Article
Engineering, Environmental
Haoxiao Yan, Liulan Zhao, Qishuang He, Yifan Hu, Quanxi Li, Kuo He, Dongmei Zhang, Qiao Liu, Jie Luo, Wei Luo, Shiyi Chen, Lisen Li, Song Yang
Summary: In this study, the researchers investigated the effects of 4 weeks of intermittent hypoxic exposure (IHE) on liver angiogenesis and related regulatory mechanisms in largemouth bass. The findings revealed that IHE reduced the O2 tension for loss of equilibrium and increased the concentrations of red blood cells (RBC) and hemoglobin. The study also identified a correlation between increased angiogenesis and the expression of regulators such as Jagged, phosphoinositide-3-kinase (PI3K), and mitogen-activated protein kinase (MAPK). Additionally, the overexpression of factors related to angiogenesis processes mediated by HIF-independent pathways was associated with lactic acid (LA) accumulation in the liver.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Donna C. Kennedy, Antony M. Wheatley, Karl J. A. McCullagh
Summary: Angiogenesis plays a crucial role in tissue homeostasis and the treatment of muscle diseases associated with vascular defects. This study demonstrates that myoblast cells transfected with VEGF-A gene can enhance endothelial cell proliferation, migration, and tube formation, leading to increased angiogenesis.
Article
Clinical Neurology
Masayuki Tanaka, Miho Kanazashi, Hiroyo Kondo, Hidemi Fujino
Summary: This study investigated the effects of inactivity on capillarization in the soleus muscle and examined the time-dependent changes in the expression of pro-angiogenic VEGF-A and anti-angiogenic TSP-1. The findings showed that muscle atrophy and capillary regression worsened with longer periods of inactivity. The expression patterns of VEGF-A and TSP-1 varied depending on the duration of inactivity.
Review
Endocrinology & Metabolism
Ian M. Williams, David H. Wasserman
Summary: The transport from microcirculation to muscle interstitium is the rate-limiting step for skeletal muscle glucose uptake. Capillary endothelium acts as a barrier that delays muscle insulin action. The number of perfused capillaries and the permeability of capillary walls to insulin determine muscle insulin access.
Article
Physiology
Adam J. Sterczala, Joseph R. Pierce, Brian R. Barnes, Maria L. Urso, Ronald W. Matheny, Dennis E. Scofield, Shawn D. Flanagan, Carl M. Maresh, Edward J. Zambraski, William J. Kraemer, Bradley C. Nindl
Summary: This investigation examined the effects of 12-week ballistic resistance training programs on the IGF-I system in circulation, interstitial fluid, and skeletal muscle. The results showed that training decreased basal levels of circulating and interstitial IGF-I, but did not alter intramuscular IGF-I protein activity. Additionally, acute exercise-induced increases in interstitial IGF-I were strongly correlated with intramuscular IGF-I expression and signaling, highlighting the localized role of IGF-I in hypertrophic adaptations.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Keerat Kaur, Yoav Hadas, Ann Anu Kurian, Magdalena M. Zak, Jimeen Yoo, Asharee Mahmood, Hanna Girard, Rinat Komargodski, Toshiro Io, Maria Paola Santini, Nishat Sultana, Mohammad Tofael Kabir Sharkar, Ajit Magadum, Anthony Fargnoli, Seonghun Yoon, Elena Chepurko, Vadim Chepurko, Efrat Eliyahu, Dalila Pinto, Djamel Lebeche, Jason C. Kovacic, Roger J. Hajjar, Shahin Rafii, Lior Zangi
Summary: The study demonstrates the success of reprogramming non-cardiomyocytes into cardiomyocyte-like cells using a modified mRNA gene delivery platform. This approach has shown promising therapeutic potential for cardiac regeneration in conditions such as ischemic heart disease, improving cardiac function and scar size after myocardial infarction.
Article
Biochemistry & Molecular Biology
Jessica S. Yu, Neda Bagheri
Summary: The study examines how vascular structure and function influence emergent cell population behavior using an agent-based model. The model allows researchers to mix and match different cell agents, subcellular modules, and microenvironment components, showcasing the bilateral relationship between cells and nearby vasculature.
Article
Neurosciences
Robert D. Hyldahl, Paul S. Hafen, W. Bradley Nelson, Mohadeseh Ahmadi, Brandon Pfeifer, Jack Mehling, Jayson R. Gifford
Summary: The study demonstrates that limb disuse has negative effects on vascular function and muscle health, but daily muscle heating through diathermy can mitigate the adverse effects of inactivity on vascular function.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Cell Biology
Michael G. Stencel, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
Summary: Calmodulin (CaM) is a crucial protein for multiple functions of vascular smooth muscle cells (VSMCs) and its expression and interactions with target proteins in VSMCs can be regulated by endothelial cells (ECs). In this study, it was discovered that proliferating ECs can upregulate total CaM expression and enhance Ca2+-bound CaM levels in VSMCs co-cultured with ECs. This endothelium-dependent upregulation of CaM in VSMCs is mediated by vascular endothelial growth factor receptors. These findings reveal a new role of ECs in regulating vascular functions through upregulating CaM and its interactions in VSMCs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Article
Biology
Ana Guerra, Jorge Belinha, Naside Mangir, Sheila MacNeil, Renato Natal Jorge
Summary: Angiogenesis, the formation of new blood vessels from pre-existing ones, is mainly influenced by vascular endothelial growth factor (VEGF) and can be mimicked by a meshless-based model proposed in this study. Both the experimental assay and simulation results showed that treatments with VEGF increased the total vessel number and length. The model accurately simulates capillary network patterns for lower VEGF concentrations, but may show some discrepancies for higher concentrations due to changes in blood vessel width.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Johan Onslev, Martin Thomassen, Jorgen Wojtaszewski, Jens Bangsbo, Morten Hostrup
Summary: Exercise attenuates the effect of beta(2)-agonist salbutamol on leg glucose uptake, but this attenuation diminishes in recovery. Salbutamol increases leg lactate release in recovery, which may relate to glycolytic trafficking due to excessive myocellular glucose uptake.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Physiology
Danny Christiansen, Casper B. L. Olsen, Frederik Kehler, Anders P. Hansen, Seren Jessen, Peter M. Christensen, Jens Bangsbo
Summary: This study investigated the impact of IPC-Ex on intense endurance exercise performance, finding that IPC-Ex resulted in a higher mean power output compared to IPC-rest, with no significant difference between IPC-rest and SHAM. IPC-Ex affected perceived exertion and blood pH levels.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2022)
Article
Peripheral Vascular Disease
Jennifer van der Horst, Salome Rognant, Ylva Hellsten, Christian Aalkjaer, Thomas A. Jepps
Summary: This study demonstrates that colchicine and ciliobrevin D can improve Kv7.4 channel function in arteries from spontaneously hypertensive rats, thereby enhancing vasodilation mediated by beta 2-adrenoceptors.
Review
Neurosciences
Andrea Tamariz-Ellemann, Kate Aiko Wickham, Line Boel Norregaard, Lasse Gliemann, Ylva Hellsten
Summary: Although ageing affects cardiovascular health in both men and women, the decline happens at different times. The loss of estrogen during menopause leads to a rapid decline in cardiovascular health in women. Exercise can counteract the loss of estrogen and improve cardiovascular health. Starting exercise soon after menopause may be more effective.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Kate A. Wickham, Line B. Norregaard, Martina H. Lundberg Slingsby, Stephen S. Cheung, Ylva Hellsten
Summary: Exercise training can increase the sensitivity of platelets to the inhibitory effects of prostacyclin, thereby reducing thrombotic risk in postmenopausal women.
Article
Biochemical Research Methods
Martin Thomassen, Jens Bangsbo, Morten Hostrup
Summary: Immunoblotting is commonly used in muscle physiology for protein regulation analysis, but different protocols may lead to different outcomes. This study investigated the impact of various homogenization procedures on protein abundance determination in muscle biopsies. Differences in protein abundance between healthy individuals and type-2 diabetics were also examined, as well as the effect of data normalization. The findings suggest that fractionated and non-fractionated immunoblotting samples yield similar data for certain proteins, except for actin, which is not suitable for data normalization in human skeletal muscle immunoblotting studies.
ANALYTICAL BIOCHEMISTRY
(2023)
Review
Physiology
Mark Ross, Christopher K. Kargl, Richard Ferguson, Timothy P. Gavin, Ylva Hellsten
Summary: Exercise-induced skeletal muscle angiogenesis is a physiological adaptation that leads to performance benefits and improvements in cardiovascular and skeletal tissue health. It can improve oxygen exchange and waste extraction, enhancing fatigue resistance. This process also promotes better cardiovascular and metabolic health, preventing conditions like diabetes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Stefanie L. L. Ruediger, Faith K. K. Pizzey, Jodie L. L. Koep, Jeff S. S. Coombes, Christopher D. D. Askew, Tom G. G. Bailey
Summary: The study aimed to compare peripheral and cerebrovascular function between healthy premenopausal, early postmenopausal, and late postmenopausal females, while also considering nitric oxide and estradiol levels. The main finding is that no differences in vascular and cerebrovascular function were observed between these groups, contradicting previous cross-sectional observations. Therefore, longitudinal studies are needed to assess vascular and cerebrovascular outcomes across the menopausal transition. This study is important for understanding the relationship between menopause and the risk of cardiovascular and cerebrovascular diseases in aging females.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Sport Sciences
Thomas S. S. Ehlers, Sophie Moller, Camilla C. C. Hansen, Andrea S. S. Tamariz-Ellemann, Tyler D. D. Vermeulen, J. Kevin Shoemaker, Lasse Gliemann, Ylva Hellsten
Summary: This study showed that training can reduce sympathetic nerve activity and improve baroreflex control in both hypertensive and normotensive men, but only lowers blood pressure in hypertensive men.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Biochemistry & Molecular Biology
Anders K. K. Lemminger, Matteo Fiorenza, Kasper Eibye, Jens Bangsbo, Morten Hostrup
Summary: This study investigated whether high-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts. The results showed that high-intensity exercise training not only enhances the ability to counter exercise-related ionic shifts, but also potentiates the effect of N-acetylcysteine on ionic shifts during exercise.
Article
Pharmacology & Pharmacy
Thomas S. Ehlers, Jennifer van der Horst, Sophie Moller, Peter K. Piil, Lasse Gliemann, Christian Aalkjaer, Thomas A. Jepps, Ylva Hellsten
Summary: The aim of this study was to investigate the effects of colchicine on beta adrenoceptor-mediated vasodilation in humans. The results showed that acute treatment with colchicine increased vasodilation induced by beta adrenoceptor agonist and nitric oxide in humans with essential hypertension. This finding has important implications for the treatment of hypertension.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Oncology
Huong Duong, Meegan Walker, Michelle Maugham-Macan
Summary: This paper reviews the safety of exercise for patients with bone metastases by comparing in-person and remote delivery of exercise intervention. The results show that both in-person and remote exercise therapy is safe and effective for patients with bone metastases.
Article
Cardiac & Cardiovascular Systems
Line Boel Norregaard, Kate Aiko Wickham, Thomas Ehlers, Marcos Paulo Rocha, Mads Fischer, Martina Lundberg H. Slingsby, Stephen S. Cheung, Phillip Adrian Evans, Jens Bangsbo, Ylva Hellsten
Summary: The study found that high-intensity exercise training initiated soon after menopause can reduce thrombotic risk in postmenopausal females, while its effects on those who have been in postmenopause for a long time remain uncertain.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Sport Sciences
Patrick J. Owen, Shelley E. Keating, Christopher D. Askew, Kelly M. Clanchy, Paul Jansons, Ralph Maddison, Andrew Maiorana, Jenna McVicar, Suzanne Robinson, Christopher Neason, Matthew J. Clarkson, Niamh L. Mundell
Summary: This study examined the effectiveness of exercise physiology services provided during the COVID-19 pandemic. The results showed that these services improved a range of client reported outcomes regardless of delivery mode. Further exploration of cost-effectiveness is warranted.
SPORTS MEDICINE-OPEN
(2023)