期刊
NATURE CHEMISTRY
卷 7, 期 6, 页码 489-495出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/NCHEM.2261
关键词
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资金
- Sanofi
- University of Nottingham
- Bill and Melinda Gates Foundation [1070294]
- Engineering and Physical Sciences Research Coucil (EPSRC) [EP/L021889/1]
- Royal Society
- EPSRC
- Bill and Melinda Gates Foundation
- EPSRC [EP/L021889/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/L021889/1] Funding Source: researchfish
Artemisinin is an important antimalarial drug, but, at present, the environmental and economic costs of its semi-synthetic production are relatively high. Most of these costs lie in the final chemical steps, which follow a complex acid-and photocatalysed route with oxygenation by both singlet and triplet oxygen. We demonstrate that applying the principles of green chemistry can lead to innovative strategies that avoid many of the problems in current photochemical processes. The first strategy combines the use of liquid CO2 as solvent and a dual-function solid acid/photocatalyst. The second strategy is an ambient-temperature reaction in aqueous mixtures of organic solvents, where the only inputs are dihydroartemisinic acid, O-2 and light, and the output is pure, crystalline artemisinin. Everything else-solvents, photocatalyst and aqueous acid-can be recycled. Some aspects developed here through green chemistry are likely to have wider application in photochemistry and other reactions.
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