Article
Biochemistry & Molecular Biology
Wangyuan Yao, Muhammad Fakhar-e-Alam Kulyar, Yanmei Ding, Haitao Du, Jiajia Hong, Kyein San Loon, Shah Nawaz, Jiakui Li
Summary: The interaction between miR-140 and HDAC4 plays a crucial role in bone disorders such as tibial dyschondroplasia. Low miR-140 expression is associated with poor pathological characteristics and low chondrocyte survival. HDAC4 inhibits MEF2C and Runx2 and interacts with Col-II, Col-X, and COMP, leading to uncontrolled chondrocyte proliferation, differentiation, and dysplastic growth. Targeting the miR-140 and HDAC4 feedback loop may provide a promising therapeutic approach for chondrocyte-related bone disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yali Yu, Guixiang Dong, Zijun Li, Yan Zheng, Zhisong Shi, Guanghui Wang
Summary: This study discovered that circ-LRP6 inhibits the proliferation, migration, and invasion of osteosarcoma cells by regulating the miR-141-3p/HDAC4/HMGB1 axis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Fangyuan Chen, Juanli Li, Tao Zheng, Tao Chen, Zuyi Yuan
Summary: This study reveals the role of Kruppel-like factor 7 (KLF7) in atherosclerosis (AS) lesions by regulating glucose metabolic reprogramming (GMR) in macrophages. KLF7 activates HDAC4 to inhibit miR-148b-3p and promote NCOR1 transcription, thereby limiting GMR in macrophages and alleviating AS lesions.
Article
Engineering, Biomedical
Jing Wang, Hong-Lin Qian, Sheng-Yu Chen, Wei-Pin Huang, Dan-Ni Huang, Hong-Ye Hao, Ke-Feng Ren, Yun-Bing Wang, Guo-Sheng Fu, Jian Ji
Summary: MicroRNAs have been identified as potent gene medicine for regulating endothelial cells and smooth muscle cells in response to vascular injury. In this study, a microRNA-eluting cardiovascular stent was developed using a self-healing encapsulation process based on an amphipathic triblock copolymer network, effectively inhibiting in-stent restenosis.
BIOACTIVE MATERIALS
(2021)
Article
Neurosciences
Patrick Main, Wei Jun Tan, David Wheeler, Helen L. Fitzsimons
Summary: Dysregulation of histone deacetylase HDAC4 is linked to neurodevelopmental and neurodegenerative disorders, with impaired cognitive function being a common feature. Research in Drosophila indicates that alterations in the subcellular distribution of HDAC4 can lead to deficits in mushroom body morphogenesis, eye development, and long-term memory, potentially through mechanisms independent of MEF2 activity. Understanding the role of HDAC4 in neural dysfunction offers new insights into therapeutic strategies for neurological disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Oncology
Changjian Shao, Kai Guo, Liqun Xu, Yimeng Zhang, Hongtao Duan, Yingtong Feng, Minghong Pan, Di Lu, Xiaoya Ren, Apar Kishor Ganti, Taiki Hakozaki, Jing Han, Xiaolong Yan, Zhiqiang Ma
Summary: SMP30 expression is frequently downregulated in NSCLC tissue and its low expression is associated with poorer overall survival. Overexpression of SMP30 significantly inhibits NSCLC cell proliferation and may exert its function by regulating the level of HDAC4.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Yaju Feng, Lumeng Wang, Ting Wang, Ying Li, Qingqing Xun, Renya Zhang, Lin Liu, Lei Li, Wei Wang, Yixuan Tian, Lili Yang, Xiao Zhi, Bijiao Zhou, Xin Chen, Tao Sun, Yanrong Liu
Summary: Tumor budding is considered a poor prognostic marker in breast cancer patients, and promoting tumor vessel normalization through regulating the structure and function of endothelial cells may help improve therapeutic efficacy.
Article
Pharmacology & Pharmacy
Fengchen Shen, Xiying Hou, Tingting Li, Jianjun Yu, Huizhen Chen, Na Liu, Andong Qiu, Shougang Zhuang
Summary: HDAC4 plays a critical role in renal fibrosis and tubular injury, and could be a potential therapeutic target for chronic fibrotic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Dan Zhang, Jian Du, Min Yu, Linna Suo
Summary: The specific effects and underlying mechanism of urine-derived stem cells-extracellular vesicles (USCs-EVs) on osteoporosis in diabetes rats were studied. It was found that USCs-EVs carrying miR-26a-5p activated the HIF-1α/VEGFA pathway through HDAC4 inhibition to prevent diabetic osteoporosis (DOP).
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Cell Biology
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Summary: This study reveals the mechanism of MeCP2/miR-199a axis in regulating neural stem cell differentiation, further confirming the importance of BMP signaling in RTT brain development, and proposing the MeCP2/miR-199a/Smad1 axis as a potential therapeutic target for RTT.
Article
Cell & Tissue Engineering
L. Guo, H. Guo, Y. Zhang, Z. Chen, J. Sun, G. Wu, Y. Wang, X. Wei, P. Li
Summary: This study explored the novel molecular mechanisms of HDAC4 in chondrocytes using RNA sequencing analysis. The results showed that HDAC4 significantly improved the survival rate and biofunction of chondrocytes, and RNA sequencing analysis revealed significant gene expression changes induced by HDAC4, particularly in ribosomes. Validation experiments confirmed the key role of the enhanced ribosome pathway in the mechanism by which HDAC4 improves chondrocyte survival rate and biofunction.
BONE & JOINT RESEARCH
(2023)
Article
Medical Laboratory Technology
Yujia Fang, Dong Yan, Lixin Wang, Jie Zhang, Qingfang He
Summary: This study analyzed the differential expression of miRNAs between HCC patients and controls and found that miR-16 and miR-122 were significantly upregulated in early-stage HCC patients. Combining these miRNAs with AFP improved the diagnostic efficacy for HCC. Furthermore, miR-16 and miR-122 were found to regulate a number of potential target genes involved in cancer pathways.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Medicine, General & Internal
Qi Ning, Ye-Hua Gan, Rui-Rui Shi, Juan-Hong Meng
Summary: The study found that HDAC4 has an inhibitory effect on IL-1 beta-induced chondrocyte extracellular matrix degradation, which is partially regulated through the WNT3A/beta-catenin signaling pathway.
CHINESE MEDICAL JOURNAL
(2021)
Article
Cell Biology
Mei Wu, Zehong Huang, Wenfang Huang, Mengyu Lin, Weifeng Liu, Kexuan Liu, Cai Li
Summary: This study investigates the role of microRNA (miR)-124-3p in sepsis-induced myocardial injury and identifies its mechanism of action through targeted regulation of SP1 to alleviate inflammation, oxidative stress, and apoptosis, thus improving myocardial injury in septic rats.
CELL DEATH DISCOVERY
(2022)
Article
Chemistry, Multidisciplinary
Paul A. Advincula, Jacob L. Beckham, Chi Hun Choi, Weiyin Chen, Yimo Han, Dmitry Kosynkin, Alexander Lathem, Alvaro Mayoral, Miguel Jose Yacaman, James M. Tour
Summary: We demonstrate the synthesis of a solvent- and gas-free 2D carbon nanotube/graphene network through flash Joule heating of pristine carbon nanotubes. The proportion of each morphology in the hybrid material can be controlled by varying the pulse time. Epoxy composites made with the hybrid material show significantly increased hardness and Young's modulus compared to neat epoxy, indicating that flash Joule heating can effectively convert carbon nanotubes into a hybrid network for reinforcement.
Article
Chemistry, Physical
Paul A. Advincula, Victoria Granja, Kevin M. Wyss, Wala A. Algozeeb, Weiyin Chen, Jacob L. Beckham, Duy Xuan Luong, C. Fred Higgs, James M. Tour
Summary: Carbon nanomaterial additives, such as graphene, can significantly improve tribological performance as lubricant additives. Flash graphene (FG) derived from post-consumer plastic and metallurgical coke is added to poly(alpha olefin) 6 or 9, resulting in a significant decrease in friction coefficient, wear scar diameter, and roughness.
Article
Chemistry, Organic
Alexis van Venrooy, Aaron M. Wyderka, Victor Garcia-Lopez, Lawrence B. Alemany, Angel A. Marti, James M. Tour
Summary: Understanding the rotary cycle of molecular motors is crucial for advancing cell opening research. In-situ analysis of illuminated light-active molecular motors using nuclear magnetic resonance spectroscopy revealed that the presence of N,N-dimethylethylenediamine at a conjugated position to the central olefin affects the rotation and decreases the photostability of a second-generation Feringa-type molecular motor. Various techniques like modulating light dose, dilution, and stirring were found to mitigate degradation, while the presence of moisture affects the motor's rotation rate.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Paul A. Advincula, Wei Meng, Lucas J. Eddy, Jacob L. Beckham, Ivan R. Siqueira, Duy Xuan Luong, Weiyin Chen, Matteo Pasquali, Satish Nagarajaiah, James M. Tour
Summary: Graphene has been proven to be a valuable additive for composites, but its expensive synthesis has hindered its industrial application. However, a method called Flash Joule heating can rapidly synthesize graphene from coal materials like metallurgical coke. This study investigates the properties of graphene-epoxy composites with higher nanofiller content than previously reported. The results show that these composites exhibit improved mechanical properties and reduced environmental impact.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ana L. Santos, Jacob L. Beckham, Dongdong Liu, Gang Li, Alexis van Venrooy, Antonio Oliver, George P. Tegos, James M. Tour
Summary: 405-nm-visible-light-activated synthetic molecular machines (MMs) effectively eliminate fungal infections without resistance development. They bind to fungal mitochondrial phospholipids and produce a drilling effect upon visible light activation, leading to mitochondrial dysfunction and cell death. Additionally, they enhance the effectiveness of conventional antifungals by impairing energy-dependent efflux pumps.
Article
Chemistry, Multidisciplinary
Monika Schied, Deborah Prezzi, Liu Dongdong, Stefan Kowarik, Peter A. Jacobson, Stefano Corni, James M. Tour, Leonhard Grill
Summary: This study investigates the behavior of molecular motors on solid surfaces. Single motor molecules adsorbed on a Cu(111) surface are excited by voltage pulses from an STM tip, leading to their rotation around a fixed pivot point. The rotation direction of each molecule is found to be enantiomer-specific, determined by its chirality.
Article
Chemistry, Multidisciplinary
Mingjin Du, Paul A. Advincula, Xiangdong Ding, James M. Tour, Changsheng Xiang
Summary: With the global commitment to reach carbon peak by 2030 and net zero by 2050, the use of coal as an energy source is encountering unprecedented challenges. The International Energy Agency (IEA) predicts that global annual coal demand will decrease from over 5640 million tonnes of coal equivalent (Mtce) in 2021 to 540 Mtce in 2050 under the net zero emission scenario, with renewable energy like solar and wind replacing most of it. Hence, the coal industry is actively searching for alternative applications to sustain its development, and nanotechnology can be a contributing factor. This article outlines the challenges and proposes a path towards commercialization in coal-based carbon nanomaterial syntheses. Coal-based carbon nanomaterials hold promise in the concept of clean coal conversion, transforming it from an energy source to a high-value-added carbon source.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Bernhard Ramsauer, Grant J. Simpson, Johannes J. Cartus, Andreas Jeindl, Victor Garcia-Lopez, James M. Tour, Leonhard Grill, Oliver T. Hofmann
Summary: We demonstrate a reinforcement learning algorithm that can control a single dipolar molecule in the electric field of a scanning tunneling microscope. After 2250 iterations of training, the algorithm successfully manipulates the molecule to specific positions and provides insights into the molecular movement and orientation.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Physical
Grant J. Simpson, Victor Garcia-Lopez, A. Daniel Boese, James M. Tour, Leonhard Grill
Summary: In this study, the researchers demonstrate how they can use the tip of a scanning tunneling microscope (STM) to control the translation direction of a single polar molecule. Through the interaction between the dipole moment of the molecule and the electric field of the STM junction, both translations and rotations of the molecule are observed. By considering the relative position of the tip to the dipole moment axis, the order of rotation and translation can be deduced. While the molecule-tip interaction is dominant, computational results suggest that translation is influenced by the surface direction.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Green & Sustainable Science & Technology
Paul E. Savas, Wala A. Algozeeb, Zhe Wang, Carter Kittrell, Xiaowei Wu, Jacklyn N. Hall, Thomas B. Malloy, Praveen Bollini, James M. Tour
Summary: The plastic waste from textile and construction industries is successfully converted into a microporous sorbent that has a high selectivity for carbon dioxide adsorption through the pyrolysis process. The properties of the sorbent can be controlled by changing the parent plastic type. The effectiveness of the sorbent in CO2 separation has been demonstrated in various tests.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Nanoscience & Nanotechnology
James O. Larkin, Sarah C. Mozden, Yieu Chyan, Qingxin Zheng, Paul Cherukuri, James M. Tour, Zachary T. Ball
Summary: This study validates the use of laser-induced graphene as an effective structure for producing therapeutic cold plasma for the treatment of bacterial infections. Ozone is identified as the primary mediator of antibacterial activity in graphene-mediated cold plasmas under the studied conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Paul Andrade Advincula, Wei Meng, Jacob L. Beckham, Satish Nagarajaiah, James M. Tour
Summary: CO2 emissions and waste plastic contribute greatly to environmental problems, and researchers are developing technologies for capturing, sequestrating, and utilizing CO2. Two methods, molten carbonate electrolysis and flash Joule heating, have shown promise in converting gaseous CO2 into solid carbon feedstocks and flash graphene. The combination of flash graphene and waste plastic as a reinforcing additive in composite applications can increase material properties and reduce CO2 emissions, water consumption, and energy consumption.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Jinhang Chen, Weiyin Chen, Bing Deng, Bowen Li, Carter Kittrell, James M. Tour
Summary: A thin conductive interphase is constructed between lithium aluminum titanium phosphate and lithium cobalt oxide using a rapid sintering method. This method is used to make solid-state batteries with thick composite cathodes that demonstrate a high initial capacity of approximate to 120 mAh g-1 over 200 cycles at room temperature.
Article
Chemistry, Multidisciplinary
Kianoosh Sattari, Lucas Eddy, Jacob L. Beckham, Kevin M. Wyss, Richard Byfield, Long Qian, James M. Tour, Jian Lin
Summary: Flash Joule heating is a non-equilibrium processing method for converting low-value carbon-based materials to flash graphene. By constructing a scientific machine learning model, the graphene yield can be predicted with increased accuracy.
Article
Chemistry, Multidisciplinary
Jacob L. Beckham, Thomas S. Bradford, Ciceron Ayala-Orozco, Ana L. Santos, Dallin Arnold, Alexis R. van Venrooy, Victor Garcia-Lopez, Robert Pal, James M. Tour
Summary: Molecular motors are small molecule actuators that can permeabilize lipid bilayers, kill cancer cells and microorganisms, and control cell signaling. A roadmap is provided detailing how to distinguish the photomechanical action characteristic to these motors from photothermal and photodynamic effects. It is hoped that this framework leads to a robust criterion for the isolation of the effects of molecular motion as the community seeks to use molecular motors for new and distinctive applications.
ADVANCED MATERIALS
(2023)