Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

A CALR Mutation Preceding BCR-ABL1 in an Atypical Myeloproliferative Neoplasm

(2015) Xénia Cabagnols et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

Common germline variation at theTERTlocus contributes to familial clustering of myeloproliferative neoplasms

(2014) Roland Jäger et al.   AMERICAN JOURNAL OF HEMATOLOGY

CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis

(2014) E. Rumi et al.   BLOOD

Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms

(2014) P. Lundberg et al.   BLOOD

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells

(2014) C. Kishi-Itakura et al.   JOURNAL OF CELL SCIENCE

Thrombocytopenia-associated mutations in the ANKRD26 regulatory region induce MAPK hyperactivation

(2014) Dominique Bluteau et al.   JOURNAL OF CLINICAL INVESTIGATION

Emergence of a BCR-ABL Translocation in a Patient With the JAK2V617F Mutation: Evidence for Secondary Acquisition of BCR-ABL in the JAK2V617F Clone

(2014) Osamu Yamada et al.   JOURNAL OF CLINICAL ONCOLOGY

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressingJAK2-V617F

(2014) Pontus Lundberg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The germline sequence variant rs2736100_C in TERT associates with myeloproliferative neoplasms

(2014) A Oddsson et al.   LEUKEMIA

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

The landscape of somatic mutations in Down syndrome–related myeloid disorders

(2013) Kenichi Yoshida et al.   NATURE GENETICS

Heterozygous and Homozygous JAK2V617F States Modeled by Induced Pluripotent Stem Cells from Myeloproliferative Neoplasm Patients

(2013) Joseph Saliba et al.   PLoS One

High frequency of GATA2 mutations in patients with mild chronic neutropenia evolving to MonoMac syndrome, myelodysplasia, and acute myeloid leukemia

(2012) M. Pasquet et al.   BLOOD

Long term follow up of 93 families with myeloproliferative neoplasms: life expectancy and implications of JAK2V617F in the occurrence of complications

(2012) Sandra Malak et al.   BLOOD CELLS MOLECULES AND DISEASES

Germline copy number variations and cancer predisposition

(2012) Ana Cristina Victorino Krepischi et al.   Future Oncology

Role of Germline Genetic Factors in MPN Pathogenesis

(2012) Ashot S. Harutyunyan et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells

(2012) S. T. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

(2012) G. A. MacLean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of genomic aberrations associated with disease transformation by means of high-resolution SNP array analysis in patients with myeloproliferative neoplasm

(2011) Elisa Rumi et al.   AMERICAN JOURNAL OF HEMATOLOGY

Lack of autophagy in the hematopoietic system leads to loss of hematopoietic stem cell function and dysregulated myeloid proliferation

(2011) Monika Mortensen et al.   Autophagy

Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression

(2011) T. Klampfl et al.   BLOOD

Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

(2011) Christopher N Hahn et al.   NATURE GENETICS

Analysis of genomic aberrations and gene expression profiling identifies novel lesions and pathways in myeloproliferative neoplasms

(2011) K L Rice et al.   Blood Cancer Journal

Genetic Analysis of Transforming Events That Convert Chronic Myeloproliferative Neoplasms to Leukemias

(2010) O. Abdel-Wahab et al.   CANCER RESEARCH

Germline copy number variation and cancer risk

(2010) Roland P Kuiper et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Analysis of the Ten-Eleven Translocation 2 (TET2) gene in familial myeloproliferative neoplasms

(2009) C. Saint-Martin et al.   BLOOD

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis

(2009) O. Klimchenko et al.   BLOOD

GSKIP, an inhibitor of GSK3β, mediates the N-cadherin/β-catenin pool in the differentiation of SH-SY5Y cells

(2009) Ching-Chih Lin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms

(2009) Damla Olcaydu et al.   NATURE GENETICS

A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms

(2009) Outi Kilpivaara et al.   NATURE GENETICS

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms

(2009) Amy V Jones et al.   NATURE GENETICS

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3  is a negative regulator of platelet function and thrombosis

(2008) D. Li et al.   BLOOD

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

(2008) N. Takayama et al.   BLOOD

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders

(2008) I. Plo et al.   BLOOD

Inhibition of GSK-3β promotes survival and proliferation of megakaryocytic cells through a β-catenin-independent pathway

(2008) Mie Soda et al.   CELLULAR SIGNALLING

Frameshift mutations of autophagy-related genesATG2B, ATG5, ATG9BandATG12in gastric and colorectal cancers with microsatellite instability

(2008) Mi Ran Kang et al.   JOURNAL OF PATHOLOGY

Improved Efficiency and Pace of Generating Induced Pluripotent Stem Cells from Human Adult and Fetal Fibroblasts

(2008) Prashant Mali et al.   STEM CELLS