Article
Biochemistry & Molecular Biology
Svetlana P. Chumakova, Olga I. Urazova, Vladimir M. Shipulin, Sergey L. Andreev, Olga A. Denisenko, Margarita V. Gladkovskaya, Larisa S. Litvinova, Mikhail A. Bubenchikov
Summary: This study aimed to investigate the angiopoietic endothelial dysfunction in ischemic cardiomyopathy (ICMP) patients. It was found that there was an imbalance in the number of endothelial progenitor cells (EPCs) and desquamated cells (EDCs) in ICMP patients. Additionally, alterations in the levels of HIF-1α, HIF-2α, ADMA, and endothelin-1 were observed in ICMP patients.
Article
Cardiac & Cardiovascular Systems
Stefan P. Schumacher, Wijnand J. Stuijfzand, Ruben W. de Winter, Pepijn A. van Diemen, Michiel J. Bom, Henk Everaars, Roel S. Driessen, Lara Kamperman, Marly Kockx, Bram S. H. Hagen, Pieter G. Raijmakers, Peter M. van de Ven, Albert C. van Rossum, Maksymilian P. Opolski, Alexander Nap, Paul Knaapen
Summary: This study aimed to evaluate the impact of ischemic burden reduction after CTO PCI on long-term prognosis and cardiac symptom relief. Through various analyses, it was found that ischemic burden reduction and residual ischemia levels were closely related to prognosis outcomes and relief of cardiac symptoms.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cell & Tissue Engineering
Deping Wang, Bowen Li, Shuchao Wang, Yingjian Hao, Hua Wang, Wei Sun, Jimin Cao, Xin Zhou, Bin Zheng
Summary: In this study, a novel inhalation nanotherapeutic agent, P/D@Mn/Co3O4, was developed for the effective treatment of ischemic cerebrovascular disease. It effectively scavenged excess ROS, reduced oxidative stress, and protected neural cells from apoptosis. Additionally, it induced mitophagy and eliminated abnormal mitochondria, thereby preventing the continuous overproduction of ROS.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Medicine, General & Internal
Maria Lucia Narducci, Giampaolo Niccoli, Francesco Flore, Francesco Perna, Gianluigi Bencardino, Rocco Antonio Montone, Gemma Pelargonio, Filippo Crea
Summary: This study found that chronic coronary total occlusions (CTO) are not predictive of ventricular arrhythmias (VAs) recurrence after catheter ablation, instead LV dysfunction is the predictive factor.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yuchen Shi, Ze Zheng, Yanci Liu, Yongxin Wu, Ping Wang, Jinghua Liu
Summary: A machine learning algorithm was used to develop a clinical tool for predicting chronic total occlusion (CTO) in patients with coronary artery disease (CAD). The tool showed good concordance indices and can support clinicians in early discerning CTO in CAD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Puja K. Mehta, Odayme Quesada, Ahmed Al-Badri, Jerome L. Fleg, Annabelle Santos Volgman, Carl J. Pepine, C. Noel Bairey Merz, Leslee J. Shaw
Summary: Patients with ischemia and no obstructive coronary artery disease (INOCA) have an increased risk of adverse cardiovascular events due to underlying coronary microvascular dysfunction (CMD), leading to recurrent clinical presentations, impaired function, and high healthcare costs.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dongfeng Zhang, Haoran Xing, Rui Wang, Jinfan Tian, Zhiguo Ju, Lijun Zhang, Hui Chen, Yi He, Xiantao Song
Summary: This study aims to predict guidewire crossing within 30 minutes of chronic total occlusion (CTO) lesions based on plaque composition. The results showed that grouping lesions into soft and hard CTO based on the proportion of necrotic core was reasonable and necessary for predicting guidewire crossing. Different plaque types have variable predictive factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emil Nielsen Holck, Naja Stausholm Winther, Lone Juul Hune Mogensen, Evald Hoj Christiansen
Summary: This study investigated the cost-effectiveness of percutaneous coronary intervention (PCI) in patients with chronic total occluded coronary arteries (CTO). The results showed that fully revascularized patients had a more cost-efficient treatment. However, confirmation in a randomized controlled trial is needed due to potential residual confounding after adjustment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Ana Gabaldon-Perez, Victor Marcos-Garces, Jose Gavara, Cesar Rios-Navarro, Gema Minana, Antoni Bayes-Genis, Oliver Husser, Juan Sanchis, Julio Nunez, Francisco Javier Chorro, Vicente Bodi
Summary: The development of coronary revascularization techniques has been crucial in reducing mortality rates in acute coronary syndrome, but controversial in extending life expectancy in patients with chronic coronary syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yanjun Song, Kongyong Cui, Min Yang, Chenxi Song, Dong Yin, Qiuting Dong, Ying Gao, Kefei Dou
Summary: This study aims to evaluate the association of the triglyceride-glucose index (TyG) and the stress hyperglycaemia ratio (SHR) with long-term prognosis in patients with chronic total occlusion (CTO). The results showed that high TyG index and high SHR were significantly correlated with poor clinical outcomes, and the combination of these two biomarkers can better predict adverse prognosis in CTO patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Environmental Sciences
Qing Chen, Qi Chen, Qingqing Wang, Ruijun Xu, Tingting Liu, Yuewei Liu, Zhen Ding, Hong Sun
Summary: Short-term exposure to ambient PM2.5, PM10, and O-3 may lead to deaths from CIHD. These findings suggest that reducing exposure to polluted air can alleviate premature deaths in CIHD patients.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Frederik Faergemann Lau, Signe Bollerup, Frederik Engsig, Henrik Krarup, Lone Hagens Mygind, Jesper Bach Hansen, Lone Galmstrup Madsen, Peter Thielsen, Ulla Balslev, Lars Norregaard Nielsen, Toke S. Barfod, Mette Rye Clausen, Lise Hobath, Alex Lund Laursen, Britta Tarp, Birgit T. Rooge, Jan Gerstpft, Peer Brehm Chirstensen, Nina Weis
Summary: This study compared the rate of ischemic heart disease (IHD) between patients with chronic hepatitis B virus (CHB) and the general population. After adjusting for confounding factors, CHB was not found to have a significant effect on the rate of IHD.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Indre Matuleviciute, Agne Sidaraite, Vacis Tatarunas, Audrone Veikutiene, Olivija Dobiliene, Dalia Zaliuniene
Summary: This study used optical coherence tomography and optical coherence tomography angiography to investigate the relationship between retinal and choroidal microvascular changes and coronary heart disease. The results showed that a decrease in retinal and choroidal thickness as well as decreased vascular density may predict coronary artery disease. This study suggests that OCT and OCTA could be a significant, safe, and noninvasive tool for the prediction of coronary artery disease.
Review
Cardiac & Cardiovascular Systems
Carlo A. Pivato, Rishi Chandiramani, Marija Petrovic, Johny Nicolas, Alessandro Spirito, Davide Cao, Roxana Mehran
Summary: Depression is common in patients with ischemic heart disease, and depressed patients are more likely to develop atherosclerosis and experience major cardiac events compared with the general population. The underlying pathophysiological mechanisms of these two diseases are highly interwoven and include an increased release of stress hormones, dysregulation of the autonomic nervous system, alterations of pathways related to primary and secondary hemostasis, endothelial dysfunction, and higher level of residual inflammation. Furthermore, depression negatively impacts compliance with medication regimens. Early recognition and treatment of depression provide the opportunity to improve outcomes of patients with ischemic heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mitchel A. Molenaar, Berto J. Bouma, Casper F. Coerkamp, Jelle P. P. Man, Ivana Isgum, Niels J. Verouden, Jasper L. Selder, Steven A. J. Chamuleau, Mark J. Schuuring
Summary: According to the 2019 ESC guidelines, echocardiographic measurement of left ventricular function is recommended for risk stratification in patients with chronic coronary syndrome (CCS). However, there is limited data on the impact of valvular heart disease (VHD) in CCS patients. This study found that moderate or severe VHD is significantly associated with mortality risk in CCS patients, independent of LV function and other covariables.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Hematology
Wei Xie, Pei Lin, Sergej Konoplev
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Editorial Material
Hematology
Wei Xie, Jie Xu
Article
Hematology
Wei Xie, Shimin Hu, Jie Xu, Zhining Chen, L. Jeffrey Medeiros, Guilin Tang
ANNALS OF HEMATOLOGY
(2019)
Article
Hematology
Wei Xie, Guiling Tang, Endi Wang, Young Kim, Adam Cloe, Qi Shen, Yi Zhou, Guillermo Garcia-Manero, Sanam Loghavi, Aileen Y. Hu, Sa Wang, Carlos E. Bueso-Ramos, Hagop M. Kantarjian, L. Jeffrey Medeiros, Shimin Hu
ANNALS OF HEMATOLOGY
(2020)
Article
Pathology
Wei Xie, Jie Xu, Shimin Hu, Shaoying Li, Wei Wang, C. Cameron Yin, Gokce Toruner, Zhenya Tang, L. Jeffrey Medeiros, Guilin Tang
Review
Oncology
Wei Xie, L. Jeffrey Medeiros, Shaoying Li, C. Cameron Yin, Joseph D. Khoury, Jie Xu
CURRENT HEMATOLOGIC MALIGNANCY REPORTS
(2020)
Letter
Hematology
Mahsa Khanlari, Guilin Tang, Suyang Hao, Yun Gong, Shaoying Li, Roberto N. Miranda, Pei Lin, Swaminathan Iyer, Cameron C. Yin, Wei Xie, Francisco Vega, L. J. Medeiros, Jie Xu
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Pathology
Hong Fang, Sa A. Wang, Wei Xie, Zhenya Tang, Shimin Hu, Savitri Krishnamurthy, L. Jeffrey Medeiros, Wei Wang
Summary: This study reports on 6 patients with myelodysplastic syndrome (MDS) who underwent lymph node biopsies showing MDS infiltration, with distorted architecture and myeloid cell expansion. Despite treatment, all patients had poor responses and short survival times.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Peng Li, Thomas White, Wei Xie, Wei Cui, Deniz Peker, Gang Zeng, Huan-You Wang, Jennie Vagher, Sara Brown, Margaret Williams, Tibor Kovacsovics, Jay L. Patel
Summary: The study reveals that DDX41 mutations in AML manifest as male predominance, often lack of family history, indolent course, low proliferative potential, frequent somatic DDX41 mutations, and a favorable overall survival.
Article
Oncology
Wei Xie, Philipp W. Raess, Jennifer Dunlap, Cristina Magallanes Hoyos, Hongmei Li, Peng Li, Ronan Swords, Susan B. Olson, Fei Yang, Tauangtham Anekpuritanang, Shimin Hu, Joanna Wiszniewska, Guang Fan, Richard D. Press, Stephen R. Moore
Summary: Adult AML-NUP98 is associated with an unfavorable outcome, often accompanied by cryptic translocations. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.
LEUKEMIA & LYMPHOMA
(2022)
Article
Hematology
Peng Li, Sara Brown, Margaret Williams, Thomas White, Wei Xie, Wei Cui, Deniz Peker, Li Lei, Christian A. Kunder, Huan-You Wang, Sarah S. Murray, Jennie Vagher, Tibor Kovacsovics, Jay L. Patel
Summary: The study revealed significant differences between patients with HM carrying DDX41 CV and those with VUS, including older age, male predominance, frequent co-occurrence of somatic DDX41 variants, and lower somatic mutation burden in CV patients. These findings underscore the distinct clinical entity defined by germline DDX41 variants and emphasize the need for gene-specific diagnostic and clinical management guidelines.
Review
Biochemistry & Molecular Biology
Wei Xie, L. Jeffrey Medeiros, Shaoying Li, Guilin Tang, Guang Fan, Jie Xu
Summary: PD-1 ligands, including PD-L1 and PD-L2, are highly expressed in certain CD30+ large cell lymphomas, often due to genetic alterations in chromosome 9p24.1. The JAK/STAT pathway and mechanisms such as EBV infection and MAPK pathway activation also contribute to the overexpression of PD-L1 and PD-L2. Blockade of PD-1/PD-L1 has shown significant efficacy in treating relapsed/refractory lymphomas and may be a viable option for newly diagnosed patients.
Letter
Hematology
Mark Kavesh, Maedeh Mohebnasab, Marcela Riveros Angel, Wei Xie, Philipp W. Raess, Wei Cui, Richard D. Press, Guang Yang, Peng Li
Article
Biochemistry & Molecular Biology
Maedeh Mohebnasab, Peng Li, Bo Hong, Jennifer Dunlap, Elie Traer, Guang Fan, Richard D. Press, Stephen R. Moore, Wei Xie
Summary: Cytogenetically cryptic acute promyelocytic leukemia (APL) is a rare disease characterized by typical clinical and morphological features, but lacks detectable genetic translocation. Prompt diagnosis and treatment are crucial due to potential life-threatening complications. This study presents four cases of cryptic APL and reviews previous reports, highlighting the importance of parallel testing methods, especially reverse transcriptase polymerase chain reaction (RT-PCR), for accurate and effective diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Barina Aqil, Wei Xie, M. Tarek Elghetany, Reka Szigeti
Summary: The value of bronchoalveolar lavage (BAL) in diagnosing pulmonary diseases is widely accepted. Flow cytometric (FC) evaluation aids in early diagnosis of hematological neoplasms and provides timely diagnosis, especially important for critically ill patients.
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2021)