期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 111, 期 6, 页码 1877-1887出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00313.2011
关键词
acupuncture; brain protection; infarction; neurological deficits
资金
- National Natural Science Foundation of China [30672721]
- National Basic Research Program of China [12CB518502]
- Science and Technology Commission of Shanghai Municipality [09DZ1974303, 10DZ1975800]
- National Institutes of Health [AT-004422, HD-034852]
Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y. Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: dependence on stimulation intensity and frequency. J Appl Physiol 111: 1877-1887, 2011. First published August 11, 2011; doi:10.1152/japplphysiol.00313.2011.-Stroke causes ischemic brain injury and is a leading cause of neurological disability and death. There is, however, no promising therapy to protect the brain from ischemic stress to date. Here we show an exciting finding that optimal electroacupuncture (EA) effectively protects the brain from ischemic injury. The experiments were performed on rats subjected to middle cerebral artery occlusion (MCAO) with continuous monitoring of cerebral blood flow. EA was delivered to acupoints of Shuigou (Du 26) and Baihui (Du 20) with different intensities and frequencies to optimize the stimulation parameters. The results showed that 1) EA at 1.0-1.2 mA and 5-20 Hz remarkably reduced ischemic infarction, neurological deficit, and death rate; 2) the EA treatment increased the blood flow by >100%, which appeared immediately after the initiation of EA and disappeared after the cessation of EA; 3) the EA treatment promoted the recovery of the blood flow after MCAO; 4) nonoptimal parameters of EA (e. g., <0.6 mA or >40 Hz) could not improve the blood flow or reduce ischemic injury; and 5) the same EA treatment with optimal parameters could not increase the blood flow in naive brains. These novel observations suggest that appropriate EA treatment protects the brain from cerebral ischemia by increasing blood flow to the ischemic brain region via a rapid regulation. Our findings have far-reaching impacts on the prevention and treatment of ischemic encephalopathy, and the optimized EA parameters may potentially be a useful clue for the clinical application of EA.
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