Article
Chemistry, Analytical
Xichen Xu, Qunfeng Tang, Zhencheng Chen
Summary: We proposed a new method using deep learning to estimate cardiac output, which outperformed traditional methods and met clinical acceptability standards.
Review
Acoustics
Anders Hagen Jarmund, Sindre Andre Pedersen, Hans Torp, Jeroen Dudink, Siri Ann Nyrnes
Summary: Cerebral Doppler ultrasound is an important tool in pediatric diagnostics and prognostics. However, the measured spectrum is often simplified to numerical parameters. A scoping review of primary studies on cerebral Doppler arterial waveforms in infants identified variations in the waveforms related to physiological changes, pathology, and medical interventions. The review highlights the need for standardized terminology and precise definitions of Doppler parameters.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Physiology
Sole Lindvag Lie, Jonny Hisdal, Lars Oivind Hoiseth
Summary: The study indicates that during reductions in cardiac output, both MAP and cardiac output have independent effects on CBF. Furthermore, there is a statistically significant interaction effect between MAP and cardiac output on ICAV and ScO2.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Surgery
Samuel Huthart, Crispian Oates, John Allen, Kathia Fiaschi, Andrew J. Sims, Gerard Stansby
Summary: The study validates the diagnostic performance of the standardised DUS scoring system for the identification of peripheral arterial disease (PAD), as well as its capacity to grade disease severity. The system shows moderate agreement with ankle brachial pressure index (ABPI) in determining disease severity.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Medical Informatics
Hyun-Lim Yang, Chul-Woo Jung, Seong Mi Yang, Min-Soo Kim, Sungho Shim, Kook Hyun Lee, Hyung-Chul Lee
Summary: An open-source algorithm developed in this study using convolutional neural network and transfer learning technique showed better performance in estimating cardiac output compared to commercial APCO devices. The deep learning model had significantly smaller absolute errors and may be helpful in optimizing patient care for high-risk individuals.
JMIR MEDICAL INFORMATICS
(2021)
Article
Peripheral Vascular Disease
Lasse Gliemann, Andrea Tamariz-Ellemann, Camilla Collin Hansen, Thomas Svarre Ehlers, Sophie Moller, Ylva Hellsten
Summary: Contrary to the hypothesis, the study shows that Pannexin-1 does not contribute to elevated blood pressure in essential hypertension in humans, which opposes the findings in preclinical models.
Article
Cardiac & Cardiovascular Systems
Moe Kojima, Naoya Tanabe, Yu Kojima, Koichi Tamura, Hiroo Takahashi, Jun Ito
Summary: This study investigated a new, simple, and quantitative method for vascular access (VA) management using the Pocket LDF laser blood flowmeter. Peripheral circulation flow was measured in 82 hemodialysis patients with an arteriovenous fistula (AVF). The shunt symmetry index (SSI) was calculated and used for microcirculation evaluation. The results suggest that AVF reduces peripheral circulation flow and SSI can be used to screening for proximal vein stenosis.
CARDIORENAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Wang, Yan Li, Siyu Wang, Na Ma, Junhong Ren
Summary: Contrast-enhanced ultrasound (CEUS) has a significant role in evaluating patients with suspected renal artery stenosis, and its diagnostic performance is comparable to digital subtraction angiography (DSA). By combining CEUS with hemodynamic indicators, the accurate diagnosis rate of renal artery stenosis can be improved.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Engineering, Multidisciplinary
Lirui Xu, Pang Wu, Pan Xia, Fanglin Geng, Saihu Lu, Peng Wang, Xianxiang Chen, Zhenfeng Li, Lidong Du, Shuping Liu, Li Li, Hongbo Chang, Zhen Fang
Summary: This study presents an ultrasound system that can noninvasively measure local pulse pressure and blood pressure waveforms continuously. The system uses a low-computational method to evaluate pulse wave velocity and diameter waveforms, allowing the measurement of PP and blood pressure without calibration. The system has been validated in vitro and in vivo, demonstrating high accuracy and showing promise for diagnosing and preventing cardiovascular diseases.
Review
Critical Care Medicine
Anders Aneman, Petter Wilander, Frank Zoerner, Miklos Lipcsey, Michelle S. Chew
Summary: The systematic review investigated the effects of vasopressors on hemodynamic changes in adults with shock. It was found that vasopressors led to significant increases in mean arterial pressure and systemic vascular resistance, impacting cardiac output and heart pump efficiency in a heterogeneous manner. The comprehensive analysis illustrated the inadequacy of using mean arterial pressure as the sole clinical endpoint for vasopressor therapy optimization.
Article
Critical Care Medicine
Florian Ajavon, Fabien Coisy, Laura Grau-Mercier, Jules Fontaine, Antonia Perez Martin, Pierre-Geraud Claret, Xavier Bobbia
Summary: This study aimed to investigate the correlation between femoral arterial diameter variations (fADVs) and stroke volume (SV) during hemorrhagic shock management and resuscitation in anesthetized piglets. The results showed a strong correlation between fADVs and SV.
Article
Cardiac & Cardiovascular Systems
Ryan L. Hoiland, Philip N. Ainslie, Cheryl L. Wellington, Jennifer Cooper, Sophie Stukas, Sonny Thiara, Denise Foster, Nicholas A. Fergusson, Edward M. Conway, David K. Menon, Peter Gooderham, Veronica Hirsch-Reinshagen, Donald E. Griesdale, Mypinder S. Sekhon
Summary: The study quantified the impact of secondary brain hypoxia on injury to the neurovascular unit in patients with HIBI. It was found that secondary brain hypoxia is associated with de novo neuroglial injury and cerebral release of IL-6. Mitigating cerebrovascular-to-parenchymal limitations to O-2 transport is a promising therapeutic strategy for patients with HIBI with secondary brain hypoxia.
CIRCULATION RESEARCH
(2021)
Article
Medicine, General & Internal
Manoj Kumar Choudhary, Emmi Varri, Niina Matikainen, Jenni Koskela, Antti J. Tikkakoski, Mika Kahonen, Onni Niemel, Jukka Mustonen, Pasi Nevalainen, Ilkka Porsti
Summary: Medicated PA patients exhibit higher systemic vascular resistance and wave reflection compared to medicated EH patients, but show higher extracellular water volume, cardiac output, and arterial stiffness. Further studies are needed to determine if evaluating these features systematically would benefit the clinical diagnostics of PA.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Thibaut Markarian, Laura Grau-Mercier, Celine Occelli, Florian Ajavon, Pierre-Geraud Claret, Fabien Coisy, Xavier Bobbia
Summary: This study demonstrated a strong correlation between the cardiac output flow index (COF) and cardiac output measured by thermodilution (COth) in a controlled hemorrhagic shock model in anesthetized piglets. The COF, which automatically calculates CO using sub-aortic VTI and heart rate without requiring LVOT measurement, could be a rapid and reliable tool for clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Csaba Eke, Andras Szabo, Adam Nagy, Balazs Szecsi, Rita Szentgroti, Andras Denes, Miklos D. Kertai, Levente Fazekas, Attila Kovacs, Balint Lakatos, Istvan Hartyanszky, Kalman Benke, Bela Merkely, Andrea Szekely
Summary: This study aimed to evaluate the association between hepatic congestion and fluid management in patients undergoing cardiac surgery by examining hepatic venous flow patterns using Doppler ultrasound. The results showed that positive fluid balance was associated with increased retrograde hepatic venous flow, decreased right ventricular function, and longer ventilation times. Measurement of hepatic vein ratios can guide fluid therapy and hemodynamic management.
Article
Cardiac & Cardiovascular Systems
Toru Kawada, Hiromi Yamamoto, Kazunori Uemura, Yohsuke Hayama, Takuya Nishikawa, Can Zheng, Meihua Li, Tadayoshi Miyamoto, Masaru Sugimachi
Summary: The study showed that under beta-blockade, ivabradine (IVA) increased the high-frequency dynamic gain during low- and moderate-intensity vagal nerve stimulation. This effect may be attributed to the untethering of the hyperpolarizing effect of acetylcholine-sensitive potassium channels after IVA injection.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Shigehiko Ogoh, Takuro Washio, Benjamin S. Stacey, Hayato Tsukamoto, Angelo Iannetelli, Thomas S. Owens, Thomas A. Calverley, Lewis Fall, Christopher J. Marley, Shotaro Saito, Hironori Watanabe, Takeshi Hashimoto, Soichi Ando, Tadayoshi Miyamoto, Damian M. Bailey
Summary: The study demonstrates site-specific regulation of cerebral blood flow in hypoxia, preserving oxygen delivery in the posterior but not anterior cerebral circulation, with minimal contribution from the central respiratory chemoreflex. Vasodilatation of the external carotid artery may be an unexplored haemodynamic risk factor in the pathophysiology of acute mountain sickness.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Neurosciences
Toru Kawada, Keita Saku, Tadayoshi Miyamoto
Summary: The arterial baroreflex system is a closed-loop negative feedback system involving neural and peripheral arcs, which makes it challenging to identify open-loop characteristics. The study compared different analysis methods and found that unknown central and peripheral noise can affect estimation accuracy in closed-loop identification. Prior knowledge of the open-loop dynamic characteristics of the system may improve the assessment of baroreflex function under closed-loop conditions in the future.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Physiology
Toru Kawada, Takuya Nishikawa, Yohsuke Hayama, Meihua Li, Can Zheng, Kazunori Uemura, Keita Saku, Tadayoshi Miyamoto, Masaru Sugimachi
Summary: Clonidine, as a first-generation central antihypertensive, reduces sympathetic nerve activity, but the extent to which its peripheral vasoconstriction offsets its blood pressure-lowering effect is unknown. However, it was found that the vasoconstrictive effect of high-dose clonidine partially offset the centrally mediated blood pressure-lowering effect.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Yutaka Igarashi, Atsuya Toya, Kazunobu Okazaki
Article
Physiology
Tadayoshi Miyamoto, Daisuke Sotobayashi, Go Ito, Eriko Kawai, Hidehiro Nakahara, Shinya Ueda, Takeshi Toyama, Keita Saku, Yasuto Nakanishi, Hiroshi Kinoshita
Summary: This study aimed to investigate the variations in anticipatory cardiorespiratory responses depending on the intensity of subsequent exercise bout, and the importance of these adjustments in enhancing exercise performance during high-intensity exercise. The results showed that anticipatory cardiorespiratory adjustments played a crucial role in minimizing the time delay of circulatory response and enhancing performance after the onset of high-intensity exercise.
PHYSIOLOGICAL REPORTS
(2022)
Article
Physiology
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
Summary: Endurance training under hot conditions improves thermoregulation, but does not attenuate exercise-induced hepcidin elevation.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Shigehiko Ogoh, Jun Sugawara, Shigeki Shibata
Summary: Heart failure (HF) in patients may increase the risk of cognitive dysfunction and stroke due to physiological factors associated with cardiac dysfunctions affecting cerebral circulation. Reduced cerebral blood flow and abnormal autoregulation in chronic HF can lead to decreased perfusion, metabolic insufficiency, and structural deteriorations in the brain. The mechanism underlying HF-induced brain disease is still unclear, and future studies should focus on physiological factors to prevent brain disease and cardiovascular dysfunction in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
Summary: The study aimed to investigate the effects of heat acclimation on gastrointestinal damage and gastric emptying rate following endurance exercise. The results showed that endurance training in a hot environment improved thermoregulation, but did not further attenuate exercise-induced GI damage and delay in gastric emptying rate compared to training in a cool environment.
Editorial Material
Medicine, General & Internal
Shigehiko Ogoh
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Hisayo Yokoyama, Daiki Imai, Yuta Suzuki, Akira Ogita, Hitoshi Watanabe, Haruka Kawabata, Takaaki Miyake, Izumi Yoshii, Shinji Tsubouchi, Yoshimasa Matsuura, Kazunobu Okazaki
Summary: This study evaluated the current state of health literacy (HL) among college students and explored the factors influencing HL, as well as the relationship between HL and health conditions. The majority of participants had problematic or unsatisfactory HL levels. Those with healthy lifestyles scored higher on HL, and higher HL levels were associated with better subjective health. Educational intervention programs for college students should be established to improve their HL levels.
Meeting Abstract
Sport Sciences
Daichi Sumi, Haruna Nagatsuka, Kaori Matsuo, Kazunobu Okazaki, Kazushige Goto
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Sport Sciences
Hisayo Yokoyama, Miwako Deguchi, Nobuko Hongu, Hitoshi Watanabe, Akira Ogita, Daiki Imai, Yuta Suzuki, Kazunobu Okazaki
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Tadayoshi Miyamoto, Go Ito
Meeting Abstract
Biochemistry & Molecular Biology
Ito Go, Otsuki Shingo, Nakata Hideomi, Nakahara Hidehiro, Miyamoto Tadayoshi
