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Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise

JOURNAL OF APPLIED PHYSIOLOGY (2012)

期刊

JOURNAL OF APPLIED PHYSIOLOGY

卷 112, 期 9, 页码 1520-1528

出版社

AMER PHYSIOLOGICAL SOC

DOI: 10.1152/japplphysiol.01267.2011

关键词

BFR; KAATSU; vascular occlusion training; fractional synthetic rate; resistance exercise

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Physiology Sport Sciences

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National Institute of Arthritis and Musculoskeletal and Skin Diseases [AR049877]
National Institute on Aging [P30 AG024832]
National Institute of Child Health and Human Development [T32-HD07539]
National Center for Advancing Translation Sciences [1UL1RR029873-01]

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摘要

Gundermann DM, Fry CS, Dickinson JM, Walker DK, Timmerman KL, Drummond MJ, Volpi E, Rasmussen BB. Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise. J Appl Physiol 112: 1520-1528, 2012. First published February 23, 2012; doi:10.1152/japplphysiol.01267.2011.-Blood flow restriction (BFR) to contracting skeletal muscle during low-intensity resistance exercise training increases muscle strength and size in humans. However, the mechanism(s) underlying these effects are largely unknown. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) signaling and muscle protein synthesis (MPS) are stimulated following an acute bout of BFR exercise. The purpose of this study was to test the hypothesis that reactive hyperemia is the mechanism responsible for stimulating mTORC1 signaling and MPS following BFR exercise. Six young men (24 +/- 2 yr) were used in a randomized crossover study consisting of two exercise trials: low-intensity resistance exercise with BFR (BFR trial) and low-intensity resistance exercise with sodium nitroprusside (SNP), a pharmacological vasodilator infusion into the femoral artery immediately after exercise to simulate the reactive hyperemia response after BFR exercise (SNP trial). Postexercise mixed-muscle fractional synthetic rate from the vastus lateralis increased by 49% in the BFR trial (P < 0.05) with no change in the SNP trial (P > 0.05). BFR exercise increased the phosphorylation of mTOR, S6 kinase 1, ribosomal protein S6, ERK1/2, and Mnk1-interacting kinase 1 (P < 0.05) with no changes in mTORC1 signaling in the SNP trial (P > 0.05). We conclude that reactive hyperemia is not a primary mechanism for BFR exercise-induced mTORC1 signaling and MPS. Further research is necessary to elucidate the cellular mechanism(s) responsible for the increase in mTOR signaling, MPS, and hypertrophy following acute and chronic BFR exercise.

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Is There a Minimum Effective Dose for Vascular Occlusion During Blood Flow Restriction Training?

Arpan Das, Bruce Paton

Summary: This review explores the optimal combination of limb occlusion pressure (LOP) and one repetition max weight (1RM) for significant results using blood flow restriction (BFR) training. The findings suggest that training with a minimum of 30%1RM with BFR can achieve strength gains comparable to non-BFR high intensity training. Additionally, moderate intensity BFR training (40-60%1RM) may produce better results than non-BFR high intensity training, although there is limited literature available.

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