期刊
NATURE METHODS
卷 13, 期 2, 页码 147-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NMETH.3691
关键词
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资金
- US National Institutes of Health [F31-NS07842A, F32-NS083099, R01-NS26539, DP1-OD006411, R00-NS060996, R01-NS070911, R01-DA031367]
- Mallinckrodt Foundation
- Rita Allen Foundation
- Brain and Behavior Research Foundation
The zebrafish (Danio rerio) is a useful vertebrate model system in which to study neural circuits and behavior, but tools to modulate neurons in freely behaving animals are limited. As poikilotherms that live in water, zebrafish are amenable to thermal and pharmacological perturbations. We exploit these properties by using transient receptor potential (TRTRP) channels to activate or ablate specific neuronal populations using the chemical and thermal agonists of heterologously expressed TRPV1, TRPM8 and TRPA1.
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