期刊
JOURNAL OF APPLIED ORAL SCIENCE
卷 19, 期 2, 页码 125-129出版社
UNIV SAO PAULO FAC ODONTOLOGIA BAURU
DOI: 10.1590/S1678-77572011000200008
关键词
Genes; homeobox. Carcinoma; squamous cell. Gene expression. RT-PCR; neoplasm staging
资金
- FAPESP [2001/13644-6]
- CAPES
Human HOX genes encode transcription factors that act as master regulators of embryonic development. They are important in several processes such as cellular morphogenesis and differentiation. The HOXB5 gene in particular has been reported in some types of neoplasm, but not in oral cancer. Objective: The present study investigated the expression of HOXB5 in oral squamous cell carcinoma (SCC) and in non-tumoral adjacent tissues, focusing on verifying its possible role as a broad tumor-associated gene and its association with histopathological and clinical (TNM) characteristics. Material and Methods: RT-PCR was performed to amplify HOXB5 mRNA in 15 OSCCs and adjacent non-tumoral epithelium. A possible association with TNM and histopathologic data was verified by the chi-square and post-hoc t-test. Results: HOXB5 was amplified in 60% non-tumoral epithelium and in 93.3% carcinomas. No statistically significant differences were found regarding the HOXB5 mRNA expression and TNM or histological grade. Conclusion: HOXB5 is expressed in OSCCs and its role in cancer progression should be further investigated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据