Article
Biochemistry & Molecular Biology
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Linda Grimaud, Coralyne Proux, Laurent Loufrani, Francoise Lenfant, Coralie Fontaine, Jean-Francois Arnal, Daniel Henrion
Summary: Flow-mediated dilation (FMD) of resistance arteries is essential for tissue perfusion but decreases with ageing. Membrane ER alpha plays an important role in FMD and its early defect recapitulates phenotypically and functionally ageing in these resistance arteries. Oxidative stress is a key event in the decline of FMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela Cl Garcia, Lea Rethore, Rana Zahreddine, Morgane Davezac, Chanaelle Febrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Francoise Lenfant, Coralie Fontaine, Jean-Francois Arnal, Daniel Henrion
Summary: The study found that endothelial membrane ER alpha promotes NO bioavailability through inhibition of oxidative stress, and thereby participates in the regulation of flow-mediated dilation (FMD).
Article
Engineering, Biomedical
Bchara Sidnawi, Zhen Chen, Chandra Sehgal, Sridhar Santhanam, Qianhong Wu
Summary: The study introduces a physics-based mathematical model to describe mechanotransduction during flow-mediated dilation of the brachial artery. The model successfully predicts the artery's dilation and could potentially aid in detecting early stages of cardiovascular diseases.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Cell Biology
Wei-Li Wang, Li-Jing Chen, Shu-Yi Wei, Yu-Tsung Shih, Yi-Hsuan Huang, Pei-Lin Lee, Chih- Lee, Mei-Cun Wang, Ding-Yu Lee, Shu Chien, Jeng-Jiann Chiu
Summary: MicroRNAs and bone morphogenetic protein receptor-specific Smads are responsive to mechanical stimuli and play crucial roles in modulating endothelial cell (EC) functions in response to blood flow. The interaction between miR-487a and Smad5 is involved in regulating EC proliferation under different flow patterns. MiR-487a expression is upregulated by disturbed flow with oscillatory shear stress and promotes EC proliferation by inhibiting its direct targets CBP and p53.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dermatology
Nazli Caf, Tugba ozkok Akbulut, Mehmet Mustafa Can, Mustafa Sari, Ayse Nilhan Atsu, Zafer Turkoglu
Summary: This study aimed to assess endothelial dysfunction in rosacea patients using the flow-mediated dilatation (FMD) method. The results showed a significant decrease in FMD values in rosacea patients compared to healthy controls. Rosacea patients also exhibited a higher prevalence of metabolic syndrome, abnormal blood pressure, and altered cell indicators. Therefore, rosacea is not restricted to skin involvement but may have systemic implications, increasing the risk of atherosclerosis.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Engineering, Biomedical
Bchara Sidnawi, Sridhar Santhanam, Chandra Sehgal, Qianhong Wu
Summary: In this study, mechanotransduction is investigated using a viscoelastic model to describe the arterial diameter response during a brachial artery flow mediated dilation (BAFMD) test. The results show that the mechanical behavior of the arterial wall is predominantly elastic.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Kuin T. Pang, Mean Ghim, Mehwish Arshad, Xiaomeng Wang, Peter D. Weinberg
Summary: Research has shown that shear stress imposed on the arterial wall by blood flow affects endothelial cell morphology and function. Different shear stress characteristics have varying effects on endothelial cell phenotype, with limitations in current research methods. A potential method involves culturing endothelial cells on an orbital shaker and using specialized coating and treatment techniques to restrict cells to specific shear stress characteristics.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Cardiac & Cardiovascular Systems
Ivana Jukic, Zrinka Mihaljevic, Anita Matic, Martina Mihalj, Natasa Kozina, Kristina Selthofer-Relatic, Dubravka Mihaljevic, Akos Koller, Ivana Tartaro Bujak, Ines Drenjancevic
Summary: The study reveals that blocking AT(1)R decreases dilation of middle cerebral arteries in rats under physiological conditions, increases oxidative stress levels, and reduces antioxidant enzyme activity.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mehwish Arshad, Shuyu Cheng, Maarten van Reeuwijk, Spencer J. Sherwin, Peter D. Weinberg
Summary: Simple alterations were made in the swirling well method to alleviate the issues associated with shear flow. Numerical simulation was used to obtain flows, and various modifications were tested to achieve similar flow conditions and separate different shear metrics. These improvements overcome the limitations of the baseline model.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Sport Sciences
Francisco Javier Soto-Rodriguez, Eva Isidoro Cabanas, Jose Manuel Perez-Marmol
Summary: Prolonged sitting can affect endothelial function, and strategies that interrupt sitting have shown significant improvements in shear rate, flow-mediated dilation, and blood flow, thus playing a crucial role in preventing endothelial dysfunction.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Multidisciplinary Sciences
Y. Y. Ban, T. W. Lei
Summary: Quantification of rill erosion processes is important for both model parameter estimations and model performance verification. This study presents a mathematical method to determine the physics-based rill erosion process using the feedback relationship of transport capacity and detachment capacity. Experimental data sets were used to determine the transport and detachment capacities under different slope gradients, and these capacities were then used to determine the sediment delivery processes under different hydraulic regimes. The results showed good agreement between the mathematical model and experimental data.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Xi Wu, Silvia Moimas, Raoul Hopf, Costanza Giampietro, Andreas Kourouklis, Volkmar Falk, Edoardo Mazza, Aldo Ferrari
Summary: The study introduces a novel surface micro-topography design method through endothelialization strategies, which effectively supports the survival and growth of endothelial cells under complex hemodynamic conditions. The new structuring method uses water droplet condensation and evaporation to introduce microscale wells array, greatly outperforming traditional flat surfaces.
Article
Cardiac & Cardiovascular Systems
Gilles Soulat, Michael B. Scott, Bradley D. Allen, Ryan Avery, Robert O. Bonow, S. Chris Malaisrie, Patrick McCarthy, Paul W. M. Fedak, Alex J. Barker, Michael Markl
Summary: This study evaluated the predictive role of wall shear stress (WSS) in the growth of the ascending aorta (AAo). It found that higher rates of AAo dilation were associated with larger areas of elevated WSS in patients with bicuspid aortic valve (BAV), suggesting that measuring WSS can help identify BAV patients who require closer follow-up.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Biology
Yash T. Katakia, Satyadevan Kanduri, Ritobrata Bhattacharyya, Srinandini Ramanathan, Ishan Nigam, Bhanu Vardhan Reddy Kuncharam, Syamantak Majumder
Summary: The angle of blood vessel bifurcation is an important determinant of atherosclerosis and endothelial dysfunction, as it can alter hemodynamics and impact endothelial structure and function.
COMMUNICATIONS BIOLOGY
(2022)