Article
Multidisciplinary Sciences
Nickolay Korabel, Alessandro Taloni, Gianni Pagnini, Viki Allan, Sergei Fedotov, Thomas Andrew Waigh
Summary: Transport processes of structures in living cells display anomalous diffusion and heterogeneity in space and time. Quantification of heterogeneities using single particle trajectories can lead to accurate mathematical models, enabling the design of applications such as drug delivery systems. The analysis of anomalous dynamics involves ergodicity and statistical ageing, and it is believed that non-ergodicity and ageing occur concurrently. However, the anomalous dynamics of endosomes are paradoxical as they are ergodic but show ageing. This paradoxical behavior is caused by ensemble heterogeneity, which is an inherent property of endosomal motion.
SCIENTIFIC REPORTS
(2023)
Article
Physics, Fluids & Plasmas
Daniel Han, Marco A. A. da Silva, Nickolay Korabel, Sergei Fedotov
Summary: This study introduces a persistent random walk model to explain how exponentially distributed runs self-organize into truncated Levy walks observed in active intracellular transport. The PDF of particle position derived in the study shows bimodal density in the superdiffusive regime, which is not observed in classical linear hyperbolic and Levy walk models. Exact solutions for the first and second moments, as well as criteria for the transition to superdiffusion, are also found.
Article
Optics
Mark L. Watson, Darren L. Brown, Alexander B. Stilgoe, Jennifer L. Stow, Halina Rubinsztein-Dunlop
Summary: Studying the mechanical properties of living cells has provided insights into the biological functions of macropinocytosis. This study used a high-resolution rotational geometry to trap and monitor a photonic probe within a macropinosome in vivo, enabling successful measurement of shear viscosity. It lays the foundation for dynamic mechanobiological studies of intracellular vesicles.
Article
Nanoscience & Nanotechnology
Barbora Smolkova, Tara MacCulloch, Tyler F. Rockwood, Minghui Liu, Skylar J. W. Henry, Adam Frtus, Mariia Uzhytchak, Mariia Lunova, Martin Hof, Piotr Jurkiewicz, Alexandr Dejneka, Nicholas Stephanopoulos, Oleg Lunov
Summary: DNA nanostructures can be controlled and programmed in a EE-DN manner, and are increasingly used in various biomedical applications such as therapeutic agent delivery. Most nanomaterials become covered by a protein corona when exposed to biological liquids, affecting their cellular uptake and biological response. Studies have shown that cellular uptake of functionalized DNs is linearly dependent on cell size, and the protein corona plays a role in determining the endolysosomal vesicle escape efficiency of DNs coated with an endosome escape peptide.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Joan Miguel-Avila, Maria Tomas-Gamasa, Jose L. Mascarenas
Summary: The development of new-to-nature chemical reactions allows scientists to perform these reactions within living cells and organisms, transforming the way biological processes are studied and manipulated. Recent advancements in bioorthogonal and cell-compatible reactions have incorporated transition metal-mediated processes, expanding the toolbox for researchers. Despite the low efficiency, organometallic catalysis shows promise in performing bond-forming, synthetically relevant reactions and assembling biorelevant products at specific biological sites.
TRENDS IN CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
A. Carrere, J. d'Alessandro, O. Cochet-Escartin, J. Hesnard, N. Ghazi, C. Riviere, C. Anjard, F. Detcheverry, J. -p. Rieu
Summary: This study discovers that living cells can spontaneously self-assemble into finite-sized domains, similar to the microphase separation in inert matter.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Artem Ryabov, Mykola Tasinkevych
Summary: The physics of self-propelled objects at the nanoscale is a rapidly developing research field. However, the theoretical understanding of the possible self-propulsion mechanisms at this scale is limited. This study demonstrates that the fundamental principle of microscopic reversibility (MR) can increase particle mobility and diffusion coefficients, and external forces can further enhance these coefficients. These findings shed new light on the interpretation of measured diffusivities and help test the relevance of MR for the active motion of individual nanoswimmers.
Article
Chemistry, Physical
Yuhui Li, Ondrej Kucera, Damien Cuvelier, David M. Rutkowski, Mathieu Deygas, Dipti Rai, Tonja Pavlovic, Filipe Nunes Vicente, Matthieu Piel, Gregory Giannone, Dimitrios Vavylonis, Anna Akhmanova, Laurent Blanchoin, Manuel Thery
Summary: Microtubules respond to mechanical compression by deforming, becoming more stable, which results in CLASP2 recruitment to the distorted shaft-a process crucial for cell migration through confined spaces.
Article
Chemistry, Physical
G. C. Antunes, P. Malgaretti, J. Harting
Summary: This study develops a semi-analytical model for self-diffusioosmotic transport in active pores. The authors investigate the spontaneous symmetry breaking in fore-aft symmetric pores and find that the pumping transition is controlled by three timescales. Introducing asymmetry to the pore reveals a second type of advection-enabled transition.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Herbert Levine, Daniel I. Goldman
Summary: We propose the integration of active matter physics with principles of regulatory interactions and control to develop a field called smart active matter. This field can provide insights into important principles in living systems and aid in the engineering of responsive, robust, and functional collectives.
Article
Psychology, Multidisciplinary
Huijiao Wu, Xinglin Zhou, Danrui Chen, Yue Zheng, Jianing You
Summary: Social media exposure and NSSI behaviors among adolescents have a bidirectional association, even after controlling for depression. The findings suggest that interventions promoting media education may help reduce the influence of media on the contagion of NSSI.
CURRENT PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jialei Song, Chengling Wu, Yan Zhao, Min Yang, Qingxin Yao, Yuan Gao
Summary: A bioorthogonal disassembly strategy was developed to prompt clearance of supramolecular assemblies within living cells. The enzyme-instructed self-assembly process led to the disruption of pi-pi stacking and induced disassembly of the assemblies, depriving them of potency and addressing their unintended retention and cellular toxicity. This strategy leverages biosafety in developing nanomaterials for drug delivery systems.
Article
Biochemistry & Molecular Biology
Wei Qin, Joleen S. Cheah, Charles Xu, James Messing, Brian D. Freibaum, Steven Boeynaems, J. Paul Taylor, Namrata D. Udeshi, Steven A. Carr, Alice Y. Ting
Summary: The ability to map trafficking for thousands of endogenous proteins at once in living cells reveals biology currently invisible to microscopy and mass spectrometry. The method TransitID uses proximity labeling enzymes TurboID and APEX to map endogenous proteome trafficking with nanometer spatial resolution. TransitID allows for distinguishing protein populations based on their origin compartment or cell type.
Article
Multidisciplinary Sciences
Priyam Banerjee, Guan-Yu Xiao, Xiaochao Tan, Veronica J. Zheng, Lei Shi, Maria Neus Bota Rabassedas, Hou-Fu Guo, Xin Liu, Jiang Yu, Lixia Diao, Jing Wang, William K. Russell, Jason Roszik, Chad J. Creighton, Jonathan M. Kurie
Summary: Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish a front-rear polarity axis that facilitates motility and invasion. The EMT activator ZEB1 influences vesicular trafficking dynamics to execute cell polarity change, impacting cancer cell motility.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Raj Kumar Manna, Oleg E. Shklyaev, Anna C. Balazs
Summary: The inhibitor-promoter feedback loop plays a crucial role in controlling functionality in living systems. It involves the production of chemical A promoting the production of chemical B, while B inhibits the production of A. This loop leads to buoyancy-driven fluid flows and deformation of neighboring soft material. A bioinspired system was modeled to investigate the interrelationship among chemistry, hydrodynamics, and fluid-structure interactions, revealing the intimate coupling between form and function in this system.
Article
Materials Science, Ceramics
Qiang Zhi, Bo Wang, Shan Zhao, Zhao Zhang, Yu-Chen Deng, Bao-Qiang Hou, Nan-Long Zhang, Jian-Feng Yang
Summary: This study successfully developed highly porous Si3N4 ceramic monoliths composed of ultrafine fibrous grains with high flexural strength through a novel vapor-solid carbothermal reduction nitridation reaction. By controlling the content of alpha-Si3N4 diluents and density of CNT green bodies, porous Si3N4 monoliths with porosity ranging from 61-78% were achieved.
CERAMICS INTERNATIONAL
(2021)
Article
Polymer Science
Bo Wang, Jinsheng Sun, Feng Shen, Kaihe Lv, Jintang Wang
Summary: This study proposed a potential lost circulation material, GP-A, for treating drilling fluid loss; experimental results showed that GP-A has a high initial decomposition temperature and flow characteristics conforming to the Herschel-Bulkley model; further analysis revealed that GP-A gel has a 3D spatial network structure with good recoverability.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Baoqiang Hou, Haixia Guo, Nanlong Zhang, Qiang Zhi, Bo Wang, Jianfeng Yang
Summary: This study prepared and tested graphite flakes/copper composites with specific dihedral angles, showing an increase in friction coefficient with larger dihedral angles due to adhesion, and a decrease due to ploughing. The friction coefficients were lower at 30 to 60 degrees, and the wear rate decreased monotonically as the dihedral angle increased.
Article
Materials Science, Ceramics
Wenjia Jing, Baoqiang Hou, Jinxiao Wang, Qiang Zhi, Jianfeng Yang, Bo Wang
Summary: This study reports the successful synthesis of fluorine-terminated urchin-like ZrO2 hollow microspheres with exposed (010) facets using a fluoride mediately solvothermal method. Density functional theory calculations confirm the stabilization effect of fluorine adsorption on (010) surfaces. Furthermore, the fluorinated ZrO2 hollow microspheres exhibit tunable photocatalytic selectivity in dye degradation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Yanchao Zhang, Caijun Zhang, Yang Han, Bo Wang, Liguang Zhu, Qingjun Zhang
Summary: A high-Mach-number oxygen lance was designed and forged in response to problems during a Chinese steel mill's transition to automatic steelmaking. The nozzle was found to be most stable at oxygen-supply pressures ranging from 0.9 to 1.01 MPa. By considering various factors, a combined top- and bottom-blowing process was determined to optimize the mixing effect of the nozzle on the molten pool.
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
(2021)
Article
Materials Science, Composites
Zhong-Yu Wang, Xiao-Nan Zhou, Zi-Xuan Li, Song-Song Xu, Liu-Cheng Hao, Jun-Ping Zhao, Bo Wang, Jian-Feng Yang, Kozo Ishizaki
Summary: By mixing alumina particles with different diameter ratios, the thermal conductivity of polymer composites can be optimized, leading to higher thermal conductivity and stability. The proper proportion and particle size of hybrid fillers can enhance the thermal properties of composites.
POLYMER COMPOSITES
(2022)
Article
Multidisciplinary Sciences
Bo Wang, Chao Zhang, Xiao-xin Du, Jian-fei Zhang
Summary: Computer aided research of lncRNA-disease association is an important method to study the development of lncRNA-disease. The LFMP prediction model proposed in this paper uses existing data to predict unknown lncRNA-disease associations, showing better performance than previous studies. Through case studies, LFMP effectively infers undetected lncRNA-disease associations.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Xiaonan Zhou, Songsong Xu, Zhongyu Wang, Liucheng Hao, Zhongqi Shi, Junping Zhao, Qiaogen Zhang, Kozo Ishizaki, Bo Wang, Jianfeng Yang
Summary: This article presents a facile and effective method to fabricate anisotropic polymer composites using biotemplate ceramization technology. By replicating the hierarchical microstructure of wood in the cellular biomass derived SiC framework, an epoxy composite with vertically aligned dense SiC microchannels is achieved, which exhibits interesting properties including high thermal conductivity, significant enhancement efficiency, and outstanding anisotropic thermal conductivity ratio.
Article
Materials Science, Ceramics
Nan-Long Zhang, Yu-Chen Deng, Bao-Qiang Hou, Qiang Zhi, Hua Cheng, Jian-Feng Yang, Bo Wang, Wei Wang
Summary: In this study, highly porous SiC frameworks were fabricated, showing excellent corrosion resistance, oxidation resistance, and high-temperature thermal stability, making them a good candidate for high-temperature thermal insulators.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Physical
Zhilei Wei, Siyu Liu, Dangui Liu, Jinling Wu, Hongyan Xia, Bo Wang, Zhongqi Shi
Summary: W/Si3N4 functionally graded materials were fabricated via spark plasma sintering for sealing liquid metal batteries. By adjusting the MgO content of the central Si3N4 layer, thermal stress of the products was effectively reduced, leading to good interface bonding and high performance.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Materials Science, Ceramics
Qiang Zhi, Shan Zhao, Nan-Long Zhang, Bao-Qiang Hou, Bo Wang, Jian-Feng Yang
Summary: Novel highly porous fibrous Si3N4 three-dimensional (3D) scaffolds were fabricated through directional freezing and high-temperature sintering, which exhibited ultrahigh porosities and superior compressive strength.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Ceramics
Songsong Xu, Xiaonan Zhou, Qiang Zhi, Junjie Gao, Liucheng Hao, Zhongqi Shi, Bo Wang, Jianfeng Yang, Kozo Ishizaki
Summary: Inspired by the transport behavior of water and ions through the aligned channels in trees, the researchers demonstrate a facile, scalable approach for constructing biomorphic cellular Si3N4 ceramic frameworks with well-aligned nanowhisker arrays. The porous Si3N4 ceramics exhibit outstanding thermal conductivity, flexural strength, and anisotropy, making them promising for multifunctional ceramics.
JOURNAL OF ADVANCED CERAMICS
(2022)
Article
Materials Science, Multidisciplinary
Zhicheng Wu, Jiasheng Fan, Xieyu Yuan, Yuxiao Zhao, Bo Wang, Qiaogen Zhang, Licheng Li
Summary: In this study, PAA films prepared from polycrystalline pure Al foils were used to investigate the relationship between crystallographic orientation and PAA morphology. A spatial mapping relationship was established using a scratch marking method, and it was found that the size of LDG regions in PAA was positively correlated with grain boundary misorientation. The effect of misorientation on LDG was explained using a volume expansion model. This study contributes to a better understanding of the PAA longitudinal growth mechanism.
Article
Chemistry, Physical
Yu-Chen Deng, Nan-Long Zhang, Qiang Zhi, Bo Wang, Jian-Feng Yang
Summary: Dense SiC ceramics were fabricated using SiC nanoarrays as crystal seeds in a HTPVT growth process, achieving high density, large grain size, high hardness, high flexural strength, and good thermal conductivity.
Article
Engineering, Civil
Bo Wang, Hengjun Hou, Zhengwei Zhu, Wang Xiao
Summary: This study proposes an objective framework for analyzing the influence of three key factors on transparent soils' transparency and shear strength, with XGBoost identified as the optimal machine learning model. The importance scores from XGBoost indicate that the solute solution ratio (SSR) is the most important factor affecting both shear strength and transparency.
SMART STRUCTURES AND SYSTEMS
(2021)