Review
Biochemistry & Molecular Biology
Roberto Castelli, Antonio Gidaro, Gavino Casu, Pierluigi Merella, Nicia I. Profili, Mattia Donadoni, Margherita Maioli, Alessandro P. Delitala
Summary: Aging leads to significant changes in the structural proprieties of the arterial wall, such as loss of elasticity and reduced compliance. Arterial hypertension, diabetes mellitus, and chronic kidney disease are major factors contributing to these changes. Arterial stiffness, evaluated by non-invasive methods like pulse wave velocity, is crucial in assessing vessel elasticity. Early assessment of stiffness is important as it can precede clinical signs of cardiovascular disease. While there is no specific pharmacological target for arterial stiffness, managing its risk factors can improve arterial wall elasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Zhuoting Zhu, Yifan Chen, Wei Wang, Yueye Wang, Wenyi Hu, Xianwen Shang, Huan Liao, Danli Shi, Yu Huang, Jason Ha, Zachary Tan, Katerina Kiburg, Xueli Zhang, Shulin Tang, Honghua Yu, Xiaohong Yang, Mingguang He
Summary: The study found a significant association between retinal age gap and arterial stiffness index as well as incident cardiovascular disease events, indicating the potential of this novel biomarker in identifying individuals at high risk of future CVD events.
Article
Peripheral Vascular Disease
Qianhui Ling, Qirui Song, Jingjing Bai, Shouling Wu, Weili Zhang, Mulei Chen, Jun Cai
Summary: This study examined the temporal relationship between arterial stiffness and systolic blood pressure (SBP), and found that arterial stiffening precedes SBP, particularly in the intensive treatment group, and leads to difficulty in achieving the target SBP.
Article
Peripheral Vascular Disease
Hirofumi Tomiyama, Takumi Imai, Kazuki Shiina, Yukihito Higashi, Hiroki Nakano, Takamichi Takahashi, Masatsune Fujii, Chisa Matsumoto, Akira Yamashina, Taishiro Chikamori
Summary: This study examines the association of cardiovascular risk factors (CVRFs) with the rate of progression of arterial stiffness based on long-term repeated measurements. Smoking, heavy alcohol intake, hypertension, diabetes, hypertriglyceridemia, and hyperuricemia were found to be independently associated with a fast progression of arterial stiffness, while lower values in certain biomarkers were associated with a slow progression. The findings highlight the importance of early interventions to control CVRFs in maintaining arterial health.
Review
Cardiac & Cardiovascular Systems
Elisabetta Bianchini, Mai Tone Lonnebakken, Peter Wohlfahrt, Senol Piskin, Dimitrios Terentes-Printzios, Jordi Alastruey, Andrea Guala
Summary: Magnetic resonance imaging and computed tomography accurately assess arterial state and function, but the complexity and technical requirements of some biomarkers hinder their widespread use. This review summarizes current biomarkers related to aortic aging, their principles, required sequences and postprocessing, and their predictive values for cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Sophia A. Mahoney, Ravinandan Venkatasubramanian, Mary A. Darrah, Katelyn R. Ludwig, Nicholas S. Vandongen, Nathan T. Greenberg, Abigail G. Longtine, David A. Hutton, Vienna E. Brunt, Judith Campisi, Simon Melov, Douglas R. Seals, Matthew J. Rossman, Zachary S. Clayton
Summary: This study found that fisetin can improve arterial function and reduce arterial stiffness by reducing vascular cell senescence and inflammation. Fisetin enhances endothelial function by increasing the bioavailability of nitric oxide and reducing oxidative stress.
Article
Cardiac & Cardiovascular Systems
Frederic Roca, Michele Iacob, Thomas Duflot, Nathalie Donnadieu, Caroline Thill, Jeremy Bellien, Robinson Joannides
Summary: Heart rate reduction may increase arterial wall energy dissipation, but this effect may be influenced by age. Older individuals have poorer arterial stiffness and cardiovascular coupling, and lower energy dissipation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Amy J. Hein, Kristin M. Hansen, Jill N. Barnes, Naomi C. Chesler, Claudia E. Korcarz, Adam D. Gepner
Summary: This study found that exercise increases arterial stiffness in older individuals, independently of blood pressure. The increase in arterial stiffness is associated with an increase in postexercise systolic blood pressure, which could contribute to exercise-induced hypertension in older adults.
JOURNAL OF HYPERTENSION
(2023)
Article
Cell Biology
Md Torikul Islam, Shelby A. Hall, Tavia Dutson, Samuel I. Bloom, R. Colton Bramwell, John Kim, Jordan R. Tucker, Daniel R. Machin, Anthony J. Donato, Lisa A. Lesniewski
Summary: Inhibition of mTOR can delay aging and improve age-related conditions, but the specific mechanisms and tissues involved are unclear. This study found that activation of mTOR in endothelial cells is associated with arterial and metabolic dysfunction. Reducing endothelial mTOR can reverse arterial stiffening, improve arterial and metabolic function, and reduce senescence, inflammation, and oxidative stress in arteries, lungs, adipose tissue, and liver.
Article
Biotechnology & Applied Microbiology
Vasiliki Bikia, Georgios Rovas, Stamatia Pagoulatou, Nikolaos Stergiopulos
Summary: A non-invasive method for estimating aortic characteristic impedance and total arterial compliance was proposed in this study, achieving high accuracy through regression analysis and training on virtual subjects. This approach could be a valuable tool for non-invasively screening elastic vascular properties in humans.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Physiology
Nicholas A. Carlini, Spencer Romanowski, Emily N. Rabalais, Brandon M. Kistler, Marilyn S. Campbell, I. M. Krishnakumar, Matthew P. Harber, Bradley S. Fleenor
Summary: Nutraceutical-based interventions, such as coconut sap powder (CSP), have the potential to reduce blood pressure and arterial stiffness. A study on middle-aged and older adults showed that CSP lowered systolic blood pressure and mechanical stiffness in the arteries, indicating a cardioprotective effect.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Adrian Noriega de la Colina, Atef Badji, Maxime Lamarre-Cliche, Louis Bherer, Helene Girouard, Navin Kaushal
Summary: The study found that physical activity has beneficial effects on cognition in older adults, but its impact is moderated by the interaction of arterial stiffness and age. Physical activity has a positive effect on cognition when arterial stiffness is high and age is low, as well as when arterial stiffness is low and age is high. However, the effect of physical activity on cognition is limited when both arterial stiffness and age are high or when both are low.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Akio Ishida, Akihiro Isotani, Michiko Fujisawa, Eva Garcia del Saz, Kiyohito Okumiya, Yumi Kimura, Indrajaya Ida Bagus Manuaba, Andreas Lallo Rantetampang, Yusuke Ohya, Kozo Matsubayashi
Summary: In indigenous Papuans, diastolic function of the left ventricle decreases with age, while systolic function remains preserved. Arterial stiffening is inversely related to left ventricular diastolic function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Owais Mian, Nicolas Santi, Munir Boodhwani, Luc Beauchesne, Kwan-Leung Chan, Carole Dennie, George A. Wells, Thais Coutinho
Summary: Arterial age is independently associated with accelerated aneurysm expansion, while chronological age is not. A noninvasive and inexpensive assessment of arterial age can potentially be useful for TAA risk stratification and disease monitoring as compared with the current clinical standard (chronological age).
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biology
Cristina Andreea Adam, Razvan Anghel, Dragos Traian Marius Marcu, Ovidiu Mitu, Mihai Roca, Florin Mitu
Summary: Vascular aging is closely related to the occurrence of cardiovascular diseases. Sodium-glucose cotransporter 2 inhibitors can reduce arterial stiffness and vascular resistance, improve endothelial function, and decrease the risk of cardiovascular events.
Article
Geriatrics & Gerontology
Kumiko Nagai, Hitomi Koshiba, Shigeki Shibata, Toshifumi Matsui, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2015)
Article
Neurosciences
Yoshiyuki Okada, Stuart A. Best, Sara S. Jarvis, Shigeki Shibata, Rosemary S. Parker, Brian M. Casey, Benjamin D. Levine, Qi Fu
JOURNAL OF PHYSIOLOGY-LONDON
(2015)
Article
Cardiac & Cardiovascular Systems
Shuaib M. Abdullah, Kyler W. Barkley, Paul S. Bhella, Jeffrey L. Hastings, Susan Matulevicius, Naoki Fujimoto, Shigeki Shibata, Graeme Carrick-Ranson, M. Dean Palmer, Nainesh Gandhi, Laura F. DeFina, Benjamin D. Levine
CIRCULATION-CARDIOVASCULAR IMAGING
(2016)
Article
Physiology
Graeme Carrick-Ranson, Naoki Fujimoto, Keri M. Shafer, Jeffrey L. Hastings, Shigeki Shibata, M. Dean Palmer, Kara Boyd, Benjamin D. Levine
JOURNAL OF APPLIED PHYSIOLOGY
(2016)
Article
Geriatrics & Gerontology
Toshimasa Obara, Kumiko Nagai, Shigeki Shibata, Ai Hirasawa, Hitomi Koshiba, Hiroshi Hasegawa, Takae Ebihara, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2018)
Article
Physiology
Michinari Hieda, Erin Howden, Shigeki Shibata, Takashi Tarumi, Justin Lawley, Christopher Hearon, Dean Palmer, Qi Fu, Rong Zhang, Satyam Sarma, Benjamin D. Levine
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Neurosciences
Shigeki Shibata, Naoki Fujimoto, Jeffrey L. Hastings, Graeme Carrick-Ranson, Paul S. Bhella, Christopher M. Hearon, Benjamin D. Levine
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Taiki Miyazawa, Shigeki Shibata, Kumiko Nagai, Ai Hirasawa, Yoshio Kobayashi, Hitomi Koshiba, Koichi Kozaki
JOURNAL OF APPLIED PHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Michinari Hieda, Erin Howden, Shigeki Shibata, Naoki Fujimoto, Paul S. Bhella, Jeffrey L. Hastings, Takashi Tarumi, Satyam Sarma, Qi Fu, Rong Zhang, Benjamin D. Levine
Article
Geriatrics & Gerontology
Graeme Carrick-Ranson, Francis G. Spinale, Paul S. Bhella, Satyam Sarma, Shigeki Shibata, Naoki Fujimoto, Jeffrey L. Hastings, Benjamin D. Levine
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Qi Fu, Shigeki Shibata, Jeffrey L. Hastings, Steven H. Platts, Douglas M. Hamilton, Michael W. Bungo, Michael B. Stenger, Christine Ribeiro, Beverley Adams-Huet, Benjamin D. Levine
Article
Physiology
Shigehiko Ogoh, Kazuya Suzuki, Takuro Washio, Kazuki Tamiya, Shotaro Saito, Tom G. Bailey, Shigeki Shibata, Go Ito, Tadayoshi Miyamoto
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Clinical Neurology
Chueh-Lung Hwang, Kazunobu Okazaki, Shigeki Shibata, Yu-Lun Liu, Qi Fu
Summary: This study investigated the effects of the menstrual cycle on muscle sympathetic nerve activity burst amplitude distribution during an orthostatic challenge in young women. The results showed that the mean and median values of relative burst amplitude increased from supine to upright position, regardless of menstrual cycle phases. However, the skewness and kurtosis of burst amplitude distribution varied between the early follicular phase and mid-luteal phase.
CLINICAL AUTONOMIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Shinya Matsushima, Minoru Yoshida, Hitoshi Yokoyama, Yosuke Watanabe, Hidetaka Onodera, Haruaki Wakatake, Hiroki Saito, Masahiko Kimura, Shigeki Shibata
Summary: The study showed that critically ill patients in the ICU with higher protein intake had better muscle strength at discharge and recovered to independent walking faster compared to those with lower protein intake.
Article
Physiology
Yoshiyuki Okada, Shigeki Shibata, Naoki Fujimoto, Stuart A. Best, Benjamin D. Levine, Qi Fu
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)