Review
Pharmacology & Pharmacy
Xiaoling Li, Benedikt Preckel, Jeroen Hermanides, Markus W. Hollmann, Coert J. Zuurbier, Nina C. Weber
Summary: SGLT-2is improve cardiovascular outcomes by directly affecting endothelial function through various pathways. These effects include reducing oxidative stress and inflammatory reactions, restoring vasodilation, and regulating angiogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Xiaoling Li, Gregor Romer, Raphaela P. Kerindongo, Jeroen Hermanides, Martin Albrecht, Markus W. Hollmann, Coert J. Zuurbier, Benedikt Preckel, Nina C. Weber
Summary: The study suggests that SGLT-2i can improve endothelial cell permeability under mechanical stretch through anti-oxidative effects, potentially mediated by scavenging of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biology
Xiaowei Zheng, Sampath Narayanan, Cheng Xu, Sofie Eliasson Angelstig, Jacob Grunler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A. Forsberg, Ao Zhang, Kerstin Brismar, Tomas A. Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Summary: Excessive production of mitochondrial reactive oxygen species (ROS) in diabetes complications is mainly caused by impaired responses to hypoxia due to the inhibition of hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Restoring HIF-1 function can attenuate ROS overproduction, protect cells against apoptosis and renal injury in diabetes. These findings suggest that targeting HIF-1 repression could be a potential therapeutic strategy for diabetic complications.
Article
Cell Biology
Yizeng Li, Xiaohan Zhou, Sean X. Sun
Summary: Cells without a stiff cell wall, such as mammalian cells, must actively regulate their volume, with water flow determining cell volume variation. Proton and bicarbonate play significant roles in cell volume regulation, and cells need redundant mechanisms to maintain homeostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Peripheral Vascular Disease
Matthew J. Rossman, Rachel A. Gioscia-Ryan, Jessica R. Santos-Parker, Brian P. Ziemba, Kara L. Lubieniecki, Lawrence C. Johnson, Natalie E. Poliektov, Nina Z. Bispham, Kayla A. Woodward, Erzsebet E. Nagy, Nathan S. Bryan, Julie A. Reisz, Angelo D'Alessandro, Michel Chonchol, Amy L. Sindler, Douglas R. Seals
Summary: Inorganic nitrite supplementation improves endothelial function in older adults by increasing NO, decreasing mitochondrial reactive oxygen species/oxidative stress, and increasing mitochondrial stress resistance.
Article
Biochemistry & Molecular Biology
Michael O. Isei, Don Stevens, Collins Kamunde
Summary: The research found that heart mitochondria show different responses to copper and thermal stress, and the consumption capacity of H2O2 is influenced by the type of substrate, temperature, and copper. The NADPH-dependent peroxidase system is the centerpiece of ROS scavenging in heart mitochondria, and copper has the ability to inhibit specific mitochondrial ROS scavenging pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Hulya Gizem Oezkan, Andriy Mokhir
Summary: Hybrid drugs containing ferrocene and phenol residues exhibit potent anticancer activity, but their mode of action, specificity, and metabolism need further investigation. In this study, we synthesized prodrugs of aminoferrocene-phenol hybrids and confirmed their activation in cancer cells while remaining inactive in normal cells. The anticancer activity of the prodrug relies on the generation of reactive oxygen species in cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Juliana C. Fantinelli, Liceth N. Cuellar Alvarez, Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Paula L. Galeano Garcia, Guillermo R. Schinella, Susana M. Mosca
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Physiology
A. M. Yeves, J. I. Burgos, A. J. Medina, M. C. Villa-Abrille, I. L. Ennis
Article
Medicine, Research & Experimental
Hernan Gonzalo Villagarcia, Maria Cecilia Castro, Luisa Gonzalez Arbelaez, Guillermo Schinella, Maria Laura Massa, Eduardo Spinedi, Flavio Francini
Article
Plant Sciences
Tatiana C. Gavilanez Bunay, German A. Colareda, Maria Ines Ragone, Milena Bonilla, Benjamin A. Rojano, Guillermo R. Schinella, Alicia E. Consolini
Article
Pathology
Andres J. Medina, Oscar A. Pinilla, Enrique L. Portiansky, Claudia I. Caldiz, Irene L. Ennis
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2019)
Review
Chemistry, Medicinal
Flavio Francini, Guillermo R. Schinella, Jose-Luis Rios
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2019)
Review
Plant Sciences
Jose-Luis Rios, Isabel Andujar, Guillermo R. Schinella, Flavio Francini
Article
Pharmacology & Pharmacy
Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Juliana C. Fantinelli, Benjamin Rojano, Guillermo R. Schinella, Susana M. Mosca
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2020)
Article
Plant Sciences
Maria Cecilia Castro, Hernan Villagarcia, Ada Nazar, Luisa Gonzalez Arbelaez, Maria Laura Massa, Hector Del Zotto, Jose Luis Rios, Guillermo R. Schinella, Flavio Francini
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Gisela M. Gaddi, Romina A. Gisonno, Silvana A. Rosu, Lucrecia M. Curto, Eduardo D. Prieto, Guillermo R. Schinella, Gabriela S. Finarelli, M. Fernanda Cortez, Letizia Bauza, Esteban E. Elias, Nahuel A. Ramella, M. Alejandra Tricerri
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Romina A. Gisonno, Eduardo D. Prieto, Juan P. Gorgojo, Lucretia M. Curto, M. Eugenia Rodriguez, Silvana A. Rosu, Gisela M. Gaddi, Gabriela S. Finarelli, M. Fernanda Cortez, Guillermo R. Schinella, M. Alejandra Tricerri, Nahuel A. Ramella
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
Review
Biochemistry & Molecular Biology
Jose M. Prieto, Guillermo R. Schinella
Summary: This experimental review explores the relationship between Traditional Chinese Medicine (TCM) herbal drugs and lipid peroxidation in the context of topical inflammation. The study finds that certain herbal drugs with bitter and cold properties inhibit both lipid peroxidation and eicosanoids production, while sweet drugs specifically inhibit eicosanoids production. The therapeutic value of other drugs may be based on their actions on the Qi. The study suggests potential translation between the two medical systems and provides insights for the treatment of skin conditions.
Article
Medicine, General & Internal
Maria Cecilia Castro, Hernan Gonzalo Villagarcia, Carolina Lisi Roman, Barbara Maiztegui, Luis Emilio Flores, Guillermo Raul Schinella, Maria Laura Massa, Flavio Francini
Summary: A study on normal rats found that a fructose-rich diet (FRD) triggered a series of events, including increased circulating triglycerides, liver fat deposit and metabolic disturbances, liver and pancreatic inflammation, pancreatic beta-cell dysfunction, and peripheral insulin resistance. These findings are helpful in preventing the progression from prediabetes to Type 2 diabetes (T2D) triggered by unhealthy diets.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
C. Bergna, G. H. Marin, M. Maiz, H. Bruzzoni-Giovanelli, C. Ponzinibbio, G. Schinella, J. Errecalde, A. Rebollo
CEYLON MEDICAL JOURNAL
(2019)
Review
Biochemistry & Molecular Biology
Luisa F. Gonzalez Arbelaez, Alejandro Ciocci Pardo, Juliana C. Fantinelli, Guillermo R. Schinella, Susana M. Mosca, Jose-Luis Rios