Freeze–thaw cycles as drivers of complex ribozyme assembly

Heat flux across an open pore enables the continuous replication and selection of oligonucleotides towards increasing length

(2015) Moritz Kreysing et al.   Nature Chemistry

Dry Polymerization of 3′,5′-Cyclic GMP to Long Strands of RNA

(2014) Matthias Morasch et al.   CHEMBIOCHEM

Salt-Promoted Synthesis of RNA-like Molecules in Simulated Hydrothermal Conditions

(2014) Laura Da Silva et al.   JOURNAL OF MOLECULAR EVOLUTION

Imbalance between Anion and Cation Distribution at Ice Interface with Liquid Phase in Frozen Electrolyte As Evaluated by Fluorometric Measurements of pH

(2014) Hiroki Watanabe et al.   Journal of Physical Chemistry C

Non-canonical 3′-5′ Extension of RNA with Prebiotically Plausible Ribonucleoside 2′,3′-Cyclic Phosphates

(2014) Hannes Mutschler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Crowding Accelerates Ribozyme Docking and Catalysis

(2014) Bishnu P. Paudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A cross-chiral RNA polymerase ribozyme

(2014) Jonathan T. Sczepanski et al.   NATURE

Many Paths to the Origin of Life

(2014) J. Gollihar et al.   SCIENCE

Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity

(2013) Aaron E. Engelhart et al.   Nature Chemistry

In-ice evolution of RNA polymerase ribozyme activity

(2013) James Attwater et al.   Nature Chemistry

Sliding over the Blocks in Enzyme-Free RNA Copying – One-Pot Primer Extension in Ice

(2013) Philipp M. G. Löffler et al.   PLoS One

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells

(2013) K. Adamala et al.   SCIENCE

Abiotic Self-Replication

(2012) Adam J. Meyer et al.   ACCOUNTS OF CHEMICAL RESEARCH

General Acid–Base Catalysis Mediated by Nucleobases in the Hairpin Ribozyme

(2012) Stephanie Kath-Schorr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spontaneous network formation among cooperative RNA replicators

(2012) Nilesh Vaidya et al.   NATURE

Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA

(2011) Christopher Deck et al.   Nature Chemistry

An optimal degree of physical and chemical heterogeneity for the origin of life?

(2011) J. W. Szostak   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: Variations on a theme

(2011) Ricardo Flores et al.   RNA Biology

Ribozyme-Catalyzed Transcription of an Active Ribozyme

(2011) A. Wochner et al.   SCIENCE

Ice as a protocellular medium for RNA replication

(2010) James Attwater et al.   Nature Communications

Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation

(2009) Parag Kolhe et al.   BIOTECHNOLOGY PROGRESS

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

(2009) Matthew W. Powner et al.   NATURE

The dawn of the RNA World: Toward functional complexity through ligation of random RNA oligomers

(2009) C. Briones et al.   RNA

Self-Sustained Replication of an RNA Enzyme

(2009) T. A. Lincoln et al.   SCIENCE

Metal-ion catalyzed polymerization in the eutectic phase in water–ice: A possible approach to template-directed RNA polymerization

(2008) Pierre-Alain Monnard et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Template-directed synthesis of a genetic polymer in a model protocell

(2008) Sheref S. Mansy et al.   NATURE

RNA misfolding and the action of chaperones

(2007) Rick Russell   Frontiers in Bioscience-Landmark