Article
Medicine, Research & Experimental
Hossein Rezazadeh, Mohammad Reza Sharifi, Mohmmadreza Sharifi, Nepton Soltani
Summary: The study found that GABA or insulin therapy can effectively reduce blood glucose levels in type 2 diabetic patients and their offspring, while also increasing their insulin sensitivity. Additionally, GABA therapy is able to improve insulin resistance in patients by increasing the expression of GLUT4, IRS1, and Akt genes, indirectly reducing insulin resistance in their offspring.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Physiology
Ping Luo, Yaoquan Cao, Pengzhou Li, Guohui Wang, Zhi Song, Weizheng Li, Zhihong Su, Hui Zhou, Xianhao Yi, Zhibing Fu, Xulong Sun, Haibo Tang, Beibei Cui, Qianqian Yu, Liyong Zhu, Shaihong Zhu
Summary: Both LRYGB and LSG effectively induced remission of insulin resistance in patients with T2DM and a BMI of 27.5-32.5 kg/m(2). LRYGB group had a higher percentage of patients achieving the target composite endpoint compared to LSG group.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Elske Gravesteijn, Ronald P. Mensink, Jogchum Plat
Summary: This study investigated the effects of long-term almond consumption on glucose metabolism in males and females with overweight/obesity and prediabetes. The findings showed that almond consumption significantly decreased insulin sensitivity, increased postprandial glucose concentrations and fasting insulin concentrations, and also led to weight gain and increased waist circumference. These effects on glucose metabolism could not be fully explained by changes in body weight.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Ariane Delai, Patricia M. Gomes, Maria Cristina Foss-Freitas, Jorge Elias Jr, Sonir R. Antonini, Margaret Castro, Ayrton C. Moreira, Livia M. Mermejo
Summary: The study aimed to evaluate insulin sensitivity in patients with nonclassical congenital adrenal hyperplasia (NC-CAH) using the hyperinsulinemic-euglycemic clamp method. The results showed that insulin resistance was present in NC-CAH patients and was associated with prolonged use and long-acting glucocorticoid treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Faidon Magkos, Michelle H. Lee, Maybritte Lim, Alex R. Cook, Vanna Chhay, Tze Ping Loh, Kee Seng Chia, Sonia Baig, Ian Yi Han Ang, Joanne Y. Y. Tay, Chin Meng Khoo, Jeffrey B. Halter, Sue-Anne Toh
Summary: The decrease in beta-cell function and the presence of insulin resistance are the main contributors to the dysregulation of glucose homeostasis in Asians with prediabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cardiac & Cardiovascular Systems
Anders Hostrup Larsen, Henrik Wiggers, Ole Lindgard Dollerup, Nichlas Riise Jespersen, Nils Henrik Hansson, Jorgen Frokiaer, Kim Brosen, Helene Norrelund, Hans Erik Botker, Niels Moller, Niels Jessen
Summary: In HF patients, metformin treatment can lower glycated hemoglobin levels, reduce body weight, and increase fasting glucagon levels, but does not improve whole-body insulin sensitivity, endogenous glucose production, peripheral glucose disposal or oxidation.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Nutrition & Dietetics
Jamie van Son, Mireille J. Serlie, Marcus Stahlman, Fredrik Backhed, Max Nieuwdorp, Judith Aron-Wisnewsky
Summary: In overweight and obese subjects without T2D, plasma ImP concentrations were positively correlated with diastolic blood pressure but not with insulin-sensitivity.
Article
Endocrinology & Metabolism
Wenyi Wang, Ko Willems van Dijk, Carolien A. Wijsman, Maarten P. Rozing, Simon P. Mooijaart, Marian Beekman, P. Eline Slagboom, J. Wouter Jukema, Raymond Noordam, Diana van Heemst
Summary: Investigating the effects of hyperinsulinemia on metabolomic measures under euglycemic conditions revealed distinct changes in metabolites with low-dose and high-dose insulin infusion. Notably, shifts in lipoprotein particle sizes, concentrations of glycerol, 3-hydroxybutyrate, and branched-chain amino acids were among the key findings, suggesting differential insulin sensitivity and potential implications for cardiovascular disease risk.
Article
Biochemistry & Molecular Biology
Heraldo Mendes Garmes, Alejandro Rosell Castillo, Sarah Monte Alegre, Aglecio Luiz de Souza, Yeelen Ballesteros Atala, Denise Engelbrecht Zantut-Wittmann
Summary: The pattern of insulin sensitivity in patients with GH deficiency (GHD) is contradictory, and this study assessed the insulin sensitivity and body composition in adults with hypopituitarism. It was found that patients with childhood-onset GHD showed higher insulin sensitivity compared to controls, while patients with adulthood-onset GHD had similar insulin sensitivity as the control group.
Article
Nutrition & Dietetics
William V. Trim, Jean -Philippe Walhin, Francoise Koumanov, James E. Turner, Natalie F. Shur, Elizabeth J. Simpson, Ian A. Macdonald, Paul L. Greenhaff, Dylan Thompson
Summary: Long-term physical inactivity increases glycemia despite energy balance, but does not affect glycemic variability.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Chiara M. A. Cefalo, Elena Succurro, Alessia Riccio, Maria Adelaide Marini, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study aimed to investigate the association between LDL levels and insulin sensitivity and secretion in a cohort of adult first-degree relatives of patients with type 2 diabetes. The results showed that LDL-cholesterol levels were not independently associated with insulin-stimulated glucose disposal but exhibited a positive association with insulin secretion. The study suggested that LDL cholesterol is a positive modulator of insulin secretion and the impaired insulin secretion due to the cholesterol-lowering effect of statins might explain the deterioration in glycemic control observed during treatment with statins.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Yukie Natsume, Takako Yamada, Tetsuo Iida, Nobuaki Ozaki, Yang Gou, Yoshiharu Oshida, Teruhiko Koike
Summary: The study investigated the effects of D-allulose on a high-sucrose diet-induced insulin resistance model. The results showed that D-allulose improved systemic insulin resistance and reversed both systemic and muscular insulin resistance. This study is the first to demonstrate that D-allulose enhances systemic and muscle insulin sensitivity in conscious rats.
Article
Endocrinology & Metabolism
Marta Rydzewska, Agnieszka Nikolajuk, Natalia Matulewicz, Magdalena Stefanowicz, Monika Karczewska-Kupczewska
Summary: The study found that serum SFRP5 concentration is associated with insulin sensitivity in a young healthy population, mainly dependent on adiponectin. Insulin can decrease SFRP5 levels, while free fatty acids abolish this effect. Insulin appears to be a more important factor in regulating circulating SFRP5 levels compared to free fatty acids.
Article
Surgery
Pim W. Gilijamse, Ahmet Demirkiran, Bart A. van Wagensveld, Mariette T. Ackermans, Johannes A. Romijn, Max Nieuwdorp, Kasper W. ter Horst, Mireille J. Serlie
Summary: The study found that postprandial GLP-1 concentrations are positively correlated with insulin sensitivity in subjects with class II/III obesity without diabetes, both before and 1 year after RYGB. Participants one year after RYGB surgery experienced increased GLP-1, insulin, and glucose levels after a meal, with a persistent positive association between postprandial GLP-1 response and peripheral insulin sensitivity. Increased GLP-1 signaling in post-bariatric patients may contribute to improvements in insulin sensitivity and metabolic health.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Endocrinology & Metabolism
Camille E. Powe, Joseph J. Locascio, Larraine Huston Gordesky, Jose C. Florez, Patrick M. Catalano
Summary: The study found that Stumvoll and AUC(ins)/AUC(glu) are valid OGTT-based measures of insulin secretory response during pregnancy, and can effectively reflect the changes in insulin secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Katie C. Coate, Guillaume Kraft, Masakazu Shiota, Marta S. Smith, Ben Farmer, Doss W. Neal, Phil Williams, Alan D. Cherrington, Mary Courtney Moore
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Endocrinology & Metabolism
Jason G. Anderson, Giorgio Ramadori, Rafael M. Ioris, Mirco Galie, Eric D. Berglund, Katie C. Coate, Teppei Fujikawa, Stefania Pucciarelli, Benedetta Moreschini, Augusto Amici, Cristina Andreani, Roberto Coppari
MOLECULAR METABOLISM
(2015)
Article
Endocrinology & Metabolism
Mary Courtney Moore, Marta S. Smith, Ben Farmer, Katie C. Coate, Guillaume Kraft, Masakazu Shiota, Phillip E. Williams, Alan D. Cherrington
Article
Endocrinology & Metabolism
Katie C. Coate, Guillaume Kraft, Mary Courtney Moore, Marta S. Smith, Christopher Ramnanan, Jose M. Irimia, Peter J. Roach, Ben Farmer, Doss W. Neal, Phil Williams, Alan D. Cherrington
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Editorial Material
Biochemistry & Molecular Biology
Katie C. Coate, Steven A. Kliewer, David J. Mangelsdorf
Article
Cell Biology
Bryn M. Owen, Xunshan Ding, Donald A. Morgan, Katie Colbert Coate, Angie L. Bookout, Kamal Rahmouni, Steven A. Kliewer, David J. Mangelsdorf
Article
Endocrinology & Metabolism
Katie C. Coate, Marta S. Smith, Masakazu Shiota, Jose M. Irimia, Peter J. Roach, Ben Farmer, Phillip E. Williams, Mary Courtney Moore
Article
Endocrinology & Metabolism
Katie C. Coate, Guillaume Kraft, Jose M. Irimia, Marta S. Smith, Ben Farmer, Doss W. Neal, Peter J. Roach, Masakazu Shiota, Alan D. Cherrington
Article
Radiology, Nuclear Medicine & Medical Imaging
Aliya Gifford, Joel Kullberg, Johan Berglund, Filip Malmberg, Katie C. Coate, Phillip E. Williams, Alan D. Cherrington, Malcolm J. Avison, E. Brian Welch
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2014)
Article
Endocrinology & Metabolism
Visumnathan Saraswathi, Christopher J. Ramnanan, Anson W. Wills, Cyrus V. Desouza, Amy A. Eller, Ganesan Murali, Ramesh Ramalingam, Ginger L. Milne, Katie C. Coate, Dale S. Edgerton
METABOLISM-CLINICAL AND EXPERIMENTAL
(2013)
Article
Endocrinology & Metabolism
Mary Courtney Moore, Katie C. Coate, Melanie Scott, Guillaume Kraft, James E. Vath, Thomas E. Hughes, Ben Farmer, Alan D. Cherrington
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Cell Biology
Katie C. Coate, Jeeyeon Cha, Shristi Shrestha, Wenliang Wang, Luciana Mateus Goncalves, Joana Almaca, Meghan E. Kapp, Maria Fasolino, Ashleigh Morgan, Chunhua Dai, Diane C. Saunders, Rita Bottino, Radhika Aramandla, Regina Jenkins, Roland Stein, Klaus H. Kaestner, Golnaz Vahedi, Marcela Brissova, Alvin C. Powers
Article
Endocrinology & Metabolism
Guillaume Kraft, Katie C. Coate, Jason J. Winnick, Dominique Dardevet, E. Patrick Donahue, Alan D. Cherrington, Phillip E. Williams, Mary Courtney Moore
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2017)
Article
Medicine, Research & Experimental
Dale S. Edgerton, Guillaume Kraft, Marta Smith, Ben Farmer, Phillip E. Williams, Katie C. Coate, Richard L. Printz, Richard M. O'Brien, Alan D. Cherrington
Article
Cell Biology
Katie C. Coate, Genaro Hernandez, Curtis A. Thorne, Shengyi Sun, Thao D. V. Le, Kevin Vale, Steven A. Kliewer, David J. Mangelsdorf