期刊
JOURNAL OF APPLIED PHYSICS
卷 107, 期 7, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3340861
关键词
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资金
- National Science Council of Taiwan [98-2323-B-003-001-CC2, 98-2112-M-003-003, 98-221-E-003-001-MY2, 98-2752-M-002-016-PAE]
- Ministry of Economic Affairs [1Z970688, S09800226-203]
- Department of Helath [DOH98-TD-N-111-008, 99G0012]
Via immunomagnetic reduction assay, biomolecules can be quantitatively detected with aid of biofunctionalized magnetic nanoparticles, which are used as labeling markers for specific biomolecules. To achieve ultra-high sensitivity in detecting biomolecules, superconducting quantum interference device (SQUID) is a promising candidate to act as a sensor to the magnetic signal related to the concentration of detected biomolecules. In the past, we developed a single channel SQUID-based magnetosusceptometry. In order to increase the detection through-put, multichannel SQUID-based magnetosusceptometry is developed. In this work, the design and working principle of four-channel SQUID-based magnetosusceptometry are introduced. Using utilizing scanning technology, four samples can be simultaneously logged into the SQUID-based magnetosusceptometry. Notably, only single SQUID magnetometer is used in the magnetosusceptometry. The precision and sensitivity in detecting biomolecules using the four-channel SQUID-based magnetosusceptometry are investigated. (C) 2010 American Institute of Physics. [doi:10.1063/1.3340861]
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