Review
Pharmacology & Pharmacy
Ritama Paul, Jay F. Dorsey, Yi Fan
Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Wookyeom Yang, Dasol Kim, Dae Kyoung Kim, Kyung Un Choi, Dong Soo Suh, Jae Ho Kim
Summary: Ovarian cancer is a fatal gynecological malignancy, and its treatment remains a challenge. Cancer stem cells (CSCs) play a key role in cancer relapse and treatment resistance, with their malignancy regulated by cell surface receptors and intracellular factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Hector Mayani, Antonieta Chavez-Gonzalez, Karla Vazquez-Santillan, Jorge Contreras, Monica L. Guzman
Summary: This review article summarizes the biology of cancer stem cells (CSCs) and their significance in tumor development. CSCs are not only capable of initiating tumor growth, but also drive tumor progression and metastasis, exhibit resistance to cancer drugs, and are responsible for cancer relapse. Therefore, CSCs are attractive targets for the development of more effective oncologic treatments.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Adam E. Hall, Sebastian Other-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Summary: This study identifies dysregulated RNA splicing as a key driver of tumour cell plasticity in colorectal cancer. The splicing factor SRSF1 controls Kras splicing and maintains stemness in CRC cells, and its expression correlates with cancer stem cell markers in human tumours.
NATURE COMMUNICATIONS
(2022)
Review
Cell & Tissue Engineering
Feng Ju, Manar M. Atyah, Nellie Horstmann, Sheraz Gul, Razi Vago, Christiane J. Bruns, Yue Zhao, Qiong-Zhu Dong, Ning Ren
Summary: This review summarizes the latest findings on the morphology, signaling pathways, and interactions of cancer stem cell (CSC) niches, as well as the genetic and epigenetic modulations involved in CSC maintenance. The crosstalk between CSCs and their niche plays a crucial role in therapy resistance and recurrence.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Xiaobin Zeng, Chengxiao Liu, Jie Yao, Haoqiang Wan, Guoqing Wan, Yingpeng Li, Nianhong Chen
Summary: Both hereditary and sporadic breast cancer may stem from a subcomponent of stem cells with dysregulated self-renewal pathways. Cancer stem cells play a crucial role in treatment resistance and tumor initiation, highlighting the importance of therapeutic strategies targeting these cells.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Caitlin Molczyk, Rakesh K. Singh
Summary: Therapy resistance is a concern in treating malignant disease, as evidence suggests that a subset of cancer cells called cancer stem cells (CSCs) promote tumor survival, therapy resistance, and relapse. The inflammatory tumor microenvironment, particularly the CXCR1/2 pathway, plays a crucial role in maintaining the CSC pool. CXCR1 is known for its role as a CSC marker and potential therapeutic target in solid tumors.
Article
Oncology
Huan He, Shaozheng Wang, Wen Zhang, Shanshan Gao, Hua Guan, Pingkun Zhou
Summary: TAB182 plays a role in DNA damage repair and radio-/chemosensitivity regulation in various tumors, but its role in breast cancer, especially triple-negative breast cancer (TNBC), was unclear. This study found that TAB182 expression is lower in TNBC and its knockdown promotes tumor cell proliferation, migration, and invasion. The downregulation of TAB182 leads to enhanced cancer stem-like cell properties and resistance to certain drugs. These findings suggest that TAB182 may serve as a tumor suppressor gene and has potential therapeutic implications for TNBC patients.
Review
Oncology
Wen Jess Li, Xiaozhuo Liu, Emily M. Dougherty, Dean G. Tang
Summary: The article reviews the tumor suppressive role of miRNA-34a in prostate cancer and discusses therapeutic development strategies for advanced prostate cancer patients.
Article
Biochemistry & Molecular Biology
Satya Prakash Shukla, Aaron Raymond, Vineeta Rustagi, Samanth R. Kedika, Olivia Tran, Liye Wang, Bin Guo, D. Gomika Udugamasooriya
Summary: The study identified a highly specific peptidomimetic PCS2D1.2 that displayed highly specific cytotoxicity towards CSCs, effectively blocking colony formation and cell migration of CSCs without affecting non-CSCs. Furthermore, PCS2D1.2 reduced plectin expression and/or plectin-rich CSCs in both in vitro and in vivo studies, showing potential as a highly CSC specific drug candidate for combination therapy with current anti-cancer drugs.
BIOORGANIC CHEMISTRY
(2021)
Review
Clinical Neurology
Sheila Alcantara Llaguno, Luis F. Parada
Summary: Recent studies have revealed the complexity of glioma cancer stem cells (CSCs), including developmental origins, plasticity, cellular states, and interactions with the microenvironment. These cells exhibit diverse transcriptional cellular states, susceptible to transitions, playing important roles in treatment resistance and immune evasion.
CURRENT OPINION IN NEUROLOGY
(2021)
Review
Oncology
Matthew S. Gillespie, Ciara M. Ward, Clare C. Davies
Summary: Cancer stem cells (CSCs) play a crucial role in cancer development, progression, metastasis, and relapse. They are highly drug resistant due to enhanced DNA repair efficiency. This review discusses the mechanisms of CSC drug resistance and strategies for targeting the DNA damage response to improve cancer treatment efficacy.
Article
Oncology
Zhihui Weng, Jiacheng Lin, Jiaozi He, Lin Gao, Sien Lin, Lai Ling Tsang, Hang Zhang, Xiaoyan He, Guang Wang, Xuesong Yang, Hu Zhou, Hui Zhao, Gang Li, Lin Zou, Xiaohua Jiang
Summary: The study found that MYCN regulates the expression of CD55 gene, and high expression of CD55 is associated with poor prognosis in MYCN-amplified neuroblastoma. CD55 promotes tumor growth and cancer stemness through the regulation of the JNK pathway. Targeting CD55 with neutralizing antibodies effectively inhibits tumor growth and improves survival.
Review
Cell Biology
Nan Jing, Wei-Qiang Gao, Yu-Xiang Fang
Summary: Cancer stem cells have been proposed as key players in tumorigenesis and progression, regulated by genetic and epigenetic factors and influenced by the tumor microenvironment. Therapeutic strategies targeting CSCs involve regulating key factors in formation, stemness maintenance, and therapeutic resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Psychiatry
Pawel Karpinski, Jerzy Samochowiec, Maria M. Sasiadek, Lukasz Laczmanski, Blazej Misiak
SCHIZOPHRENIA RESEARCH
(2020)
Article
Medicine, General & Internal
Robert Smigiel, Mateusz Biela, Krzysztof Szmyd, Michal Bloch, Elzbieta Szmida, Pawel Skiba, Anna Walczak, Piotr Gasperowicz, Joanna Kosinska, Malgorzata Rydzanicz, Piotr Stawinski, Anna Biernacka, Marzena Zielinska, Waldemar Golebiowski, Agnieszka Jalowska, Grazyna Ohia, Bozena Glowska, Wojciech Walas, Barbara Krolak-Olejnik, Pawel Krajewski, Jolanta Sykut-Cegielska, Maria M. Sasiadek, Rafal Ploski
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Genetics & Heredity
Ryszard Slezak, Robert Smigiel, Malgorzata Rydzanicz, Agnieszka Pollak, Joanna Kosinska, Piotr Stawinski, Maria Malgorzata Sasiadek, Rafal Ploski
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Oncology
Izabela Laczmanska, Lukasz Laczmanski, Maria M. Sasiadek
ANTICANCER RESEARCH
(2020)
Article
Oncology
Agata Pastorczak, Anna Hogendorf, Zuzanna Urbanska, Edyta Budzynska, Dorota Jesionek-Kupnicka, Agnieszka Gach, Wanda Hawula, Robert Smigiel, Pawel Skiba, Maria Sasiadek, Monika Lejman, Maria Constatinou, Beata S. Lipska-Zietkiewicz, Wojciech Mlynarski
Summary: Microdeletions of 7p12.1 encompassing the IKZF1 gene locus are rare, with a potential link to childhood acute lymphoblastic leukemia (ALL). Among 4581 Polish individuals, two cases of 7p12.1 deletion were identified, with one individual developing ALL.
GENES CHROMOSOMES & CANCER
(2021)
Review
Biochemistry & Molecular Biology
Stanislaw Supplitt, Pawel Karpinski, Maria Sasiadek, Izabela Laczmanska
Summary: Transcriptome profiling has emerged as a powerful approach in oncology, providing prognostic and predictive utility for cancer management. It enables the identification of cancer biomarkers, gene signatures, and molecular targets for anticancer therapies, contributing to a change in the holistic understanding of cancer from histopathological to molecular classifications. Further advancements in transcriptome profiling may lead to standardization and cost reduction of its analysis, making it a canon of contemporary cancer medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dominika Wokolorczyk, Wojciech Kluzniak, Klaudia Stempa, Bogna Rusak, Tomasz Huzarski, Jacek Gronwald, Katarzyna Gliniewicz, Aniruddh Kashyap, Sylwia Morawska, Tadeusz Debniak, Anna Jakubowska, Marek Szwiec, Pawel Domagala, Jan Lubinski, Steven A. Narod, Mohammad R. Akbari, Cezary Cybulski
Summary: In Poland, PALB2 mutations predispose individuals to an aggressive and lethal form of prostate cancer, with carriers having significantly lower survival rates.
BRITISH JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Magdalena Klaniewska, Maria Jedrzejowska, Malgorzata Rydzanicz, Justyna Paprocka, Mateusz Biela, Ewelina Wolanska, Agnieszka Pollak, Emilia Debek, Maria Sasiadek, Rafal Ploski, Monika Gos, Robert Smigiel
Summary: PIEZO2 protein is involved in mechanotransduction pathways and its loss-of-function variants are associated with DAIPT. Exome sequencing identified 6 new PIEZO2 variants in three DAIPT patients, one of whom is the youngest diagnosed child to date, presenting with typical symptoms and severe motor development delay.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Witold Jozef Swiatowy, Hanna Drzewiecka, Michalina Kliber, Maria Sasiadek, Pawel Karpinski, Andrzej Plawski, Pawel Piotr Jagodzinski
Summary: Physical activity influences human physiology through changes in gene expression and chromatin structure. DNA methylation, an important epigenetic modification, plays a key role in regulating gene transcription and expression in response to exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Karpinski Pawel, Sasiadek Maria Malgorzata
Summary: The CpG island methylator phenotype (CIMP) is an important manifestation of epigenetic instability in cancer. It has been extensively studied in various tumor types, but its use as a diagnostic marker and therapeutic target in solid tumors is limited by the lack of generalizability and reproducibility of epigenetic markers, as well as its poor predictive value in clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tomasz P. Lehmann, Urszula Guderska, Klaudia Kalek, Maria Marzec, Agnieszka Urbanek, Alicja Czernikiewicz, Maria Sasiadek, Pawel Karpinski, Andrzej Plawski, Maciej Glowacki, Pawel P. Jagodzinski
Summary: This article describes recent examples of miRNA regulation in the gene expression involved in bone matrix construction. The study shows that miRNA has a significant impact on collagen formation and mineralisation. The review reveals the tissue variability of miRNA regulation in collagen maturation and mineralisation processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Madej Malgorzata, Sasiadek Maria, Witt Michal
Summary: Direct-to-consumer tests offer individuals the opportunity to access genetic information freely without medical supervision, but they also carry the risk of false results and potential negative health and psychological consequences. European countries and organizations have implemented legal frameworks to regulate the DTC market, focusing on principles such as patient protection, informed consent, and medical information confidentiality.
JOURNAL OF APPLIED GENETICS
(2022)
Article
Obstetrics & Gynecology
Piotr Sieroszewski, Olga Haus, Mariusz Zimmer, Miroslaw Wielgos, Anna Latos-Bielenska, Maciej Borowiec, Dariusz Borowski, Wojciech Cnota, Bartosz Czuba, Mariusz Dubiel, Lucjusz Jakubowski, Katarzyna Janiak, Piotr Kaczmarek, Sebastian Kwiatkowski, Beata Nowakowska, Marek Pietryga, Krzysztof Piotrowski, Krzysztof Preis, Mariola Ropacka-Lesiak, Maria M. Sasiadek, Malgorzata Swiatkowska-Freud, Piotr Wegrzyn, Agata Wloch, Hanna Moczulska
GINEKOLOGIA POLSKA
(2022)
Article
Genetics & Heredity
Katarzyna Kowalczyk, Magdalena Bartnik-Glaska, Marta Smyk, Izabela Plaskota, Joanna Bernaciak, Marta Kedzior, Barbara Wisniowiecka-Kowalnik, Marta Deperas, Justyna Domaradzka, Alicja Luszczek, Daria Dutkiewicz, Agata Kozar, Dominika Grad, Magdalena Niemiec, Kamila Ziemkiewicz, Roza Magdziak, Natalia Braun-Walicka, Artur Barczyk, Maciej Geremek, Jennifer Castaneda, Anna Kutkowska-Kazmierczak, Pawel Wlasienko, Krystyna Jakubow-Durska, Marzena Debska, Anna Kucinska-Chahwan, Szymon Kozlowski, Boyana Mikulska, Tadeusz Issat, Tomasz Roszkowski, Agnieszka Nawara-Baran, Agata Runge, Anna Jakubiuk-Tomaszuk, Anna Kruczek, Ewa Kostyk, Grzegorz Pietras, Janusz Limon, Jerzy Zwolinski, Karolina Ochman, Tomasz Szajner, Piotr Wegrzyn, Miroslaw Wielgos, Maria Sasiadek, Ewa Obersztyn, Beata Anna Nowakowska
Summary: The aim of this study was to determine the suitability of the aCGH technique for prenatal diagnosis and assess the frequency of chromosomal aberrations not included in the diagnostic report. The study included 7400 prenatal cases and found a 27.2% chromosomal aberration detection rate, with 71.2% being numerical aberrations and 28.8% being structural aberrations. Clinically significant CNVs were detected in 6.8% of cases, and variants of unknown clinical significance were found in 0.7% of cases. The detection rate of clinically significant submicroscopic CNVs varied among different indications for invasive testing.
Review
Medicine, General & Internal
Malgorzata Madej, Pawel Karpinski, Hayane Akopyan, Michal Witt, Maria M. Sasiadek
Summary: The progress in molecular biology has changed our understanding of human diseases. Whole genome analyses have allowed for the identification of unknown diseases. Molecular diagnosis is replacing clinical diagnosis in difficult cases. Construction and sharing of large databases are crucial for genetic research and clinical characteristics of rare diseases. Legal and ethical issues surrounding genetic testing and personal data protection must be addressed. This paper explores the benefits and risks of international sharing of genetic databases and discusses legal provisions in the EU, US, and China.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
