Article
Agricultural Engineering
Huazhong Ma, Jianglin Zhao, Ying Liu, Liang Liu, Juan Yu, Yimin Fan
Summary: An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Adam Kasinski, Agata Swierczek, Monika Zielinska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak
Summary: The aim of this study was to develop a dual-stimuli-responsive smart hydrogel local drug delivery system (LDDS) that can be used for simultaneous chemotherapy and magnetic hyperthermia (MHT) antitumor treatment. The hydrogels were made from a biocompatible and biodegradable copolymer and characterized for their gel-forming and rheological properties. Magnetic iron oxide nanoparticles (MIONs) were created using the coprecipitation method and showed superparamagnetic properties when subjected to an alternating magnetic field (AMF). The MIONs/hydrogel matrices displayed controlled and prolonged release of paclitaxel (PTX), making them promising for combined chemotherapy and hyperthermia treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Faiqa Nazir, Tanveer A. Tabish, Fatima Tariq, Shanza Iftikhar, Rijja Wasim, Gul Shahnaz
Summary: This review summarizes recent developments in stimuli-based targeted drug delivery systems for the site-specific release of antibiotics. By utilizing various stimuli, controlled and timely release of antibiotics at the site of infection can be achieved.
DRUG DISCOVERY TODAY
(2022)
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Review
Biochemistry & Molecular Biology
Yuhan Xia, Zhiyuan Ma, Xuechen Wu, Huidan Wei, Han Zhang, Guang Li, Yuqi Qian, Mina Shahriari-Khalaji, Kai Hou, Ran Cao, Meifang Zhu
Summary: Sustainable and controllable drug transport is an efficient method for disease treatment. Chitosan hydrogel, characterized by high biocompatibility, good biodegradability, and low costs, has been widely used in biomedical fields. The abundant amino and hydroxyl groups in chitosan hydrogel allow it to interact with human tissues and enable drugs to pass through biological barriers. The multi-responsive nature of chitosan hydrogel, including pH, temperature, ions strength, and magnetic field, makes precise drug release possible. This review summarizes the synthesis methods, modification strategies, stimuli-responsive mechanisms, and recent progress of chitosan-based hydrogels in drug delivery, focusing on subcutaneous, oral, and facial administration. The challenges towards clinical application and future prospects are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Physical
Seyithan Kansiz, Yasar Murat Elcin
Summary: Liposomes and polymersomes are self-assembled vesicles that can encapsulate hydrophilic and hydrophobic therapeutics, making them important in drug delivery research. They have versatile designs for different drug delivery applications. This review article discusses the physical and biological barriers to efficient drug delivery and explores the design approaches, properties, targeting strategies, and stimuli response of liposomes and polymersomes. The challenges, recent clinical developments, and future perspectives are also addressed.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Engineering, Chemical
Nandita Srivastava, Anirban Roy Choudhury
Summary: Hydrogels are soft materials that undergo cross-linking to form a hydrophilic three-dimensional network. Stimuli-responsive hydrogels have the ability to undergo reversible transitions in response to external cues. Recently, polysaccharide-based hydrogels with stimuli-responsive properties have shown promising applications in biotechnology due to their biodegrability, biocompatibility, and functional properties.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Review
Polymer Science
Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes
Summary: Stimuli-responsive hydrogel drug delivery systems that release drugs under external stimuli, such as ultrasound, have gained importance in the field of drug delivery. This review summarizes the current understanding of ultrasound-responsive hydrogels, including mechanisms of drug release, innovative formulations, and applications in cancer treatment and tissue engineering.
Review
Chemistry, Multidisciplinary
Xiao Li, Minghao Li, Lisa Tang, Diwei Shi, Emily Lam, Jinhye Bae
Summary: This review explores the potential of stimuli-responsive hydrogels in mimicking the morphing behavior of living tissues or organisms, and discusses how functional additives can be combined with hydrogels to extend their functionalities. It also highlights the potential applications of stimuli-responsive composite hydrogels in various fields including soft robotics, information encryption/decryption, biomedical research, flexible electronics, and engineering living materials.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Polymer Science
Louise Van Gheluwe, Igor Chourpa, Coline Gaigne, Emilie Munnier
Summary: Progress in stimuli-responsive polymers has led to advancements in smart drug delivery systems (SDDS) which can address targeted drug delivery and personalized medicine challenges. SDDS, mainly explored in oncology, are now extending to dermatology and cosmetics fields. pH and temperature are the most commonly used stimuli for controlled release of active ingredients.
Article
Polymer Science
Moises Bustamante-Torres, Victor H. Pino-Ramos, David Romero-Fierro, Sandra P. Hidalgo-Bonilla, Hector Magana, Emilio Bucio
Summary: The design of a new pH-sensitive hydrogel for localized prophylactic release of ciprofloxacin and silver nanoparticles was presented in this study. The hydrogel was copolymerized using gamma rays and characterized using various analytical techniques. The antimicrobial activity of the hydrogel against E. coli and MRSA was evaluated in vitro.
Article
Materials Science, Multidisciplinary
Shuaiwei Yuan, Tianwen Dai, Xinyue Jiang, Huawei Zou, Pengbo Liu
Summary: By constructing a semi-IPN structure, a transparent hydrogel with EMI shielding performance and good mechanical properties was fabricated. The addition of lithium chloride improved the dehydration resistance and flexibility of the hydrogel, and it also exhibited attractive electrical conductivity.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Polymer Science
Fayaz Ali, Imran Khan, Jianmin Chen, Kalsoom Akhtar, Esraa M. Bakhsh, Sher Bahadar Khan
Summary: This review discusses the application of hydrogels as carriers in drug delivery systems, and presents the fabrication strategies and applications of hydrogels in various fields.
Review
Polymer Science
Elena Ruxandra Radu, Augustin Semenescu, Stefan Ioan Voicu
Summary: Doxorubicin is a commonly used drug in liver cancer treatment. However, traditional chemotherapy with this drug has limitations, including side effects. Researchers have explored responsive drug delivery systems that can control the release of doxorubicin in liver cancer therapy, using internal and external stimuli. The future prospects of these smart delivery systems in liver cancer therapy are also discussed.
Review
Pharmacology & Pharmacy
Dmitriy Berillo, Zharylkasyn Zharkinbekov, Yevgeniy Kim, Kamila Raziyeva, Kamila Temirkhanova, Arman Saparov
Summary: Despite the conventional use of oral and intravenous routes for drug administration, they face limitations such as reduced bioavailability and invasiveness. Therefore, alternative delivery routes and modifications to drug formulations using stimuli-responsive polymers can improve drug release and bioavailability.