An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins

Biosynthesis of Versipelostatin: Identification of an Enzyme-Catalyzed [4+2]-Cycloaddition Required for Macrocyclization of Spirotetronate-Containing Polyketides

(2015) Takuya Hashimoto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the field of bioactive tetronates

(2014) Laura Vieweg et al.   NATURAL PRODUCT REPORTS

Unusual Acetylation-Elimination in the Formation of Tetronate Antibiotics

(2013) Chompoonik Kanchanabanca et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE

(2013) Pauli Kallio et al.   BIOCHEMISTRY

Spiroketal Formation and Modification in Avermectin Biosynthesis Involves a Dual Activity of AveC

(2013) Peng Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis

(2013) Peng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase

(2013) Sumei Li et al.   ORGANIC LETTERS

Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line

(2012) Hai-Yan He et al.   CHEMISTRY & BIOLOGY

Current developments and challenges in the search for a naturally selected Diels-Alderase

(2012) Hak Joong Kim et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Insights into Pyrroindomycin Biosynthesis Reveal a Uniform Paradigm for Tetramate/Tetronate Formation

(2012) Qiongqiong Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Abyssomicin Biosynthesis: Formation of an Unusual Polyketide, Antibiotic-Feeding Studies and Genetic Analysis

(2011) Elvira M. Gottardi et al.   CHEMBIOCHEM

A “Diels-Alderase” at Last

(2011) Craig A. Townsend   CHEMBIOCHEM

Biochemistry: Life imitates art

(2011) Wendy L. Kelly   NATURE

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation

(2011) Shunji Takahashi et al.   Nature Chemical Biology

Mechanistic Insights on Riboflavin Synthase Inspired by Selective Binding of the 6,7-Dimethyl-8-ribityllumazine Exomethylene Anion

(2010) Ryu-Ryun Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vitro reconstruction of tetronate RK-682 biosynthesis

(2010) Yuhui Sun et al.   Nature Chemical Biology

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

(2009) S. M. Ma et al.   SCIENCE

Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases

(2008) David H. Kwan et al.   CHEMISTRY & BIOLOGY

Cloning and Characterization of the Tetrocarcin A Gene Cluster from Micromonospora chalcea NRRL 11289 Reveals a Highly Conserved Strategy for Tetronate Biosynthesis in Spirotetronate Antibiotics

(2008) J. Fang et al.   JOURNAL OF BACTERIOLOGY

Intramolecular cyclizations of polyketide biosynthesis: mining for a “Diels–Alderase”?

(2008) Wendy L. Kelly   ORGANIC & BIOMOLECULAR CHEMISTRY