Article
Cardiac & Cardiovascular Systems
Meryl Musicante, Hannah H. Kim, Yuanjian Chen, Fang Liao, Syamal K. Bhattacharya, Lu Lu, Yao Sun
Summary: This study revealed that eNOS plays a beneficial role in preventing cardiac myocyte hypertrophy and fibrosis, supporting the idea that eNOS may modify the severity of HCM phenotypes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Marijana Tadic, Cesare Cuspidi
Summary: Obstructive sleep apnea (OSA) is an important sleep-related breathing disorder that is associated with increased cardiovascular morbidity and mortality. OSA leads to damage in multiple organ systems, including the cardiovascular system, resulting in atherosclerosis, arterial stiffness, retinal damage, microalbuminuria, and cardiac remodeling. In addition to left ventricular (LV) hypertrophy and dysfunction, OSA also induces right ventricular (RV) remodeling, which can contribute to cardiovascular complications. Traditional echocardiographic parameters are not sensitive enough to detect subtle changes in RV function, but newer techniques like speckle tracking echocardiography and 3D echocardiography have provided more accurate assessments. Continuous positive airway pressure (CPAP) therapy is the main treatment for OSA, and studies have shown that it can improve RV systolic function and mechanics. This review aims to summarize the current understanding of RV changes in OSA patients and the effects of CPAP therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tao Li, Bin Liu, Xiu-Ju Luo, Jun Peng
Summary: This study demonstrates that VPO1 promotes right ventricular remodeling in pulmonary arterial hypertension (PAH) by catalyzing hypochlorous acid (HOCl) production and activating the ERK signaling pathway. VPO1 may serve as a potential therapeutic target for PAH.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biology
Maria Laggner, Felicitas Oberndorfer, Bahar Golabi, Jonas Bauer, Andreas Zuckermann, Philipp Hacker, Irene Lang, Nika Skoro-Sajer, Christian Gerges, Shahrokh Taghavi, Peter Jaksch, Michael Mildner, Hendrik Jan Ankersmit, Bernhard Moser
Summary: This study investigated the gene expression profiles of hypertrophic and regenerated right hearts of two subtypes of pulmonary hypertension (PH) patients. The findings revealed unique gene alteration signatures in different PH subtypes, as well as the identification of a profibrotic factor, early growth response 1 (EGR1), in both subtypes. These findings may contribute to the identification of therapeutic candidates for PH patients who are not eligible for surgical treatment.
Article
Cardiac & Cardiovascular Systems
Jing Huang, Wei Zhang, Cai-lian Zhang, Lei Wang
Summary: IL-17 is likely to induce right ventricular hypertrophy, especially under hypoxic conditions. The study found that IL-17 promotes cardiomyocyte apoptosis and hypertrophy through the STAT3 pathway.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Sreenath Reddy Nayakanti, Aleksandra Friedrich, Poonam Sarode, Leili Jafari, Giovanni Maroli, Mario Boehm, Alice Bourgeois, Yann Grobs, Fatemeh Khassafi, Carsten Kuenne, Stefan Guenther, Swati Dabral, Jochen Wilhelm, Astrid Weiss, Astrid Wietelmann, Baktybek Kojonazarov, Wiebke Janssen, Mario Looso, Frances de Man, Steeve Provencher, Khodr Tello, Werner Seeger, Sebastien Bonnet, Rajkumar Savai, Ralph T. Schermuly, Soni Savai Pullamsetti
Summary: The ability of the right ventricle to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. The Wnt signaling pathway plays an important role in the development of the right ventricle and may also be implicated in adult cardiac remodeling.
CIRCULATION RESEARCH
(2023)
Article
Genetics & Heredity
Chenxi Zhu, Zhehao Piao, Li Jin
Summary: HDAC5 may suppress the activation of the ERK/EGR1 signaling pathway to regulate MEF2A expression and participate in cardiac pathophysiology.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yufan Qian, Xinghan Zhao, Bing-Hua Chen, Ruo-Yang Shi, Chen Zhang, Xiaohai Ma, Yan Zhou, Lei Zhao, Lian-Ming Wu
Summary: RV GLS and RV GCS are independent predictors of HCM with and without RVH, respectively, and provide additional values for predicting the risk of adverse events.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Do-Yang Park, Woon Heo, Miran Kang, Taeyoung Ahn, DoHyeon Kim, Ayeon Choi, Lutz Birnbaumer, Hyung-Ju Cho, Joo Young Kim
Summary: Patients with obstructive sleep apnea (OSA) often have pulmonary hypertension and right ventricular (RV) hypertrophy. The exact molecule responsible for this is unknown, but the lack of TRPC3 is associated with RV dilation and dysfunction in response to pressure from the pulmonary vasculature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas K. Brown, Haben Berhane, Katheryn Gambetta, Michael Markl, Cynthia K. Rigsby, Joshua D. Robinson, Nazia Husain
Summary: TPM can be used to assess myocardial velocities in DMD patients and correlate them with myocardial structure, function, and clinical variables.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Wenqian Zhai, Yunfei Li, Yongjuan Luo, Weidong Gao, Shan Liu, Jiange Han, Jie Gen
Summary: Sevoflurane has potential benefits for right heart function in rats with experimental pulmonary arterial hypertension, reducing pulmonary vascular remodeling and RVH by down-regulating inflammatory factors, decreasing oxidative stress levels, and inhibiting NF-kappa B and MAPK pathways.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Hassen Ibn Hadj Amor, Imen Touil, Rihab Chebbi, Soumaya Bouchareb, Skander Bouchnak, Yosra Brahem, Leila Boussoffara, Nedia Boudawara, Jalel Kneni
Summary: The study found that OSA is independently associated with structural alterations of the RV early in the disease course, without causing RV dysfunction. This emphasizes the importance of early detection and treatment to reverse the harmful effects of OSA on the RV.
SLEEP AND BREATHING
(2022)
Article
Medicine, Research & Experimental
Stanislav Keranov, Oliver Doerr, Leili Jafari, Christoph Liebetrau, Till Keller, Christian Troidl, Jessica Riehm, Wiebke Rutsatz, Pascal Bauer, Steffen Kriechbaum, Sandra Voss, Manuel J. Richter, Khodr Tello, Henning Gall, Hossein A. Ghofrani, Stefan Guth, Werner Seeger, Christian W. Hamm, Holger Nef
Summary: This study demonstrated that OPN may serve as a potential biomarker for maladaptive right ventricular remodeling, while Gal-3 did not differentiate between adaptive and maladaptive RV remodeling. Additionally, OPN and Gal-3 levels were not correlated with parameters of left ventricular remodeling.
BIOMARKERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Nicolas Dayer, Zied Ltaief, Lucas Liaudet, Benoit Lechartier, John-David Aubert, Patrick Yerly
Summary: Right ventricular failure (RVF) is often caused by increased afterload and disrupted coupling between the right ventricle (RV) and the pulmonary arteries (PAs). This article reviews the concept of RV-PA coupling, assessment techniques, and management strategies for RVF. Treatment options range from fluid management and afterload reduction to vasopressor therapy and mechanical circulatory support.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Charles E. Norton, Joshua R. Sheak, Simin Yan, Laura Weise-Cross, Nikki L. Jernigan, Benjimen R. Walker, Thomas C. Resta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Cell Biology
Charles E. Norton, Nicole L. Jacobsen, Shenghua Y. Sinkler, Camila Manrique-Acevedo, Steven S. Segal
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Charles E. Norton, Laura Weise-Cross, Rosstin Ahmadian, Simin Yan, Nikki L. Jernigan, Michael L. Paffett, Jay S. Naik, Benjimen R. Walker, Thomas C. Resta
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Selina M. Garcia, Alexander G. Obukhov, Lindsay M. Herbert, Benjimen R. Walker, Thomas C. Resta, Nikki L. Jernigan
Article
Physiology
Joshua R. Sheak, David T. Jones, Benjamin J. Lantz, Levi D. Maston, Danielle Vigil, Thomas C. Resta, Micaela M. Resta, Tamara A. Howard, Nancy L. Kanagy, Yan Guo, Ewa Jankowska-Gan, Jeremy A. Sullivan, Rudolf K. Braun, William J. Burlingham, Laura V. Gonzalez Bosc
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Review
Cardiac & Cardiovascular Systems
Rebecca L. Shaw, Charles E. Norton, Steven S. Segal
Summary: Oxidative stress can lead to apoptosis of vascular cells, with smooth muscle cells (SMCs) showing greater susceptibility compared to endothelial cells (ECs). Further research is needed to validate these findings in intact resistance arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Charles E. Norton, Elizabeth A. Grunz-Borgmann, Marcia L. Hart, Benjamin W. Jones, Craig L. Franklin, Erika M. Boerman
Summary: Inflammatory bowel disease (IBD) significantly impairs sensory vasodilation and sympathetic vasoconstriction in mesenteric arteries, with decreased SP-containing nerve density and increased NK1 receptor expression. CGRP dilation, nerve density, and receptor expression remain unchanged. Blocking NK1 receptors restores sensory vasodilation and enhances CGRP-mediated dilation, suggesting interference of SP with CGRP signaling may contribute to impaired vasodilation in IBD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Neurosciences
Nikki L. Jernigan, Jay S. Naik, Thomas C. Resta
Summary: Pulmonary hypertension is characterized by sustained vasoconstriction and remodeling of the small pulmonary arteries. Acid-sensing ion channel 1 (ASIC1) plays a role in chronic hypoxia-induced pulmonary hypertension and contributes to the depolarization of pulmonary arterial smooth muscle cells. Na+ influx, mediated by ASIC1, is essential for the persistent depolarization in PASMCs during chronic hypoxia.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Nicole L. Jacobsen, Charles E. Norton, Rebecca L. Shaw, D. D. W. Cornelison, Steven S. Segal
Summary: Skeletal muscle injury disrupts capillary supply due to myofibre degeneration. Regeneration of microvascular networks accompanies the recovery of blood flow regulation. BaCl2-induced microcirculation response sheds light on the nature of microvascular damage and repair.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Hematology
Charles E. Norton, Erika M. Boerman, Steven S. Segal
Summary: The study demonstrates that substance P and CGRP can affect the membrane potential of vascular smooth muscle and endothelium through different mechanisms involving K+ channels, thereby regulating mesenteric blood flow.
Article
Physiology
Charles E. Norton, Rebecca L. Shaw, Ron Mittler, Steven S. Segal
Summary: This study found that endothelial cells (ECs) are more resistant to oxidative stress than smooth muscle cells (SMCs) in cerebral arteries. The endothelium protects SMCs by reducing calcium ion entry through TRPC3 channels. These findings provide insights into the cellular response to acute oxidative stress in the cerebral vascular supply.
Article
Hematology
Kelli L. Jablon, Victoria L. Akerstrom, Min Li, Stephen E. Braun, Charles E. Norton, Jorge A. Castorena-Gonzalez
Summary: A method for routine isolation and short-term culture of primary lymphatic endothelial cells (LECs) from specific collecting vessels was developed. The method was validated and shown to successfully isolate and culture functional primary LECs. This study provides an innovative tool for the study of LECs.
Article
Physiology
Scott D. Zawieja, Grace A. Pea, Sarah E. Broyhill, Advaya Patro, Karen H. Bromert, Min Li, Charles E. Norton, Jorge A. Castorena-Gonzalez, Edward J. Hancock, Christopher D. Bertram, Michael J. Davis
Summary: The study reveals the critical role of IP3R1 in regulating pressure-dependent chronotropy and contractile regulation in lymphatic vessels. IP3R1-mediated calcium release is identified as the primary calcium source driving Anoctamin1 activation during diastole, controlling diastolic depolarization. These findings contribute to a better understanding of the regulatory mechanisms in lymphatic vessels.
JOURNAL OF GENERAL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Charles E. Norton, Rebecca L. Shaw, Steven S. Segal
Summary: High-fat, western-style diets increase vascular oxidative stress. We hypothesized that smooth muscle cells and endothelial cells adapt during the consumption of high-fat diets to become more resilient to acute oxidative stress. Our results showed that during acute exposure to H2O2, smooth muscle cell and endothelial cell death were reduced in PCAs from mice fed a western-style diet, and selective inhibition of TRPV4 or TRPC3 channels reduced cell death and eliminated differences between diets.
Article
Cardiac & Cardiovascular Systems
Charles E. Norton, Nikki L. Jernigan, Benjimen R. Walker, Thomas C. Resta
PULMONARY CIRCULATION
(2020)