Article
Microbiology
Ravalona Jessica Zemtsa, Michel Noubom, Luria Leslie Founou, Brice Davy Dimani, Patrice Landry Koudoum, Aurelia Djeumako Mbossi, Charles Kouanfack, Raspail Carrel Founou
Summary: This study investigated the prevalence and characteristics of multidrug-resistant Enterobacterales (MDR-E) and extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) in women living with HIV in Cameroon. The results showed a high prevalence of MDR-E and ESBL-PE in these women, with resistance observed against commonly used antibiotics. The study highlights the need for a monitoring system for antimicrobial resistant bacteria and strengthened infection prevention control strategies.
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Review
Medicine, General & Internal
Herve Boutal, Christian Moguet, Lilas Pommies, Stephanie Simon, Thierry Naas, Herve Volland
Summary: The global spread of antimicrobial resistant bacteria poses a significant public health concern. Detecting and identifying resistance mechanisms is challenging, but lateral flow assays (LFA) have emerged as cost-effective and rapid tools to combat antimicrobial resistance. This review examines the versatility and performance of LFA for detecting antimicrobial resistance, focusing on beta-lactamase triggers. It also discusses potential modifications to broaden clinical sensitivity and improve sample handling processes. Additionally, the use of LFA in detecting amplified genetic determinants of antimicrobial resistance is explored.
Article
Environmental Sciences
Didrik H. Grevskott, Fatemeh Z. Ghavidel, Cecilie S. Svanevik, Nachiket P. Marathe
Summary: This study analyzed antibiotic resistance profiles and diversity of beta-lactamases in Escherichia coli from city sewage surveillance, identifying clinically important antibiotic resistance genes, various sequence types, and isolates carrying multiple virulence factors. The findings suggest potential health concerns and highlight the need for population-based surveillance of antibiotic resistance.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Microbiology
Delia Gambino, Valeria Gargano, Gaspare Butera, Sonia Sciortino, Mariangela Pizzo, Giuseppa Oliveri, Cinzia Cardamone, Chiara Piraino, Giovanni Cassata, Domenico Vicari, Antonella Costa
Summary: The study focused on antibiotic susceptibility profiles and ESBL production of Salmonella spp. strains, revealing the presence of MDR strains and ESBL producers, posing potential risks in food safety. Further research on antibiotic resistance genes in foodborne strains, especially from a One Health perspective, is warranted.
Article
Infectious Diseases
Brice Davy Dimani, Raspail Carrel Founou, Jessica Ravalona Zemtsa, Aurelia Mbossi, Patrice Landry Koudoum, Luria Leslie Founou, Charles Kouanfack, Lucien Honore Etame Sone
Summary: This study reveals the prevalence and resistance characteristics of multidrug-resistant Enterobacterales (MDR-E) and extended-spectrum β-lactamase-producing Enterobacterales (ESBL-PE) in the gut of people living with HIV in Yaounde, Cameroon. The study highlights the need for real-time surveillance of these resistant bacteria to improve infection management among people living with HIV.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Microbiology
Marita Vedovelli Cardozo, Apostolos Liakopoulos, Michael Brouwer, Arie Kant, Lucas Jose Luduverio Pizauro, Mariana Monezi Borzi, Dik Mevius, Fernando Antonio de Avila
Summary: This study in Sao Paolo, Brazil, investigated the phylogenetic diversity and epidemiology of ESBL-producing E. coli and K. pneumoniae from chicken, chicken meat, and human clinical isolates. The ESBL genes were characterized and their location determined on plasmids. The study found genetic diversity in isolates from chickens, chicken meat, and human feces, suggesting possible transmission of ESBL-producing pathogens from chickens to humans.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Woo Bin Hyun, Hai Seong Kang, Jae Won Lee, Haftom Baraki Abraha, Kwang-Pyo Kim
Summary: This study identified a newly isolated B. subtilis BSC35 with strong antimicrobial activity against C. perfringens, highlighting the potential of BLIS as an effective inhibitor of this pathogen under optimized culture conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Immunology
Dariusz A. Hareza, Sara E. Cosgrove, Patricia J. Simner, Anthony D. Harris, Yehudit Bergman, Rick Conzemius, Emily Jacobs, Stephan Beisken, Pranita D. Tamma
Summary: This study investigated the clinical outcomes and optimal treatment methods for patients with ESBL-E bloodstream infections that do not produce CTX-M. The findings suggest that non-CTX-M and CTX-M ESBL-E infections are equally concerning and associated with similar clinical outcomes. Meropenem may be associated with improved survival in patients with non-CTX-M ESBL-E infections, highlighting the potential benefit of comprehensive molecular diagnostics for early antibiotic optimization in ESBL-E infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Qian Wu, Jing Shi, Juan Huang, Delu Gan, Lijun Zhang, Pu Li
Summary: The impact of different ESBL genotypes of E. coli on the resistance to Cefepime (FEP) was investigated in this study. The results showed that ESBL-positive E. coli induces an increase in the MIC value of FEP, leading to an increase in FEP resistance. Additionally, the inoculation effect also causes a significant increase in the MPC value of FEP, indicating selective enrichment and amplification of drug-resistant mutants, resulting in clinical treatment failure.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Svetoslav Dimitrov Todorov, Richard Weeks, Igor Popov, Bernadette Dora Gombossy de Melo Franco, Michael Leonidas Chikindas
Summary: This study focuses on two strains of lactic acid bacteria that produce bacteriocin-like inhibitor substances (BLIS) active against Candida albicans. The BLIS showed antimicrobial activity against both Listeria monocytogenes and C. albicans. It was found that the adsorption levels of BLIS to C. albicans were influenced by factors such as temperature, pH, and the presence of a contraceptive.
Article
Microbiology
Jyoti Verma, Diamond Jain, Dhriti Mallik, Anindya S. Ghosh
Summary: This study reveals that the amino acids E169 and N173, located outside the active site of CTX-M-15, play a crucial role in its beta-lactamase activity.
FEMS MICROBIOLOGY LETTERS
(2022)
Article
Astronomy & Astrophysics
Rumen Bachev, Tushar Tripathi, Alok C. Gupta, Pankaj Kushwaha, Anton Strigachev, Alexander Kurtenkov, Yanko Nikolov, Svetlana Boeva, Goran Damljanovic, Oliver Vince, Milan Stojanovic, Shubham Kishore, Haritma Gaur, Vinit Dhiman, Junhui Fan, Nibedita Kalita, Borislav Spassov, Evgeni Semkov
Summary: In this study, we observed rapid intra-night optical variations in flux and polarization of the blazar BL Lacertae during its high state of brightness. The object exhibited significant flux variability and some color changes without detectable time delays between optical bands. The linear polarization also showed high variability in both polarization degree and angle. Our observations suggest that changing Doppler factor in independent emitting regions traveling along a curved jet closely aligned with the line of sight can explain these variations during the outburst. This study provides one of the most extensive investigations of the intra-night variability in the optical polarization of a blazar.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Marwan Osman, Rafael Mahieu, Matthieu Eveillard
Summary: Through whole-genome sequencing and machine-learning analysis, researchers discovered that recurrent infections are often caused by different strains and developed a personalized algorithm to reduce antimicrobial resistance at the individual-patient level.
TRENDS IN MICROBIOLOGY
(2022)
Article
Mathematics
Hashem Bordbar
Summary: This paper investigates the binary block code generated by an arbitrary BL-algebra and its properties. It introduces the concept of BL-functions and BL-subsets to study the structure of the BL-algebra and defines a new order on the generated code.
Article
Medicine, General & Internal
Inbar Lavie, Michael Lavie, Ofek Dayan, Anat Gafter-Gvili, Dafna Yahav, Dror Kozlovski, Tomer Avni
Summary: This study did not find a pattern of 'weekend effect' or 'night effect' on all-cause mortality among hospitalised patients in internal medicine wards. However, higher mortality rates were observed on Fridays when sepsis was the cause of death. The findings suggest that death from sepsis may be used as a surrogate for measuring understaffing or quality of care.
INTERNAL MEDICINE JOURNAL
(2023)
Editorial Material
Infectious Diseases
Ana Belkin, Avshalom Leibowitz, Liat Shargian, Dafna Yahav
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Giusy Tiseo, Ili Margalit, Marco Ripa, Vanni Borghi, Hefziba Green, Virginie Prendki, Niccolo Riccardi, Yael Dishon, Giovanni Battista Perego, Alessandro Grembiale, Laura Galli, Marco Tinelli, Antonella Castagna, Cristina Mussini, Dafna Yahav, Mical Paul, Marco Falcone
Summary: The objective of this study was to identify predictors of 30-day survival in elderly patients with COVID-19. A retrospective cohort study was conducted on elderly patients hospitalized in six European sites. A predictive score (FLAMINCOV) was developed using logistic regression and validated in a separate cohort. The FLAMINCOV score showed good discrimination in predicting survival outcomes and may be beneficial for triage and management of elderly patients with COVID-19.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Geriatrics & Gerontology
Adi Turjeman, Fidi Koppel, Erica Franceschini, Dafna Yahav, Giovanni Dolci, Erica Bacca, Tanya Babich, Ebtehal Khazem, Eyal Baum, Rima Nassar, Roni Bitterman, Yael Dishon-Benatta, Nasreen Hassoun-Kheir, Antonella Santoro, Noa Eliakim-Raz, Itamar Poran, Barak Pertzov, Anat Stern, Yaakov Dickstein, Elias Maroun, Marina Raines, Marianna Meschiari, Jihad Bishara, Elad Goldberg, Claudia Venturelli, Mario Sarti, Cristina Mussini, Mical Paul, Leonard Leibovici
Summary: The study shows that RCTs do not represent the whole spectrum of patients and exclude a population with more severe illness.
Article
Infectious Diseases
Alaa Atamna, Ili Margalit, Gida Ayada, Tanya Babich, Pontus Naucler, John Karlsson Valik, Christian G. Giske, Natividad Benito, Ruben Cardona, Alba Rivera, Celine Pulcini, Manal Abdel Fattah, Justine Haquin, Alasdair Macgowan, Bibiana Chazan, Anna Yanovskay, Ronen Ben Ami, Michal Landes, Lior Nesher, Adi Zaidman-Shimshovitz, Kate McCarthy, David L. Paterson, Evelina Tacconelli, Michael Buhl, Susanna Mauer, Jesus Rodriguez-Bano, Marina de Cueto, Antonio Oliver, Enrique Ruiz de Gopegui, Angela Cano, Isabel Machuca, Monica Gozalo-Marguello, Luis Martinez-Martinez, Eva M. Gonzalez-Barbera, Iris Gomez Alfaro, Miguel Salavert, Bojana Beovic, Andreja Saje, Manica Mueller-Premru, Leonardo Pagani, Virginie Vitrat, Diamantis Kofteridis, Maria Zacharioudaki, Sofia Maraki, Yulia Weissman, Mical Paul, Yaakov Dickstei, Dafna Yahav
Summary: This study aimed to evaluate outcomes of P. aeruginosa bacteremia among older adults (> 80 years) and found that disease severity, place of acquisition, and background conditions were associated with mortality, while antimicrobial regimen was not. Therefore, preventive efforts and early diagnosis might be beneficial for improving outcomes in older adults with P. aeruginosa bacteremia.
Article
Medicine, General & Internal
Adi Turjeman, Elodie von Dach, Jose Molina, Erica Franceschini, Fidi Koppel, Dana Yelin, Yael Dishon-Benattar, Cristina Mussini, Jesus Rodriguez-Bano, Jose Miguel Cisneros, Angela Huttner, Mical Paul, Leonard Leibovici, Dafna Yahav
Summary: This study aims to compare the effect of short and long-term treatment in Gram-negative bacteremia on all-cause mortality in pre-specified subgroups. The results show that in patients with stable hemodynamics and normal temperature for 48 hours prior to discontinuation, seven days of antibiotic therapy for enterobacterales bacteremia result in similar outcomes as 14 days.
Article
Infectious Diseases
Anat Wieder-Feinsod, Tal Zilberman, Oran Erster, Gal Wagner Kolasko, Asaf Biber, Ruth Gophen, Tomer Hoffman, Vladislav Litchevsky, Liraz Olmer, Dafna Yahav, Itzchak Levy
Summary: This study aimed to describe the characteristics of overlooked cases of monkeypox infection in the 2022 outbreak. The clinical characteristics of 26 patients who were misdiagnosed with other diseases were described. The study found that monkeypox might still be commonly overlooked, especially in patients presenting with fever and sore throat or solitary ulcer as sole manifestations.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Ili Margalit, Giusy Tiseo, Marco Ripa, Vanni Borghi, Hefziba Green, Virginie Prendki, Niccolo Riccardi, Giovanni Battista Perego, Alessandro Grembiale, Laura Galli, Marco Tinelli, Antonella Castagna, Cristina Mussini, Marco Falcone, Dafna Yahav
Summary: This study assessed the effect of remdesivir on COVID-19 mortality among elderly individuals using real-world data. The results showed that remdesivir reduced mortality in patients requiring oxygen support or non-invasive mechanical ventilation, but no association was found among patients necessitating invasive mechanical ventilation.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Immunology
Matteo Rinaldi, Cecilia Bonazzetti, Mena Gallo, Giuseppe Ferraro, Maristela Freire, Debora Raquel Benedita Terrabuio, Francesco Tandoi, Renato Romagnoli, Francesco Giuseppe De Rosa, Alessandra Mularoni, Alberto Ferrarese, Patrizia Burra, Marcia Halpern, Elizabeth Balbi, Jacques Simkins, Lilian Abbo, Ignacio Morras, Mireia Cantero, Laura Alagna, Alessandra Bandera, Wanessa Trinidade Clemente, Maricela Valerio, Ainhoa Fernandez, Patricia Munoz, Liran Statlender, Dafna Yahav, Luis Fernando Aranha Camargo, Evelyne Santana Girao, Paolo Grossi, Pierluigi Viale, Stefania Curti, Maddalena Giannella
Summary: This study highlights the importance of managing infections in solid organ transplant recipients. Both the INCREMENT-SOT-CPE score and the SOFA score were identified as strong predictors of all-cause 30-day mortality in these patients.
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Microbiology
Hadas Kon, Amichay Hameir, Amir Nutman, Elizabeth Temkin, Alona Keren Paz, Jonathan Lellouche, David Schwartz, David S. Weiss, Keith S. Kaye, George L. Daikos, Anna Skiada, Emanuele Durante-Mangoni, Yael Dishon Benattar, Dafna Yahav, Vered Daitch, Mariano Bernardo, Domenico Iossa, Lena E. Friberg, Ursula Theuretzbacher, Leonard Leibovici, Yaakov Dickstein, Dina Pollak, Sigal Mendelsohn, Mical Paul, Yehuda Carmeli, AIDA Study Grp
Summary: This study investigates the prevalence of colistin heteroresistance (HR) in carbapenem-resistant Acinetobacter baumannii, its evolution into full resistance, and its clinical consequences. The results show a high prevalence of HR (67.1%) and 80.2% of the HR strains evolved into full resistance. In patients with bacteremia, HR was significantly associated with 14-day mortality.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Tomer Hoffman, Or Kriger, Shoshana Cohen, Shiraz Gefen-Halevi, Dafna Yahav, Sharon Amit
Summary: This study compared the diagnostic performance of culture-based methods, 16S rRNA PCR and sequencing, and BioFire Joint Infection Panel. It found that BioFire had equivalent diagnostic accuracy and shorter turnaround time compared to conventional methods.
INFECTIOUS DISEASES AND THERAPY
(2023)
Review
Immunology
Lior Nave, Ili Margalit, Noam Tau, Ido Cohen, Dana Yelin, Florian Lienert, Dafna Yahav
Summary: This study evaluated the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. The results provide reassuring evidence of MVA's immunogenicity and safety, but further research is needed to confirm the immunogenicity of a single dose and its clinical effectiveness.
Article
Medicine, General & Internal
Dana Yelin, Ran Levi, Chinanit Babu, Roi Moshe, Dorit Shitenberg, Alaa Atamna, Ori Tishler, Tanya Babich, Irit Shapira-Lichter, Donna Abecasis, Nira Cohen Zubary, Leonard Leibovici, Dafna Yahav, Ili Margalit
Summary: This study assessed the functional capacity of individuals with long COVID and found that even mild cases resulted in decreased physical capacity. Severe cases and impaired diffusing capacity or myalgia during recovery were identified as risk factors.
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2023)
Review
Geriatrics & Gerontology
Katrine Bukan, Toby Pearce-Slade, Mads Eiberg, Marco Tinelli, Dafna Yahav, Jose Tuells, Olivier Epaulard, Jon G. Holler, Casper Roed, Christian Soborg, Jens-Ulrik Staehr Jensen, Zitta Barrella Harboe
Summary: During the COVID-19 pandemic, there was a decrease in the exclusion of older adults from vaccine trials, but no significant change in the inclusion of immunocompromised individuals.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Correction
Immunology
Nick Anagnostou, Sophia Archuleta, Eugene Athan, Lauren Barina, Emma Best, Max Bloomfield, Jennifer Bostock, Carly Botheras, Asha Bowen, Philip Britton, Hannah Burden, Anita Campbell, Hannah Carter, Matthew Cheng, Ka Lip Chew, Ivor Russel Lee Ming Chong, Geoffrey Coombs, Peter Daley, Nick Daneman, Jane Davies, Joshua Davis, Yael Dishon-Benattar, Ravindra Dotel, Adrian Dunlop, Felicity Flack, Katie Flanagan, Hong Foo, Nesrin Ghanem-Zoubi, Stefano Giulieri, Anna Goodman, Jennifer Grant, Daniel Gregson, Stephen Guy, Amanda Gwee, Erica Hardy, Andrew Henderson, George Heriot, Benjamin Howden, Fleur Hudson, Jennie Johnstone, Shirin Kalimuddin, Dana de Kretser, Andrea Kwa, Todd Lee, Amy Legg, Roger Lewis, Martin Llewelyn, Thomas Lumley, David Lye, Derek MacFadden, Robert Mahar, Isabelle Malhame, Michael Marks, Julie Marsh, Marianne Martinello, Gail Matthews, Colin McArthur, Anna McGlothlin, Genevieve McKew, Brendan McMullan, Zoe McQuilten, Eliza Milliken, Jocelyn Mora, Susan Morpeth, Srinivas Murthy, Clare Nourse, Matthew O'Sullivan, David Paterson, Mical Paul, Neta Petersiel, Lina Petrella, Sarah Pett, David Price, Jason Roberts, James Owen Robinson, Benjamin Rogers, Benjamin Saville, Matthew Scarborough, Marc Scheetz, Oded Scheuerman, Kevin Schwartz, Simon Smith, Thomas Snelling, Marta Soares, Christine Sommerville, Andrew Stewardson, Neil Stone, Archana Sud, Robert Tilley, Steven Tong, Rebecca Turner, Jonathan Underwood, Sebastiaan van Hal, Lesley Voss, Genevieve Walls, Rachel Webb, Steve Webb, Lynda Whiteway, Heather Wilson, Terence Wuerz, Dafna Yahav
CLINICAL INFECTIOUS DISEASES
(2023)