Article
Physiology
Joshua T. Royal, Ola Eiken, Michail E. Keramidas, Adam C. McDonnell, Igor B. Mekjavic
Summary: This study retrospectively assessed individual variation in hematological responses to bed rest and hypoxia, finding that females had larger erythropoietin responses than males. Bed rest duration did not impact the heterogeneity of erythropoietin, reticulocytes, and red blood cell responses.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Microbiology
Hui Sun, Qian Zhou, Pengyan Qiao, Di Zhu, Bingmu Xin, Bin Wu, Chuhua Tang
Summary: This study investigates the effects of microgravity on oral salivary secretion function and the salivary microbiome by simulating microgravity using a ground-based test. The results show minimal effect on salivary secretion function but significant changes in the salivary microbiome, with an increase in oral disease-related bacteria and a decrease in oral health-related commensal bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Benoit Smeuninx, Yasir S. Elhassan, Konstantinos N. Manolopoulos, Elizabeth Sapey, Alison B. Rushton, Sophie J. Edwards, Paul T. Morgan, Andrew Philp, Matthew S. Brook, Nima Gharahdaghi, Kenneth Smith, Philip J. Atherton, Leigh Breen
Summary: Short-term resistance exercise prehabilitation increased myofibrillar protein synthesis rates in older men, but did not prevent the decline in myofibrillar protein synthesis and muscle mass during bed rest.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Physiology
Stefan Mendt, Katharina Brauns, Anika Friedl-Werner, Daniel L. Belavy, Mathias Steinach, Thomas Schlabs, Andreas Werner, Hanns-Christian Gunga, Alexander C. Stahn
Summary: Long-term bed rest weakens the entrainment of the circadian system to the 24-hour day, possibly due to immobility and reduced physical activity levels associated with HDBR. Our findings highlight the importance of monitoring circadian rhythms in circumstances where gravity or physical activity levels are altered, given the critical role of diurnal rhythms for various physiological functions and behavior.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhi-Yuan Pan, Yu-Xiao Chang, Ni Han, Feng-Yi Hou, B. J. Yang Lee, Fa-Chao Zhi, Rui-Fu Yang, Yu-Jing Bi
Summary: Hydroxychloroquine has significant effects on the gut microbiota of mice, reducing microbial diversity and altering the relative abundance of certain bacterial phyla. However, short-term high dose HCQ challenge does not affect intestinal integrity and immune responses in mice. Special attention should be paid to the effects of HCQ on intestinal microecology in future clinical use.
Article
Immunology
Pramod N. Nehete, Bharti P. Nehete, Akash G. Patel, Sriram Chitta, Henrieta Scholtzova, Lawrence E. Williams
Summary: The study found that nonhuman primates experience significant changes in hematological and immunological parameters, including lymphocytes, T cells, B cells, and natural killer cells, when subjected to stress factors such as relocation.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Computer Science, Artificial Intelligence
Jingyi Zhang, Yonghong Luo, Boya Wang, Chao Lu, Jennie Si, Jie Song
Summary: In this study, an innovative solution approach to the challenging dynamic load-shedding problem in large power grids is introduced. The proposed approach, called DQN-LS, takes into account spatial and temporal information of the power system and uses a ConvLSTM network to capture dynamic features. It provides real-time, fast, and accurate load-shedding decisions to increase the quality and probability of voltage recovery.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Neurosciences
Roberto Gammeri, Adriana Salatino, Maria Pyasik, Emanuele Cirillo, Claudio Zavattaro, Hilary Serra, Lorenzo Pia, Donna R. Roberts, Anna Berti, Raffaella Ricci
Summary: Self-produced somatosensory stimuli on Earth are perceived as less intense than externally generated stimuli, a phenomenon called somatosensory attenuation (SA). This study investigated the effect of temporary modulation of gravitational input by head-down tilt bed rest (HDBR) on somatosensory perception. The results showed that somatosensory stimuli were perceived as less intense during HDBR, regardless of the stimulus generator. Participants experiencing SA showed a disappearance of the phenomenon during HDBR, while participants with reversed SA were not affected by HDBR.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Neurosciences
Jeroen Van Cutsem, Nathalie Pattyn, Olivier Mairesse, Berenice Delwiche, Helio Fernandez Tellez, Martine Van Puyvelde, Emilie Lacroix, Adam C. McDonnell, Ola Eiken, Igor B. Mekjavic
Summary: This study investigated the separate and combined effects of inactivity (simulated with the experimental bed rest model) and hypoxia on sleep characteristics in women. The results demonstrated that hypoxia and bed rest negatively impacted sleep in terms of efficiency, quality, and respiratory function. Interestingly, hypoxia appeared to have less adverse effects on sleep macrostructure when participants were inactive compared to when they were ambulatory.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Marta Murgia, Lorenza Brocca, Elena Monti, Martino V. V. Franchi, Maximilian Zwiebel, Sophia Steigerwald, Emiliana Giacomello, Roberta Sartori, Sandra Zampieri, Giovanni Capovilla, Mladen Gasparini, Gianni Biolo, Marco Sandri, Matthias Mann, Marco V. V. Narici
Summary: This study used mass spectrometry-based proteomics to analyze the changes in plasma protein abundance after 10 days of bed rest. The results showed that inactivity affected the concentration of complement cascade proteins, lipid carriers, and proteins derived from tissue leakage. Additionally, the study identified several proteins that could potentially serve as biomarkers to distinguish individuals prone to muscle atrophy from those resistant to it.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Business, Finance
Thomas Cauthorn, Maurice Dumrose, Julia Eckert, Christian Klein, Bernhard Zwergel
Summary: This paper provides important evidence on the effects of ESG rating changes on companies' stock performance by replicating the calendar-time portfolio analysis for US stocks. Contradictory results are found, which are robust to the omnipresent rating heterogeneity problem. The differences in the results can be explained by four methodological mistakes in the original study.
FINANCE RESEARCH LETTERS
(2023)
Article
Sport Sciences
Fabio Sarto, Elena Monti, Bostjan Simunic, Rado Pisot, Marco V. Narici, Martino V. Franchi
Summary: This study aimed to investigate the changes in fascicle length of biceps femoris long head after 10 days of bed rest using four different ultrasound methods. The results showed that different methods led to different outcomes, recommending the use of EFOV technique or MLE for assessing fascicle length changes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Engineering, Aerospace
Gilles R. Clement, Brian E. Crucian, Meghan Downs, Stephanie Krieger, Steve S. Laurie, Stuart M. C. Lee, Edwin Mulder, Peter G. Roma, Jean D. Sibonga, Scott M. Smith, Michael B. Stenger, Scott J. Wood, Sara R. Zwart
Summary: The VaPER study conducted in the envihab facility in Cologne, Germany in 2017 found that strict 30-day bed rest at 6 degrees head down tilt in an elevated CO2 environment may lead to mild immunological dysregulation, changes in nutritional status, and optic disc edema in some subjects. Interestingly, subjects with optic disc edema exhibited higher body temperature, anxiety, and insomnia levels during bed rest.
Article
Engineering, Aerospace
Gilles R. Clement, Brian E. Crucian, Meghan Downs, Stephanie Krieger, Steve S. Laurie, Stuart M. C. Lee, Brandon R. Macias, Edwin Mulder, Eric Rivas, Peter G. Roma, Marissa J. Rosenberg, Jean D. Sibonga, Scott M. Smith, Elisabeth R. Spector, Sara E. Whiting, Scott J. Wood, Sara R. Zwart
Summary: The AGBRESA study conducted by ESA aimed to investigate the physiological changes induced by simulated spaceflight environment through bed rest experiment, as well as the mitigation effects of centrifugation. The study found that subjects without centrifugation exhibited significant decreases in bone density, muscle strength, aerobic capacity, and psychological state, while daily exposure to centrifugation helped slow down these changes.
Article
Mechanics
Yongliang Yang, Zhe Feng, Mengqi Zhang
Summary: This paper presents the results of numerical simulations and linear stability analyses on the flow past a cylinder. The effects of aspect ratios and Reynolds numbers on vortex shedding are investigated, and a new steady wake pattern is discovered.
JOURNAL OF FLUID MECHANICS
(2022)
Article
Pharmacology & Pharmacy
Pieter Colin, Douglas J. Eleveld, Johannes P. van den Berg, Hugo E. M. Vereecke, Michel M. R. F. Struys, Gustav Schelling, Christian C. Apfel, Cyrill Hornuss
CLINICAL PHARMACOKINETICS
(2016)
Article
Anesthesiology
I. Freytag, J. Bucher, M. Schoenberg, M. Stangl, G. Schelling
Article
Urology & Nephrology
Ulf Schoenermarck, Christina Dengler, Annegret Gmeinwieser, Siegfried Praun, Gustav Schelling, Michael Fischereder, Anne-Laure Boulesteix, Michael E. Dolch
CLINICAL NEPHROLOGY
(2016)
Article
Biochemistry & Molecular Biology
Dominik Buschmann, Anna Haberberger, Benedikt Kirchner, Melanie Spornraft, Irmgard Riedmaier, Gustav Schelling, Michael W. Pfaffl
NUCLEIC ACIDS RESEARCH
(2016)
Article
Pharmacology & Pharmacy
Andrea Berardi, Gustav Schelling, Patrizia Campolongo
PHARMACOLOGICAL RESEARCH
(2016)
Article
Cell Biology
Marlene Reithmair, Dominik Buschmann, Melanie Maerte, Benedikt Kirchner, Daniel Hagl, Ines Kaufmann, Martina Pfob, Alexander Chouker, Ortrud K. Steinlein, Michael W. Pfaffl, Gustav Schelling
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Behavioral Sciences
C. Strewe, R. Zeller, M. Feuerecker, M. Hoerl, I. Kumprej, A. Crispin, B. Johannes, T. Debevec, I. Mekjavic, G. Schelling, A. Chouker
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2017)
Article
Allergy
Matthias Feuerecker, Brian E. Crucian, Roel Quintens, Judith-Irina Buchheim, Alex P. Salam, Ales Rybka, Marjan Moreels, Claudia Strewe, Raymond Stowe, Satish Mehta, Gustav Schelling, Manfred Thiel, Sarah Baatout, Clarence Sams, Alexander Chouker
Article
Oncology
Dominik Buschman, Ricardo Gonzalez, Benedikt Kirchner, Claudia Mazzone, Michael W. Pfaffl, Gustav Schelling, Ortrud Steinlein, Marlene Reithmair
INTERNATIONAL JOURNAL OF ONCOLOGY
(2018)
Article
Cell Biology
Stefanie Hermann, Dominik Buschmann, Benedikt Kirchner, Melanie Borrmann, Florian Brandes, Stefan Kotschote, Michael Bonin, Anja Lindemann, Marlene Reithmair, Gustav Schelling, Michael W. Pfaff
JOURNAL OF EXTRACELLULAR VESICLES
(2019)
Article
Biochemistry & Molecular Biology
Agnes S. Meidert, Alexander Chouker, Siegfried Praun, Gustav Schelling, Michael E. Dolch
Summary: Markers of oxidative stress, including acetone, isoprene, and propionaldehyde, can be detected in the oxygenator outflow gas of severe ARDS patients treated with veno-venous extracorporeal membrane oxygenation (ECMO). The concentrations of these volatile organic compounds (VOCs) in breath and oxygenator outflow gas are comparable, showing a parallel course with time.
Article
Psychiatry
Alexander Behnke, Anja Maria Gumpp, Roberto Rojas, Timo Saenger, Sabine Lutz-Bonengel, Dirk Moser, Gustav Schelling, Aniko Krumbholz, Iris-Tatjana Kolassa
Summary: This study characterized the proinflammatory status in female MDD patients beyond CRP and IL-6 levels by investigating alterations of immunoregulatory biomolecules. The results showed higher CRP and AEA levels in MDD patients, and a positive association of CRP and AEA levels with current depressive symptoms.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Immunology
Nikolai Hulde, Nina Rogenhofer, Florian Brettner, Nicole C. Eckert, Isabella Goetzfried, Thu Nguyen, Judith-I. Pagel, Tobias Kammerer, Klaus F. Hofmann-Kiefer, Gustav Schelling, Andreas Dendorfer, Markus Rehm, Christian J. Thaler
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Review
Respiratory System
Marco Confalonieri, Francesco Salton, Francesco Fabiano
EUROPEAN RESPIRATORY REVIEW
(2017)
Article
Behavioral Sciences
Maria Morena, Andrea Berardi, Andrea Peloso, Daniela Valeri, Maura Palmery, Viviana Trezza, Gustav Schelling, Patrizia Campolongo
BEHAVIOURAL BRAIN RESEARCH
(2017)