Article
Cardiac & Cardiovascular Systems
Ji-Jian Chow, Kevin M. W. Leong, Matthew J. J. Shun-Shin, Julian O. M. Ormerod, Michael Koa-Wing, David C. C. Lefroy, Phang Boon Lim, Nicholas W. F. Linton, Fu Siong Ng, Norman A. A. Qureshi, Zachary I. I. Whinnett, Nicholas S. S. Peters, Darrel P. P. Francis, Amanda M. M. Varnava, Prapa Kanagaratnam
Summary: Exercise-induced changes in ventricular conduction stability can distinguish patient groups with different ventricular arrhythmic pathophysiological conditions and identify patients susceptible to ventricular fibrillation. Patients with idiopathic ventricular fibrillation show increased activation heterogeneity following exercise, which requires further investigation as a measurable manifestation of underlying myocardial abnormalities.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alan Rozanski, Robert J. H. Miller, Heidi Gransar, Donghee Han, Piotr Slomka, Damini Dey, Sean W. Hayes, John D. Friedman, Louise Thomson, Daniel S. Berman
Summary: This study evaluated the relationship between stress-induced myocardial ischemia, revascularization, and all-cause mortality, and found that early myocardial revascularization was associated with a significant reduction in mortality among patients with inducible myocardial ischemia.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Physiology
Olesya G. Bernikova, Alena S. Tsvetkova, Mikhail A. Gonotkov, Alexey O. Ovechkin, Marina M. Demidova, Jan E. Azarov, Pyotr G. Platonov
Summary: This study found that in the early stage of acute ischemia, the occurrence of ventricular fibrillation is associated with the prolongation of QTc interval in the early ECG. In vitro cell experiments showed that IK(ATP) may play a role in the dynamics of cardiac repolarization during early ischemia.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biology
Eleni-Taxiarchia Mouchtouri, Thomas Konstantinou, Panagiotis Lekkas, Theofilos M. Kolettis
Summary: This article summarizes the current research progress on arrhythmias in acute coronary syndromes, emphasizing the mechanisms of early-phase arrhythmogenesis and highlighting potential areas for future research.
Article
Chemistry, Multidisciplinary
Yi-Chong Zhang, Min-Yao Wang, Chong-Yu Zhang, Yun-Fei Fan, Jun Wu, Shu-Hong Li, Anne Fu, Yu Sun, Terrance M. Yau, Ting-Hsuan Lu, Hsing-Wen Sung, Ren-Ke Li
Summary: Conductive polymers have been investigated as a potential solution for rewiring cardiac tissue to restore proper electrical signaling. In this study, a specific conductive polymer (PAMB-G) was fabricated and implanted onto the atrium of a rat model with atrial fibrillation (AF). The results showed that the PAMB-G group had improved AF recovery and higher conduction velocity compared to the control group, indicating the suitability of PAMB-G as a medium for restoring proper cardiac electrical signaling in AF hearts.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Kurt D. D. Marshall, Paula J. J. Klutho, Lihui Song, Rajika Roy, Maike Krenz, Christopher P. P. Baines
Summary: This study demonstrates that cardiac-specific overexpression of FASTKD1 in mice provides protection against myocardial infarction-induced cardiac rupture and modulates inflammatory, extracellular matrix, and antioxidant responses following myocardial infarction. These effects are associated with enhanced activation of the integrated stress response.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Alena S. Tsvetkova, Olesya G. Bernikova, Natalya J. Mikhaleva, Darya S. Khramova, Alexey O. Ovechkin, Marina M. Demidova, Pyotr G. Platonov, Jan E. Azarov
Summary: The study evaluated the electrophysiological and antiarrhythmic effects of melatonin in a porcine model of acute myocardial infarction, finding that melatonin has the potential to prevent early ventricular fibrillation caused by myocardial ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Cheng Li, Haicheng Wang, Mohan Li, Xiangjun Qiu, Qunshan Wang, Jian Sun, Mei Yang, Xiangfei Feng, Shu Meng, Pengpai Zhang, Bo Liu, Wei Li, Mu Chen, Yan Zhao, Rui Zhang, Binfeng Mo, Yuling Zhu, Baohong Zhou, Min Chen, Xia Liu, Yuelin Zhao, Mingzhen Shen, Jinkang Huang, Li Luo, Hong Wu, Yi-Gang Li
Summary: This study investigated the prevalence of atrial fibrillation (AF) in the Chinese community population in 2019 and the association with other arrhythmias and myocardial ischemia (MI) events. The results showed a higher prevalence of AF in the Chinese community population than previously reported, and AF patients, especially elderly males, had a higher risk of developing myocardial infarction. Stricter measures should be taken to control the common risk factors of AF and coronary heart disease, and more attention should be paid to identifying fatal arrhythmias in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Rodrigue Garcia, Eloi Marijon, Nicole Karam, Kumar Narayanan, Frederic Anselme, Olivier Cesari, Laure Champ-Rigot, Vladimir Manenti, Raphael Martins, Etienne Puymirat, Jean Ferrieres, Francois Schiele, Tabassome Simon, Nicolas Danchin
Summary: The incidence and mortality of ventricular fibrillation (VF) among patients hospitalized for acute myocardial infarction (AMI) have significantly decreased over the past 20 years. However, VF remains associated with a 10-fold increased relative risk of in-hospital mortality, without affecting post-discharge mortality. These findings highlight the need for interventions during hospitalization to further reduce mortality in VF patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tomoki Yamaguchi, Siamak Salavatian, Yuki Kuwabara, Abigail Hellman, Bradley K. Taylor, Kimberly Howard-Quijano, Aman Mahajan
Summary: This study suggests that local administration of RTX to thoracic DRGs can reduce ventricular arrhythmia in a porcine model of IR by inhibiting spinal afferent hyperactivity in the cardio-spinal sympathetic pathways.
Review
Biochemistry & Molecular Biology
Ramon Rodrigo, Jaime Gonzalez-Montero, Camilo G. Sotomayor
Summary: Reactive oxygen species (ROS) have dual effects on vascular function, with overproduction leading to harmful impacts on cardiovascular health. Increased ROS levels are implicated in conditions such as hypertension and cardiac diseases. While antioxidants may hold promise as a therapeutic approach, more research is needed to fully understand their role in combating cardiovascular diseases.
Article
Chemistry, Multidisciplinary
Zihui Geng, Lian Jin, Honglei Zhu, Jianfei Wang, Xiaomei Wu
Summary: Myocardial ischemia can lead to ventricular tachycardia and ventricular fibrillation. Simulation results indicate that susceptibility peaks at 12mM due to the effect of extracellular potassium on repolarization dispersion and effective refractory period. The study also analyzes reentrant patterns during non-transmural ischemia, providing insights for clinical ablation targets.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Sheldon Cheskes, P. Richard Verbeek, Ian R. R. Drennan, Shelley L. L. McLeod, Linda Turner, Ruxandra Pinto, Michael Feldman, Matthew Davis, Christian Vaillancourt, Laurie J. J. Morrison, Paul Dorian, Damon C. C. Scales
Summary: This study found that among patients with shock-refractory ventricular fibrillation, survival to hospital discharge occurred more frequently in those who received double sequential external defibrillation or vector-change defibrillation compared to standard defibrillation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Veterinary Sciences
Alexandra-Maria Stommel, Sandra Hoegler, Matthias Mueller, Ingrid Anna Maria Magnet, Petra Kodajova, Benjamin Ullram, Alexander Szinovatz, Felix Paul Panzer, Anna Engenhart-Seyrl, Julia Kaschmekat, Tamara Schuetz, Michael Holzer, Wolfgang Weihs
Summary: This study established a reproducible ECPR rat model of VFCA and evaluated the neurological function of rats surviving for 14 days. The results showed that both the 6 min and 8 min CA groups exhibited neuronal damage, but the survival rate was significantly decreased in the 8 min CA group.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Physiology
S. R. Roof, J. Boslett, D. Russell, C. del Rio, J. Alecusan, J. L. Zweier, M. T. Ziolo, R. Hamlin, P. J. Mohler, J. Curran
Article
Veterinary Sciences
Nakkawee Saengklub, Brad Youngblood, Carlos Del Rio, Suwanakiet Sawangkoon, Robert L. Hamlin, Anusak Kijtawornrat
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2016)
Article
Pharmacology & Pharmacy
D. N. Q. Cunha, C. L. del Rio, B. L. Youngblood, E. L. Ferris, G. E. Geist, Y. Ueyama, L. C. Franz, S. Mathur, R. L. Hamlin
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
(2018)
Article
Physiology
Steve R. Roof, Yukie Ueyama, Reza Mazhari, Robert L. Hamlin, J. Craig Hartman, Mark T. Ziolo, John E. Reardon, Carlos L. del Rio
FRONTIERS IN PHYSIOLOGY
(2017)
Review
Pharmacology & Pharmacy
Najah Abi-Gerges, Carrie McMahon, Hugo Vargas, Philip Sager, Ray Chui, Dale Stevens, Jonathan Davila, Johanna R. Schaub, Joseph C. Wu, Carlos del Rio, Chris Mathes, Paul E. Miller, Leigh Ann Burns-Naas, Andre Ghetti
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Beth Geist, Amanda LaRose, Yukie Ueyama, Bradley L. Youngblood, McKenna Palmieri, Carlos del Rio, Robert Hamlin
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Amanda LaRose, Gail E. Geist, Yukie Ueyama, McKenna Palmieri, Bradley L. Youngblood, Michael Mandic-Nowac, Daniel Fronk, Carlos del Rio, Robert Hamlin
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Carlos L. del Rio, Christopher Zambataro, Heather Bogie, A. J. Yucel, Brain Ferguson, Marcus P. Henze, Sarah Fernandes, Marc J. Evanchik
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Beth Geist, Bradley L. Youngblood, Yukie Ueyama, Amanda LaRose, Robert Hamlin, Marc J. Evanchik, Carlos del Rio
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Meeting Abstract
Pharmacology & Pharmacy
Yukie Ueyama, Carlos del Rio, McKenna Palmieri, Beth Geist, Robert Hamlin
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2019)
Article
Cardiac & Cardiovascular Systems
Adriaan A. Voors, Jean-Francois Tamby, John G. Cleland, Michael Koren, Leslie B. Forgosh, Dinesh Gupta, Lars H. Lund, Albert Camacho, Ravi Karra, Henk P. Swart, Pierpaolo Pellicori, Frank Wagner, Ray E. Hershberger, Narayana Prasad, Robert Anderson, Anu Anto, Kaylyn Bell, Jay M. Edelberg, Liang Fang, Marcus Henze, Cynthia Kelly, Gregory Kurio, Wanying Li, Kate Wells, Chun Yang, Sam L. Teichman, Carlos L. del Rio, Scott D. Solomon
EUROPEAN JOURNAL OF HEART FAILURE
(2020)
Article
Cardiac & Cardiovascular Systems
Weikang Ma, Marcus Henze, Robert L. Anderson, Henry Gong, Fiona L. Wong, Carlos L. Del Rio, Thomas Irving
Summary: Stretching of porcine myocardium increases calcium sensitivity and maximum calcium-activated force during diastole by recruiting reserve myosin heads, resulting in cross-bridge formation. The findings suggest that structural changes in the thick filament play a crucial role in the length-dependent activation and systolic consequences in ventricular muscle.
CIRCULATION RESEARCH
(2021)
Review
Multidisciplinary Sciences
Suman Nag, Sampath K. Gollapudi, Carlos L. del Rio, James A. Spudich, Robert McDowell
Summary: Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder characterized by left ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart. Mavacamten is a small molecule designed to regulate cardiac function by selectively inhibiting the enzymatic activity of myosin. It has been approved for the treatment of obstructive HCM under the commercial name Camzyos.
Article
Cardiac & Cardiovascular Systems
J. Craig Hartman, Carlos L. del Rio, John E. Reardon, Kefei Zhang, Hani N. Sabbah
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2018)
Article
Cardiac & Cardiovascular Systems
Neal L. Eigler, Carlos L. del Rio, Stefan Verheye, Patrick I. McConnell, Scott M. Lilly, Robert George, Robert L. Hamlin, Yukie Ueyama, Bradley L. Youngblood, Sergio Shkurovich, Gad Keren, William T. Abraham
STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM
(2017)