Article
Infectious Diseases
Qian Liu, Sanwang Li, Feifan Xie
Summary: This study aimed to provide a population PK analysis of linezolid in patients undergoing renal replacement therapy (RRT), and evaluate the target attainment of linezolid standard dosing. The results showed that standard linezolid dosing is adequate for anuric RRT patients with MIC <= 2 mg/L. The probability of target attainment was low for RRT patients with preserved renal function.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Gina Patel, Keith A. Rodvold, Vipul K. Gupta, Jon Bruss, Leanne Gasink, Floni Bajraktari, Yang Lei, Akash Jain, Praveen Srivastava, Angela K. Talley
Summary: This study evaluated the safety, tolerability, and pharmacokinetics of Tebipenem pivoxil hydrobromide (TBP-PI-HBr) in healthy subjects and patients with renal impairment. The results showed that TBP-PI-HBr had higher plasma exposure in patients with renal impairment, highlighting the importance of the renal route in TBP elimination. Dose adjustment may be needed for patients with renal impairment. Overall, TBP-PI-HBr was well tolerated in different cohorts.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Xiangru Luo, Shiyi Wang, Dong Li, Jun Wen, Na Sun, Guangjun Fan
Summary: The study aimed to develop a pharmacokinetic model for tigecycline in critically ill patients and optimize dosing regimens. Results showed that APACHEII score and age significantly influenced the drug's clearance and distribution volume. The standard dose regimen often failed to achieve satisfactory therapeutic effects for critically ill patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Mohammad H. Al-Shaer, Carolyn D. Philpott, Christopher A. Droege, Joshua D. Courter, Daniel P. Healy, Molly E. Droege, Neil E. Ernst, Eric W. Mueller, Charles A. Peloquin
Summary: Sepsis contributes to 50% of acute kidney injuries in the ICU, often requiring CRRT which impacts antimicrobial exposure. A cefepime PK model was built for CRRT ICU patients, showing good target attainment with intermittent infusion regimens at MICs <= 8 mg/l and extended infusion at MICs of 16 mg/l. This regimen may be considered for resistant bacterial infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Medicinal
Sha He, Zeneng Cheng, Feifan Xie
Summary: This study developed a population pharmacokinetic (PK) model of gentamicin in continuous renal replacement therapy (CRRT) patients, and inferred the optimal dosing regimen for gentamicin. The results indicated that a combination of 7 mg/kg gentamicin q24h and 40 mL/kg/h CRRT dose might be considered as a starting treatment option for CRRT patients, and drug monitoring is required to manage toxicity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Infectious Diseases
Wanlika Yonwises, Noppadol Wacharachaisurapol, Suvaporn Anugulruengkitt, Passara Maimongkol, Wanchai Treyaprasert
Summary: By conducting a prospective study on 35 patients, population pharmacokinetic parameters of meropenem were determined, with factors such as weight and creatinine clearance influencing its clearance and volume of distribution. Model evaluation results indicated the robustness and good predictability of the final model.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Sebastian G. Wicha, Andrea Mair, Ute Chiriac, Otto R. Frey, Thomas Fuchs, Max Gaasch, Stefan Hagel, Daniel C. Richter, Jason A. Roberts, Anka C. Roehr, Markus A. Weigand, Alexander Brinkmann
Summary: This study described the pharmacokinetic characteristics of continuous infusion of linezolid in critically ill patients and established the relationship between linezolid exposure and platelet count over time. It suggested that optimizing linezolid dosing based on creatinine clearance and body weight can maximize therapeutic exposures and that therapeutic drug monitoring may be necessary due to high variability in individual doses.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Pharmacology & Pharmacy
Lingling Ye, Xiang You, Jie Zhou, Chaohui Wu, Meng Ke, Wanhong Wu, Pinfang Huang, Cuihong Lin
Summary: A PBPK model was used to assess the pharmacokinetics of daptomycin in children with renal impairment, showing increased exposure levels in children with varying degrees of renal impairment, indicating the need for further dose adjustments of daptomycin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Mei Yang, Libo Zhao, Xiaohui Wang, Chen Sun, Hengmiao Gao, Xiaoling Wang, Suyun Qian
Summary: This study evaluated the population pharmacokinetic properties of linezolid in critically ill children and established an optimal dosage regimen based on developmental PopPK/PD model and simulation. Factors such as body weight and AST levels were found to significantly affect the variability in linezolid pharmacokinetics in the pediatric population. Dosage adjustment according to AST levels was deemed necessary for treatment success.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Yaru Peng, Zeneng Cheng, Feifan Xie
Summary: This study aimed to investigate the optimal dosing regimen for meropenem in critically ill patients undergoing continuous renal replacement therapy (CRRT) through a population PK/PD meta-analysis. The results suggested that in non-trauma patients, the regimens of 1 g every 6 h infused over 30 min, 1 g every 8 h infused over 3 h, and 2 to 4 g every 24 h infused over 24 h could achieve adequate efficacy and low risk of toxicity. For trauma patients with MICs of <= 0.5 mg/L, continuous infusion of 3 to 4 g every 24 h was suitable.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Xu-ben Yu, Xiao-Shan Zhang, Ye-Xuan Wang, Yu-Zhen Wang, Hong-Min Zhou, Fang-Min Xu, Jun-Hui Yu, Li-Wen Zhang, Ying Dai, Zi-Ye Zhou, Chun-Hong Zhang, Guan-Yang Lin, Jing-Ye Pan
Summary: Colistin sulfate was effective in treating carbapenem-resistant organism infections, with clinical treatment success achieved in 59.52% of patients and successful bacteria elimination in 69.06% of patients. Pharmacokinetic modeling showed that renal function significantly affects colistin sulfate clearance, with a recommended dose regimen calculated for various MIC values. Monte Carlo simulations indicated the need to adjust dosage for patients based on renal function to avoid subtherapeutic exposure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Teresa Garcia-Martinez, Maria Dolores Belles-Medall, Maria Garcia-Cremades, Raul Ferrando-Piqueres, Victor Mangas-Sanjuan, Matilde Merino-Sanjuan
Summary: This study aimed to develop a population pharmacokinetic/pharmacodynamic model of daptomycin and establish optimal dose recommendations in patients with normal and impaired renal function. The results indicate that bactericidal effects for Gram+ strains can be achieved with specific daily doses based on body weight and renal function. By evaluating the impact of different dosing regimens on treatment outcomes, the study provides insights for optimizing the use of daptomycin.
Article
Infectious Diseases
Noemie de Cacqueray, Deborah Hirt, Yi Zheng, Emmanuelle Bille, Pierre Louis Leger, Jerome Rambaud, Julie Toubiana, Anais Chosidow, Sophie Vimont, Delphine Callot, Laurent Chouchana, Agathe Beranger, Jean Marc Treluyer, Sihem Benaboud, Mehdi Oualha
Summary: The study aimed to build a population pharmacokinetic (PK) model for cefepime in critically ill children and optimize individual initial dosing regimens. The results showed that body weight and estimated glomerular filtration rate were associated with drug clearance. According to the simulations, continuous intravenous infusion of cefepime was more likely to achieve the PK target in patients with renal failure, while intermittent intravenous infusion was adequate for patients with normal or augmented renal clearance. Close therapeutic drug monitoring is necessary for cefepime treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Chemistry, Medicinal
Yifan Wang, Fen Yao, Shenglong Chen, Xin Ouyang, Jinhua Lan, Zheng Wu, Yirong Wang, Jingchun Chen, Xipei Wang, Chunbo Chen
Summary: This study aimed to develop a population pharmacokinetic model for teicoplanin concentrations in ICU patients and provide detailed dosing regimens using Monte Carlo simulations. The two-compartment model adequately described the concentration-time data. The simulations showed that the standard dosage regimen was only sufficient for patients with severe renal dysfunction (eGFR ≤ 30 mL/min/1.73 m²). Increasing dose and adjusting the administration times of loading doses were preferred options for achieving target concentrations based on renal function and infection type.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Danhong Liang, Zhi Liang, Guoliang Deng, Anfen Cen, Dandan Luo, Chen Zhang, Suiqin Ni
Summary: The use of Polymyxin B is increasing due to the global spread of multidrug-resistant gram-negative bacteria. However, unsatisfactory therapeutic effects have been observed in critically ill patients. This study aims to determine the pharmacokinetic characteristics of polymyxin B, identify influencing factors, and optimize dosing regimens for clinical effectiveness.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Niccolo Buetti, Olivier Mimoz, Leonard Mermel, Stephane Ruckly, Nicolas Mongardon, Claire Dupuis, Jean-Paul Mira, Jean-Christophe Lucet, Bruno Megarbane, Sebastien Bailly, Jean-Jacques Parienti, Jean-Francois Timsit
Summary: Analysis of nearly 5000 patients revealed that using ultrasound guidance for catheter insertion is associated with increased risk of infection, especially in jugular and femoral veins.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Sigismond Lasocki, Thibault Loupec, Elsa Parot-Schinkel, Bruno Vielle, Marc Danguy des Deserts, Antoine Roquilly, Maria Lahlou-Casulli, Vincent Collange, Olivier Desebbe, Alexis Duchalais, Bertrand Drugeon, Pierre Bouzat, Delphine Garrigue, Benjamin Mounet, Franck Hamard, Jean-Stephane David, Maxime Leger, Emmanuel Rineau
Summary: The HiFIT trial is evaluating the impact of iron and TXA on transfusion rates in hip fracture patients.
Article
Critical Care Medicine
Simon Poignant, Bernard Vigue, Patricia Balram, Mathieu Biais, Romain Carillon, Vincent Cottenceau, Claire Dahyot-Fizelier, Vincent Degos, Thomas Geeraerts, Patrick Jeanjean, Emmanuel Vega, Sigismond Lasocki, Fabien Espitalier, Marc Laffon
Summary: In French ICUs, midazolam and sufentanil are often used for sedation/analgesia in patients with brain injury, instead of alternative drugs. The use of cerebral monitoring devices is insufficient, although efforts should be made to emphasize the use of multiple monitoring modes and adherence to indications for sedation to improve care for these patients. Nursing use of sedation and pain scales could help reduce the dosages of midazolam and sufentanil administered in management of patients with brain injury.
NEUROCRITICAL CARE
(2022)
Article
Microbiology
N. Layios, C. Visee, V Mistretta, R. Denooz, N. Maes, J. Descy, F. Frippiat, S. Marchand, N. Gregoire
Summary: This article describes the population pharmacokinetics of temocillin administered via continuous infusion versus intermittent infusion in critically ill patients with pneumonia. The study also examines the penetration ratios of the drug in the epithelial lining fluid/plasma and determines the probability of achieving target concentrations for a range of MICs. The results show that continuous infusion provides better PK/PD indexes but still falls below recommended doses for systemic infections, unless the patient has moderate renal impairment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Grace Akrong, Alexia Chauzy, Vincent Aranzana-Climent, Mathilde Lacroix, Luc Deroche, Laure Prouvensier, Julien M. Buyck, William Couet, Sandrine Marchand
Summary: The inoculum effect of Acinetobacter baumannii on polymyxin B activity was evaluated and a PKPD model was developed to capture this phenomenon. The results showed that polymyxin B displayed reduced activity with increasing starting inoculum. However, there were no significant effects on the studied genes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Critical Care Medicine
Jean-Pierre Gangneux, Eric Dannaoui, Arnaud Fekkar, Charles-Edouard Luyt, Francoise Botterel, Nicolas De Prost, Jean-Marc Tadie, Florian Reizine, Sandrine Houze, Jean-Francois Timsit, Xavier Iriart, Beatrice Riu-Poulenc, Boualem Sendid, Saad Nseir, Florence Persat, Florent Wallet, Patrice Le Pape, Emmanuel Canet, Ana Novara, Melek Manai, Estelle Cateau, Arnaud W. Thille, Sophie Brun, Yves Cohen, Alexandre Alanio, Bruno Megarbane, Muriel Cornet, Nicolas Terzi, Lionel Lamhaut, Estelle Sabourin, Guillaume Desoubeaux, Stephan Ehrmann, Christophe Hennequin, Guillaume Voiriot, Gilles Nevez, Cecile Aubron, Valerie Letscher-Bru, Ferhat Meziani, Marion Blaize, Julien Mayaux, Antoine Monsel, Frederique Boquel, Florence Robert-Gangneux, Yves Le Tulzo, Philippe Seguin, Helene Guegan, Brice Autier, Matthieu Lesouhaitier, Romain Pelletier, Sorya Belaz, Christine Bonnal, Antoine Berry, Jordan Leroy, Nadine Francois, Jean-Christophe Richard, Sylvie Paulus, Laurent Argaud, Damien Dupont, Jean Menotti, Florent Morio, Marie Soulie, Carole Schwebel, Cecile Garnaud, Juliette Guitard, Solene Le Gal, Dorothee Quinio, Jeff Morcet, Bruno Laviolle, Jean-Ralph Zahar, Marie-Elisabeth Bougnoux
Summary: This study demonstrates a high prevalence of invasive pulmonary aspergillosis and candidemia in mechanically ventilated patients with severe COVID-19, and a high mortality associated with pr/pb CAPA. These findings highlight the importance of active surveillance for fungal pathogens in patients with severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2022)
Review
Cell Biology
Elise Lelou, Anne Corlu, Nicolas Nesseler, Claudine Rauch, Yannick Malledant, Philippe Seguin, Caroline Aninat
Summary: In recent years, there has been an increasing number of research publications on the role of catecholamines in liver diseases. However, the mechanisms behind these effects are not well understood. This review focuses on the interaction between the liver and catecholamines, the expression of adrenergic and dopaminergic receptors in liver cells, and the involvement of catecholamines in physiological and pathophysiological processes. The importance of understanding these mechanisms for potential therapeutic use of adrenergic and dopaminergic antagonists is highlighted.
Editorial Material
Anesthesiology
Olivier Collange, Nicolas Mongardon, Bernard Allaouchiche, Jordi Miatello, Belaid Bouhemad, Pierre Trouiller, Benjamin Chousterman, Yoann Launey, Nicolas Mayeur, Emmanuel Besnier, Jean-Michel Constantin, Olivier Langeron, Vincent Degos, Enora Atchade, Roland Amathieu, Jerome Morel, Fanny Bounes, Claire Dahyot-Fizelier
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Infectious Diseases
Manon Prat, Jeremy Guenezan, Bertrand Drugeon, Christophe Burucoa, Olivier Mimoz, Maxime Pichon
Summary: This study aimed to compare the effects of different antiseptic procedures and medical device types on skin bacterial communities. The results showed that antiseptic procedures and PVC types can alter the representation of specific bacteria and are associated with changes in metabolic pathways. This study highlights the importance of optimizing the management of patients with invasive medical devices.
Article
Infectious Diseases
Aart van der Meijden, Vincent Aranzana-Climent, Heleen van der Spek, Brenda C. M. de Winter, William Couet, Joseph Meletiadis, Anouk E. Muller, Sanne van den Berg
Summary: In this study, the pharmacokinetics and pharmacodynamics of polymyxin B were determined in neutropenic infected mice. The fAUC/MIC index was found to best describe the drug’s effectiveness. However, the standard dosing regimen did not achieve the PK/PD targets for the majority of clinical isolates, suggesting that polymyxin B may be ineffective as monotherapy for serious infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Anesthesiology
Herve Quintard, Vincent Degos, Mikael Mazighi, Jerome Berge, Pierre Boussemart, Russel Chabanne, Samy Figueiredo, Thomas Geeraerts, Yoann Launey, Ludovic Meuret, Jean -Marc Olivot, Julien Pottecher, Francesca Rapido, Sebastien Richard, Suzana Saleme, Virginie Siguret-Depasse, Olivier Naggara, Hugues De Courson, Marc Garnier
Summary: The purpose of this article is to provide recommendations for the anaesthetic and peri-operative management for thrombectomy procedure in stroke patients. A consensus committee of experts formulated 18 professional practice recommendations based on the analysis of literature and using the GRADE methodology. These recommendations aim to optimize the anaesthetic management for thrombectomy in patients suffering from stroke and were agreed upon by experts.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Article
Microbiology
Romain Aubry, Julien Buyck, Laure Prouvensier, Jean-Winoc Decousser, Patrice Nordmann, Sebastian G. Wicha, Sandrine Marchand, Nicolas Gregoire
Summary: The study characterized the pharmacodynamic interaction over time between ceftazidime/avibactam and colistin against multidrug-resistant Klebsiella pneumoniae. While synergy or antagonism were observed under specific conditions, overall an additive interaction was found between the antibiotics. Simulations indicated that the combination at clinical concentrations should prevent the emergence of resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Computer Science, Software Engineering
Justine Saint-Aubert, Melanie Cogne, Isabelle Bonan, Yoann Launey, Anatole Lecuyer
Summary: This paper shows that the impression of walking in Virtual Reality (VR) can be extended to other postures and locomotion exercises. Two user studies were conducted with participants wearing a VR headset and observed a first-person avatar performing virtual exercises. The results indicate that participants experienced the impression of locomotion regardless of their posture, but a specific posture significantly affected their embodiment and perception of locomotion.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)
Article
Computer Science, Software Engineering
Justine Saint-Aubert, Julien Manson, Isabelle Bonan, Yoann Launey, Anatole Lecuyer, Melanie Cogne
Summary: This study investigates how underfoot vibrotactile feedback can enhance the impression of walking and embodiment in static users. The results show that both constant and phase-based vibrotactile rendering significantly improve the walking impression in both first and third-person perspectives. Interestingly, phase-based rendering has a greater impact on the walking impression in the third-person perspective. Furthermore, receiving vibrotactile feedback improves embodiment in both perspectives of the avatar.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)