Article
Pharmacology & Pharmacy
Isabel Blanco, Maribel Marquina, Olga Tura-Ceide, Elisabet Ferrer, Ana M. Ramirez, Manuel Lopez-Meseguer, Maria Callejo, Francisco Perez-Vizcaino, Victor Ivo Peinado, Joan Albert Barbera
Summary: This study aimed to explore the potential role of survivin in the pathogenesis of pulmonary arterial hypertension (PAH) and the effects of its inhibition. The results showed that survivin expression was increased in the pulmonary arteries and lung tissue of the PAH mouse model, along with upregulation of proliferation-related genes. Treatment with the survivin inhibitor YM155 effectively reduced PAH symptoms and downregulated the expression of survivin and proliferation-related genes. Similar findings were observed in lungs from patients with PAH. These findings suggest that survivin may play a role in the development of PAH and that inhibiting its activity could be a potential therapeutic approach.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Andre L. D. Hovnanian, Eduardo L. Costa, Susana Hoette, Caio J. C. S. Fernandes, Carlos V. P. Jardim, Bruno A. Dias, Luciana T. K. Morinaga, Marcelo B. P. Amato, Rogerio Souza
Summary: This study found that pulmonary arterial hypertension (PAH) patients had significantly reduced impedance variation of lung perfusion (ΔZ(Q)), which showed significant correlation with hemodynamic parameters. Patients with lower ΔZ(Q) had worse prognosis, indicating electrical impedance tomography (EIT) as a promising tool for monitoring patients with pulmonary vascular disease.
Review
Biochemistry & Molecular Biology
Anastasia Gorelova, Mariah Berman, Imad Al Ghouleh
Summary: Endothelial-to-mesenchymal transition (EndMT) is a process that involves transcriptional reprogramming of endothelial cells towards mesenchymal phenotypes, contributing to various pathologies in adults, particularly in cardiovascular diseases and pulmonary hypertension. This review provides an overview of the current knowledge on the role of EndMT in pulmonary hypertension and discusses potential therapeutic strategies for disease management.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Physiology
Christopher Tossas-Betancourt, Nathan Y. Li, Sheikh M. Shavik, Katherine Afton, Brian Beckman, Wendy Whiteside, Mary K. Olive, Heang M. Lim, Jimmy C. Lu, Christina M. Phelps, Robert J. Gajarski, Simon Lee, David A. Nordsletten, Ronald G. Grifka, Adam L. Dorfman, Seungik Baek, Lik Chuan Lee, C. Alberto Figueroa
Summary: This study developed and calibrated two multi-scale high-resolution closed-loop computational models using clinical data from pediatric PAH patients. The models were constructed using open-source software and aimed to capture the ventricular-arterial interactions in PAH. The study also discussed the inconsistencies in anatomical and hemodynamic data routinely acquired in PAH patients and proposed strategies to mitigate these inconsistencies. The results showed that several model-derived metrics were strongly correlated with clinically assessed disease severity, suggesting that computational models may aid in assessing PAH severity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Byron A. Zambrano, Nathan McLean, Xiaodan Zhao, Ju-Le Tan, Liang Zhong, C. Alberto Figueroa, Lik Chuan Lee, Seungik Baek
Summary: The study found that patients with pulmonary arterial hypertension (PAH) have stiffer and larger pulmonary artery walls, reduced relative area change, higher total resistance, and lower total compliance. Additionally, PAH patients have lower wall shear stress values at the main pulmonary arteries.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Neurosciences
Susan R. Hopkins, Rui C. Sa, G. Kim Prisk, Ann R. Elliott, Nick H. Kim, Beni J. Pazar, Beth F. Printz, Howaida G. El-Said, Christopher K. Davis, Rebecca J. Theilmann
Summary: The study found that patients with Fontan physiology and pulmonary arterial hypertension (PAH) have increased heterogeneity in pulmonary perfusion compared to controls, which may be attributed to vascular remodeling in PAH and possibly in Fontan physiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Respiratory System
Robert Naeije, Manuel J. Richter, Lewis J. Rubin
Summary: Pulmonary arterial hypertension is a rare condition characterized by increased pulmonary vascular resistance and right ventricular failure. Despite extensive pulmonary vascular remodeling, lung function is generally well preserved in patients with pulmonary arterial hypertension, with only mild changes in oxygen and carbon dioxide levels. Exercise limitation in pulmonary arterial hypertension is primarily due to cardiovascular issues rather than respiratory or muscular problems.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Physiology
Danial Sharifi Kia, Kang Kim, Marc A. Simon
Summary: Pulmonary arterial hypertension (PAH) leads to increased right ventricular (RV) afterload and remodeling, with recent biomechanical studies revealing important connections between RV biomechanics and physiological function. The current understanding of RV structure and function in PAH is highlighted, along with recent research on the biomechanics of RV remodeling at various levels. The clinical relevance of RV biomechanics in PAH, as well as gaps in knowledge and future research directions, are also discussed.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Critical Care Medicine
Carrie L. Pistenmaa, P. Nardelli, S. Y. Ash, C. E. Come, A. A. Diaz, F. N. Rahaghi, R. G. Barr, K. A. Young, G. L. Kinney, J. P. Simmons, R. C. Wade, J. M. Wells, J. E. Hokanson, G. R. Washko, R. San Jose Estepar
Summary: This study reveals a significant association between pulmonary arterial pruning and rapid progression of emphysema percentage and decline in FEV1 to FVC ratio over 5 years in ever smokers. These findings suggest that pulmonary vascular differences may play a crucial role in the progression of the disease.
Review
Medicine, General & Internal
Athenais Boucly, Christian Gerges, Laurent Savale, Xavier Jais, Mitja Jevnikar, David Montani, Olivier Sitbon, Marc Humbert
Summary: Pulmonary arterial hypertension (PAH) is a rare and progressive disease that requires a complete work-up for a correct diagnosis. Current treatments target the specific pathways of endothelial dysfunction and the choice of therapy depends on the severity of the condition. Recent advances have led to the development of promising emerging therapies targeting dysfunctional pathways beyond endothelial dysfunction.
Review
Cardiac & Cardiovascular Systems
Jianying Deng
Summary: Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole, leading to right heart failure and death. Pulmonary vascular resistance plays an irreplaceable role in the pathophysiology, diagnosis, and treatment of pulmonary arterial hypertension.
JOURNAL OF CARDIOTHORACIC SURGERY
(2021)
Article
Agriculture, Dairy & Animal Science
Ryohei Suzuki, Yunosuke Yuchi, Takahiro Saito, Yuyo Yasumura, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
Summary: This study confirms the efficacy of beraprost sodium in treating canine pulmonary hypertension and observes improvements in cardiac function and circulation.
Review
Immunology
Shao-Fei Liu, Netra Nambiar Veetil, Qiuhua Li, Mariya M. M. Kucherenko, Christoph Knosalla, Wolfgang M. M. Kuebler
Summary: Pulmonary hypertension is a progressive disease caused by inflammation, which leads to pulmonary arterial stiffness and vascular remodeling, driving the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
John H. Newman
Summary: The study discusses a new approach to treating pulmonary arterial hypertension by targeting the TGF-beta pathway. Genetics play a significant role in both heritable and idiopathic forms of the disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Matthew J. Koch, Phan Q. Duy, Benjamin L. Grannan, Aman B. Patel, Scott B. Raymond, Pankaj K. Agarwalla, Kristopher T. Kahle, William E. Butler
Summary: This study reveals the coupling between arterial and venous pulse waves in the brain through the analysis of cerebral angiogram images. This phenomenon may serve as a physiological mechanism for the brain to maintain mechanical equilibrium and provides a significant avenue for studying neurological pathologies linked to mechanical disequilibrium.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
D. A. Schreier, T. A. Hacker, D. M. Tabima, M. O. Platt, N. C. Chesler
Summary: The release of cell free hemoglobin from fragile SCD red blood cells in vivo increases the total right ventricular afterload, potentially impairing RV function more than the SCD red blood cells themselves.
EXPERIMENTAL MECHANICS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kelly R. Stevens, Kristyn S. Masters, P. I. Imoukhuede, Karmella A. Haynes, Lori A. Setton, Elizabeth Cosgriff-Hernandez, Muyinatu A. Lediju Bell, Padmini Rangamani, Shelly E. Sakiyama-Elbert, Stacey D. Finley, Rebecca K. Willits, Abigail N. Koppes, Naomi C. Chesler, Karen L. Christman, Josephine B. Allen, Joyce Y. Wong, Hana El-Samad, Tejal A. Desai, Omolola Eniola-Adefeso
Summary: The racial funding disparity by NIH is identified as a significant barrier to success for Black faculty members, prompting a collective effort to address and dismantle it.
Article
Medicine, General & Internal
Gregory P. Barton, Philip A. Corrado, Christopher J. Francois, Naomi C. Chesler, Marlowe W. Eldridge, Oliver Wieben, Kara N. Goss
Summary: This study found that adults born prematurely exhibit an exaggerated cardiac contractile response to acute hypoxia, particularly in the right ventricle, which may increase their risk for late right ventricular failure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biophysics
Michelle A. Bartolo, M. Umar Qureshi, Mitchel J. Colebank, Naomi C. Chesler, Mette S. Olufsen
Summary: Isolated post-capillary pulmonary hypertension (Ipc-PH) is caused by left heart failure, while combined pre-/post-capillary PH (Cpc-PH) is associated with increased mortality. Mechanical forces and biological signaling likely contribute to the transition from Ipc-PH to Cpc-PH. This study used a computational fluid dynamics model to examine the dynamics of mechanical forces in the pulmonary circulation.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Yacob Tedla, Claudia E. Korcarz, Matthew C. Tattersall, James H. Stein, Naomi C. Chesler, Adam D. Gepner
Summary: Elastic arteries stiffen through two main mechanisms: load-dependent stiffening from higher blood pressure and structural stiffening due to changes in the vessel wall. This study found that as people age, there is a greater increase in total, structural, and load-dependent stiffening. Structural stiffening is the primary mechanism, but some individuals also experience more load-dependent stiffening. These differences in arterial stiffening mechanisms may influence the development of cardiovascular disease.
Article
Physiology
Tik-Chee Cheng, Diana M. Tabima, Laura R. Caggiano, Andrea L. Frump, Timothy A. Hacker, Jens C. Eickhoff, Tim Lahm, Naomi C. Chesler
Summary: This study found that women have better clinical outcomes than men with severe right ventricular pressure overload. Despite sex-dependent differences in contractile and fibrotic responses, right ventricular mechanoenergetic adaptation was comparable between the sexes, suggesting a homeostatic target.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biophysics
Ryan J. Pewowaruk, Omid Forouzan, Farhan Raza, Adam D. Gepner, Naomi C. Chesler
Summary: Estimating mPAP and other pulmonary hemodynamics measures from 2D PC MRI images showed promising diagnostic ability for distinguishing pulmonary hypertension patients from control subjects, indicating the potential of non-invasive estimation of pulmonary hemodynamics using an MRI and arterial mechanics approach. Further studies are needed to determine the clinical utility of this method.
JOURNAL OF BIOMECHANICS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Cassandra K. Conway-O'Donnell, Naomi C. Chesler
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Betty J. J. Allen, Hailey Frye, Rasika Ramanathan, Laura R. R. Caggiano, Diana M. M. Tabima, Naomi C. C. Chesler, Jennifer L. L. Philip
Summary: Combined pre-/postcapillary pulmonary hypertension (Cpc-PH), a complication of left heart failure, leads to higher mortality rates compared to isolated postcapillary pulmonary hypertension alone. However, little is known about the mechanisms responsible for the progression from isolated postcapillary pulmonary hypertension (Ipc-PH) to Cpc-PH. This review focuses on the biomechanical and mechanobiological impact of left heart failure on pulmonary circulation, including the altered biological signaling and detrimental remodeling that drive the progression to Cpc-PH. Understanding these mechanisms may help identify potential pharmacologic approaches to prevent right heart failure and subsequent mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Laura R. Caggiano, Naomi C. Chesler
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Engineering, Biomedical
M. J. Colebank, R. Taylor, T. A. Hacker, N. C. Chesler
Summary: Computational models are a useful tool for integrating different scales, but parameterization and matching with experimental data can be challenging. Recent advancements in data collection and model analyses have helped to overcome these challenges.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Farhan Raza, Naomi C. Chesler
Summary: In recent years, pulmonary vascular health has been found to be related to exercise intolerance and clinical outcomes. The health of pulmonary blood vessels can be quantified by the hemodynamic load faced by the right ventricle, which includes steady and pulsatile components. Different metrics, such as pulmonary arterial compliance, pulmonary vascular impedance, and pulmonary vascular distensibility with exercise, can assess the pulsatile load.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Engineering, Biomedical
Elizabeth M. M. Cosgriff-Hernandez, Brian A. A. Aguado, Belinda Akpa, Gabriella Coloyan Fleming, Erika Moore, Ana Maria Porras, Patrick M. M. Boyle, Deva D. D. Chan, Naomi Chesler, Karen L. L. Christman, Tejal A. A. Desai, Brendan A. C. Harley, Gregory A. A. Hudalla, Megan L. L. Killian, Katharina Maisel, Kristen C. C. Maitland, Shelly R. R. Peyton, Beth L. L. Pruitt, Sarah E. E. Stabenfeldt, Kelly R. R. Stevens, Audrey K. K. Bowden
Summary: We offer a roadmap for revamping faculty hiring processes to remove barriers that have historically excluded certain groups.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Amirreza Kachabi, Mitchel J. Colebank, Naomi C. Chesler
Summary: This article investigates the impact of chronic thromboembolic pulmonary hypertension (CTEPH) on pulmonary artery stiffness and hemodynamics using computational fluid dynamics. The results demonstrate that CTEPH increases pulmonary artery wall stiffness and decreases blood flow shear stress.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher J. Francois, Gregory P. Barton, Philip A. Corrado, Aimee T. Broman, Naomi C. Chesler, Marlowe W. Eldridge, Oliver Wieben, Kara N. Goss
Summary: A study using cardiac MRI (CMR) found that young adults born prematurely have significantly higher native T1 values compared to term-born individuals. These T1 values are also associated with cardiac volumes and mass index, and may be related to cardiac strain.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2022)
