Article
Quantum Science & Technology
Yun-Yi Pai, Claire E. Marvinney, Chengyun Hua, Raphael C. Pooser, Benjamin J. Lawrie
Summary: Magneto-optical sensors, such as spin noise spectroscopies and magneto-optical Kerr effect microscopies, are essential tools for materials characterization, providing insights into spin dynamics and other interactions. Quantum-enhanced spin noise measurements offer higher sensitivity and lower operating temperatures, presenting a significant advantage over classical measurements.
ADVANCED QUANTUM TECHNOLOGIES
(2022)
Review
Engineering, Biomedical
Bernhard Burtscher, Pamela Allison Manco Urbina, Chiara Diacci, Simone Borghi, Marcello Pinti, Andrea Cossarizza, Carlo Salvarani, Magnus Berggren, Fabio Biscarini, Daniel T. Simon, Carlo A. Bortolotti
Summary: The overview of cytokine biosensing on organic electronic platforms highlights the importance of monitoring inflammation biomarkers in real time. The technologies provided by OECTs and EGOFETs offer low-cost point-of-care solutions that can significantly benefit the healthcare system and professionals.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kunli Cao, Miao Wu, Jiabao Bai, Zhen Wen, Jianwei Zhang, Tianyi Wang, Meiwen Peng, Tao Liu, Zheng Jia, Zhiqiang Liang, Lin Jiang
Summary: The development of robotic skins capable of handling complex external pressure environments is highly desired, but remains a major challenge due to the lack of pressure sensing materials that can combine extremely low detection limits and wide detection ranges. Inspired by the synergistic strategy of dual mechanoreceptors in human skin, laminated graphene pressure sensing materials have been designed and 3D printed to achieve a low detection limit and wide detection range, showing great potential for applications such as electronic skin and human-machine interfaces.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Tongjun Liu, Cheng-Hung Chi, Jun-Yu Ou, Jie Xu, Eng Aik Chan, Kevin F. MacDonald, Nikolay I. Zheludev
Summary: By using deep-learning analysis of topologically structured light scattering, we have achieved optical imaging and metrology of nanostructures with subatomic precision, bridging the resolution gap between optical techniques and atomic-scale transmission electron microscopy.
Article
Materials Science, Multidisciplinary
Xun Zhao, Austin Chang, Justin Li, Jing Xu, John Hollister, Ziyuan Che, Xiao Wan, Junyi Yin, Shaolei Wang, Shinyoung Lee, Pirouz Kavehpour, Jun Chen
Summary: Advances in wearable bioelectronics have the potential to transform healthcare from reactive to proactive by focusing on disease prevention and health promotion. This study presents the development of an air-permeable textile (APT) bioelectronics that utilizes a liquid metal electrode encapsulated between layers of electrospun Polycaprolactone textile. The APT bioelectronics demonstrates stable performance, producing an open-circuit voltage of 12 V and a short-circuit current of 0.12 mA. With a drying rate of 5.07% min(-1), the APT bioelectronics offers improved breathability and wearing comfort compared to conventional fabrics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Chemistry, Multidisciplinary
Jehyung Ok, Sumin Park, Yei Hwan Jung, Tae-il Kim
Summary: Wearable and implantable electronic devices have been developed to continuously monitor and analyze the concentration of cortisol, a hormone released in response to stress. These devices provide wireless real-time analysis, overcoming the limitations of traditional cortisol measurement methods. This technology holds great potential for stress monitoring and management.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Gary Kwok Ki Chik, Na Xiao, Xudong Ji, Anderson Chun On Tsang, Gilberto Ka Kit Leung, Shiming Zhang, Chung Tin, Paddy Kwok Leung Chan
Summary: Researchers have developed a flat neural probe based on a highly flexible microelectrode array, which addresses the high impedance and mechanical mismatch caused by electrode miniaturization. The probe is coated with conductive polymers and hydrogel coatings, enhancing the signal-to-noise ratio and providing a low-cost solution to brain interfaces.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Physical
Vishesh Kashyap, Junyi Yin, Xiao Xiao, Jun Chen
Summary: This review discusses the application of bioinspired nanomaterials in wearable sensing and human-machine interface technologies, including bioinspired capacitive sensors, piezoresistive sensors, piezoelectric sensors, triboelectric sensors, magnetoelastic sensors, and electrochemical sensors. It also presents the challenges hindering scientific advancement and commercialization in academia and industry.
Article
Chemistry, Physical
Si Meng, Yuyan Zhang, Nihuan Wu, Cheng Peng, ZhiYao Huang, Zhengjie Lin, Cheng Qi, Zhou Liu, Tiantian Kong
Summary: The development of implantable bioelectronics is driven by emerging applications including continuous health monitoring and human-machine interfacing. However, the mechanical mismatch between the implanted bioelectronics and tissues compromises device accuracy and causes interference with tissues. To address this issue, researchers have developed an ultrasoft and biocompatible fiber strain sensor using bacterial cellulose. This fiber possesses stretchability and elastic modulus similar to that of soft tissues, and it demonstrates high sensitivity to tiny tensile force/strain and low cell cytotoxicity. The bacterial cellulose-based sensing fiber shows potential for monitoring subtle motions of organs in implantable bioelectric devices.
Article
Physics, Multidisciplinary
Jens A. H. Nielsen, Jonas S. Neergaard-Nielsen, Tobias Gehring, Ulrik L. Andersen
Summary: The modern scientific method relies on precise measurements of physical parameters. The measurement of optical phase, for example, is conventionally limited by the Heisenberg limit. However, deterministic phase estimation with N00N states has not yet reached or surpassed this limit. In this study, we use a scheme based on Gaussian squeezed vacuum states and high-efficiency homodyne detection to achieve phase estimates with extreme sensitivity that surpasses the shot noise limit and even the conventional Heisenberg limit.
PHYSICAL REVIEW LETTERS
(2023)
Article
Physics, Multidisciplinary
Utkarsh Mishra, Abolfazl Bayat
Summary: The ground-state criticality of many-body systems provides a resource for quantum-enhanced sensing, but the sensing capabilities may be limited for systems with partial accessibility. By periodically driving the Hamiltonian and utilizing local steady states, the precision of quantum sensing can be significantly enhanced, even surpassing the Heisenberg limit for low frequencies. This proposal is applicable to integrable models and can be implemented on existing quantum devices.
PHYSICAL REVIEW LETTERS
(2021)
Article
Physics, Multidisciplinary
Si-Ran Zhao, Yu-Zhe Zhang, Wen-Zhao Liu, Jian-Yu Guan, Weijun Zhang, Cheng-Long Li, Bing Bai, Ming-Han Li, Yang Liu, Lixing You, Jun Zhang, Jingyun Fan, Feihu Xu, Qiang Zhang, Jian-Wei Pan
Summary: The experiment demonstrates the application of distributed quantum sensing in practice, successfully achieving the unconditional violation of the shot-noise limit and testing sensing for long distances and random parameters. This represents an important step towards a practical quantum sensing network.
Article
Chemistry, Physical
Qikun Wei, Guorui Chen, Hong Pan, Zongbiao Ye, Christian Au, Chunxu Chen, Xun Zhao, Yihao Zhou, Xiao Xiao, Huiling Tai, Yadong Jiang, Guangzhong Xie, Yuanjie Su, Jun Chen
Summary: The research utilized helium plasma irradiation to fabricate a molybdenum microstructured electrode, combined with a Ti3C2Tx nanosheet-immersed polyurethane sponge to create a flexible piezoresistive pressure sensor with high sensitivity and good linearity in pressure detection. By modulating the hierarchical structures with pore size, plasma bias, and MXene concentration, the sensing performance was significantly improved.
Article
Engineering, Environmental
Ming Yang, Xiaoning Ren, Taotao Yang, Chao Xu, Yongqin Ye, Zhaowei Sun, Linghao Kong, Bin Wang, Zhiqiang Luo
Summary: Novel conductive hydrogels with excellent biocompatibility and high conductivity have been developed for various applications in bioelectronics, such as biosensors and real-time monitoring of cell proliferation. The strategy of assembling conjugated polymer hydrogel with conductive crosslinker offers new insight for constructing highly conductive hydrogels.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Multidisciplinary
Jagadeesh Suriyaprakash, Lianwei Shan, Neeraj Gupta, Hao Wang, Lijun Wu
Summary: This study developed a flexible point-of-care sensor using a Janus carbon nanocomposite (JCC) consisting of asymmetric molecular engineered porous/highly ordered carbon nanomaterial for the specific detection of ascorbic acid (AA) at a low concentration. The JCC was constructed through a new strategy of simultaneous covalent and non-covalent molecular grafting techniques, resulting in improved charge mobility, electron transfer, energy density, and stability. The integrated flexible device exhibited high selectivity, durability, stability, and reproducibility, making it a promising platform for developing high-performance sensors.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biophysics
Jiu Pang, Luqi Tao, Xiaoling Lu, Qun Yang, Vivek Pachauri, Zeping Wang, Sven Ingebrandt, Xianping Chen
BIOSENSORS & BIOELECTRONICS
(2019)
Article
Chemistry, Analytical
Mehran Khorshid, Patricia Losada-Perez, Peter Cornelis, Michele Dollt, Sven Ingebrandt, Christ Glorieux, Frank Uwe Renner, Bart van Grinsven, Ward De Ceuninck, Ronald Thoelen, Patrick Wagner
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Abhiroop Bhattacharjee, Thanh Chien Nguyen, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu
Summary: Using silicon nanowire field-effect transistors (SiNW-FETs) for impedance sensing shows potential for label-free detection of biomolecules by overcoming the Debye-screening limitation. Employing an electronic circuit model in SPICE, we quantitatively evaluated the influence of various device parameters on the transfer function of the SiNW-FETs and investigated how biomolecule binding affects impedance spectra. Mathematical analysis and simulation results led to proposed methods for improving the impedimetric readout of SiNW-FET biosensors.
Review
Engineering, Biomedical
Yuanying Liang, Andreas Offenhausser, Sven Ingebrandt, Dirk Mayer
Summary: Understanding the physiology and pathology of electrogenic cells requires quantitative investigation of ion transmission and chemical signal release. The use of organic conducting materials, especially organic electrochemical transistors like PEDOT:PSS, shows promise in interfacing electronics and biological matter for recording electrophysiological and biochemical signals.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Chemistry, Analytical
Marcel Tintelott, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu
Summary: SiNW-FET sensors have been developed as highly sensitive detectors for a variety of molecules due to their exceptional electrical properties. The bottom-up approach allows for the synthesis of silicon nanowires in a range of diameters, while the top-down approach utilizes advanced lithography techniques to fabricate SiNW out of high-quality SOI wafers. Despite the advancements in fabrication techniques, sensor-to-sensor variation remains a challenge for large-scale production in commercial applications.
Article
Chemistry, Analytical
Yuan Cao, Julia Floehr, Sven Ingebrandt, Uwe Schnakenberg
Summary: A three-level DFR lamination process using SUEX for a microfluidic chip with vertically arranged microelectrodes for electrical impedance measurements is presented. The setup traps and fixes objects under test to the electrodes using an aperture in the center of ring-shaped electrodes and a microfluidic suction channel. The electrical impedance measurements show higher values when spheres are trapped, with the magnitude depending on the sizes of the spheres.
Article
Chemistry, Analytical
Marcel Tintelott, Tom Kremers, Sven Ingebrandt, Vivek Pachauri, Xuan Thang Vu
Summary: A stable reference electrode is crucial for ion-sensitive field-effect transistors (ISFETs) in bio/chemical sensing applications. In this paper, a micro-scale solid-state pseudo-reference electrode (pRE) based on PEDOT:PSS and GO is presented, showing highly stable potential and low cross-sensitivity to ionic strength.
Article
Engineering, Biomedical
Jiri Ehlich, Ludovico Migliaccio, Ihor Sahalianov, Marta Nikic, Jan Brodsky, Imrich Gablech, Xuan Thang Vu, Sven Ingebrandt, Eric Daniel Glowacki
Summary: The study evaluated oxygen reduction reactions (ORR) at different electrode materials and found significant differences in onset potentials and H2O2 production between materials. It concluded that typical charge-balanced biphasic pulse protocols can lead to irreversible ORR, inducing hypoxic conditions and accumulation of hydrogen peroxide near the electrode surface. These findings emphasize the importance of considering faradaic ORR in neural interface devices and highlight potential physiological consequences of hypoxia and H2O2.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Andrea Kauth, Anne-Kathrin Mildner, Lena Hegel, Joachim Wegener, Sven Ingebrandt
Summary: When cells or tissues are exposed to a pulsed electric field, the cellular membrane permeabilizes, allowing gene electrotransfer (GET) to occur. GET using micro-/nano technology offers higher spatial resolution and lower voltage amplitudes compared to conventional bulk electropermeabilization (EP). In this study, we developed a specialized microelectrode array (MEA) for localized EP of adherent cells, demonstrating its functionality through loading of a fluorophore dye and subsequent expression of green fluorescent protein.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Felix Jiang, Guangzhen Xie, Jochen Heiss, Zhongkai Zhang, Sven Ingebrandt, Xuan Thang Vu
Summary: In this study, the electrical resistivity, Seebeck coefficient, and power factor of an indium tin oxide (ITO) and nickel-chromium (NiCr) thermocouple were investigated. The thicknesses of ITO and NiCr were varied from 10 to 430 nm. The measured Seebeck coefficients were between 12.8 and (21.4 +/- 1.5) mu V K-1, respectively. The results showed that a reduction in thickness generally led to an increase in the Seebeck coefficient until a maximum value was reached. Among the measured samples, the optimal Seebeck coefficients were found with an ITO thickness of (111 +/- 4) nm and NiCr thickness of (18 +/- 2) nm. Finally, the power factor of the thermocouples was determined, with a maximum power factor of (84 +/- 7) mu W m(-1 )K(-2) for the ITO thickness of (111 +/- 4) nm and nickel-chromium thickness of (42 +/- 5) nm.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Mechanics
Marcel Tintelott, Pradnya Gharpure, Yannick Coffinier, Xuan Thang Vu, Alexis Vlandas, Sven Ingebrandt, Vivek Pachauri
Summary: In this study, a chip platform combining biochemical reaction networks (BRNs) with nanoscale biologically sensitive field-effect transistor (BioFET) arrays was designed, which achieved spatial and temporal control over mass transport through a physical diffusion barrier. Computational and numerical methods were used to solve partial differential equations numerically for precise control over mass transport. By monitoring BRNs with a limit of detection (LoD) of 0.5 pM via a single-stranded deoxyribonucleic acid (ssDNA) output, it was demonstrated that compartmentalized mass transport could be achieved without crosstalk, which could be advantageous for simplified multiplexed point-of-care biosensors.
Article
Instruments & Instrumentation
Felix Jiang, Meguya Ryu, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu, Junko Morikawa
Summary: A device for measuring the thermal diffusivity of SiNx membranes was developed, and the phenomenon was detected using the photothermal method and contact detection of temperature response at different frequency ranges. The measured thermal diffusivity values were smaller than those of bulk material, likely due to the confined state of phonons in the membrane's nanoscale geometry.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Chemistry, Multidisciplinary
Ruifeng Zhu, Gabriela Figueroa-Miranda, Lei Zhou, Ziheng Hu, Bohdan Lenyk, Sven Ingebrandt, Andreas Offenhaeusser, Dirk Mayer
Summary: A dual-signal protocol was developed, combining electrochemical and optical detection methods using gold nanopit arrays, to improve aptamer-based biosensors. The non-fully penetrating AuNpA showed better plasmonic properties and enlarged the electrochemical active surface area compared to fully penetrating structures. The simultaneous use of electrochemical and optical transducers led to different detection limits, dynamic ranges, and sensitivities, providing new opportunities for disease diagnosis and point-of-care testing.
Article
Biophysics
Milad Eyvazi Hesar, Niloofar Sadat Seyedsadrkhani, Dibyendu Khan, Adib Naghashian, Mateusz Piekarski, Henning Gall, Ralph Schermuly, Hossein Ardeschir Ghofrani, Sven Ingebrandt
Summary: This research presents a wearable epidermal electronic system for continuous monitoring of a prognostic parameter for hypertension. The system is flexible, wireless, and smartphone-enabled, allowing real-time monitoring of electrocardiograms and seismocardiograms. The system shows promising performance in predicting hypertension.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Milad Eyvazi Hesar, Dibyendu Khan, Niloofar Sadat Seyedsadrkhani, Sven Ingebrandt
Summary: Seismocardiography (SCG) is a technique that measures microscale vibrations of the chest, with this study demonstrating a contactless wearable patch using piezoelectric polymer foil. NFC technology is used for power and wireless data recording, showing good correlation between SCG signals and ECG recordings.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
