Article
Medicine, General & Internal
Ki Hwan Kwak, Young Jeong Lee, Jae Yong Lee, Jae Hoon Cho, Ji Ho Choi
Summary: This meta-analysis assessed the effect of pharyngeal OSA surgery on PAP therapy parameters and found that the surgery lowered optimal PAP levels and increased PAP usage time.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biology
Shengmao Lin, Thyagaseely Sheela Premaraj, Peshala T. Gamage, Pengfei Dong, Sundaralingam Premaraj, Linxia Gu
Summary: This study evaluates the upper airway flow characteristics and anatomical features in patients with OSA, and finds that AHI alone is not sufficient to determine the severity of OSA. The degree of airway narrowing is associated with airway collapse. The relative contribution of anatomical and non-anatomical causes to OSA severity can vary between patients.
Article
Biophysics
Daniel Ignatiuk, Qiwei Xiao, Keith McConnell, Robert Fleck, Christine Schuler, Andreas Schuh, Raouf Amin, Alister Bates
Summary: Neuromuscular control of the upper airway plays a significant role in obstructive sleep apnea (OSA). This study validates power transfer as an accurate measure of neuromuscular activity using cine computed tomography (CT) imaging and computational fluid dynamics (CFD) analysis in a 3D-printed airway model. The findings suggest that power transfer can be used to phenotype OSA patients and personalize treatment strategies.
JOURNAL OF BIOMECHANICS
(2022)
Review
Medicine, General & Internal
Shahrokh Javaheri, Sogol Javaheri
Summary: This review provides a comprehensive overview of the current knowledge of obstructive sleep apnea (OSA) and congestive heart failure (HF), including the pathophysiologic mechanisms, observational data, treatment options, and future research needs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Andre Silva de Sousa, Aline Pereira da Rocha, Daniela Regina Brandao Tavares, Jane Erika Frazao Okazaki, Marcia Valeria de Andrade Santana, Virginia Fernandes Moca Trevisani, Ana Carolina Pereira Nunes Pinto
Summary: This review evaluates the effectiveness and safety of respiratory muscle training in the treatment of obstructive sleep apnea. The findings suggest that inspiratory muscle training may improve systolic blood pressure and sleepiness. However, it may not be superior to sham treatment for diastolic blood pressure, apnea-hypopnea index, and various respiratory and sleep quality measures.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Pediatrics
Kelly K. Hady, Caroline U. A. Okorie
Summary: Pediatric obstructive sleep apnea syndrome is a disorder characterized by breathing difficulties during sleep, affecting 2-4% of children worldwide. Surgical intervention is the primary treatment, but positive airway pressure therapy is often used for those not suitable for surgery or with residual symptoms. This therapy is effective, but additional considerations exist for pediatric patients.
Article
Medicine, General & Internal
Maryam Maghsoudipour, Brandon Nokes, Naa-Oye Bosompra, Rachel Jen, Yanru Li, Stacie Moore, Pamela N. DeYoung, Janelle Fine, Bradley A. Edwards, Dillon Gilbertson, Robert Owens, Todd Morgan, Atul Malhotra
Summary: The study aimed to assess the efficacy of upper airway muscle training as an adjunct treatment for OSA, but the results showed that the intervention did not have a significant impact on AHI, PSQI, ESS, SF-36, and PVT parameters, and the changes were not associated with the type of treatment. Further research is needed to determine the effectiveness of upper airway muscle training exercise as an adjunct treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Jan Lim, Hisham Alshaer, Nasim Montazeri Ghahjaverestan, T. Douglas Bradley
Summary: The purpose of this study was to investigate the relationship between alteration in airflow induced by negative pressure and the severity of obstructive sleep apnea (OSA) as determined by the apnea-hypopnea index (AHI). The results showed a strong correlation between AHI and the exponentially transformed negative pressure ratio (ExpNPR), which was independent of demographic factors related to AHI.
SLEEP AND BREATHING
(2023)
Article
Clinical Neurology
Daniel Vena, Luigi Taranto-Montemurro, Ali Azarbarzin, Sara Op de Beeck, Melania Marques, Olivier M. Vanderveken, Bradley A. Edwards, Laura Gell, Nicole Calianese, Lauren B. Hess, Reza Radmand, Garun S. Hamilton, Simon A. Joosten, Johan Verbraecken, Marc Braem, David P. White, Susan Redline, Scott A. Sands, Andrew Wellman
Summary: Among several candidates, event depth, Fhypopneas, and apnea index were identified as preferred pharyngeal collapsibility surrogates for use in the clinical arena.
Article
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Helena Baecher, Martin Kauke-Navarro, Doha Obed, Cosima C. Hoch, Yannick F. Diehm, Peter S. Vosler, Ulrich Harreus, Ulrich Kneser, Adriana C. Panayi
Summary: This study retrospectively analyzed the outcomes of OSA surgery at a national level, and identified risk factors for complications such as alkaline phosphatase levels, male gender, extreme BMI, and diabetes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yiran E. Li, Jun Ren
Summary: Obstructive sleep apnea (OSA) is a common respiratory disorder closely associated with cardiovascular diseases. Early diagnosis and appropriate treatment are essential for preventing adverse clinical outcomes.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Medicine, General & Internal
Jae Hyuk Choi, Eunkyu Lee, Sang Duk Hong, Seung Kyu Chung, Yong Gi Jung, Hyo Yeol Kim
Summary: A retrospective analysis of OSA patients undergoing CPAP therapy showed significant improvements in laryngopharyngeal reflux symptoms and examination findings, independent of body mass index or OSA severity.CPAP treatment has the potential to reduce laryngeal reflux symptoms and improve laryngeal examination results in OSA patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Amy Brown, Steven Jones, Guillermo Perez-Algorta
Summary: This study conducted a systematic review and qualitative metasynthesis of PAP user experience, revealing barriers to PAP use and suggesting ways services can address these barriers.
Article
Clinical Neurology
Bertien Buyse, Alexandros Kalkanis, Dries Testelmans
Summary: This study describes a peculiar groaning entity called Catathrenia, which has not been previously described. Patients experience expiratory groaning episodes during sleep, which occur after a cortical arousal and rescue respiration following obstructive events. Positive airway pressure eliminates these events.
Article
Clinical Neurology
Daniel J. Gottlieb, David J. Lederer, John S. Kim, Russell P. Tracy, Su Gao, Susan Redline, Sanja Jelic
Summary: This study assessed the impact of positive airway pressure (PAP) therapy on alveolar epithelial and endothelial injury and extracellular matrix remodeling in patients with obstructive sleep apnea (OSA). The findings suggest a possible adverse impact of PAP therapy on vascular endothelium.