Review
Cardiac & Cardiovascular Systems
Emilio Y. Lucero Garcia Rojas, Cleva Villanueva, Richard A. Bond
Summary: Cardiovascular diseases are the leading cause of death in industrialized countries, with hypoxia playing a central role in their pathogenesis. The review highlights the importance of HIFs and derived factors in the development and perpetuation of hypoxia in these diseases, categorizing them into acute and chronic hypoxic states to better understand the temporal relevance of HIFs in disease progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Critical Care Medicine
Jeremy E. Orr, Indu Ayappa, Danny J. Eckert, Jack L. Feldman, Chandra L. Jackson, Shahrokh Javaheri, Rami N. Khayat, Jennifer L. Martin, Reena Mehra, Matthew T. Naughton, Winfried J. Randerath, Scott A. Sands, Virend K. Somers, M. Safwan Badr
Summary: The international multidisciplinary group identified 11 specific research priorities regarding central sleep apnea (CSA) in heart failure patients, focusing on areas such as control of breathing, variability across individuals, examination techniques, treatment impact, and implementation strategies. Advancing care for patients with CSA in the context of heart failure will require progress in translational, epidemiological, and patient-centered outcome research. Priority should be given to targeted research to improve knowledge of CSA pathogenesis and treatment, given the increasing prevalence of heart failure and its substantial burden.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Environmental Sciences
Jun Zhou, Zhuo-Yi Zhu, Huan-Ting Hu, Gui-Ling Zhang, Qian-Qian Wang
Summary: The study revealed that oxygen depletion in the near-bottom waters off the Changjiang Estuary is caused by water column respiration and sedimentary oxygen respiration, with contributions of 53% and 47% respectively to the total apparent oxygen utilization. Below the pycnocline, the contribution of water column respiration to the total AOU varied from 24% to 69%, while sedimentary oxygen respiration varied from 31% to 76%.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Limnology
Cory P. McDonald, Mahta Naziri Saeed, Dale M. Robertson, Stephanie Prellwitz
Summary: Green Lake, located in central Wisconsin, has experienced annuals metalimnetic oxygen minima since the early 20th century. The severity of this phenomenon has increased over time and late-summer dissolved oxygen concentrations have been consistently low. High-frequency observations reveal that oxygen depletion occurs most rapidly in the metalimnion and shows synchrony throughout the hypolimnion. The severity of the metalimnetic oxygen minimum is determined by the amount of labile organic matter at the onset of stratification and the increase in productivity in the lake.
Article
Environmental Sciences
Alain de Verneil, John A. Burt, Matthew Mitchell, Francesco Paparella
Summary: The Arabian Gulf is the warmest sea during summer with high salinity and extreme temperature fluctuations. Research showed recurrent summer hypoxia events in southern Gulf reefs, although currently they are short enough to prevent mass mortality. Future predictions require further study of the causes of oxygen fluctuations in the Gulf.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Medicine, General & Internal
Padmanabhan Ramnarayan, Alvin Richards-Belle, Laura Drikite, Michelle Saull, Izabella Orzechowska, Robert Darnell, Zia Sadique, Julie Lester, Kevin P. Morris, Lyvonne N. Tume, Peter J. Davis, Mark J. Peters, Richard G. Feltbower, Richard Grieve, Karen Thomas, Paul R. Mouncey, David A. Harrison, Kathryn M. Rowan
Summary: This study aimed to compare high-flow nasal cannula (HFNC) with continuous positive airway pressure (CPAP) as the first-line noninvasive respiratory support following extubation in critically ill children. The results showed that HFNC did not meet the criteria for noninferiority in terms of time to liberation from respiratory support.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Critical Care Medicine
L. Imeen van der Wal, Chloe C. A. Grim, Michael R. del Prado, David J. van Westerloo, E. Christiaan Boerma, Hilda G. Rijnhart-de Jong, Auke C. Reidinga, Bert G. Loef, Pim L. J. van der Heiden, Marnix J. Sigtermans, Frederique Paulus, Alexander D. Cornet, Maurizio Loconte, F. Jeannette Schoonderbeek, Nicolette F. de Keizer, Ferishta Bakhshi-Raiez, Saskia Le Cessie, Ary Serpa Neto, Paolo Pelosi, Marcus J. Schultz, Hendrik J. F. Helmerhorst, Evert de Jonge
Summary: A low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy in mechanically ventilated ICU patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Kristen H. Shanahan, Michael C. Monuteaux, Joshua Nagler, Richard G. Bachur
Summary: A large cohort study in children's hospitals from 2010 to 2018 found significant increases in both noninvasive and invasive ventilation for infants with bronchiolitis. While high hospital-level noninvasive ventilation utilization was not associated with a reduction in invasive ventilation, it was linked to higher rates of cardiac arrest. Further investigation into the unintended risk of cardiac arrest with noninvasive ventilation in bronchiolitis is needed.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ana Lucia Castrillon-Cifuentes, Fernando A. Zapata, Alan Giraldo, Christian Wild
Summary: Dissolved oxygen concentration is a main limiting factor for benthic species distribution, and low oxygen conditions may occur in coral reefs of the Eastern Tropical Pacific. The Spatio-temporal changes of DO in coral reefs of Gorgona Island were characterized and the critical oxygen tension for Pocillopora capitata was calculated. Low DO conditions were due to upwelling, and hypoxic events sporadically occurred at 10 m depth. Oxygen conditions lower than 2.3 mg L-1 coincided with the deepest distribution of scattered colonies of Pocillopora. Hypoxic events could pose a threat if eutrophication increases.
Article
Chemistry, Physical
Ping Dong, Jialing Hu, Shuyi Yu, Yizhuo Zhou, Tianhui Shi, Yun Zhao, Xiuyuan Wang, Xiaoqing Liu
Summary: A mitochondria-targeted reactive oxygen species amplifier was constructed to reverse hypoxia resistance and enhance tumor sensitivity to photodynamic therapy. This approach showed promising anticancer performance in both in vitro and in vivo experiments, suggesting a potential clinical strategy for hypoxia-related tumor treatment.
Article
Clinical Neurology
Mahssa Karimi, Jan Hedner, Ludger Grote
Summary: Adaptive Servo Ventilation (ASV) treatment improves sleep quality, neurocognition, and daytime performance in patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR).
Editorial Material
Physiology
Elias T. Polymeropoulos, William K. Milsom
Summary: This collection of research articles was compiled in honor of respiratory physiologist Professor Peter Frappell's academic achievements, covering various topics related to the oxygen transport cascade. Frappell has had a significant impact in the field of comparative physiology, promoting novel perspectives, methodologies, and research techniques.
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2021)
Review
Multidisciplinary Sciences
Ruvistay Gutierrez-Arias, Pamela INTRehab Res Grp, Gabriel Salgado-Maldonado, Paola Letelier Valdivia, Francisco Salinas-Barahona, Carmen Echeverria-Valdebenito, Pamela Seron
Summary: This review aims to summarize the evidence on the frequency and methods of assessment of swallowing disorders in adult HFNC users, in order to promote routine swallowing assessment in this population and guide new studies in less researched areas.
Review
Medicine, General & Internal
G. Klefti, A. T. Hill
Summary: This study, through a meta-analysis, found that non-invasive ventilation (NIV) significantly reduced the rate of endotracheal intubation and the proportion of patients meeting the criteria for intubation, as well as ICU mortality rate, compared to standard medical care for severe community-acquired pneumonia in adults. However, no significant effect on hospital mortality rate was found. The quality of evidence for the outcomes related to intubation and proportion of patients meeting intubation criteria was rated as 'Moderate', while the quality of evidence for ICU and hospital mortality rate was rated as 'Low'.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2022)
Review
Anesthesiology
Jihad Mallat, Nadeem Rahman, Fadi Hamed, Glenn Hernandez, Marc-Olivier Fischer
Summary: Oxygen is essential for cellular functions and its delivery to tissues is determined by convective and diffusive processes. The body adjusts oxygen extraction to maintain constant tissue oxygen consumption, with the endothelium playing a crucial role. Different mechanisms, such as circulatory, anaemic, hypoxic, and cytopathic, can lead to tissue hypoxia.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Review
Peripheral Vascular Disease
James E. Sharman, Isabella Tan, George S. Stergiou, Carolina Lombardi, Francesca Saladini, Mark Butlin, Raj Padwal, Kei Asayama, Alberto Avolio, Tammy M. Brady, Alan Murray, Gianfranco Parati
Summary: Automated oscillometric blood pressure measuring devices have replaced manual auscultatory blood pressure measurement by mercury sphygmomanometers in clinical settings. These validated devices provide similar blood pressure values to manual measurement, making them the recommended standard for hypertension diagnosis and management globally.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Vincenzo Russo, Erika Parente, Antonella Groppelli, Giulia Rivasi, Marco Tomaino, Alessio Gargaro, Daniele Giacopelli, Andrea Ungar, Gianfranco Parati, Artur Fedorowski, Richard Sutton, J. Gert van Dijk, Michele Brignole
Summary: This review discusses the timing of tilt-induced asystole and loss of consciousness (LOC) in tilt-testing methodology. The commonly used Italian protocol is not always followed strictly, allowing for reassessment of the incidence of asystole during early tilt-down compared to late, established LOC. Asystole is less common in early tilt down and decreases with increasing age, but more common if LOC is established as the test-end point, and it is age-independent. The review also highlights the usefulness of asystole occurrence as a guide for pacemaker therapy in highly symptomatic older vasovagal syncope patients.
Editorial Material
Cardiac & Cardiovascular Systems
Oliver O'Sullivan, Rienk Rienks, David Holdsworth, Constantinos H. Davos, Martin Halle, Alexander Bennett, Gianfranco Parati, Norbert Guettler, Edward Nicol
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gianfranco Parati, Alexandra Goncalves, David Soergel, Rosa Maria Bruno, Enrico Gianluca Caiani, Eva Gerdts, Felix Mahfoud, Lorenzo Mantovani, Richard J. McManus, Paola Santalucia, Thomas Kahan
Summary: Hypertension is a common and preventable risk factor for cardiovascular disease, but a large number of patients are undiagnosed or inadequately treated. A comprehensive approach is needed to improve hypertension management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Peripheral Vascular Disease
Gianfranco Parati, Grzegorz Bilo, Anastasios Kollias, Martino Pengo, Juan Eugenio Ochoa, Paolo Castiglioni, George S. Stergiou, Giuseppe Mancia, Kei Asayama, Roland Asmar, Alberto Avolio, Enrico G. Caiani, Alejandro De La Sierra, Eamon Dolan, Andrea Grillo, Przemyslaw Guzik, Satoshi Hoshide, Geoffrey A. Head, Yutaka Imai, Eeva Juhanoja, Thomas Kahan, Kazuomi Kario, Vasilios Kotsis, Reinhold Kreutz, Konstantinos G. Kyriakoulis, Yan Li, Efstathios Manios, Anastasia S. Mihailidou, Pietro Amedeo Modesti, Stefano Omboni, Paolo Palatini, Alexandre Persu, Athanasios D. Protogerou, Francesca Saladini, Paolo Salvi, Pantelis Sarafidis, Camilla Torlasco, Franco Veglio, Charalambos Vlachopoulos, Yuqing Zhang
Summary: Blood pressure is not static, but fluctuates continuously due to environmental and behavioral factors. Increased blood pressure variability may indicate impaired cardiovascular regulation and is associated with increased mortality and disease incidence.
JOURNAL OF HYPERTENSION
(2023)
Article
Nutrition & Dietetics
Daniela Lucini, Eleonora Pagani, Francesco Capria, Michele Galiano, Marcello Marchese, Stefano Cribellati, Gianfranco Parati
Summary: Workplace health promotion programs and services provided by insurers are important in fostering health and preventing chronic diseases. These programs should be tailored to meet the specific needs and characteristics of companies and employees. Age is an important factor to consider, as younger workers have different lifestyle patterns and stress levels compared to older workers.
Article
Environmental Sciences
Alessio Pellegrino, Samuele Bacci, Francesco Guido, Andrea Zoppi, Loira Toncelli, Laura Stefani, Maria Boddi, Alessandra Modesti, Pietro Amedeo Modesti
Summary: This study investigated the relationship between regional distribution of childhood obesity in Italy, family environment, and adolescent's dietary habits, physical activity, nutritional knowledge, and obesity. The findings showed that parental BMI had a direct influence on adolescent's BMI, independent of parental nutritional knowledge and habits. It was also found that parents transmitted eating and physical activity habits to their children. The study concluded that family-based approaches should be considered in the prevention of childhood obesity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Respiratory System
Filippo Cattazzo, Martino F. Pengo, Alice Giontella, Davide Soranna, Grzegorz Bilo, Antonella Zambon, Janaka Karalliedde, Luigi Gnudi, Miguel angel Martinez-Garcia, Pietro Minuz, Carolina Lombardi, Gianfranco Parati, Cristiano Fava
Summary: This meta-analysis aimed to investigate whether Continuous Positive Airway Pressure (CPAP) could improve glucose and lipid metabolism in patients with obstructive sleep apnoea (OSA). The findings revealed that CPAP modestly improved insulin sensitivity and total cholesterol levels, but with low effect size. The study suggests that CPAP does not substantially improve metabolic dysregulation in an unselected OSA population, but may have a higher effect in specific subgroups of patients.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Medicine, General & Internal
Paolo Salvi, Andrea Grillo, Fausto Brunacci, Francesca Severi, Luca Montaguti, Sylvie Gautier, Lucia Salvi, Enzo Pretolani, Gianfranco Parati, Athanase Benetos
Summary: The study aimed to evaluate the microcirculatory adaptive mechanisms at different altitudes and found that high altitude causes important and significant microcirculatory adaptations, which should be considered when planning training and physical activity at altitude.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniela Pedicino, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rocco Vergallo, Massimo Volpe
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Damiano Magri, Giovanna Gallo, Massimo Piepoli, Elisabetta Salvioni, Massimo Mapelli, Carlo Vignati, Emiliano Fiori, Melwyn Luis Muthukkattil, Ugo Corra, Marco Metra, Stefania Paolillo, Antonello Maruotti, Pierfrancesco Alaimo Di Loro, Michele Senni, Rocco Lagioia, Domenico Scrutinio, Michele Emdin, Claudio Passino, Gianfranco Parati, Gianfranco Sinagra, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Andrea Di Lenarda, Piergiuseppe Agostoni, Pasquale Perrone Filardi
Summary: This study found an association between chronotropic incompetence, exercise capacity, and cardiovascular death risk in patients with HFmrEF. Larger prospective studies are needed to determine the potential use of chronotropic incompetence in HFmrEF management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carlo Vignati, Mauro Contini, Elisabetta Salvioni, Carolina Lombardi, Sergio Caravita, Grzegorz Bilo, Erik R. Swenson, Gianfranco Parati, Piergiuseppe Agostoni
Summary: Patients with chronic heart failure may safely spend time at altitudes <3500 m, but may experience decreased exercise capacity proportional to the severity of heart failure and altitude. Specialized 'hypoxic-tailored treatment' is necessary to avoid pharmacological interference with altitude adaptation mechanisms.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Simonetta Genovesi, Elena Tassistro, Giulia Lieti, Ilenia Patti, Marco Giussani, Laura Antolini, Antonina Orlando, Paolo Salvi, Gianfranco Parati
Summary: This study investigated the mechanical properties of different arteries and their influencing factors in children and adolescents at increased cardiovascular risk. The results showed that diastolic blood pressure and heart rate are associated with the distensibility of the upper limb vascular district, while systolic and diastolic blood pressure values and central obesity are associated with aortic stiffness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Gennaro Tartarisco, Giovanni Cicceri, Roberta Bruschetta, Alessandro Tonacci, Simona Campisi, Salvatore Vitabile, Antonio Cerasa, Salvatore Distefano, Alessio Pellegrino, Pietro Amedeo Modesti, Giovanni Pioggia
Summary: This paper presents a Medical Cyber-Physical System (MCPS) for the automatic classification of heart valve diseases onsite. The proposed system combines different neural network models and has been validated on a new dataset, demonstrating high accuracy and feasibility.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)