Article
Critical Care Medicine
Ary Serpa Neto, Tomoko Fujii, Mairead Mcnamara, James Moore, Paul J. Young, Sandra Peake, Michael Bailey, Carol Hodgson, Alisa M. Higgins, Emily J. See, Paul Secombe, Lewis Campbell, Meredith Young, Mikihiro Maeda, David Pilcher, Alistair Nichol, Adam Deane, Elisa Licari, Kyle White, Craig French, Yahya Shehabi, Anthony Cross, Matthew Maiden, Umesh Kadam, Khaled El Khawas, Jamie Cooper, Rinaldo Bellomo, Andrew Udy
Summary: This study aims to identify the best population, intervention design, and assess between-group biochemical separation in preparation for a future phase III trial. The study includes 30 patients aged 18 and above who were admitted to the ICU within 48 hours, receiving vasopressor treatment, and presenting metabolic acidosis. The findings confirm the feasibility of a larger phase III trial on sodium bicarbonate.
CRITICAL CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Yunting Wang, Ling Chen, Guangfeng Guo, Youyuan Gao, Hua Gan
Summary: This study found that sodium bicarbonate (SB) infusion did not have a beneficial effect on hospital mortality in AKI patients with metabolic acidosis overall. However, it was observed to have a significant correlation with improved hospital mortality in patients with high anion gap (AG) metabolic acidosis. Larger randomized controlled trials are needed to confirm these results.
FRONTIERS IN MEDICINE
(2023)
Review
Anesthesiology
Misty A. Radosevich, Patrick M. Wieruszewski, Erica D. Wittwer
Summary: Tris-hydroxymethyl aminomethane (THAM) is an amino alcohol used clinically to buffer acid loads and raise pH in acidotic conditions. Available since 2020 in the United States, THAM may have clinical utility in managing acid-base derangements in conditions such as liver transplantation and acute respiratory distress syndrome (ARDS). However, clinical evidence supporting its use is limited, and high-quality evaluations are necessary.
ANESTHESIA AND ANALGESIA
(2023)
Review
Urology & Nephrology
Marcin Adamczak, Stanislaw Surma
Summary: Metabolic acidosis in CKD patients is common and can contribute to disease progression and various complications, worsening patient prognosis. Currently, sodium bicarbonate is the main treatment for metabolic acidosis. The role of the new drug veverimer in metabolic acidosis therapy requires further study.
Article
Endocrinology & Metabolism
Hannah G. Caldwell, Ryan L. Hoiland, Kurt J. Smith, Patrice Brassard, Anthony R. Bain, Michael M. Tymko, Connor A. Howe, Jay Mjr Carr, Benjamin S. Stacey, Damian M. Bailey, Audrey Drapeau, Mypinder S. Sekhon, David B. MacLeod, Philip N. Ainslie
Summary: The study found that increases and decreases in systemic [HCO3-] during acute respiratory/exercise-induced metabolic acidosis differentially affect cerebrovascular acid-base balance via trans-cerebral [HCO3-] exchange.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Sai Huang, Yaojun Peng, Lili Wang, Jing Wang, Xuan Zhou, Xiang Cui, Li Chen, Bo Yang, Cong Feng
Summary: This study aimed to explore the effectiveness of sodium bicarbonate infusion on mortality in elderly septic patients with acute metabolic acidosis. The results suggested that sodium bicarbonate infusion could improve both ICU and hospital survival for elderly septic patients with acute metabolic acidosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huabin Wang, Rui Liang, Tianqi Liang, Songyao Chen, Yulong Zhang, Lidan Zhang, Chun Chen
Summary: Sodium bicarbonate (SB) infusion does not reduce in-hospital mortality in severely ill children with metabolic acidosis and is associated with increased risk of hypernatraemia, hypokalaemia, and hypocalcaemia. Efforts should be focused on eliminating the causes of metabolic acidosis rather than using SB excessively.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tomoko Fujii, Andrew A. Udy, Alistair Nichol, Rinaldo Bellomo, Adam M. Deane, Khaled El-Khawas, Naorungroj Thummaporn, Ary Serpa Neto, Hannah Bergin, Robert Short-Burchell, Chin-Ming Chen, Kuang-Hua Cheng, Kuo-Chen Cheng, Clemente Chia, Feng-Fan Chiang, Nai-Kuan Chou, Timothy Fazio, Pin-Kuei Fu, Victor Ge, Yoshiro Hayashi, Jennifer Holmes, Ting-Yu Hu, Shih-Feng Huang, Naoya Iguchi, Sarah L. Jones, Toshiyuki Karumai, Shinshu Katayama, Shih-Chi Ku, Chao-Lun Lai, Bor-Jen Lee, Wen-Jinn Liaw, Chelsea T. W. Ong, Lisa Paxton, Chloe Peppin, Owen Roodenburg, Shinjiro Saito, John D. Santamaria, Yahya Shehabi, Aiko Tanaka, Ravindranath Tiruvoipati, Hsiao-En Tsai, An-Yi Wang, Chen-Yu Wang, Yu-Chang Yeh, Chong-Jen Yu, Kuo-Ching Yuan
Summary: Metabolic acidosis is a major complication of critical illness. Early sodium bicarbonate therapy may improve mean arterial pressure in critically ill patients and reduce the risk of ICU mortality.
Review
Chemistry, Multidisciplinary
Yue Wang, Xueer Zhou, Wenxuan Wang, Yongyao Wu, Zhiyong Qian, Qiang Peng
Summary: Cancer poses a serious threat to humans, and traditional therapies may not be sufficient for the increasing demands of patients. NaHCO3 has been found to potentially treat cancer by reversing the acidic tumor microenvironment.
CHINESE CHEMICAL LETTERS
(2021)
Review
Nutrition & Dietetics
Jorge Lorenzo Calvo, Huanteng Xu, Daniel Mon-Lopez, Helios Pareja-Galeano, Sergio Lorenzo Jimenez
Summary: The meta-analysis found that ingestion of NaHCO3 can improve anaerobic metabolism, especially in terms of energy supply by the glycolytic system.
JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
(2021)
Article
Sport Sciences
Mathew J. Mildenhall, Ed Maunder, Daniel J. Plews, Michael I. Lindinger, Simeon P. Cairns
Summary: This study aimed to investigate the effect of plasma acidosis on mechanical performance and whether bicarbonate supplementation can attenuate plasma acidosis and arterial oxygen desaturation in elite cyclists. The results showed that plasma acidosis was not associated with the decline of peak power output, and bicarbonate supplementation failed to improve arterial oxygen desaturation or mechanical performance.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Critical Care Medicine
Eddine Bendiab, Fanny Garnier, Marion Soler, Maxime Fosset, Samir Jaber, Nicolas Molinari, Boris Jung
Summary: The long-term prognosis of ICU survivors with severe acidemia upon admission is unknown. This study aimed to determine their long-term health-related quality of life and survival. The study found that the health-related quality of life was reduced in both the control and the sodium bicarbonate groups, especially in the physical domains. Survival rate after 5 years was 30%, with no significant difference between groups.
CRITICAL CARE MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Ujjawal Bairagi, Simran Kaur Rainu, Neetu Singh, Josemon Jacob
Summary: We report on cytocompatible, charged polyzwitterionic nanogels (PZNGs) that can efficiently fix and release bicarbonate anions for the treatment of metabolic acidosis. The PZNGs show good stability and cytocompatibility, and exhibit sustained release of bicarbonate anions for up to 168 hours.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Urology & Nephrology
Beverley Beynon-Cobb, Panayiotis Louca, Ewout J. J. Hoorn, Cristina Menni, Sandosh Padmanabhan
Summary: This systematic review and meta-analysis examined the effects of sodium bicarbonate on systolic blood pressure and antihypertensive medication use in individuals with chronic kidney disease (CKD). The results suggest that sodium bicarbonate supplementation does not adversely affect systolic blood pressure in CKD patients and does not increase the use of antihypertensive medication.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Sport Sciences
Jacquelyn Nagle Zera, Elizabeth F. Nagle, Takashi Nagai, Mita Lovalekar, John P. Abt, Scott M. Lephart
Summary: The study aimed to evaluate the reliability and validity of a 30-second maximal tethered freestyle swimming test (TST) in relation to swimming performance, as well as its associations with a land-based anaerobic test (WAnT). Results showed strong reliability and moderate correlations between TST and swimming performance, suggesting its potential use as an assessment tool in competitive swimming training programs.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Engineering, Chemical
Modesto P. Junior, Moises T. da Silva, Frederico G. Guimaraes, Thiago A. M. Euzebio
Summary: In this paper, a fuzzy multivariable controller is designed for an industrial rotary drying system to save energy and improve performance. The controller aims to keep the exhaust gas temperature at the dryer outlet as close as possible to the optimum value, thereby achieving a reduction in energy consumption.
Article
Automation & Control Systems
Moises T. da Silva, George A. Junior, Pericles R. Barros
Summary: An iterative method is proposed in this paper to identify first-order plus dead-time (FOPDT) models, using least-squares algorithm to estimate model parameters and approximating time delay for improved accuracy. Experimental results demonstrate the effectiveness and robustness of the method for parameter estimation.
JOURNAL OF CONTROL AUTOMATION AND ELECTRICAL SYSTEMS
(2022)
Article
Biochemistry & Molecular Biology
Nayara Alves de Sousa, Mariela M. Marani, Andre Luis Fernandes Lopes, Emanuelle Morais Silva, Eder Alves Barbosa, Andreanne Gomes Vasconcelos, Felipe T. B. Kuzniewski, Suellen Sousa Lustosa, Karina Pereira Gomes, Diego Basile Colugnati, Jefferson A. Rocha, Lucianna Helene Santos, Marcelo P. Benquerer, Patrick Quelemes, Leiz Veras, Daniel C. Moreira, Kalinne Kelly Lima Gadelha, Pedro Jorge Caldas Magalhaes, Alexandra Placido, Peter Eaton, Lucas Nicolau, Jand Venes R. Medeiros, Jose R. S. A. Leite
Summary: BR-bombesin is a novel bombesin-like peptide that may play a role in regulating gastrointestinal motility and gastric acid secretion by affecting smooth muscle contraction and stomach secretion.
Editorial Material
Gastroenterology & Hepatology
Moises Tolentino Bento da Silva, Armenio Aguiar dos Santos
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Virology
Marco Clementino, Karene F. Cavalcante, Vania A. F. Viana, Dayara de Oliveira Silva, Caroline R. Damasceno, Jessica Fernandes de Souza, Rafhaella N. D. G. Gondim, Daniel M. de Melo Jorge, Lyvia M. V. C. Magalhaes, Erico A. G. de Arruda, Roberto da J. P. Neto, Melissa S. Medeiros, Arnnenio A. dos Santos, Pedro J. C. Magalhaes, Liana P. Mello, Eurico Arruda, Aldo A. M. Lima, Alexandre Havt
Summary: This study adopted the RT-LAMP technique to detect SARS-Cov-2 in patient samples and compared it with the RT-qPCR technique. The results showed that the RT-LAMP technique using primers N5 and Orf9 had a sensitivity of 96% and specificity of 85%, with accurate diagnosis obtained only in nasopharyngeal swabs processed via an extraction kit.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Psychology, Biological
Pedro Victor Nogueira Telles, Juliana Soares Severo, Lucia Castro Santos de Oliveira, Jessica Fernanda Reis e Sousa, Ana Karolina Martins Cavalcante, Alda Cassia Alves da Silva, Armenio Aguiar dos Santos, Moises Tolentino
Summary: Anaerobic resistance training (ART) appears to have a protective effect against the gastric motility and cardiovascular side effects induced by dexamethasone. Dexamethasone resulted in weight loss, reduced food intake, tachycardia, and decreased gastric emptying, while ART partially alleviated these negative impacts.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Oncology
Gisele F. P. Rangel, Marcio Ramos, Luana D. do Carmo, Liviane M. A. Rabelo, Alfredo A. Silva, Tamiris F. G. de Sousa, Roberto C. P. Lima Junior, Deysi V. T. Wong, Renata F. C. Leitao, Pedro J. C. Magalhaes, Brandon F. Sousa, Marisa J. S. Frederico, Nylane M. N. Alencar
Summary: This study investigates the effects of LP-PII-IAA derived from the latex of Calotropis procera on irinotecan-induced intestinal mucositis. The results show that animals treated with LP-PII-IAA had reduced mortality, absence of diarrhea, and normalized intestinal functions. These effects were accompanied by decreased inflammation and oxidative stress markers. The findings suggest that the peptidases from C. procera are instrumental in suppressing the adverse effects of irinotecan.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Automation & Control Systems
Diego S. Torga, Moises T. da Silva, Lucas A. Reis, Thiago A. M. Euzebio
Summary: This paper proposes a method for simultaneous tuning of cascade controllers to improve system performance under load disturbance. By formulating a cost function for a nonlinear optimization problem and defining robustness constraints, designers can explicitly and independently address the trade-off between performance and robustness. Simulation and experimental results demonstrate that the proposed method successfully reduces the integrated absolute error under load disturbance.
TRANSACTIONS OF THE INSTITUTE OF MEASUREMENT AND CONTROL
(2022)
Article
Green & Sustainable Science & Technology
L. Junior Enio, Moises T. da Silva, Thiago A. M. Euzebio
Summary: High water usage is necessary in mineral processing plants, but a dewatering system filters the final ore pulp product to remove water and reuse it in previous processes. This paper proposes an advanced control strategy for the dewatering system to increase production time even under filter failure or changes in pulp characteristics.
Article
Gastroenterology & Hepatology
Joan W. Chen, Abraham Khan, Reena V. Chokshi, John O. Clarke, Ronnie Fass, Jose M. Garza, Milli Gupta, C. Prakash Gyawali, Anand S. Jain, Philip Katz, Vani Konda, Adriana Lazarescu, Kristle L. Lynch, Felice Schnoll-Sussman, Stuart J. Spechler, Marcelo F. Vela, Rena Yadlapati, Jacob M. Schauer, Peter J. Kahrilas, John E. Pandolfino, Dustin A. Carlson
Summary: This study assessed the interrater agreement and accuracy of HRM and FLIP interpretations. The results showed a high level of agreement and accuracy among raters for most metrics in HRM and FLIP interpretations. This supports the use of HRM and FLIP as primary or complementary tools in the evaluation of esophageal motility disorders.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jennifer Beatriz Silva Morais, Kyria Jayanne Climaco Cruz, Ana Raquel Soares de Oliveira, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Stefany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Juliana Soares Severo, Suelem Torres de Freitas, Gilberto Simeone Henriques, Moises Tolentino Bento da Silva, Francisco Erasmo Oliveira, Dilina do Nascimento Marreiro
Summary: This is a cross-sectional study that compares women with obesity (n = 80) to a control group (n = 94). The study found that women with obesity had higher levels of GPx and TBARS, and lower levels of SOD compared to the control group. The obese women also showed higher concentrations of cortisol in their serum and urine, as well as lower levels of zinc, selenium, and magnesium, and increased excretion of these minerals in their urine. Additionally, there were correlations between cortisol/cortisone ratio and zinc and selenium concentrations, as well as positive correlations between GPx and SOD activity and zinc and selenium concentrations. However, the study was unable to determine the impact of these findings on the antioxidant defense system and insulin sensitivity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Wenna Lucia Lima Santos, Clailson da Silva Pinheiro, Raisa de Oliveira Santos, Alda Cassia Alves da Silva, Juliana Soares Severo, Pedro Henrique Moraes Mendes, Luiza Carolinda de Sousa, Olga Maria Castro de Sousa, Brenda Lois Barros dos Santos, Kelly Beatriz Vieira de Oliveira, Antonio Klingem Freitas, Francisco Leonardo Torres-Leal, Armenio Aguiar dos Santos, Moises Tolentino Bent da Silva
Summary: PCOS affects body composition and nutritional parameters, and induces changes in oxidative stress in BAT. Physical exercise can prevent these alterations.
Article
Nutrition & Dietetics
Juliana Soares Severo, Vilk Jane da Silva Barros, Pedro Henrique Moraes Mendes, Brenda Lois Barros dos Santos, Alda Cassia Alves da Silva, Kelly Beatriz Vieira de Oliveira, Mayara Storel Bezerra de Moura, Poliana Cristina de Almeida Fonseca Viola, Nadir do Nascimento Nogueira, Jose Miguel Luz Parente, Murilo Moura Lima, Armenio Aguiar dos Santos, Moises Tolentino Bento Silva
Summary: In this study, the relationship between phase angle (PhA), consumption of ultra-processed foods, oxidative stress, body composition, and biochemical parameters in patients with inflammatory bowel diseases (IBD) was investigated. The results showed that PhA was positively correlated with glutathione (GSH) and superoxide dismutase (SOD). IBD patients consumed higher amounts of ultra-processed foods, but had better consumption of unprocessed or minimally processed foods. Additionally, the consumption of ultra-processed foods was positively correlated with malondialdehyde (MDA) levels.
CLINICAL NUTRITION ESPEN
(2023)
Article
Biology
K. B. V. de Oliveira, J. S. Severo, A. C. A. da Silva, B. L. B. dos Santos, P. H. M. Mendes, J. P. J. Sabino, A. L. M. M. Filho, P. Correia-de-Sa, A. A. dos Santos, M. T. B. da Silva
Summary: This study aimed to investigate the involvement of the P2X7 receptor blocker Brilliant Blue G (BBG) in gastric emptying and oxidative stress changes in the gastrointestinal tract of spontaneously hypertensive rats (SHR), and to study its relationship with the renin-angiotensin system. The results showed that BBG improved gastric emptying delay and oxidative stress markers in SHR animals, and this preventive effect was abrogated by the renin-angiotensin system.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Thiago M. Sales, Humberto B. Da Costa, Maria Klayre A. Sousa, Monalisa C. Souza, Kalynne K. Gadelha, Genilson J. Dias Junior, Kerolayne M. Nogueira, Suliana M. Paula, Pedro J. Magalhaes, Miguel Angelo N. Souza, Pedro Soares, Daniel Sifrim, Marcellus H. Souza
