Article
Multidisciplinary Sciences
Nader S. Abutaleb, Ahmed E. M. Elhassanny, Daniel P. Flaherty, Mohamed N. Seleem
Summary: Dorzolamide demonstrates potent activity against clinical VRE isolates and shows synergistic and additive interactions with gentamicin. In an in vivo mouse model, dorzolamide outperforms linezolid in reducing VRE colonization, suggesting it as a promising treatment option for VRE infections.
Article
Public, Environmental & Occupational Health
Jens Thomsen, Najiba M. Abdulrazzak, Hussain AlRand, Godfred Antony Menezes, Carole A. Moubareck, Dean B. Everett, Abiola Senok, Andreas Podbielski
Summary: Enterococci are causing concern due to their increasing resistance to antibiotics in the Middle East and North Africa region, and there is a lack of AMR surveillance data for enterococci in this area.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
He-Ning Wu, Er-Yan Yuan, Wen-Bin Li, Min Peng, Qing-Yu Zhang, Ke-liang Xie
Summary: This study retrospectively analyzed the microbiological and clinical data of bloodstream infection (BSI) patients in an ICU in Tianjin, China. The results showed that Gram-negative bacteria had the highest drug resistance rate and resulted in more severe brain damage, renal function damage, and thrombocytopenia. The test index of procalcitonin (PCT) could be used to distinguish Gram-negative bacteremia from Gram-positive and differentiate bacteremia from fungemia, but further research is needed.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Nader S. Abutaleb, Ahmed Elkashif, Daniel P. Flaherty, Mohamed N. Seleem
Summary: Acetazolamide showed promising inhibitory effects against enterococci and outperformed linezolid in VRE mouse models, suggesting it as a potential treatment option for VRE infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Public, Environmental & Occupational Health
Veronica Weterings, Anita van Oosten, Ellen Nieuwkoop, Jolande Nelson, Andreas Voss, Bas Wintermans, Joris van Lieshout, Jan Kluytmans, Jacobien Veenemans
Summary: A hospital in the Netherlands experienced an outbreak of vancomycin-resistant Enterococcus faecium from December 2014 to February 2017. A control strategy was implemented, involving targeted screening and isolation, periodic hospital-wide point prevalence screening, measures to improve compliance with standard infection control precautions, and enhanced environmental cleaning. This strategy successfully controlled the outbreak within nine months, with a reduction in isolation days and cultures taken.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Biology
Kristyna Hricova, Magdalena Roderova, Petr Frycak, Volodymyr Pauk, Ondrej Kurka, Kristyna Mezerova, Tatana Stosova, Jan Bardon, David Milde, Pavla Kucova, Milan Kolar
Summary: Residues of multiple antibiotics were found in wastewater, with vancomycin exceeding permitted levels in a small percentage of samples. VRE were detected in wastewater, but did not show a direct correlation with vancomycin concentrations.
Article
Food Science & Technology
Zining Wang, Sihao Liao, Guanwen Huang, Mengyao Feng, Rui Yin, Lin Teng, Chenghao Jia, Yicheng Yao, Min Yue, Yan Li
Summary: This study evaluated the risk of vancomycin-resistant enterococci (VRE) in Chinese infant food production chains and online-marketing infant foods. The study found that infant food production environments may serve as potential reservoirs for VRE infections in vulnerable populations.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Martin Vestergaard, Bolette Skive, Ilona Domraceva, Hanne Ingmer, Henrik Franzyk
Summary: This study identified 11 stable peptide/beta-peptoid hybrids with antibacterial activity against vancomycin-resistant Enterococcus strains, and found three analogues with bactericidal effects through membrane disruption. These findings provide promising starting points for further optimization studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Sachin Tyagi, Rahul Kunwar Singh, Shree Prakash Tiwari
Summary: Enterococci are opportunistic pathogens causing serious infections, with drug resistance worsening the situation. Antienterococcal compounds with antioxidant activity in food may help prevent foodborne infections. The study tested thermophilic cyanobacteria extracts against drug-resistant Enterococcus faecium, showing promising results.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Microbiology
Kendall Kling, Javier Rios, Laura Dirnberger, Wanda Polanco, Kevin Fritz, Michael Malczynski, Teresa Zembower, Chao Qi
Summary: Background Spectra (TM) VRE agar is a chromogenic agar with high sensitivity and specificity for VRE faecium. By optimizing the workflow, dark blue or purple colonies can be used as indicators for VRE faecium, while light blue colonies require additional testing.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2023)
Article
Microbiology
Jorge Enrique Vazquez Bucheli, Joanna Ivy Irorita Fugaban, Wilhelm Heinrich Holzapfel, Svetoslav Dimitrov Todorov
Summary: Antibiotics have been a crucial discovery in medical microbiology, but the rise of antibiotic resistance poses a dangerous threat, driving the demand for new antimicrobials. Bacteriocins, as a type of antimicrobial peptides, can be a potential alternative to conventional antibiotics, especially in controlling resistant pathogens like VRE. The study suggests that bacteriocins show promise in inhibiting VRE strains and could be used as a novel approach to combat antibiotic-resistant infections.
Article
Environmental Sciences
Lara E. Tomenchok, Afeefa A. Abdool-Ghany, Samir M. Elmir, Maribeth L. Gidley, Christopher D. Sinigalliano, Helena M. Solo-Gabriele
Summary: Based on data analysis over the past 20 years, recreational beaches in Miami-Dade County, south Florida, have shown a continuous increase in enterococci levels, with a significant spike during 2015-2019. The investigation found a significant correlation between enterococci levels and Sargassum, while population, air temperature, and sea level also demonstrated strong correlations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Abdiel E. Laureano-Rosario, Erin M. Symonds, Adriana Gonzalez-Fernandez, Omar G. R. Lizano, Darner Mora Alvarado, Pablo Rivera Navarro, Andrei Badilla-Aguilar, Digna Rueda-Roa, Daniel B. Otis, Valerie J. Harwood, Maryann R. Cairns, Frank E. Muller-Karger
Summary: Environmental conditions have a significant impact on fecal indicator bacteria levels at recreational beaches in Costa Rica. Precipitation, sea level anomalies, and wave height were found to be the most frequent factors influencing FIB variability. Multiple linear regression models explained a portion of the variability in fecal coliforms and enterococci, highlighting the importance of further investigations into unexpected interactions with factors like DNI, sea level, and turbidity.
MARINE POLLUTION BULLETIN
(2021)
Article
Infectious Diseases
Beatriz Rizzo Paschoalini, Karen Vanessa Munive Nunez, Juliana Takahashi Maffei, Helio Langoni, Felipe Freitas Guimaraes, Clarice Gebara, Natylane Eufransino Freitas, Marcos Veiga dos Santos, Carlos Eduardo Fidelis, Roberto Kappes, Monica Correia Goncalves, Nathalia Cristina Cirone Silva
Summary: This study evaluates the antimicrobial resistance and virulence characteristics of Enterococcus spp. isolated from bovine milk, showing high resistance in E. faecium and E. faecalis. The findings highlight the potential risks and the need for control strategies in dairy farms.
Article
Immunology
Lynn El Haddad, Blake M. Hanson, Cesar A. Arias, Shashank S. Ghantoji, Cynthia P. Harb, Mark Stibich, Roy F. Chemaly
Summary: The study successfully identified transmission networks of VRE strains between patients and their rooms using whole genome sequencing and phylogenetic analyses. Highly genetically related strains were observed to be transmitted between patients and their rooms in a short period of time. The research found horizontal transmission of highly drug-resistant VRE strains between HCT and LKM patients and their room environments.
CLINICAL INFECTIOUS DISEASES
(2021)