Article
Immunology
Felicia M. Michael, Samir P. Patel, Adam Bachstetter, Alexander G. Rabchevsky
Summary: High-level spinal cord injury causes sympathetic dysfunction, autonomic dysreflexia, and chronic immune suppression involving splenic leukopenia. Treatment with gabapentin or TNF-α blockade mitigates the underlying dysfunction and immune dysfunction. This study aims to examine changes in proinflammatory and immunomodulatory cytokines to determine the reason.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Hui Peng, Juping Wang, Xuhong Song, Jiangni Huang, Haoming Hua, Fanlu Wang, Ziyun Xu, Jing Ma, Jie Gao, Jing Zhao, Anna Nong, Dongyang Huang, Bin Liang
Summary: PHLDA1 is involved in the regulation of TLR4 signaling pathway and functions as a negative regulator of LPS-induced proinflammatory cytokine production. It attenuates the production of proinflammatory cytokines by inhibiting the phosphorylation levels of key molecules in TLR4/MyD88-mediated MAPK and NF-kappa B signaling pathways, and by impairing the translocation and responsive element activities of NF-kappa B and AP1. PHLDA1 also represses LPS-induced proinflammatory cytokine production by binding to Tollip and restraining TLR4 signaling pathway. These findings suggest that PHLDA1 may serve as a potential therapeutic target for the treatment of endotoxemia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Genetics & Heredity
Siavash Bolourani, Max Brenner, Ping Wang
Summary: Pulmonary fibrosis is a chronic condition characterized by progressive deposition of connective tissue, leading to a decline in lung elasticity and function. Common causes include inhalation of foreign particles, infections, autoimmune diseases, and idiopathic pulmonary fibrosis. Current therapeutics only modestly slow disease progression. This review focuses on the interplay of DAMP molecules, TLR4, and inflammatory cytokines in the pathogenesis of pulmonary fibrosis and explores potential avenues for developing effective therapeutics.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Cell Biology
Chien-Kuo Han, Wei-Fang Lee, Chin-Jung Hsu, Yuan-Li Huang, Chih-Yang Lin, Chun-Hao Tsai, Chien-Chung Huang, Yi-Chin Fong, Min-Huan Wu, Ju-Fang Liu, Chih-Hsin Tang
Summary: DPP4 plays a crucial role in rheumatoid arthritis, with its expression levels closely associated with the development of inflammatory diseases. Increasing DPP4 expression can reduce levels of inflammatory cytokines.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kazuya Nishimura, Tatsuhide Tanaka, Shoko Takemura, Kouko Tatsumi, Akio Wanaka
Summary: The study highlights the role of SNX25 in regulating proinflammatory cytokine expression in macrophages through inhibition of the NF-kappa B signal.
Article
Immunology
Xiaogao Jin, Yanlin Wang
Summary: The study revealed that globular adiponectin induced the production of inflammatory cytokines in Raw 264.7 cells, while full-length adiponectin promoted macrophage migration.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sadaf Jamal Gilani, May Nasser Bin-Jumah, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Muhammad Afzal, Sami Alzarea, Nadeem Sayyed, Imran Kazmi
Summary: The study aimed to confirm the anti-diabetic activity and mechanism of rosinidin in a laboratory setting. Treatment with rosinidin showed positive effects on diabetes, including lower blood glucose levels, increased serum insulin levels, and improved pancreatic function in rats induced with streptozotocin.
Article
Food Science & Technology
Min-Kyeong Lee, Hyeon Hak Jeong, Myeong-Jin Kim, Heeyeon Ryu, Jiwon Baek, Bonggi Lee
Summary: Glucocorticoid excess is a critical factor contributing to muscle atrophy, while applying mechanical load and providing adequate nutrients can prevent and improve muscle wasting.
Article
Immunology
Jenna L. Riis, Hedyeh Ahmadi, Katrina R. Hamilton, Tracey Hand, Douglas A. Granger
Summary: The study found that IL-1 beta, IL-6, and IL-8 in saliva were more robust to changes in sample collection and cold chain management procedures than TNF-alpha, and all cytokines were positively associated with other oral health-related measures. Based on these findings, analyte-specific guidance for measuring and interpreting salivary cytokine concentrations is recommended.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Qiaoling Wei, Xiaonan Zhuang, Jiawen Fan, Rui Jiang, Qing Chang, Gezhi Xu, Zhiqiang Yu
Summary: The concentrations of proinflammatory cytokines and angiogenesis-related growth factors were found to be elevated in the vitreous humor of highly myopic patients, indicating an increased inflammatory status and higher levels of angiogenic factors in these eyes.
Article
Dermatology
Yun-Zhu Yao, Zhi-Kai Liao, Shan Jiang, Bing-Qi Dong, Long-Fei Luo, Fang Miao, Tie -Chi Lei
Summary: This study investigated the effects of psoriasis-related proinflammatory cytokines on the proliferation and melanogenesis of melanocytes. The increased expression of IL8 and BD3 was associated with an increased number of melanocytes and reduced melanin content. IL8-CXCR2 activation promoted melanocyte proliferation, while BD3 upregulation inhibited melanin synthesis, suggesting that active psoriasis tends to prefer hypopigmentation despite chronic inflammation.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Rheumatology
Takahisa Gono, Yuka Okazaki, Masataka Kuwana
Summary: An antiviral proinflammatory network orchestrated primarily by activated monocytes/macrophages might be responsible for cytokine storm in patients with anti-MDA5-associated interstitial lung disease.
Article
Medicine, General & Internal
Elzbieta Malujlo-Balcerska, Tadeusz Pietras
Summary: This study evaluated the expression levels of certain molecules in patients with depressive disorders and controls. The results showed decreased expression of DIO2 and increased expression of IL1B, IL6, and TNFA in patients. Protein concentrations also showed corresponding changes. The AUC of IL-1 beta, IL-6, DIO1, and DIO3 proteins was >0.7, suggesting their potential as biomarkers for distinguishing patients with depressive disorders. Further studies are recommended to understand the exact role of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Tatsuro Inoue, Junko Ueshima, Fumiya Kawase, Haruko Kobayashi, Ayano Nagano, Kenta Murotani, Yoko Saino, Keisuke Maeda
Summary: Interventions for stroke-related sarcopenia are needed, but the target population is unclear. This systematic review identified prevalence trajectories and diagnostic criteria for sarcopenia in patients with stroke. Most studies included Asian patients and used the Asian Working Group for Sarcopenia criteria. Prevalence of sarcopenia increased by approximately 15% from pre-stroke to 10 days and by approximately 20% from 10 days to 1 month after stroke. Healthcare providers should be aware of the increased prevalence of sarcopenia during the acute phase in stroke patients.
Article
Hematology
Weihua Guan, Jing Cao, Brian T. Steffen, Wendy S. Post, James H. Stein, Mathew C. Tattersall, Joel D. Kaufman, Joseph P. McConnell, Daniel M. Hoefner, Russell Warnick, Michael Y. Tsai
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2015)
Article
Endocrinology & Metabolism
Brian T. Steffen, Lyn M. Steffen, Xia Zhou, Pamela Ouyang, Natalie L. Weir, Michael Y. Tsai
Article
Surgery
Nketi I. Forbang, Michael H. Criqui, Matthew A. Allison, Joachim H. Ix, Brian T. Steffen, Mary Cushman, Michael Y. Tsai
JOURNAL OF VASCULAR SURGERY
(2016)
Article
Multidisciplinary Sciences
Cassandra S. Diep, Rozenn N. Lemaitre, Tzu-An Chen, Tom Baranowski, Pamela L. Lutsey, Ani W. Manichaikul, Stephen S. Rich, David E. St-Jules, Brian T. Steffen, Michael Y. Tsai, David S. Siscovick, Alexis C. Frazier-Wood
Article
Cardiac & Cardiovascular Systems
Michael Y. Tsai, Jing Cao, Brian T. Steffen, Natalie L. Weir, Stephen S. Rich, Shuang Liang, Weihua Guan
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2016)
Article
Medicine, General & Internal
Liana C. Del Gobbo, Fumiaki Imamura, Stella Aslibekyan, Matti Marklund, Jyrki K. Virtanen, Maria Wennberg, Mohammad Y. Yakoob, Stephanie E. Chiuve, Luicito dela Cruz, Alexis C. Frazier-Wood, Amanda M. Fretts, Eliseo Guallar, Chisa Matsumoto, Kiesha Prem, Tosh Tanaka, Jason H. Y. Wu, Xia Zhou, Catherine Helmer, Erik Ingelsson, Jian-Min Yuan, Pascale Barberger-Gateau, Hannia Campos, Paulo H. M. Chaves, Luc Djousse, Graham G. Giles, Jose Gomez-Aracena, Allison M. Hodge, Frank B. Hu, Jan-Hakan Jansson, Ingegerd Johansson, Kay-Tee Khaw, Woon-Puay Koh, Rozenn N. Lemaitre, Lars Lind, Robert N. Luben, Eric B. Rimm, Ulf Riserus, Cecilia Samieri, Paul W. Franks, David S. Siscovick, Meir Stampfer, Lyn M. Steffen, Brian T. Steffen, Michael Y. Tsai, Rob M. van Dam, Sari Voutilainen, Walter C. Willett, Mark Woodward, Dariush Mozaffarian
JAMA INTERNAL MEDICINE
(2016)
Article
Pharmacology & Pharmacy
Brian T. Steffen, Weihua Guan, Alan T. Remaley, James H. Stein, Mathew C. Tattersall, Joel Kaufman, Michael Y. Tsai
JOURNAL OF CLINICAL LIPIDOLOGY
(2017)
Article
Pharmacology & Pharmacy
Brian T. Steffen, Suzette J. Bielinski, Paul A. Decker, Cecilia Berardi, Nicholas B. Larson, James S. Pankow, Erin D. Michos, Naomi Q. Hanson, David M. Herrington, Michael Y. Tsai
JOURNAL OF CLINICAL LIPIDOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Weihua Guan, Brian T. Steffen, Rozenn N. Lemaitre, Jason H. Y. Wu, Toshiko Tanaka, Ani Manichaikul, Millennia Foy, Stephen S. Rich, Lu Wang, Jennifer A. Nettleton, Weihong Tang, Xiangjun Gu, Stafania Bandinelli, Irena B. King, Barbara McKnight, Bruce M. Psaty, David Siscovick, Luc Djousse, Yii-Der Ida Chen, Luigi Ferrucci, Myriam Fornage, Dariush Mozafarrian, Michael Y. Tsai, Lyn M. Steffen
CIRCULATION-CARDIOVASCULAR GENETICS
(2014)
Article
Cardiac & Cardiovascular Systems
Parveen K. Garg, Weihua Guan, Amy B. Karger, Brian T. Steffen, Matthew Budoff, Michael Y. Tsai
Summary: The study found that elevated levels of lipoprotein (a) are associated with increased prevalence of mitral annular calcification and rapid progression of coronary artery calcification. However, there were no significant associations observed for coronary artery calcification or thoracic aortic calcification.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY
(2021)
Article
Biochemistry & Molecular Biology
Brian T. Steffen, James S. Pankow, Pamela L. Lutsey, Ryan T. Demmer, Jeffrey R. Misialek, Weihua Guan, Logan T. Cowan, Josef Coresh, Faye L. Norby, Weihong Tang
Summary: This study identified novel proteomic signatures and pathways associated with COVID-19 risk variants. Some of these proteins were associated with increased risk of incident hospitalized pneumonia and respiratory infections.
HUMAN MOLECULAR GENETICS
(2022)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Biochemistry & Molecular Biology
Kaifeng Yang, Zhiyu Kang, Weihua Guan, Sahar Lotfi-Emran, Zachary J. Mayer, Candace R. Guerrero, Brian T. Steffen, Michael A. Puskarich, Christopher J. Tignanelli, Elizabeth Lusczek, Sandra E. Safo
Summary: Metabolic disease is a significant risk factor for severe COVID-19 infection. This study aimed to characterize metabolic features that predict severe COVID-19 and define a novel baseline metabolomic signature. The results showed that metabolites related to lipid metabolism efficiently discriminated between mild and moderate/severe disease, and pathways related to amino acids were significantly enriched in severe disease. The mitogen-activated protein kinase kinase 5 (MAP2K5) regulator was differentially activated between groups, suggesting further investigation as a potential therapeutic pathway.
Article
Hematology
Brian T. Steffen, Weihua Guan, Alan T. Remaley, Pathmaja Paramsothy, Susan R. Heckbert, Robyn L. McClelland, Philip Greenland, Erin D. Michos, Michael Y. Tsai
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2015)