Article
Environmental Sciences
Xuejia He, Zhixian Pan, Lu Zhang, Didi Han
Summary: Exposure to hypoxia significantly affects the physiological and behavioral responses of the subtropical calanoid copepod Temora turbinata. The study demonstrates high sensitivity of T. turbinata to hypoxia, indicating that dissolved oxygen levels may be the main factor controlling the distribution of this species in tropical and subtropical coastal and estuarine waters.
MARINE POLLUTION BULLETIN
(2021)
Article
Neurosciences
Mei-Tsen Lin, Stephane Vinit, Kun-Ze Lee
Summary: The intermittent hypoxia associated with intermittent hypercapnia or sustained hypercapnia induced a greater ventilatory response than sustained hypercapnia during stimulus exposure. In subchronically injured animals, intermittent hypoxia associated with sustained hypercapnia or intermittent hypercapnic-hypoxia significantly enhanced tidal volume to a similar magnitude, but only intermittent hypercapnic-hypoxia and intermittent hypoxia were able to evoke long-term facilitation of tidal volume at the chronic injured stage. Mild intermittent hypercapnia did not further enhance the therapeutic effectiveness of intermittent hypoxia-induced respiratory recovery, but sustained hypercapnia associated with intermittent hypoxia may blunt ventilatory responses at the chronic injured stage.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Elisa J. Gonzalez-Rothi, Kun-Ze Lee
Summary: Acute intermittent hypoxia has shown promise as a treatment for respiratory insufficiency in individuals with spinal cord injury, through inducing neuroplasticity and functional recovery. Research in animal models has laid the foundation for the translation of this therapeutic strategy to clinical populations.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Lasse Christiansen, Bing Chen, Yuming Lei, M. A. Urbin, Michael S. A. Richardson, Martin Oudega, Milap Sandhu, W. Zev Rymer, Randy D. Trumbower, Gordon S. Mitchell, Monica A. Perez
Summary: The study investigated the effects of acute intermittent hypoxia on spinal synaptic plasticity induced by paired corticospinal-motoneuronal stimulation (PCMS). The results suggest that acute intermittent hypoxia can enhance the plasticity induced by PCMS, leading to improvements in spinal and muscular function.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Tommy Sutor, Kathryn Cavka, Alicia K. Vose, Joseph F. Welch, Paul Davenport, David D. Fuller, Gordon S. Mitchell, Emily J. Fox
Summary: The study found that a single session of acute intermittent hypoxia (AIH) can increase maximal inspiratory pressure generation in adults with chronic spinal cord injury (SCI), but does not affect other breathing functions. Further investigation into the potential therapeutic effects is warranted.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Physiology
Huaheng Mo, JingJing Zhao, Xiaofeng Wu, Wei Liu, Ke Hu
Summary: By combining intermittent electrical stimulation with acute intermittent hypoxia in CIH-pretreated rats can enhance the activity of the genioglossus discharge. This enhancement is significantly higher in CIH-pretreated rats than in normoxic rats, with increased duration and degree.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Biology
Liam R. Tigert, Patricia A. Wright, Andy J. Turko
Summary: Major ecological transitions, like the invasion of land by aquatic vertebrates, could be facilitated by positive feedback between habitat choice and phenotypic plasticity. The study used amphibious fish to test this hypothesis and found that aquatic hypoxia, emergence behavior, and respiratory plasticity create a positive feedback loop that causes fish to spend more time on land.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Pediatrics
Alicia K. Yee, Marisha Shetty, Leon S. Siriwardhana, Flora Y. Wong, Lisa M. Walter, Rosemary S. C. Horne
Summary: This study aimed to investigate whether apnoea and periodic breathing in preterm infants were associated with changes in autonomic control, exacerbating the consequences of respiratory disturbance. The results showed that periodic breathing can affect autonomic cardiovascular control.
Article
Neurosciences
Shani Folschweiller, Jonas-Frederic Sauer
Summary: Respiration-driven rhythms play a role in coordinating local activity in the mPFC, but the extent to which it engages the network in a state-dependent manner is unknown.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Waldir Heinrichs-Caldas, Vera Maria Fonseca de Almeida-Val
Summary: The response to hypoxia of Mesonauta festivus and Aequidens pallidus varies, with A. pallidus showing lower tolerance to hypoxia due to its natural normoxic environment, while M. festivus exhibits a higher decrease in metabolic rate and activation of anaerobic metabolism. The ability to tolerate hypoxia is closely related to the species' metabolic depression, indicating the importance of preserving natural dissolved oxygen levels in maintaining fish biodiversity.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Physiology
Bolival A. Mendonca-Junior, Marcos Fernandes, Daniel B. Zoccal
Summary: The study revealed that exposure to acute intermittent hypoxia in rats results in a prolonged increase in baseline minute ventilation and the occurrence of active expiration, potentially linked to the activation of serotonin receptors.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Physiology
Raphael R. Perim, Mohamed El-Chami, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: The study investigated the impact of background PaCO2 on hypoxia-induced phrenic long-term facilitation (pLTF), finding that elevated PaCO2 undermined hypoxia-induced pLTF, yielding significant results in animal experiments.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Neurosciences
Milap S. Sandhu, Monica A. Perez, Martin Oudega, Gordon S. Mitchell, William Z. Rymer
Summary: Acute intermittent hypoxia (AIH) can enhance upper-extremity function in individuals with incomplete SCI. A single AIH session improves bilateral grip and pinch strength, peaking around 3 hours post-intervention, significantly higher than sham AIH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Tong Ying Wang, Fang Yuan Xia, Jing Wen Gong, Xiao Kang Xu, Min Chao Lv, Mahanand Chatoo, Bilal Haider Shamsi, Meng Chen Zhang, Qian Ru Liu, Tian Xing Liu, Dan Dan Zhang, Xin Jiang Lu, Yang Zhao, Ji Zeng Du, Xue Qun Chen
Summary: Hypoxia induces dynamic changes in transcription factors, hormones, and receptors in the adult rat pituitary. Hypoxia activates HIF and c-Fos, which regulate the transcription of hormones and their receptors. CRHR1 plays an integrative role in the hypothalamus-pituitary-target axes and is involved in hypoxia-induced changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Marissa C. Ciesla, Yasin B. Seven, Latoya L. Allen, Kristin N. Smith, Elisa J. Gonzalez-Rothi, Gordon S. Mitchell
Summary: This study found that daily AIH increased the area of serotonergic immunolabeling in the XII motor nuclei in rats, while CIH protocols did not have the same effect, indicating that different intermittent hypoxia protocols have differential effects on XII serotonergic innervation.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Multidisciplinary Sciences
Jingyang Su, Zhi Li, Akira Yamashita, Ikue Kusumoto-Yoshida, Takuto Isomichi, Liying Hao, Tomoyuki Kuwaki
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Honami Setoyama, Yunsu Hwang, Akihiro Yamanaka, Tomoyuki Kuwaki
Article
Biochemistry & Molecular Biology
Shuichi Matsuda, Jun-Dal Kim, Fumihiro Sugiyama, Yuji Matsuo, Junji Ishida, Kazuya Murata, Kanako Nakamura, Kana Namiki, Tatsuhiko Sudo, Tomoyuki Kuwaki, Masahiko Hatano, Koichiro Tatsumi, Akiyoshi Fukamizu, Yoshitoshi Kasuya
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Physiology
Sichong Chen, Nobuaki Takahashi, Changping Chen, Jordan L. Pauli, Chiharu Kuroki, Jun Kaminosono, Hideki Kashiwadani, Yuichi Kanmura, Yasuo Mori, Shaowu Ou, Liying Hao, Tomoyuki Kuwaki
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Biology
Tomoyuki Kuwaki, Kouta Kanno
Summary: The study examined courtship behavior in orexin neuron-ablated mice (ORX-AB), a model of narcolepsy/cataplexy, and found that these mice displayed cataplexy-like behavior in response to female encounter, with a predominant presence during dark periods when exposed to chocolate. Studying cataplexy-like behavior in narcoleptic mice is useful for understanding mechanisms behind positive emotions, such as those associated with chocolate and courtship.
COMMUNICATIONS BIOLOGY
(2021)
Article
Behavioral Sciences
Hideki Kashiwadani, Yurina Higa, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The study found that linalool odor exposure still triggered analgesic effects even in TRPA1-deficient mice, and intranasal application of TRPA1 selective antagonist did not alter the analgesic effects of linalool odor, indicating that linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Biochemistry & Molecular Biology
Tomoyuki Kuwaki
Summary: This article summarizes the recent research findings of the author's research group on the role of orexin in the state-dependent adjustment of central autonomic regulation, as well as new discoveries using optogenetic manipulation of the orexin system. The study suggests that the orexin system may play a crucial role in coordinating circuits controlling autonomic functions and behaviors.
Article
Multidisciplinary Sciences
Yurina Higa, Hideki Kashiwadani, Mitsutaka Sugimura, Tomoyuki Kuwaki
Summary: The exposure to Linalool odor induces analgesic effects in mice, which are triggered by olfactory input and involve hypothalamic orexinergic neurons. Specifically, the activation of the orexinergic descending pathway by Linalool odor exposure suppresses neuronal activity in the spinal cord, leading to reduced nociceptive information flow and pain relief.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Akira Yamashita, Shunpei Moriya, Ryusei Nishi, Jun Kaminosono, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: Orexin neurons in the perifornical area of the hypothalamus play a critical role in the defense response, as shown by rapid increase in neuronal activity just prior to changes in heart rate. The memory of aversive stimulus can activate orexin neurons and increase heart rate. Targeting orexin neurons may enable treatment of psychiatric disorders associated with chronic stress and traumatic memories.
Article
Cell Biology
Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Junichi Sakaguchi, Yoko Ikoma, Yoshimune Sameshima, Yuki Kambe, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study reveals that acute nociceptive stimuli rapidly increase the activities of AS/A7 NA or B2 5-HT neurons in awake mice, while non-noxious stimuli do not have this effect. This suggests that AS/A7 NA or B2 5-HT neurons play important roles in nociceptive processing in the central nervous system.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Shi Zhou, Akira Yamashita, Jingyang Su, Yang Zhang, Wuyang Wang, Liying Hao, Akihiro Yamanaka, Tomoyuki Kuwaki
Summary: The study found that the activity of orexin-deficient mice's neurons increased before the onset of cataplexy-like behavior but decreased during the episode. This suggests that orexin neurons are moderately inhibited during cataplexy, providing insights for better understanding and treatment of cataplexy in narcolepsy patients.
Article
Physiology
Tatsuroh Kaneko, Tomoyuki Kuwaki, Hideki Kashiwadani
Summary: The study reveals that orexin neurons in the lateral hypothalamus modulate pain and itch in an opposite way, with pain relief and itch exacerbation. Most of these neurons respond to both pain and itch input.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Mayuko Yoshida, Koki Yamamoto, Tomoyuki Kuwaki
Summary: This study investigated the relationship between cataplexy and positive emotions in narcolepsy mice. The researchers found that narcolepsy mice could remember the chocolate-associated chamber and exhibited more cataplexy-like behaviors in that chamber. The activation patterns of the nucleus accumbens during spontaneous and chocolate-induced cataplexy were similar. These findings support the hypothesis that some spontaneous cataplexy in narcolepsy mice might indicate the remembering of happy moments.
Review
Neurosciences
Tomoyuki Kuwaki, Nobuaki Takahashi
Summary: TRPA1 is a member of the TRP superfamily of cation channels and is widely expressed in sensory neural pathways. It detects irritant chemicals, hypoxia, and hyperoxia. Its role in respiratory and behavioral modulation has been studied using Trpa1 knockout mice. The results show that TRPA1 is necessary for protective responses in respiration and behavior, suggesting that TRPA1 channels in the airway may play a sentinel role for environmental threats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)