Editorial Material
Oncology
Joan C. Krepinsky
Summary: The study identified upregulation of INHBB, the subunit of activin B, in kidney fibrosis, mediated by the transcription factor Sox9, which plays an important role in kidney interstitial fibroblast activation and fibrosis. These findings provide important groundwork for investigating activin B targeting as a potential therapeutic approach to attenuate kidney fibrosis.
JOURNAL OF PATHOLOGY
(2022)
Editorial Material
Nanoscience & Nanotechnology
Giulia Pacchioni
Summary: An article in Nature presents a new scanning probe microscope, called a quantum twisting microscope, which allows for momentum-resolved measurements as well as in situ tuning of the twist angle between stacked 2D materials.
NATURE REVIEWS MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Yejin Yang, Sugyeong Ha, Somi Jeong, Chae Won Jang, Jeongwon Kim, Dong-Soon Im, Hae Young Chung, Ki Wung Chung
Summary: This study compared two reliable toxin-induced mouse kidney fibrosis models in terms of fibrosis and inflammation. The adenine diet-induced kidney fibrosis model exhibited higher inflammatory response with increased fibrosis compared to the folic acid-induced kidney fibrosis model.
Review
Endocrinology & Metabolism
Myriam Dao, Helene Francois
Summary: By examining the expression and mechanism of action of CB1R in normal kidneys, as well as its effects on metabolic and non-metabolic CKD and renal fibrosis, it is found that the inhibition of CB1R can help prevent and treat kidney diseases, especially in patients with metabolic syndrome, obesity, and diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatsiana Sushko, Anton Kavaleuski, Irina Grabovec, Anna Kavaleuskaya, Daniil Vakhrameev, Sergey Bukhdruker, Egor Marin, Alexey Kuzikov, Rami Masamrekh, Victoria Shumyantseva, Kouhei Tsumoto, Valentin Borshchevskiy, Andrei Gilep, Natallia Strushkevich
Summary: Research finds that RubB efficiently transfers electrons from cognate reductases to support bacterial CYPs activity, mutations on RubB surface do not significantly decrease CYPs activity, suggesting interactions are transient and nonspecific.
BIOORGANIC CHEMISTRY
(2021)
Review
Medicine, General & Internal
Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S. Kanwar
Summary: The incidence of obesity-related renal disorders has increased dramatically in recent years, with obesity leading to irreversible kidney damage and progression of kidney disease. Inhibitors of RAAS show short-term effectiveness, while long-term strategies such as weight loss have shown better results in mitigating kidney damage. Studies suggest that fatty acid and cholesterol metabolism play critical roles in renal lipid accumulation and inflammation.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Damian Pociecha, Natasa Vaupotic, Magdalena Majewska, Ewan Cruickshank, Rebecca Walker, John M. D. Storey, Corrie T. Imrie, Cheng Wang, Ewa Gorecka
Summary: Achiral mesogenic molecules can self-assemble into liquid crystalline smectic phases with simple or double-helical structures, exhibiting photonic bandgap phenomenon when the helix pitch is comparable to the wavelength of visible light during phase transition.
ADVANCED MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Kimio Watanabe, Emiko Sato, Eikan Mishima, Mariko Miyazaki, Tetsuhiro Tanaka
Summary: Diabetic kidney disease (DKD) is the main cause of chronic kidney disease and increases the risk of cardiovascular mortality. Treatment options for DKD have advanced, but their efficacy is limited. A deeper understanding of the molecular mechanisms of DKD is necessary for the development of new treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Benjamin P. Larkin, Long T. Nguyen, Miao Hou, Sarah J. Glastras, Hui Chen, Alen Faiz, Jason Chen, Rosy Wang, Carol A. Pollock, Sonia Saad
Summary: Using a mouse model of obesity, it was found that low-dose hydralazine can prevent obesity-related chronic kidney disease independently of alterations in biometric and metabolic variables or blood pressure regulation. This discovery provides a basis for repurposing hydralazine as a novel therapy to prevent CKD progression in obese patients.
DIABETES OBESITY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Minjung Son, Ga Young Kim, Yejin Yang, Sugyeong Ha, Jeongwon Kim, Doyeon Kim, Hae Young Chung, Hyung Ryong Moon, Ki Wung Chung
Summary: The PPAR pan agonist MHY2013 effectively prevents renal fibrosis in both in vitro and in vivo models, suggesting its therapeutic potential against chronic kidney diseases. MHY2013 inhibits fibroblast activation and reduces inflammation through PPAR gamma and beta activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Luan Gaviao Prado, Angela Silva Barbosa
Summary: Leptospirosis, caused by pathogenic species of the genus Leptospira, is a neglected infectious disease that can be diagnosed through serological and molecular methods. The chronic renal disease, carrier state, and kidney fibrosis due to Leptospira infection are significant topics of discussion, with many mechanisms still overlooked in understanding the chronic status of this infectious disease. Recent findings highlight cellular communication pathways and the relationship between renal fibrosis and CKD/CKDu caused by leptospirosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Jian Zhou, Yuan Tan, Rurong Wang, Xuehan Li
Summary: This review summarizes the regulatory mechanism of ferroptosis and its roles in fibrotic diseases. Recent studies have suggested that ferroptosis may serve as an attractive therapeutic target for fibrotic diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Tingting Bao, Xiangyuan Zhang, Weinan Xie, Ying Wang, Xiuyang Li, Cheng Tang, Yingying Yang, Jun Sun, Jiaqi Gao, Tongyue Yu, Linhua Zhao, Xiaolin Tong
Summary: Ferroptosis, a form of cell death, is involved in the regulation of the body's physiological and pathological processes. Recent studies have shown its association with T2DM and its complications, indicating potential therapeutic opportunities through the suppression of ferroptosis. Natural compounds are being explored as potential treatments due to their diverse biological activities and minimal toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Aurore Devocelle, Lola Lecru, Sophie Ferlicot, Thomas Bessede, Jean-Jacques Candelier, Julien Giron-Michel, Helene Francois
Summary: IL-15 can prevent tubulointerstitial fibrosis (TIF) by directly inhibiting extracellular matrix synthesis by interstitial myofibroblasts and reducing the expression of monocyte chemoattractant protein 1 (MCP-1), thereby inhibiting macrophage infiltration in UUO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Junni Wang, Wanyun Nie, Xishao Xie, Mengqiu Bai, Yanhong Ma, Lini Jin, Liang Xiao, Peng Shi, Yi Yang, Pedro A. Jose, Ines Armando, Jianghua Chen, Weiqiang Lin, Fei Han
Summary: The study identified the role of microRNA-874-3p/ADAM19 in mediating renal fibrosis after acute kidney injury by increasing macrophage infiltration via the Notch1/CCL2 pathway. Modulating the levels of microRNA-874-3p or ADAM19 could potentially slow down the process of renal fibrosis.
Editorial Material
Cell Biology
Anat Biran, Valery Krizhanovsky
Article
Cell Biology
Adi Sagiv, Dominick G. A. Burton, Zhana Moshayev, Ezra Vadai, Felix Wensveen, Shifra Ben-Dor, Ofra Golani, Bojan Polic, Valery Krizhanovsky
Editorial Material
Cell Biology
Yossi Ovadya, Valery Krizhanovsky
Article
Multidisciplinary Sciences
Reut Yosef, Noam Pilpel, Ronit Tokarsky-Amiel, Anat Biran, Yossi Ovadya, Snir Cohen, Ezra Vadai, Liat Dassa, Elisheva Shahar, Reba Condiotti, Ittai Ben-Porath, Valery Krizhanovsky
NATURE COMMUNICATIONS
(2016)
Editorial Material
Oncology
Reut Yosef, Valery Krizhanovsky
Review
Medicine, Research & Experimental
Yossi Ovadya, Valery Krizhanovsky
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Multidisciplinary Sciences
Omer Karin, Amit Agrawal, Ziv Porat, Valery Krizhanovsky, Uri Alon
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Naama Levi, Nurit Papismadov, Inna Solomonov, Irit Sagi, Valery Krizhanovsky
Editorial Material
Neurosciences
Nurit Papismadov, Valery Krizhanovsky
Summary: Aging leads to changes in the dentate gyrus microenvironment, causing natural-killer-cell-mediated clearance of neurogenic senescent cells and resulting in cognitive decline.
NATURE NEUROSCIENCE
(2021)
Review
Cell Biology
Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d'Adda di Fagagna
Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Oncology
Hilah Gal, Julia Majewska, Valery Krizhanovsky
Summary: Cellular senescence, a stable form of cell cycle arrest with pronounced secretory activity, plays functional roles in both physiological and pathological conditions. Recent studies have shown its contribution to development, regeneration and reprogramming. Transient presence of senescent cells may be beneficial for tissue regeneration.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Cell Biology
Julia Majewska, Valery Krizhanovsky
Summary: Cellular senescence plays a crucial role in lung physiology and pathology, with transient senescent cells being essential in limiting lung damage and contributing to organ regeneration, while persistent accumulation of senescent cells drives age-related decline in organ function.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Biochemistry & Molecular Biology
Noa Rachmian, Valery Krizhanovsky
Summary: Cellular senescence is a process in which cells change their phenotype in response to stress and enter a state of prolonged cell cycle arrest. It has both beneficial and detrimental effects, and the accumulation of senescent cells in tissues may be the link between aging and age-related pathologies. In the brain, senescent cells have been found to accumulate during neurological disorders and aging. This article discusses the senescent phenotype in different brain cell populations and explores various strategies to eliminate senescent cells, with a focus on their potential to target senescent brain cells.
Article
Cell Biology
Anat Biran, Lior Zada, Paula Abou Karam, Ezra Vadai, Lior Roitman, Yossi Ovadya, Ziv Porat, Valery Krizhanovsky
Article
Biochemistry & Molecular Biology
Reut Yosef, Noam Pilpel, Nurit Papismadov, Hilah Gal, Yossi Ovadya, Ezra Vadai, Stav Miller, Ziv Porat, Shifra Ben-Dor, Valery Krizhanovsky
