Article
Biochemistry & Molecular Biology
Mona Abdollahi, Margaret Fahnestock
Summary: Nurr1 and BDNF play important roles in cognition, with Nurr1 regulating BDNF in different brain areas. However, Nurr1 does not regulate BDNF in cortical neurons. Treatment with Nurr1 agonist AQ and membrane depolarization increased Nurr1 and BDNF expression in cortical neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Suyash M. Patil, Nitesh K. Kunda
Summary: This study evaluated the anticancer potential of the antimicrobial peptide Nisin ZP in non-small cell lung cancer (NSCLC) cells. The results showed that Nisin ZP selectively targeted cancer cells, induced apoptosis and cell cycle arrest, and inhibited cancer cell growth and migration through non-membranolytic pathways.
PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Kulma, Gregor Anderluh
Summary: Pore-forming proteins (PFPs) alter membrane permeability by forming transmembrane pores, destroying target cells and potentially manipulating cellular functions. Recent evidence suggests that PFPs also induce extensive membrane reorganization, including lateral rearrangement and deformation, which can disrupt cell function and lead to death. These modifications are also part of a membrane repair system that protects cells from the lethal effects of pore formation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Madhumalar Subramanian, Charlotte Kielar, Satoru Tsushima, Karim Fahmy, Jana Oertel
Summary: The use of engineered cysteines on membrane-scaffolding protein MSP1D1 allows the formation of multimers of nanodiscs, which is crucial for membrane protein research. Minimal interference with nanodisc formation and structure was demonstrated by various analytical techniques. Transmission electron microscopy showed the growth of submicron-sized tracts of stacked nanodiscs through oligonucleotide attachment to engineered cysteines.
Article
Biochemistry & Molecular Biology
Roman S. Kirsanov, Ljudmila S. Khailova, Tatyana I. Rokitskaya, Iliuza R. Iaubasarova, Pavel A. Nazarov, Alisa A. Panteleeva, Konstantin G. Lyamzaev, Lyudmila B. Popova, Galina A. Korshunova, Elena A. Kotova, Yuri N. Antonenko
Summary: This article describes a new method of proton transport across lipid membranes using a synthesized precursor of triphenylphosphonium ylide. The precursor was found to release protons in mitochondrial, chloroplast, and artificial lipid membranes, suggesting its potential as a proton carrier. The new ylide-type protonophores show promising therapeutic properties as uncouplers.
BIOELECTROCHEMISTRY
(2023)
Article
Food Science & Technology
Yilmaz Ucar, Yesim Ozogul, Mustafa Durmus, Fatih Ozogul
Summary: The study found that different concentrations of nisin can inhibit the production of biogenic amines in seabass fillets, with Gram-positive foodborne pathogens being more sensitive to it. However, bacterial loads in the broth were not always correlated with biogenic amine formation.
Article
Plant Sciences
Sulian Lv, Fang Tai, Jie Guo, Ping Jiang, Kangqi Lin, Duoliya Wang, Xuan Zhang, Yinxin Li
Summary: High PS levels in the plasma membrane were found in the halophyte S. europaea compared to Arabidopsis, with the gene SePSS regulating PS levels and enhancing salt tolerance in plants. This suggests a potential strategy for improving plant growth under multiple stresses.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Arijit Mahapatra, Padmini Rangamani
Summary: Plasma membrane tubes are common in cellular membranes and organelle membranes, and play important roles in trafficking, ion transport, and cellular motility. They can be formed by localized forces or induced by membrane-bound proteins. A mathematical framework to model cylindrical tubular protrusions formed by proteins with anisotropic spontaneous curvature is presented. The analysis reveals that the tube radius depends on effective tension including membrane tension and protein-induced curvature. The findings have implications for processes like endocytosis, t-tubule formation in myocytes, and cristae formation in mitochondria.
Article
Biochemistry & Molecular Biology
Dayana N. Chernyshova, Alexander A. Tyulin, Olga S. Ostroumova, Svetlana S. Efimova
Summary: This study focused on the action of lantibiotic nisin on phospholipid membranes, revealing that its effectiveness depends on the membrane composition and can exert its anti-tumor activity by forming ion pores. The preferential interaction of nisin with cardiolipin-enriched bilayers was observed, and small molecules were found to enhance the membrane activity of nisin.
Article
Infectious Diseases
Nashwah G. M. Attallah, Walaa A. Negm, Engy Elekhnawy, Elshaymaa Elmongy, Najla Altwaijry, Hala El-Haroun, Thanaa A. El-Masry, Suzy A. El-Sherbeni
Summary: The study investigated the antimicrobial potential of Cupressus macrocarpa leaves against MRSA and found that its extracts demonstrated strong inhibitory effects on the bacteria, reducing both growth and efflux activity significantly. The phytochemical profiling of the leaves revealed a large number of compounds, showing promising antimicrobial properties against MRSA both in vitro and in vivo.
Article
Engineering, Environmental
Anton Ribbenstedt, James M. Armitage, Felix Gunther, Jon A. Arnot, Steven T. J. Droge, Michael S. McLachlan
Summary: This study measured the bioconcentration factors (BCFs) of 10 anionic surfactants with different alkyl chain lengths and polar head groups in rainbow trout. The results showed that biotransformation was the dominant elimination mechanism, and there was a strong positive correlation between the BCF and the membrane lipid-water distribution ratio. The dataset is important for evaluating computational and experimental methods for assessing bioaccumulation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eugenia Chartschenko, Marie Hugenroth, Irfan Akhtar, Andrea Droste, Petra Kolkhof, Maria Bohnert, Mathias Beller
Summary: Seipin protein plays a key role in lipid droplets (LDs) biogenesis, with recent findings showing a cooperation between human Seipin and Lipid droplet assembly factor 1 (LDAF1). LDAF1 proteins may have an evolutionarily conserved function in LDs biogenesis, with certain functional aspects shared between LDO and mammalian LDAF1 proteins. The relationship between LDO and LDAF1 proteins is still under debate.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemical Research Methods
Seren Ohnishi, Koki Kamiya
Summary: This study presents a novel artificial cell model employing the dual functional membrane protein OmpLA for small molecule transportation and small vesicle budding. The orientation of OmpLA was controlled by lipid composition and its enzymatic activity led to budding of small vesicles. Through this mechanism, the transportation of ions or small molecules was achieved for the first time.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Cell Biology
Hu Qian, Ting Lei, Yihe Hu, Pengfei Lei
Summary: This study identified two molecular subgroups of osteosarcoma with significantly different survival outcomes. Better prognosis was associated with specific immune characteristics and pathways related to immune response and bone remodeling. A risk model based on lipid metabolism related genes showed potential for accurate survival prediction in osteosarcoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lauren E. Ball, Liam J. Riley, Waled Hadasha, Rueben Pfukwa, Corinne J. Smith, Timothy R. Dafforn, Bert Klumperman
Summary: Polymer-based lipid nanoparticles, such as DIBMA, have shown significant advancements in the study of membrane proteins. Research indicates that DIBMA exhibits excellent performance in lipid nanodisc formation and membrane protein extraction, with better solubilization efficiency and cleaner separation compared to SMA and commercially available DIBMA.
Article
Multidisciplinary Sciences
Erik N. Trip, Dirk-Jan Scheffers
SCIENTIFIC REPORTS
(2015)
Editorial Material
Microbiology
Anabela de Sousa Borges, Dirk-Jan Scheffers
ENVIRONMENTAL MICROBIOLOGY
(2016)
Article
Microbiology
Ana R. Pereira, Jen Hsin, Ewa Krol, Andreia C. Tavares, Pierre Flores, Egbert Hoiczyk, Natalie Ng, Alex Dajkovic, Yves V. Brun, Michael S. VanNieuwenhze, Terry Roemer, Rut Carballido-Lopez, Dirk-Jan Scheffers, Kerwyn Casey Huang, Mariana G. Pinho
Article
Biochemistry & Molecular Biology
Danae Morales Angeles, Yun Liu, Alwin M. Hartman, Marina Borisova, Anabela de Sousa Borges, Niels de Kok, Katrin Beilharz, Jan-Willem Veening, Christoph Mayer, Anna K. H. Hirsch, Dirk-Jan Scheffers
MOLECULAR MICROBIOLOGY
(2017)
Article
Chemistry, Organic
Paul Dockerty, Jerre G. Edens, Menno B. Tol, Danae Morales Angeles, Arnau Domenech, Yun Liu, Anna K. H. Hirsch, Jan-Willem Veening, Dirk-Jan Scheffers, Martin D. Witte
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Microbiology
Andre S. G. Lorenzoni, Giordanni C. Dantas, Tessa Bergsma, Henrique Ferreira, Dirk-Jan Scheffers
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Microbiology
Abigail Savietto, Carlos Roberto Polaquini, Malgorzata Kopacz, Dirk-Jan Scheffers, Beatriz Carvalho Marques, Luis Octavio Regasini, Henrique Ferreira
ARCHIVES OF MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ewa Krol, Anabela de Sousa Borges, Malgorzata Kopacz, Dirk-Jan Scheffers
Article
Microbiology
Luana G. Morao, Carlos R. Polaquini, Malgorzata Kopacz, Guilherme S. Torrezan, Gabriela M. Ayusso, Guilherme Dilarri, Lucia B. Cavalca, Aleksandra Zielinska, Dirk-Jan Scheffers, Luis O. Regasini, Henrique Ferreira
Article
Microbiology
Malgorzata M. Kopacz, Andre S. G. Lorenzoni, Carlos R. Polaquini, Luis O. Regasini, Dirk-Jan Scheffers
Article
Microbiology
Danae Morales Angeles, Alicia Macia-Valero, Laura C. Bohorquez, Dirk-Jan Scheffers
Article
Biotechnology & Applied Microbiology
Zhibo Li, Reinder H. de Vries, Parichita Chakraborty, Chunxu Song, Xinghong Zhao, Dirk-Jan Scheffers, Gerard Roelfes, Oscar P. Kuipers
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Luana G. Morao, Andre S. G. Lorenzoni, Parichita Chakraborty, Gabriela M. Ayusso, Lucia B. Cavalca, Mariana B. Santos, Beatriz C. Marques, Guilherme Dilarri, Caio Zamuner, Luis O. Regasini, Henrique Ferreira, Dirk-Jan Scheffers
Article
Biochemistry & Molecular Biology
Lucia Bonci Cavalca, Ciaran W. Lahive, Fleur Gijsbers, Fernando Rogerio Pavan, Dirk-Jan Scheffers, Peter J. Deuss
Summary: Researchers have successfully synthesized a series of alkyl ethers with antibacterial activity and demonstrated their bactericidal effects against X. citri, the causative agent of citrus canker. These compounds also showed low toxicity to human cells, indicating their potential as alternative treatments in citrus orchards.
Article
Chemistry, Medicinal
Parichita Chakraborty, Dorenda Oosterhuis, Riccardo Bonsignore, Angela Casini, Peter Olinga, Dirk-Jan Scheffers
Summary: The study assessed the antibacterial activity of seven gold complexes, with one showing effective activity against Gram-positive bacteria. Mechanism of action studies revealed no induction of oxidative stress or cell membrane damage, with certain genes related to metal transport and homeostasis being upregulated. Toxicity tests on mouse tissue slices showed low toxicity, suggesting the organogold compound may be a potential antibacterial drug candidate.
