Article
Multidisciplinary Sciences
B. E. Morgado, B. Sicardy, F. Braga-Ribas, J. L. Ortiz, H. Salo, F. Vachier, J. Desmars, C. L. Pereira, P. Santos-Sanz, R. Sfair, T. de Santana, M. Assafin, R. Vieira-Martins, A. R. Gomes-Junior, G. Margoti, V. S. Dhillon, E. Fernandez-Valenzuela, J. Broughton, J. Bradshaw, R. Langersek, G. Benedetti-Rossi, D. Souami, B. J. Holler, M. Kretlow, R. C. Boufleur, J. I. B. Camargo, R. Duffard, W. Beisker, N. Morales, J. Lecacheux, F. L. Rommel, D. Herald, W. Benz, E. Jehin, F. Jankowsky, T. R. Marsh, S. P. Littlefair, G. Bruno, I. Pagano, A. Brandeker, A. Collier-Cameron, H. G. Floren, N. Hara, G. Olofsson, T. G. Wilson, Z. Benkhaldoun, R. Busuttil, A. Burdanov, M. Ferrais, D. Gault, M. Gillon, W. Hanna, S. Kerr, U. Kolb, P. Nosworthy, D. Sebastian, C. Snodgrass, J. P. Teng, J. de Wit
Summary: This study reports the discovery of an inhomogeneous ring around the trans-Neptunian body Quaoar. The detected ring orbits at a distance well outside Quaoar's classical Roche limit, suggesting that this limit does not always determine ring survival. Elastic collisions, based on laboratory experiments, are found to play a role in maintaining the ring far away from the body. The proximity of Quaoar's ring to a 1/3 spin-orbit resonance indicates the importance of this resonance in ring confinement for small bodies.
Article
Chemistry, Medicinal
Peter S. Dragovich, Wolfgang Haap, Melinda M. Mulvihill, Jean-Marc Plancher, Antonia F. Stepan
Summary: This article describes the origin of small-molecule leads pursued by the independent research organizations Roche and Genentech from 2009 to 2020. The identified chemical series were derived from various lead-finding methods, including public information, high-throughput screening, fragment-based design, DNA-encoded library technology, use of legacy internal data, in-licensing, and de novo design. The article discusses the translation of these leads into in vivo tool compounds and development candidates, as well as their associated biological target classes and therapeutic areas. The analysis identifies important trends and commonalities and differences across the two organizations.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Astronomy & Astrophysics
Victoria Antonetti, Jeremy Goodman
Summary: The hot Jupiter WASP-12b has been found to be on a decaying orbit. Its mean density is near its Roche limit, indicating mass loss. The calculated Roche density is very close to the observational estimates for the mean density. The study also discusses the shape of the planet, its lifetime before complete disruption, and the current rate of mass loss.
ASTROPHYSICAL JOURNAL
(2022)
Article
Medical Laboratory Technology
Christine L. H. Snozek, Grant M. Spears, Ann B. Porco, Sheila Erb, Erin J. Kaleta, Sandra C. Bryant, Nikola A. Baumann
Summary: There is controversy surrounding the reference intervals (RI) for ferritin, with indications that changes in lifestyle and demographics have limited the validity of RIs established decades ago. In this study, robust RIs were established utilizing retrospective patient data, with separate RIs for different age and sex groups.
CLINICAL BIOCHEMISTRY
(2021)
Article
Medical Laboratory Technology
Julien Favresse, Johan Schiettecatte, Fleur Wolff, Frederic Cotton, Marc Elsen, Christine Eucher, Catherine Rosseels, Ellen Anckaert
Summary: The performance of the Roche Elecsys Vitamin D total III assay for measuring total 25(OH)D was evaluated in this study. The results showed good agreement with liquid chromatography tandem mass spectrometry, and the assay demonstrated a higher biotin interference threshold and a broader measuring range compared to the previous generation assay. However, there was still an issue with cross-reactivity towards 3-epi-25(OH)D-3 in high titer samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jean-Claude Marquet, Trine Holm Freiesleben, Kristina Jorkov Thomsen, Andrew Sean Murray, Morgane Calligaro, Jean-Jacques Macaire, Eric Robert, Michel Lorblanchet, Thierry Aubry, Gregory Bayle, Jean-Gabriel Breheret, Hubert Camus, Pascal Chareille, Yves Egels, Emilie Guillaud, Guillaume Guerin, Pascale Gautret, Morgane Liard, Magen O'Farrell, Jean-Baptiste Peyrouse, Edit Thamo-Bozso, Pascal Verdin, Dorota Wojtczak, Christine Oberlin, Jacques Jaubert
Summary: We report on Neanderthal engravings on a cave wall in central France that are more than 57 & PLUSMN;3 thousand years old. The cave was sealed by sediments, preventing access until its discovery in the 19th century. The closure of the cave was determined using luminescence ages, and the engravings were confirmed to be anthropogenic in origin. The engravings predate the arrival of H. sapiens and are attributed to H. neanderthalensis.
Article
Microbiology
Johannes Hayer, Eva Urlaub
Summary: The study aimed to establish the performance of the SARS-CoV-2 Rapid Antibody Test (IgG and IgM) and the Elecsys Anti-SARS-CoV-2 S assay in vaccinated individuals, with good agreement rates between the two methods. The results suggest that the SARS-CoV-2 Rapid Antibody Test (IgG) is helpful in understanding the immune response postvaccination, and support its use in the vaccinated population. Serologic assays are essential for seroprevalence surveys and quality control of vaccines, and antibody titers postvaccination may be associated with protection from symptomatic SARS-CoV-2 infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Florian Lipsmeier, Kirsten Taylor, Ronald B. Postuma, Ekaterina Volkova-Volkmar, Timothy Kilchenmann, Brit Mollenhauer, Atieh Bamdadian, Werner L. Popp, Wei-Yi Cheng, Yan-Ping Zhang, Detlef Wolf, Jens Schjodt-Eriksen, Anne Boulay, Hanno Svoboda, Wagner Zago, Gennaro Pagano, Michael Lindemann
Summary: Digital health technologies have the potential to provide reliable and valid estimates of motor sign severity and progression in Parkinson's disease. The Roche PD Mobile Application v2 demonstrated good reliability and validity in measuring motor sign severity in early-stage PD participants.
SCIENTIFIC REPORTS
(2022)
Article
Astronomy & Astrophysics
Shenghua Yu, Youjun Lu, C. Simon Jeffery
Summary: The study explores the impact of mass transfer and gravitational wave radiation on the orbital evolution of contact neutron star-white dwarf binaries. Results show that while some high-mass binaries may directly coalesce after unstable mass transfer, the majority can avoid this fate through a reversal of orbital evolution. Monitoring the GW frequencies and amplitudes of NS-WD binaries near contact can provide insights into their evolutionary stage.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Medical Laboratory Technology
Nicole Mueller, Laurenz Schneider, Johannes Breuer, Noa Judith Freudenthal
Summary: Analyzing NT-proBNP in urine using the cobas h232 POC system is feasible, but the detection range needs to be adjusted. Additionally, urine NT-proBNP remains stable for at least 96 hours at room temperature, making it suitable for postal shipping.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemical Research Methods
Elena Riester, Peter Findeisen, J. Kolja Hegel, Michael Kabesch, Andreas Ambrosch, Christopher M. Rank, Florina Pessl, Tina Laengin, Christoph Niederhauser
Summary: The Elecsys Anti-SARS-CoV-2 S immunoassay demonstrated reliable performance with high specificity and sensitivity for detecting anti-SARS-CoV-2 antibodies, outperforming other commonly used similar assays.
JOURNAL OF VIROLOGICAL METHODS
(2021)
Article
Astronomy & Astrophysics
S. Mereghetti, N. La Palombara, T. Kupfer, T. R. Marsh, C. M. Copperwheat, K. Deshmukh, P. Esposito, T. Maccarone, F. Pintore, M. Rigoselli, L. Rivera Sandoval, A. Tiengo
Summary: ZTF J213056.71+442046.5 is a small binary system consisting of a white dwarf and a hot subdwarf. Analysis of its optical and spectroscopic data suggests a high orbital inclination and the presence of an accretion disk. Despite evidence of accretion, no X-rays were detected.
ASTROPHYSICAL JOURNAL
(2022)
Article
Astronomy & Astrophysics
Dimitri Veras, Nikolaos Georgakarakos, Alexander J. Mustill, Uri Malamud, Tim Cunningham, Ian Dobbs-Dixon
Summary: This study used simulations to show that the mass of planets affects the geometry of asteroid injection into the white dwarf Roche sphere, with lower planetary masses leading to increased anisotropic injection and decreased likelihood of head-on encounters. These results suggest that dynamical activity within the Roche sphere can provide insights into the hidden architectures of planetary systems.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Medical Laboratory Technology
Arish Jasani, Ivan Stevic, Vipin Bhayana, Angela C. Rutledge
Summary: The goal of this study was to determine whether the antibiotic metronidazole could interfere with spectrophotometric assays used in our laboratory. After characterizing the absorbance spectrum of metronidazole, we found that the Roche chemistry tests performed on cobas c502 and/or c702 instruments were not significantly affected by the presence of metronidazole.
CLINICAL BIOCHEMISTRY
(2023)
Article
Astronomy & Astrophysics
Jiangdan Li, Christopher A. Onken, Christian Wolf, Peter Nemeth, Mike Bessell, Zhenwei Li, Xiaobin Zhang, Jiao Li, Luqian Wang, Lifang Li, Yangping Luo, Hailiang Chen, Kaifan Ji, Xuefei Chen, Zhanwen Han
Summary: A hot subdwarf O (sdO) star and a white dwarf (WD) binary system, which has the capability of emitting low-frequency gravitational waves and possibly being the progenitor of Type Ia supernovae, has been discovered. Spectroscopy and light curve analysis provide information about the system, such as temperature, mass ratio, and disc characteristics. The binary system is believed to have originated from a common envelope ejection channel and might result in an R Coronae Borealis (R CrB) star.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)