Review
Urology & Nephrology
Ruifeng Wang, Yiping Wang, David C. H. Harris, Qi Cao
Summary: Innate immune cells, including a newly discovered group of innate lymphoid cells (ILCs), play critical roles in kidney diseases by providing immunomodulatory cytokines and guiding immune responses. Understanding the function of ILCs in normal and diseased kidneys emphasizes the emerging importance of ILC-regulated immunity for future research and therapeutic interventions.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Takahiro Matsuyama, Hiromi Matsuyama, Yoichi Dotake, Koichi Takagi, Kentaro Machida, Hiromasa Inoue
Summary: T helper type 2 cells and group 2 innate lymphoid cells play a crucial role in asthma, particularly in airway eosinophilic inflammation. These cells are activated by cytokines released by airway epithelial cells and produce high levels of type 2 cytokines. ILC2s induce airway inflammation independently of antigens and may contribute to steroid resistance. Biologics targeting these cytokines and/or their receptors have shown promise in reducing asthma exacerbations and improving lung function and quality of life in asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ramon A. Lujan, Sophia M. Vrba, Heather D. Hickman
Summary: Before the adaptive immune response, innate antiviral cells, including conventional natural killer cells (cNK) and tissue-resident ILCs (ILC1s), respond to a wide range of viruses to limit replication and virus-induced pathology. While cNK cells lyse virus-infected cells, ILC1s respond with the production of antiviral cytokines and can even induce an antiviral state in uninfected tissue. Mounting evidence suggests that ILC1s may have enhanced secondary responses to viral infections.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Review
Immunology
Bernd Heinrich, Firouzeh Korangy
Summary: Innate lymphoid cells (ILCs) are a heterogeneous population of the innate immune system that play a crucial role in maintaining immune homeostasis. They exhibit high plasticity, allowing them to quickly respond to changes in their microenvironment. ILCs can transdifferentiate into different subsets in the tumor microenvironment, influencing the immune response and tumor therapy. This review summarizes the functional and plastic heterogeneity of ILCs in homeostasis and disease, with a focus on tumor-driven plasticity and the impact of ILC-induced inflammation on the tumor microenvironment and anti-tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Christopher M. M. Thomas, R. Stokes Peebles
Summary: Innate lymphoid cells (ILCs) are crucial for the innate immune system and can produce pro-inflammatory cytokines. Recent studies have found that ILCs can also produce the anti-inflammatory cytokine IL-10, suggesting their role in maintaining lung and gut homeostasis. These IL-10 producing ILCs show potential therapeutic effects in allergic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Kong, Han-Dong Li, Dan Wang, Xiaolin Gao, Chunsheng Yang, Minshu Li, Ting Chang, Qiang Liu
Summary: The study found a correlation between the reduction of ILC2 and disease severity in neuromyelitis optica spectrum disorder (NMOSD), and expanding ILC2 could alleviate the pathological conditions.
Article
Biology
Marie Marotel, Marine Villard, Annabelle Drouillard, Issam Tout, Laurie Besson, Omran Allatif, Marine Pujol, Yamila Rocca, Michelle Ainouze, Guillaume Roblot, Sebastien Viel, Melissa Gomez, Veronique Loustaud, Sophie Alain, David Durantel, Thierry Walzer, Uzma Hasan, Antoine Marcais
Summary: Impaired function of NK cells in CHB patients may be associated with reduced expression of NKp30, CD16, and defective mTOR pathway activity. NK cell dysfunction and T cell exhaustion may share common mechanisms, including the impact of TOX transcription factor and NFAT on NK cell function.
Review
Immunology
Rodolfo R. Favaro, Katherine Phillips, Romane Delaunay-Danguy, Kaja Ujcic, Udo R. Markert
Summary: Members of the innate immune system, specifically innate lymphoid cells (ILCs), play important roles in the uterine environment, supporting pregnancy and placental development. These cells demonstrate immune memory, allowing them to remember previously encountered antigens and mount enhanced responses. By studying ILCs, we can gain insights into the immunological mechanisms underlying female fertility/infertility, placental development, and distinct outcomes in second pregnancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhiyu Ma, Jinsong Wang, Lei Hu, Songlin Wang
Summary: Periodontitis is an irreversible inflammatory response that occurs in periodontal tissues. Innate lymphoid cells (ILCs) have been found to play a crucial role in regulating immune responses in periodontitis. This review focuses on the intricate crosstalk between ILCs and the microenvironment in periodontal tissue homeostasis for the purpose of regulating or improving immune responses in periodontitis prevention and therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Xiaoxu Wang, Yue Kong, Bingqing Zheng, Xiaomin Zhao, Mingzhe Zhao, Bin Wang, Chang Liu, Peizheng Yan
Summary: Asthma, a chronic airway inflammatory disease, is on the rise globally. The study of innate lymphoid cells (ILCs) is crucial in understanding the different endotypes of asthma. Asthma is divided into type 2 high and type 2 low endotypes based on its pathological and inflammatory features. Multiple cell types, including tissue-resident ILCs and other immune cells, play a role in the complex nature of asthma. This review focuses on the phenotypes and roles of tissue-resident ILCs in asthma endotypes, as well as therapeutic strategies based on immune cell mechanisms.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Immunology
Jongho Ham, MinYeong Lim, Dongmo Kim, Hye Young Kim
Summary: Innate lymphoid cells (ILCs) are recently discovered innate immune cells that play a role in the defense against external insults in mucosal tissues. They exhibit characteristics similar to adaptive immune cells and can potentially have memory-like properties. Studies suggest that ILCs may play a significant role in the pathogenesis of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Allergy
Umit M. Sahiner, Janice A. Layhadi, Korneliusz Golebski, Zsolt Istvan Komlosi, Yaqi Peng, Bulent Sekerel, Stephen R. Durham, Helen Brough, Hideaki Morita, Mubeccel Akdis, Paul Turner, Kari Nadeau, Hergen Spits, Cezmi Akdis, Mohamed H. Shamji
Summary: Food allergy is a prevalent disease driven by uncontrolled type 2 immune response, commonly developing through skin sensitization with later allergy symptoms in the gastrointestinal tract. Recent studies suggest a possible role for innate lymphoid cells (ILCs) in driving food allergy.
Review
Immunology
Marek Wagner, Shigeo Koyasu
Summary: Innate lymphoid cells (ILCs), enriched in barrier tissues like skin, play a role in immune pathways despite lacking antigen receptors found on T and B cells. They are crucial in controlling melanoma and potentially benefiting patients with skin malignancies through their therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saimeng Shi, Longyun Ye, Kaizhou Jin, Zhiwen Xiao, Xianjun Yu, Weiding Wu
Summary: ILCs, a type of innate immune cells, play important roles in maintaining tissue homeostasis and regulating metabolism. Recent studies suggest that ILCs in the pancreas are key players in pancreatic diseases and health. Further research on the functions of ILC subsets in pancreatic diseases may lead to better treatment approaches in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
