Naheed, Shahid Mubeen, Gauhar Rahman, M. R. Alharthi, Kottakkaran Sooppy Nisar
Summary: This article establishes inequalities involving generalized Fox-Wright function and discusses new Redheffer-type inequalities for generalized hypergeometric functions and the four-parametric generalized Mittag-Leffler functions by using suitable values of exponents in generalized inequalities.
Article
Mathematics, Applied
Khaled Mehrez, Tibor K. Pogany
Summary: The focus of the paper is on establishing definite integral formulae for ratios of the Fox-Wright functions, leading to novel integral formulae for ratios of other special functions associated with Fox-Wright. Closed integral form expressions for Mathieu-type series and associated alternating versions are obtained, with functional bounding inequalities established for these series as applications.
JOURNAL OF MATHEMATICAL INEQUALITIES
(2021)
Article
Mathematics
Asifa Tassaddiq, Rekha Srivastava, Ruhaila Md Kasmani, Dalal Khalid Almutairi
Summary: A literature review reveals that the Fox-Wright function serves as more than a mere mathematical puzzle, as it naturally represents fundamental physical phenomena. Motivated by this insight, we explore a new representation of the function using complex delta functions. This representation proves useful for computing the Laplace transform of the function with respect to the third parameter γ, and it extends the one and two-parameter Mittag-Leffler functions. New identities involving the Fox-Wright function are discussed and utilized to simplify the obtained results. Additionally, we evaluate various fractional transforms and apply the new representation to obtain the solution for a fractional kinetic equation. Several new properties of the function are studied as a distribution.
Article
Mathematics, Applied
Khaled Mehrez
Summary: The main focus of this paper is to establish new summation formulas of Fox-Wright-type series containing the polygamma functions in terms of some special functions (such as the G-Meijer functions). Several interesting new special cases and consequences of the main results are also considered. Additionally, numerical results are presented to illustrate the findings of this study.
APPLIED NUMERICAL MATHEMATICS
(2022)
Article
Geography, Physical
Dongjun Chen, Linsheng Zhong, Jie Fan, Hu Yu, Ding Yang, Yuxi Zeng
Summary: Research on the function structures of the Tibetan Plateau's national parks is vital for their coordinated development. The functions of the national parks include ecological protection, recreation, and community development, with potential for scientific research and education. The degree of coupling and coordination between the functions varies among individual national parks, reflecting different function structures. This study contributes to evaluating the functions and structures of national park clusters and serves as a reference for optimizing the Tibetan Plateau National Park Cluster's development.
JOURNAL OF GEOGRAPHICAL SCIENCES
(2022)
Article
Chemistry, Physical
Harjinder Singh
Summary: This study investigates the crystal structure of 1-(4-chloro-3-nitrophenyl)-6,7-dihydro-1H-benzo[d][1,2,3]triazol-4(5H)-one and predicts its geometry and properties using different basis sets and the DFT method. Non-covalent and intra-molecular interactions are studied, and analyses of electronic structure, vibrational assignments, UV-visible spectra, and chemical reactivity descriptors are performed. Theoretical calculations and comparisons provide insights into the compound's properties and chemical behavior.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Crystallography
Penglin Fang, Wenyue Tang, Yaoguo Shen, Jinquan Hong, Yongming Li, Junrong Jia
Summary: By using the homovalent cation substitution strategy, a new sulfate compound, Cs2Ca3(SO4)(4), was successfully synthesized. The compound exhibits a unique crystal structure and a large energy band gap. The role of cations in tuning structural symmetry and birefringence was also analyzed through comparisons with similar compounds.
Review
Chemistry, Multidisciplinary
Wei Cao, Xuhao Zhou, Naneki C. McCallum, Ziying Hu, Qing Zhe Ni, Utkarsh Kapoor, Christian M. Heil, Kristine S. Cay, Tara Zand, Alex J. Mantanona, Arthi Jayaraman, Ali Dhinojwala, Dimitri D. Deheyn, Matthew D. Shawkey, Michael D. Burkart, Jeffrey D. Rinehart, Nathan C. Gianneschi
Summary: Melanin is a natural biomaterial with various functions found in living organisms, classified into different types based on chemical precursors. Despite its complexity and diversity in chemical structure, synthetic mimics have been used to study its structure-function relationships. Efforts are being made to elucidate biosynthetic pathways and characterize melanin materials for potential new opportunities in synthetic materials.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Cell Biology
Xiwu Ouyang, Lemeng Feng, Lei Yao, Jingyu Zhang, Yao Xiao, Guodong Liu, Gewen Zhang, Zhiming Wang
Summary: This study provides comprehensive evaluation of the clinical value of FOX proteins in HCC and experimental evidence supporting the role of FOXH1 in HCC development. The findings suggest that FOXH1 promotes cell growth and migration/invasion in HCC through mTOR signaling. These results contribute to the development of more effective therapies for HCC patients.
Article
Mathematics, Applied
Khaled Mehrez
Summary: This paper introduces a new set of conditions for the Fox H-functions, proving that they are non-negative. It also establishes some classes of functions involving the Fox H-function and discusses new facts regarding the Fox-Wright functions.
ANALYSIS AND MATHEMATICAL PHYSICS
(2021)
Article
Agriculture, Dairy & Animal Science
Nedzad Hadziomerovic, Ozan Gundemir, Faruk Tandir, Rizah Avdic, Muhamed Katica
Summary: This study described the morphological and morphometric features of the auditory ossicles in red foxes and provided important geometric data through analysis. The results showed that the anatomical organization of the auditory ossicles in red foxes is similar to that in other animals, which contributes to the field of auditory biology.
Article
Biochemistry & Molecular Biology
Deborah Giordano, Cassiano Langini, Amedeo Caflisch, Anna Marabotti, Angelo Facchiano
Summary: The study compares the structures and flexibility of transglutaminase enzymes from Kutzneria albida (KalbTGase) and Streptomyces mobaraensis (MTGase). It is found that KalbTGase is more rigid and has a more closed catalytic site at room temperature, indicating higher selectivity compared to MTGase. Preliminary results at higher temperature suggest enhanced flexibility of KalbTGase, potentially allowing it to adapt to different substrates, while MTGase shows reduced adaptability and catalytic activity at higher temperatures.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Mathematics
Khaled Mehrez
Summary: This paper investigates some new properties of the incomplete Fox-Wright function, including integral representation, inequalities, log-convexity, and complete monotonicity. It also establishes generating functions related to the Appell function of the first kind and provides new summation formula for the incomplete Fox-Wright function using these generating functions.
Article
Environmental Sciences
Huifeng Wu, Baoan Hu, Hairong Han, Xiaoqin Cheng, Fengfeng Kang
Summary: This study investigates the structure and functions of six types of land-use restoration in the hilly-gully region of the Loess Plateau, China. It quantifies the structure of the ecosystems through network topology and explores the relationships between structure and functions. The results suggest that mixed plantations enhance connectivity and have more balanced topological metrics and ecological functions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Hussain S. Reshamwala, Pankaj Raina, Zehidul Hussain, Shaheer Khan, Rodolfo Dirzo, Bilal Habib
Summary: This study is the first to examine the daily movement of red fox at a small temporal scale in the Trans-Himalayan landscape. The results showed that red fox prefer lower elevations with less rugged terrain and are positively associated with water sources.
Article
Biochemistry & Molecular Biology
Dominique de Seny, Dominique Baiwir, Elettra Bianchi, Gael Cobraiville, Celine Deroyer, Christophe Poulet, Olivier Malaise, Genevieve Paulissen, Marie-Joelle Kaiser, Jean-Philippe Hauzeur, Gabriel Mazzucchelli, Philippe Delvenne, Michel Malaise
Summary: This proteomic study examines the molecular-level characteristics of synovial membrane inflammation in different arthritis joint diseases. The researchers identified 10 differentially expressed proteins in the synovial membrane, with 7 of them showing significant increased expression in rheumatoid arthritis and correlation to the histological inflammatory score. This study demonstrates the potential of proteomics as a powerful tool for characterizing synovitis beyond classical histology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Gerelchimeg Bou, Shimeng Guo, Jia Guo, Zhuang Chai, Jianchao Zhao, Yan Li, Zhonghua Liu
Summary: While Nanog is important for maintaining pluripotency in pigs and mice, overexpression of NANOG in early porcine embryos does not improve the efficiency of pluripotent embryonic stem cell clone formation. Therefore, NANOG overexpression is unnecessary for the initial establishment of porcine pluripotent embryonic stem cell clones in vitro.
Article
Multidisciplinary Sciences
David Rodriguez-Temporal, Fernando Alcaide, Ivana Marekovic, James Anthony O'Connor, Rebecca Gorton, Jakko van Ingen, An Van den Bossche, Genevieve Hery-Arnaud, Clemence Beauruelle, Dorothea Orth-Hoeller, Juan-Jose Palacios-Gutierrez, Griselda Tudo, German Bou, Pieter-Jan Ceyssens, Montserrat Garrigo, Julia Gonzalez-Martin, Gilbert Greub, Jaroslav Hrabak, Andre Ingebretsen, Maria Concepcion Mediavilla-Gradolph, Marina Oviano, Begona Palop, Arthur B. Pranada, Lidia Quiroga, Maria Jesus Ruiz-Serrano, Belen Rodriguez-Sanchez
Summary: The ability of MALDI-TOF for the identification of nontuberculous mycobacteria (NTM) has been improved recently, thanks to updated databases and optimized protein extraction procedures. This study evaluated the reproducibility of MALDI-TOF in 15 laboratories across 9 European countries for NTM identification. The results showed that MALDI-TOF is a highly reproducible method and suitable for NTM identification implementation.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Eva Gato, Ahalieyah Anantharajah, Manuel J. Arroyo, Maria Jose Artacho, Juan de Dios Caballero, Ana Candela, Katerina Chudejova, Ignacio Pedro Constanso, Cristina Elias, Javier Fernandez, Jesus Jimenez, Pilar Lumbreras, Gema Mendez, Xavier Mulet, Patricia Perez-Palacios, Belen Rodriguez-Sanchez, Rafael Canton, Jaroslav Hrabak, Luis Mancera, Luis Martinez-Martinez, Antonio Oliver, Alvaro Pascual, Alexia Verroken, German Bou, Marina Oviano
Summary: In this study, the performance of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for rapid detection of carbapenemase activity in Enterobacterales was evaluated. The method demonstrated high sensitivity and specificity, with an overall agreement rate of 92.5% relative to the reference standard. Results were obtained within 60 minutes and accuracy ranged from 83.3% to 100% among different centers. MALDI-TOF MS proves to be an outstanding tool for rapid detection of carbapenemase activity in clinical microbiology laboratories.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Microbiology
Krisztina M. Papp-Wallace, Jean-Denis Docquier, Frederic Kerff, Pablo Power
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Cristina Lasarte-Monterrubio, Paula Guijarro-Sanchez, Alba Belles, Juan Carlos Vazquez-Ucha, Jorge Arca-Suarez, Carlos Fernandez-Lozano, German Bou, Alejandro Beceiro
Summary: This study characterized the development of carbapenem resistance in clinical isolates of Acinetobacter junii and Acinetobacter nosocomialis due to the acquisition of a plasmid-borne bla(OXA-24/40) gene, as well as the dissemination of this gene between species of Acinetobacter for the first time. The presence of a new plasmid carrying the carbapenem-resistance gene bla(OXA-24/40) was identified in both strains, facilitating the horizontal transfer of carbapenem resistance. The identification of plasmids similar to the GR12 group carrying bla(OXA-24/40) in multiple Acinetobacter species suggests a concerning dissemination and spread of carbapenem resistance in this bacterial genus.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
T. A. Alsenani, S. L. Viviani, V Kumar, M. A. Taracila, C. R. Bethel, M. D. Barnes, K. M. Papp-Wallace, R. K. Shields, M. H. Nguyen, C. J. Clancy, R. A. Bonomo, F. van den Akker
Summary: The structural study of KPC-2 D179 variants revealed destabilization of the Omega loop, contributing to ceftazidime-avibactam resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Magdalena A. Taracila, Christopher R. Bethel, Andrea M. Hujer, Krisztina M. Papp-Wallace, Melissa D. Barnes, Joseph D. Rutter, Jamie VanPelt, Ben A. Shurina, Focco van den Akker, Cornelius J. Clancy, M. Hong Nguyen, Shaoji Cheng, Ryan K. Shields, Richard C. Page, Robert A. Bonomo
Summary: This study investigates the susceptibility and resistance mechanism of D179Y variant of KPC-2 and -3 to carbapenems and ceftazidime and ceftazidime-avibactam, and it reveals that conformational changes and overall disorder caused by D179Y substitution contribute to the unexpected phenotype.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Letter
Microbiology
Juan Carlos Vazquez-Ucha, Cristina Lasarte-Monterrubio, Paula Guijarro-Sanchez, Marina Oviano, Laura Alvarez-Fraga, Isaac Alonso-Garcia, Jorge Arca-Suarez, German Bou, Alejandro Beceiro
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Environmental Sciences
Juan A. Vallejo, Noelia Trigo-Tasende, Soraya Rumbo-Feal, Kelly Conde-Perez, Angel Lopez-Oriona, Ines Barbeito, Manuel Vaamonde, Javier Tarrio-Saavedra, Ruben Reif, Susana Ladra, Bruno K. Rodino-Janeiro, Mohammed Nasser-Ali, Angeles Cid, Maria Veiga, Anton Acevedo, Carlos Lamora, German Bou, Ricardo Cao, Margarita Poza
Summary: The quantification of SARS-CoV-2 RNA load in wastewater has emerged as a useful tool to monitor COVID-19 outbreaks in communities. This approach was implemented in the metropolitan area of A Coruna, where wastewater analysis helped track the epidemic dynamics. Regression models allowed estimation of the number of infected individuals and served as an effective early warning tool for predicting outbreaks in the municipality.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Microbiology
Philip Hinchliffe, Catherine L. Tooke, Christopher R. Bethel, Benlian Wang, Christopher Arthur, Kate J. Heesom, Stuart Shapiro, Daniela M. Schlatzer, Krisztina M. Papp-Wallace, Robert A. Bonomo, James Spencer
Summary: This study reveals the mechanism of action of two β-lactamase inhibitors, enmetazobactam and tazobactam, on CTX-M-15 β-lactamase in Escherichia coli, including the formation of protein cross-link and epimerization of amino acids.
Article
Biochemistry & Molecular Biology
Loic Martinet, Dominique Baiwir, Gabriel Mazzucchelli, Sebastien Rigali
Summary: This study identified 43 novel ferroverdins from the cytosol of two Streptomyces lunaelactis species using high-resolution mass spectrometry. The structure of 13 of these ferroverdins was elucidated and five new alternative chelators for Fe2+-binding were discovered. Additionally, two ferroverdins that do not recruit specific ligands were reported. These findings are significant for the development of new CETP inhibitors or ferroverdins with novel bioactivities.
Article
Biotechnology & Applied Microbiology
Pablo Aja-Macaya, Soraya Rumbo-Feal, Margarita Poza, Angelina Canizares, Juan A. A. Vallejo, German Bou
Summary: A new method for extraction and enrichment of genomic MPXV DNA was developed, which significantly improved the sequencing efficiency and trustworthiness of the consensus sequences. Enriched samples contained a higher percentage of MPXV reads compared to non-enriched samples, leading to more accurate and cost-effective diagnosis of contagious diseases.
Article
Infectious Diseases
Juan Carlos Vazquez-Ucha, Isaac Alonso-Garcia, Paula Guijarro-Sanchez, Cristina Lasarte-Monterrubio, Laura Alvarez-Fraga, Arnau Cendon-Esteve, Michelle Outeda, Romina Maceiras, Andrea Pena-Escolano, Marta Martinez-Guitian, Jorge Arca-Suarez, German Bou, Alejandro Beceiro
Summary: Metallo- ,B-lactamase (MBL)-producing Enterobacterales, which are resistant to almost all ,B-lactam antibiotics, pose a significant threat due to their wide dissemination and difficulty in treatment. This study evaluated the activity of aztreonam in combination with novel ,B-lactamase inhibitors (BLIs) against clinical isolates co-producing MBLs and SBLs. The results showed that aztreonam/zidebactam, aztreonam/avibactam, and aztreonam/taniborbactam were the most effective combinations, offering promising therapeutic strategies for difficult-to-treat infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Food Science & Technology
Fernanda Gobbi Amorim, Damien Redureau, Thomas Crasset, Lou Freuville, Dominique Baiwir, Gabriel Mazzucchelli, Stefanie K. K. Menzies, Nicholas R. R. Casewell, Loic Quinton
Summary: This study applies a new generation of proteomic methodology, the MELD approach, to deeply characterize complex snake venom protein mixtures. The MELD method improves the sequencing and identification of peptides and proteins, leading to a greater identification of toxins and proteins. These results demonstrate that MELD is a credible methodology for venomic analysis and has the potential to expand global knowledge about venom composition.