期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 9, 页码 5847-5850出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00332-15
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资金
- Kanae Foundation for Asia-Oceania Collaborative Research and International Health Cooperation Research [24-S-5, 26-A-103]
- Research Program on Emerging and Re-Emerging Infectious Diseases from Japan Agency for Medical Research and Development, AMED
A novel New Delhi metallo-beta-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against beta-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher kcat/Km ratios for cefotaxime. The genetic environment of blaNDM-13 was determined to be tnpA-IS30-blaNDM-13-bleMBL-trpF-dsbC-cutA-groES-groL, with blaNDM-13 located within the chromosome.
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