Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Ritika Chatterjee, Atish Roy Chowdhury, Abhilash Vijay Nair, Dipasree Hajra, Arpita Kar, Akshay Datey, Santhosh Shankar, Rishi Kumar Mishra, Nagasuma Chandra, Dipshikha Chakravortty
Summary: This study investigates the role of the outer membrane protease PgtE in the survival and virulence of Salmonella Typhimurium. It reveals that PgtE plays a significant role in combating host antimicrobial peptides and contributes to the pathogen's survival and successful infection.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Immunology
Christopher Sie, Ravi Kant, Christian Peter, Andreas Muschaweckh, Monika Pfaller, Lucy Nirschl, Helena Dominguez Moreno, Tereza Chadimova, Gildas Lepennetier, Tanja Kuhlmann, Rupert Ollinger, Thomas Engleitner, Roland Rad, Thomas Korn
Summary: Th17 cells have an intrinsic feedback mechanism to control their pathogenicity, involving the production of IL-24 and secretion of IL-10. IL-24 interacts with Grim19 on the inner mitochondrial membrane to promote STAT3 accumulation in the mitochondrial compartment, which serves as a rheostat to regulate nuclear STAT3 activity. This mechanism plays an important role in restricting immunopathology associated with Th17 cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Editorial Material
Immunology
Joanna R. Groom, James E. Vince
Summary: A T(H)17 cell NLRP3-caspase-8-caspase-3-GSDME axis is found to release the alarmin IL-1 alpha without inducing cell death.
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biology
Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon, Kyungho Choi, Je-Min Choi, Seong Wook Kang, Won-Woo Lee
Summary: The study demonstrates the crucial role of IL-1RII receptor in regulating IL-17 responses, affecting the functionality of CD4(+) T cells by limiting IL-1 beta responsiveness.
Article
Multidisciplinary Sciences
Michael Crawford, Nicholas Borcherding, Nitin Karandikar
Summary: CD4(+) T-helper 17 (Th17) T cells play a crucial role in promoting inflammation through the secretion of IL-17 and are a major therapeutic target for autoimmune disorders. Recent studies have shown that IL-17 family cytokines can directly act on CD4(+) T cells, specifically naive cells, leading to functional changes. The differences in downstream signaling and functional consequences suggest that IL-17AF heterodimer is the most influential cytokine.
Article
Gastroenterology & Hepatology
Elodie Beaumont, Vincent Larochette, Laurence Preisser, Charline Miot, Pascale Pignon, Simon Blanchard, Bjorn-Thore Hansen, Jonathan Dauve, Caroline Poli, Minna M. Poranen, Patricia Lamourette, Marc Plaisance, Alain Morel, Helmut Fickenscher, Pascale Jeannin, Philippe Roingeard, Yves Delneste
Summary: IL-26 plays a crucial role in protecting against HCV infection in the liver of patients with chronic hepatitis C, exerting direct antiviral activity by inhibiting viral replication and interfering with RNA polymerase activity.
JOURNAL OF HEPATOLOGY
(2022)
Review
Immunology
Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu, Xueping Chen
Summary: Neurodegenerative diseases are characterized by progressive loss of neurons, and immune pathway dysregulation is a common feature. Th 17 cells and IL-17A play important roles in the pathogenesis of these diseases. Targeting IL-17A may represent a potential therapeutic approach for neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Lekha Rani, Anil Kumar, Juilee Karhade, Garima Pandey, Adrita Guha, Gyan C. Mishra, Mohan R. Wani
Summary: IL-3 inhibits the differentiation of Th17 cells and promotes the development of Treg cells, regulating the pathogenesis of rheumatoid arthritis. IL-3 treatment significantly decreases the pathogenic Th17 cell responses and arthritic scores.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Health Care Sciences & Services
Konstantinos Bartziokas, Evangelia Fouka, Stelios Loukides, Paschalis Steiropoulos, Petros Bakakos, Andriana Papaioannou
Summary: IL-26 is a cytokine that plays a role in chronic lung inflammation and has both antimicrobial and pro-inflammatory effects. It binds to extracellular DNA and can induce the gathering of neutrophils in areas of infection. However, it also exhibits inhibitory effects on airway epithelial and immune cells. Further research is needed to understand its role in smoking-related airway inflammatory disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yi-Hsun Wang, Yi-Jen Peng, Feng-Cheng Liu, Gu-Jiun Lin, Shing-Hwa Huang, Huey-Kang Sytwu, Chia-Pi Cheng
Summary: Rheumatoid arthritis (RA) is characterized by chronic inflammation, bone erosion, and joint deformation. IL-26, a member of the IL-10 family, is overexpressed in RA patients and plays a role in promoting IL-17A expression. IL-26 stimulates the expression of IL-9 and IL-17A in macrophages and activates the AKT-FoxO1 pathway. Targeting IL-26 may be a potential therapeutic strategy for RA and other diseases with IL-9 and IL-17 dominance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Stephanie M. Swedik, Abson Madola, Michelle A. Cruz, Braulio J. Llorens-Bonilla, Alan D. Levine
Summary: Tightly regulated communication between gastrointestinal epithelium and immune cells is critical for immune homeostasis and inflammation. In this study, we found that Th17-derived cytokines can synergistically enhance the expression of IL-17C, creating a novel inflammatory amplification loop in the gastrointestinal tract.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Karlhans Fru Che, Sara Tengvall, Anders Linden
Summary: IL-26, a dimeric cytokine belonging to the IL-10 family, not only induces the release of chemokines and growth factors, but also directly kills bacteria and inhibits viral replication. Studies on human airways confirm the critical role of IL-26 in host defense and its potential as a biomarker for diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
